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Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton
Open accessAbstract
Adherens junctions and Tight junctions comprise two modes of cell-cell adhesion that provide different functions. Both junctional complexes are proposed to associate with the actin cytoskeleton, and formation and maturation of cell-cell contacts involves reorganization of the actin cytoskeleton. Adherens junctions initiate cell-cell contacts, and mediate the maturation and maintenance of the contact. Adherens junctions consist of the transmembrane protein E-cadherin, and intracellular components, p120-catenin, beta-catenin and alpha-catenin. Tight junctions regulate the paracellular pathway for the movement of ions and solutes in-between cells. Tight junctions consist of the transmembrane proteins occludin and claudin, and the cytoplasmic scaffolding proteins ZO-1, -2, and -3. This review discusses the binding interactions of the most studied proteins that occur within each of these two junctional complexes and possible modes of regulation of these interactions, and the different mechanisms that connect and regulate interactions with the actin cytoskeleton.
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Self-citationProteomic Analysis of in Vivo Phosphorylated Synaptic Proteins
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Regulation of motor neuron pool sorting by differential expression of type II cadherins
Price, S. R., De Marco Garcia, N. V., Ranscht, B., & Jessell, T. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00695-5 · Cited by 304
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The intestinal epithelial barrier: a therapeutic target?
Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288
Physiology and function of the tight junction
Anderson, J. M., & Van Itallie, C. M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002584 · Cited by 1,059
Blood-brain barrier tight junction permeability and ischemic stroke
Sandoval, K. E., & Witt, K. A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.005 · Cited by 964
VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity
Giannotta, M., Trani, M., & Dejana, E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.020 · Cited by 854
Metadata
- Authors
- Hartsock, A., & Nelson, W. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 1778
- Issue
- 3
- Pages
- 660-669
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2122341732
- Cited by
- 1,559
- References
- 5
- FWCI
- 34.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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