The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Defective gap junctional intercellular communication in the carcinogenic process
Open accessAbstract
Gap junctions are membrane structures made of intercellular channels which permit the diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago, the loss of functional gap junctions has been described in cancer cells and led to the hypothesis that such type of intercellular communication is involved in the carcinogenesis process. From this time, a lot of data has been accumulated confirming that gap junctions are frequently decreased or absent in cancer cells whatever their tissue and species origins. Here, we review such data by insisting on the possible links existing between altered gap-junctional intercellular communication capacity (or the altered expression of their constitutive proteins, the connexins) and the stages of cancer progression in various cancer models. Then, we analyse particular aspects of the disturbance of connexin-mediated communication in cancer such as the cytoplasmic localization of connexins, the lack of heterologous communication between cancer cells and normal cells, the role of connexin gene mutations in cancer. In a separate part of the review, we also analyse the disturbance of gap-junctional intercellular communication during the late stages of cancer (invasion and metastasis processes).
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Cites
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Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease
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Cited by
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle
Blackiston, D. J., McLaughlin, K. A., & Levin, M. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9888 · Cited by 468
Gap junctions and cancer: communicating for 50 years
Aasen, T., Mesnil, M., Naus, C. C., Lampe, P. D., & Laird, D. W. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.105 · Cited by 369
Self-citationConnexins: a myriad of functions extending beyond assembly of gap junction channels
Dbouk, H. A., Mroue, R. M., El-Sabban, M. E., & Talhouk, R. S. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-4 · Cited by 265
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Levin, M. (2025) · BioEssays · doi:10.1002/bies.202400196 · Cited by 34
Metadata
- Authors
- Mesnil, M., Crespin, S., Avanzo, J.-L., & Zaidan-Dagli, M.-L.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 1719
- Issue
- 1-2
- Pages
- 125-145
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W1981940030
- Cited by
- 340
- References
- 89
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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