Proteomic Analysis of in Vivo Phosphorylated Synaptic Proteins

THE SYNAPTIC VESICLE CYCLE

Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491 · see citing works

Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae

Ficarro, S. B., McCleland, M. L., Stukenberg, P. T., Burke, D. J., Ross, M. M., Shabanowitz, J., Hunt, D. F., & White, F. M. (2002) · Nature Biotechnology · doi:10.1038/nbt0302-301 · Cited by 1,636 · see citing works

Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs

Obenauer, J. C. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg584 · Cited by 1,602 · see citing works

Large-scale characterization of HeLa cell nuclear phosphoproteins

Beausoleil, S. A., Jedrychowski, M. P., Schwartz, D., Elias, J. E., Villén, J., Li, J., Cohn, M. A., Cantley, L. C., & Gygi, S. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404720101 · Cited by 1,376 · see citing works

Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

Greengard, P., Valtorta, F., Czernik, A. J., & Benfenati, F. (1993) · Science · doi:10.1126/science.8430330 · Cited by 1,311 · see citing works

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

Husi, H., Ward, M. A., Choudhary, J. S., Blackstock, W. P., & Grant, S. G. N. (2000) · Nature Neuroscience · doi:10.1038/76615 · Cited by 1,194 · see citing works

Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors

Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862 · see citing works

Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities.

Carlin, R. K., Grab, D. J., Cohen, R. S., & Siekevitz, P. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.86.3.831 · Cited by 788 · see citing works

Isolation of phosphoproteins by immobilized metal (Fe3+) affinity chromatography

Andersson, L., & Porath, J. O. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90523-3 · Cited by 774 · see citing works

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

Cruz, J. C., Tseng, H.-C., Goldman, J. A., Shih, H., & Tsai, L.-H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00627-5 · Cited by 609 · see citing works

Large-scale Analysis of in Vivo Phosphorylated Membrane Proteins by Immobilized Metal Ion Affinity Chromatography and Mass Spectrometry

Nühse, T. S., Stensballe, A., Jensen, O. N., & Peck, S. C. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t300006-mcp200 · Cited by 545 · see citing works

Phosphoproteomics of the Arabidopsis Plasma Membrane and a New Phosphorylation Site Database[W]

Nühse, T. S., Stensballe, A., Jensen, O. N., & Peck, S. C. (2004) · The Plant Cell · doi:10.1105/tpc.104.023150 · Cited by 478 · see citing works

Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry

Peng, J., Kim, M. J., Cheng, D., Duong, D. M., Gygi, S. P., & Sheng, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400103200 · Cited by 473 · see citing works

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467 · see citing works

Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3‘:5‘-monophosphate-dependent protein kinase.

Kishimoto, A., Nishiyama, K., Nakanishi, H., Uratsuji, Y., Nomura, H., Takeyama, Y., & Nishizuka, Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38898-1 · Cited by 417 · see citing works

Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity

Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 380 · see citing works

Unitary Assembly of Presynaptic Active Zones from Piccolo-Bassoon Transport Vesicles

Shapira, M., Zhai, R. G., Dresbach, T., Bresler, T., Torres, V. I., Gundelfinger, E. D., Ziv, N. E., & Garner, C. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00207-1 · Cited by 354 · see citing works

Phosphoproteomic Analysis of the Developing Mouse Brain

Ballif, B. A., Villén, J., Beausoleil, S. A., Schwartz, D., & Gygi, S. P. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400085-mcp200 · Cited by 347 · see citing works

Molecular organization of the postsynaptic specialization

Sheng, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111146298 · Cited by 336 · see citing works

Proteomics Analysis of Rat Brain Postsynaptic Density

Li, K. W., Hornshaw, M. P., van der Schors, R. C., Watson, R. B., Tate, S. A., Casetta, B., Jiménez, C. R., Gouwenberg, Y., Gundelfinger, E. D., Smalla, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m303116200 · Cited by 246 · see citing works

Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses

Lónárt, G., Schoch, S., Kaeser, P. S., Larkin, C. J., Südhof, T. C., & Linden, D. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00727-x · Cited by 244 · see citing works

Structure of the SH3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding Proteins

McGee, A. W., Dakoji, S., Olsen, O., Bredt, D. S., Lim, W. A., & Prehoda, K. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00411-7 · Cited by 239 · see citing works

Protein phosphorylation and the regulation of synaptic membrane traffic

Turner, K. M., Burgoyne, R. D., & Morgan, A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01436-8 · Cited by 235 · see citing works

Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography‐tandem mass spectrometry

Yoshimura, Y., Yamauchi, Y., Shinkawa, T., Taoka, M., Donai, H., Takahashi, N., Isobe, T., & Yamauchi, T. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02136.x · Cited by 206 · see citing works

Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides

Wenschuh, H., Volkmer, R., Schmidt, M., Schulz, M., Schneider‐Mergener, J., & Reineke, U. (2000) · Biopolymers · doi:10.1002/1097-0282(2000)55:3 · Cited by 204 · see citing works

IRBIT, a Novel Inositol 1,4,5-Trisphosphate (IP3) Receptor-binding Protein, Is Released from the IP3 Receptor upon IP3 Binding to the Receptor

Ando, H., Mizutani, A., Matsuura, T., & Mikoshiba, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210119200 · Cited by 196 · see citing works

Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase.

Scott, J. D., Stofko, R. E., McDonald, J. R., Comer, J., Vitalis, E. A., & Mangili, J. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45777-8 · Cited by 186 · see citing works

Structural Characterization of the Intramolecular Interaction between the SH3 and Guanylate Kinase Domains of PSD-95

Tavares, G., Panepucci, E. H., & Brünger, A. T. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00416-6 · Cited by 163 · see citing works

Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons

Sweatt, J. D., & Kandel, E. R. (1989) · Nature · doi:10.1038/339051a0 · Cited by 132 · see citing works

Neuropathic Sensitization of Behavioral Reflexes and Spinal NMDA Receptor/CaM Kinase II Interactions Are Disrupted in PSD-95 Mutant Mice

Garry, E. M., Moss, A., Delaney, A., O’Neill, F., Blakemore, J., Bowen, J., Husi, H., Mitchell, R., Grant, S. G. N., & Fleetwood-Walker, S. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00084-8 · Cited by 125 · see citing works

CaMKII-dependent Phosphorylation Regulates SAP97/NR2A Interaction*

Gardoni, F., Mauceri, D., Fiorentini, C., Bellone, C., Missale, C., Cattabeni, F., & di Luca, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303576200 · Cited by 118 · see citing works

Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons

Kotecha, S. A., Jackson, M. F., Al‐Mahrouki, A., Roder, J., Orser, B. A., & MacDonald, J. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301946200 · Cited by 115 · see citing works

Molecular Basis for the Substrate Specificity of NIMA-related Kinase-6 (NEK6)

Lizcano, J. M., Deák, M., MORRICE, N. A., Kieloch, A., Hastie, C. J., Dong, L., Schutkowski, M., Reimer, U., & Alessi, D. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202042200 · Cited by 105 · see citing works

Phosphorylation–dependent interaction of the N‐methyl‐ d ‐aspartate receptor ε2 subunit with phosphatidylinositol 3‐kinase

Hisatsune, C., Umemori, H., Mishina, M., & Yamamoto, T. S. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00287.x · Cited by 85 · see citing works

Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents

Farr, C. D., Gafken, P. R., Norbeck, A. D., Doneanu, C. E., Stapels, M. D., Barofsky, D. F., Minami, M., & Saugstad, J. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02735.x · Cited by 82 · see citing works

Target Specificity Analysis of the Abl Kinase using Peptide Microarray Data

Rychlewski, L., Kschischo, M., Dong, L., Schutkowski, M., & Reimer, U. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.12.052 · Cited by 78 · see citing works

Diversity of Calcium Signaling by Metabotropic Glutamate Receptors

Kawabata, S., Kohara, A., Tsutsumi, R., Itahana, H., Hayashibe, S., Yamaguchi, T., & Okada, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17381 · Cited by 72 · see citing works

Analysis of Protein Phosphorylation by Hypothesis-Driven Multiple-Stage Mass Spectrometry

Chang, E. J., Archambault, V., McLachlin, D. T., Krutchinsky, A. N., & Chait, B. T. (2004) · Analytical Chemistry · doi:10.1021/ac049637h · Cited by 71 · see citing works

Identification of Phosphoproteins and Their Phosphorylation Sites in the WEHI-231 B Lymphoma Cell Line

Shu, H., Chen, S., Bi, Q., Mumby, M. C., & Brekken, D. L. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.d300003-mcp200 · Cited by 70 · see citing works

Physiological regulation of Munc18/nSec1 phosphorylation on serine‐313

Craig, T. J., Evans, G. J., & Morgan, A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01955.x · Cited by 65 · see citing works

Identification of PSD-93 as a Substrate for the Src Family Tyrosine Kinase Fyn

Nada, S., Shima, T., Yanai, H., Husi, H., Grant, S. G. N., Okada, M., & Akiyama, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303873200 · Cited by 61 · see citing works

Regulation of neuronal plasticity in the central nervous system by phosphorylation and dephosphorylation

Tokuda, M., & Hatase, O. (1998) · Molecular Neurobiology · doi:10.1007/bf02802028 · Cited by 59 · see citing works

Synapse signalling complexes and networks: machines underlying cognition

Grant, S. G. N. (2003) · BioEssays · doi:10.1002/bies.10381 · Cited by 47 · see citing works

A probability-based approach for high-throughput protein phosphorylation analysis and site localization

Beausoleil, S. A., Villén, J., Gerber, S. A., Rush, J., & Gygi, S. P. (2006) · Nature Biotechnology · doi:10.1038/nbt1240 · Cited by 1,577 · see citing works

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Hartsock, A., & Nelson, W. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.012 · Cited by 1,559 · see citing works

Proteomics by Mass Spectrometry: Approaches, Advances, and Applications

Yates, J. R., Ruse, C. I., & Nakorchevsky, A. (2009) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124934 · Cited by 1,078 · see citing works

The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View

Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works

An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets

Schwartz, D., & Gygi, S. P. (2005) · Nature Biotechnology · doi:10.1038/nbt1146 · Cited by 879 · see citing works

Quantitative Phosphoproteomics Applied to the Yeast Pheromone Signaling Pathway

Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Færgeman, N. J., Mann, M., & Jensen, O. N. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400219-mcp200 · Cited by 758 · see citing works

Large-scale phosphorylation analysis of mouse liver

Villén, J., Beausoleil, S. A., Gerber, S. A., & Gygi, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609836104 · Cited by 730 · see citing works

The Postsynaptic Organization of Synapses

Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works

Quantitative phosphoproteomic analysis of plasma membrane proteins reveals regulatory mechanisms of plant innate immune responses

Nühse, T. S., Bottrill, A. R., Jones, A. M. E., & Peck, S. C. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03192.x · Cited by 513 · see citing works

Interpreting the protein language using proteomics

Jensen, O. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1939 · Cited by 505 · see citing works

Analytical strategies for phosphoproteomics

Thingholm, T. E., Jensen, O. N., & Larsen, M. R. (2009) · PROTEOMICS · doi:10.1002/pmic.200800454 · Cited by 478 · see citing works

Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome

Collins, M., Husi, H., Yu, L., Brandon, J. M., Anderson, C. N. G., Blackstock, W., Choudhary, J., & Grant, S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03507.x · Cited by 448 · see citing works

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

Brandon, N. J., & Sawa, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3120 · Cited by 422 · see citing works

Phosphorylation Analysis by Mass Spectrometry

Steen, H., Jebanathirajah, J. A., Rush, A. J., Morrice, N. A., & Kirschner, M. W. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500135-mcp200 · Cited by 348 · see citing works

O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry

Vosseller, K., Trinidad, J. C., Chalkley, R. J., Specht, C. G., Thalhammer, A., Lynn, A. J., Snedecor, J., Guan, S., Medzihradszky, K. F., Maltby, D. A., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t500040-mcp200 · Cited by 346 · see citing works

Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics

Khidekel, N., Ficarro, S. B., Clark, P. M., Bryan, M. C., Swaney, D. L., Rexach, J. E., Sun, Y. E., Coon, J. J., Peters, E. C., & Hsieh‐Wilson, L. C. (2007) · Nature Chemical Biology · doi:10.1038/nchembio881 · Cited by 339 · see citing works

Molecular organization of the presynaptic active zone

Schoch, S., & Gundelfinger, E. D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0244-y · Cited by 334 · see citing works

‘Heads and tails’ of intermediate filament phosphorylation: multiple sites and functional insights

Omary, M. B., Ku, N., Tao, G., Toivola, D. M., & Liao, J. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.05.008 · Cited by 294 · see citing works

Integrin signalling adaptors: not only figurants in the cancer story

Cabodi, S., Leal, M. D. P. C., Stefano, P. D., & Defilippi, P. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2967 · Cited by 291 · see citing works

Targeted tandem affinity purification of PSD‐95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

Fernández, E., Collins, M. O., Uren, R. T., Kopanitsa, M. V., Komiyama, N. H., Croning, M. D. R., Zografos, L., Armstrong, J. D., Choudhary, J. S., & Grant, S. G. N. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.27 · Cited by 275 · see citing works

Architecture of the Mouse Brain Synaptome

Zhu, F., Cizeron, M., Qiu, Z., Benavides‐Piccione, R., Kopanitsa, M. V., Skene, N., Koniaris, B., DeFelipe, J., Fransén, E. A., Komiyama, N. H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.007 · Cited by 272 · see citing works

Analysis of Posttranslational Modifications of Proteins by Tandem Mass Spectrometry

Larsen, M. R., Trelle, M. B., Thingholm, T. E., & Jensen, O. N. (2006) · BioTechniques · doi:10.2144/000112201 · Cited by 253 · see citing works

Comprehensive Identification of Phosphorylation Sites in Postsynaptic Density Preparations

Trinidad, J. C., Specht, C. G., Thalhammer, A., Schoepfer, R., & Burlingame, A. L. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t500041-mcp200 · Cited by 246 · see citing works

Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts

Awadalla, P., Gauthier, J., Myers, R. A., Casals, F., Hamdan, F. F., Griffing, A. R., Côté, M., Henrion, É., Spiegelman, D., Tarabeux, J., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.019 · Cited by 235 · see citing works

Identification of protein O-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides

Chalkley, R. J., Thalhammer, A., Schoepfer, R., & Burlingame, A. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900288106 · Cited by 237 · see citing works

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

Reynolds, C. H., Garwood, C. J., Wray, S., Price, C., Kellie, S., Perera, T. P. S., Zvelebil, M., Yang, A., Sheppard, P. W., Varndell, I. M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709715200 · Cited by 226 · see citing works

Synaptic plasticity and phosphorylation

Lee, H. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.06.003 · Cited by 215 · see citing works

Multidimensional Separations-Based Shotgun Proteomics

Fournier, M. L., Gilmore, J. M., Martin‐Brown, S., & Washburn, M. P. (2007) · Chemical Reviews · doi:10.1021/cr068279a · Cited by 214 · see citing works

Enrichment techniques employed in phosphoproteomics

Fíla, J., & Honys, D. (2011) · Amino Acids · doi:10.1007/s00726-011-1111-z · Cited by 198 · see citing works

Evolutionary expansion and anatomical specialization of synapse proteome complexity

Emes, R. D., Pocklington, A., Anderson, C. N. G., Bayés, À., Collins, M., Vickers, C., Croning, M., Malik, B., Choudhary, J., Armstrong, J., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2135 · Cited by 202 · see citing works

Quantitative Analysis of Synaptic Phosphorylation and Protein Expression

Trinidad, J. C., Thalhammer, A., Specht, C. G., Lynn, A. J., Baker, P. R., Schoepfer, R., & Burlingame, A. L. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700170-mcp200 · Cited by 194 · see citing works

Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches

Kotaleski, J. H., & Blackwell, K. T. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2807 · Cited by 191 · see citing works

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation

Vanderheyden, V., Devogelaere, B., Missiaen, L., SMEDT, H. D., Bultynck, G., & Parys, J. B. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.003 · Cited by 192 · see citing works

Neuroproteomics: understanding the molecular organization and complexity of the brain

Bayés, À., & Grant, S. G. N. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2701 · Cited by 188 · see citing works

Phosphoproteomic Analysis of the Mouse Brain Cytosol Reveals a Predominance of Protein Phosphorylation in Regions of Intrinsic Sequence Disorder

Collins, M. O., Yu, L., Campuzano, I. D. G., Grant, S. G. N., & Choudhary, J. S. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700564-mcp200 · Cited by 184 · see citing works

Composition of the Synaptic PSD-95 Complex

Döṣemeci, A., Makusky, A. J., Jankowska‐Stephens, E., Yang, X., Slotta, D. J., & Markey, S. P. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700040-mcp200 · Cited by 172 · see citing works

A physical view of computational neurodynamics

Ma, J., Yang, Z., Yang, L., & Tang, J. (2019) · Journal of Zhejiang University. Science A · doi:10.1631/jzus.a1900273 · Cited by 173 · see citing works

Bassoon Specifically Controls Presynaptic P/Q-type Ca2+ Channels via RIM-Binding Protein

Davydova, D., Marini, C., King, C., Klueva, J., Bischof, F., Romorini, S., Montenegro‐Venegas, C., Heine, M., Schneider, R., Schröder, M. S., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.012 · Cited by 172 · see citing works

IRBIT Suppresses IP3 Receptor Activity by Competing with IP3 for the Common Binding Site on the IP3 Receptor

Ando, H., Mizutani, A., Kiefer, H., Tsuzurugi, D., Michikawa, T., & Mikoshiba, K. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.017 · Cited by 171 · see citing works

Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

Kosako, H., Yamaguchi, N., Aranami, C., Ushiyama, M., Kose, S., Imamoto, N., Taniguchi, H., Nishida, E., & Hattori, S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1656 · Cited by 162 · see citing works

Evolution of Synapse Complexity and Diversity

Emes, R. D., & Grant, S. G. N. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150433 · Cited by 151 · see citing works

Phosphoproteomic approaches to elucidate cellular signaling networks

Schmelzle, K., & White, F. M. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.06.004 · Cited by 155 · see citing works

Analysis of protein phosphorylation on a proteome‐scale

Collins, M. O., Yu, L., & Choudhary, J. S. (2007) · PROTEOMICS · doi:10.1002/pmic.200700145 · Cited by 150 · see citing works

Combining Protein-Based IMAC, Peptide-Based IMAC, and MudPIT for Efficient Phosphoproteomic Analysis

Cantin, G. T., Yi, W., Lu, B., Park, S. K., Xu, T., Lee, J., & Yates, J. R. (2008) · Journal of Proteome Research · doi:10.1021/pr0705441 · Cited by 145 · see citing works

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

Wang, Q., Charych, E. I., Pulito, V. L., Lee, J. B., Graziane, N., Crozier, R. A., Revilla-Sanchez, R., Kelly, M. P., Dunlop, A. J., Murdoch, H., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.87 · Cited by 141 · see citing works

Highly specific enrichment of phosphopeptides by zirconium dioxide nanoparticles for phosphoproteome analysis

Zhou, H., Tian, R., Ye, M., Xu, S., Feng, S., Pan, C., Jiang, X., Li, X., & Zou, H. (2007) · Electrophoresis · doi:10.1002/elps.200600718 · Cited by 140 · see citing works

Site-Specific Phosphorylation Profiling of Arabidopsis Proteins by Mass Spectrometry and Peptide Chip Analysis

van Bentem, S. D. L. F., Anrather, D., Dohnal, I., Roitinger, E., Csaszar, E., Joore, J., Buijnink, J., Carreri, A., Forzani, C., Lorković, Z. J., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr8000173 · Cited by 140 · see citing works

Presynaptic active zones in invertebrates and vertebrates

Ackermann, F., Waites, C. L., & Garner, C. C. (2015) · The EMBO Reports · doi:10.15252/embr.201540434 · Cited by 139 · see citing works

Systematic Review of Clinical Research on Biomarkers for Pediatric Traumatic Brain Injury

Papa, L., Ramia, M. M., Kelly, J. M., Burks, S. S., Pawlowicz, A., & Berger, R. P. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2545 · Cited by 136 · see citing works

Tandem mass spectrometry strategies for phosphoproteome analysis

Palumbo, A. M., Smith, S. A., Kalcic, C. L., Dantus, M. M., Stemmer, P. M., & Reid, G. E. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20310 · Cited by 134 · see citing works

Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks

Coba, M., Pocklington, A., Collins, M., Kopanitsa, M., Uren, R. T., Swamy, S., Croning, M., Choudhary, J., & Grant, S. (2009) · Science Signaling · doi:10.1126/scisignal.2000102 · Cited by 141 · see citing works

Phosphoproteomics strategies for the functional analysis of signal transduction

Morandell, S., Stasyk, T., Grosstessner‐Hain, K., Roitinger, E., Mechtler, K., Bonn, G. K., & Huber, L. A. (2006) · PROTEOMICS · doi:10.1002/pmic.200600058 · Cited by 128 · see citing works

Charging it up: global analysis of protein phosphorylation

Ptacek, J., & Snyder, M. P. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.08.005 · Cited by 128 · see citing works

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J. P., & Agostinho, P. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.03.006 · Cited by 129 · see citing works

Synaptic memory and CaMKII

Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works

Protection after stroke: cellular effectors of neurovascular unit integrity

Posada‐Duque, R., Barreto, G. E., & Cardona‐Gómez, G. P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00231 · Cited by 121 · see citing works

Quantitative Analysis of the Human Spindle Phosphoproteome at Distinct Mitotic Stages

Malik, R., Lenobel, R., Santamaría, A., Ries, A., Nigg, E. A., & Körner, R. (2009) · Journal of Proteome Research · doi:10.1021/pr9003773 · Cited by 122 · see citing works

Bench to bedside and back again: Molecular mechanisms of α-catenin function and roles in tumorigenesis

Benjamin, J. M., & Nelson, W. J. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.08.003 · Cited by 123 · see citing works

Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project

Shiromizu, T., Adachi, J., Watanabe, S., Murakami, T., Kuga, T., Muraoka, S., & Tomonaga, T. (2013) · Journal of Proteome Research · doi:10.1021/pr300825v · Cited by 122 · see citing works

The Role of Neuronal Complexes in Human X-Linked Brain Diseases

Laumonnier, F., Cuthbert, P. C., & Grant, S. G. N. (2007) · The American Journal of Human Genetics · doi:10.1086/511441 · Cited by 121 · see citing works

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

Li, J., Zhang, W., Yang, H., Howrigan, D. P., Wilkinson, B., Souaiaia, T., Evgrafov, O. V., Genovese, G., Clementel, V. A., Tudor, J. C., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4594 · Cited by 119 · see citing works

The MAP1B case: An old MAP that is new again

Villarroel‐Campos, D., & González-Billault, C. E. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22178 · Cited by 115 · see citing works

Drebrin contains a cryptic F-actin–bundling activity regulated by Cdk5 phosphorylation

Worth, D. C., Daly, C. N., Geraldo, S., Oozeer, F., & Gordon‐Weeks, P. R. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201303005 · Cited by 115 · see citing works

Synaptosome Proteomics

Bai, F., & Witzmann, F. A. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-5943-8_6 · Cited by 107 · see citing works

Evolution of spectrin function in cytoskeletal and membrane networks

Baines, A. J. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370796 · Cited by 107 · see citing works

Microtubule-associated Protein 1B (MAP1B) Is Required for Dendritic Spine Development and Synaptic Maturation

Tortosa, E., Montenegro‐Venegas, C., Benoist, M., Härtel, S., González-Billault, C. E., Esteban, J. A., & Ávila, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271320 · Cited by 103 · see citing works

Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

Ryan, T. J., Emes, R. D., Grant, S. G. N., & Komiyama, N. H. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-6 · Cited by 105 · see citing works

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome

Li, J., Wilkinson, B., Clementel, V. A., Hou, J., O’Dell, T. J., & Coba, M. P. (2016) · Science Signaling · doi:10.1126/scisignal.aaf6716 · Cited by 95 · see citing works

Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein

Riederer, B. M. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.11.012 · Cited by 98 · see citing works

A Population Genetic Approach to Mapping Neurological Disorder Genes Using Deep Resequencing

Myers, R. A., Casals, F., Gauthier, J., Hamdan, F. F., Keebler, J., Boyko, A. R., Bustamante, C. D., Piton, A. M., Spiegelman, D., Henrion, E., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001318 · Cited by 97 · see citing works

A protein interaction node at the neurotransmitter release site: Domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

Wang, X., Hu, B., Zieba, A., Neumann, N. G., Kasper-Sonnenberg, M., Honsbein, A., Hultqvist, G., Conze, T., Witt, W., Limbach, C., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1255-09.2009 · Cited by 96 · see citing works

A Strategy for Large-Scale Phosphoproteomics and SRM-Based Validation of Human Breast Cancer Tissue Samples

Narumi, R., Murakami, T., Kuga, T., Adachi, J., Shiromizu, T., Muraoka, S., Kume, H., Kodera, Y., Matsumoto, M., Nakayama, K. I., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr3005474 · Cited by 94 · see citing works

Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.

Scales, T., Lin, S., Kraus, M., Goold, R., & Gordon-Weeks, P. (2009) · Journal of Cell Science · doi:10.1242/jcs.040162 · Cited by 4 · see citing works

Tools for analyzing the phosphoproteome and other phosphorylated biomolecules: A review

Leitner, A., Sturm, M., & Lindner, W. F. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.07.012 · Cited by 89 · see citing works

Glial Contributions to Neural Function and Disease

Rasband, M. N. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.053744 · Cited by 88 · see citing works

Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily.

Diakowski, W., Grzybek, M., & Sikorski, A. F. (2006) · PubMed · doi:10.5603/4555 · Cited by 88 · see citing works

Calcium/Calmodulin-Stimulated Protein Kinase II (CaMKII): Different Functional Outcomes from Activation, Depending on the Cellular Microenvironment

Rostas, J. A. P., & Skelding, K. A. (2023) · Cells · doi:10.3390/cells12030401 · Cited by 85 · see citing works

Ubiquitin–Proteasome-Mediated Synaptic Reorganization: A Novel Mechanism Underlying Rapid Ischemic Tolerance

Meller, R., Thompson, S. J., Lusardi, T. A., Ordonez, A. N., Ashley, M. D., Jessick, V., Wang, W., Torrey, D. J., Henshall, D. C., Gafken, P. R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3474-07.2008 · Cited by 86 · see citing works

Recent advances in understanding the roles of Cdk5 in synaptic plasticity

Lai, K., & Ip, N. Y. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.05.001 · Cited by 86 · see citing works

The Multi-Functional Calcium/Calmodulin Stimulated Protein Kinase (CaMK) Family: Emerging Targets for Anti-Cancer Therapeutic Intervention

Brzozowski, J. S., & Skelding, K. A. (2019) · Pharmaceuticals · doi:10.3390/ph12010008 · Cited by 84 · see citing works

In vivo composition of NMDA receptor signalling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93

Delint-Ramírez, I., Fernandez, E., Bayés, À., Kicsi, E., Komiyama, N., & Grant, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1792-10.2010 · Cited by 88 · see citing works

CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation

Cai, Q., Zeng, M., Wu, X., Wu, H., Zhan, Y., Tian, R., & Zhang, M. (2021) · Cell Research · doi:10.1038/s41422-020-00439-9 · Cited by 83 · see citing works

Methods for proteomics in neuroscience

Tannu, N. S., & Hemby, S. E. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)58003-3 · Cited by 79 · see citing works

Phosphorylation of a PDZ Domain Extension Modulates Binding Affinity and Interdomain Interactions in Postsynaptic Density-95 (PSD-95) Protein, a Membrane-associated Guanylate Kinase (MAGUK)

Zhang, J., Petit, C. M., King, D., & Lee, A. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.272583 · Cited by 81 · see citing works

Cysteine string protein (CSP) and its role in preventing neurodegeneration

Burgoyne, R. D., & Morgan, A. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.03.008 · Cited by 80 · see citing works

A la carte proteomics with an emphasis on gel‐free techniques

Gevaert, K., Damme, P. V., Ghesquière, B., Impens, F., Martens, L., Helsens, K., & Vandekerckhove, J. S. (2007) · PROTEOMICS · doi:10.1002/pmic.200700114 · Cited by 80 · see citing works

The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

Sitz, J. H., Baumgärtel, K., Hämmerle, B., Papadopoulos, C., Hekerman, P., Tejedor, F. J., Becker, W. B., & Lutz, B. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.034 · Cited by 79 · see citing works

Diverse functions for the semaphorin receptor PlexinD1 in development and disease

Gay, C. M., Zygmunt, T., & Torres‐Vázquez, J. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.09.008 · Cited by 78 · see citing works

Microarray platforms for enzymatic and cell-based assays

Díaz‐Mochon, J. J., Tourniaire, G., & Bradley, M. (2006) · Chemical Society Reviews · doi:10.1039/b511848b · Cited by 76 · see citing works

Quantitative phosphoproteomics strategies for understanding protein kinase-mediated signal transduction pathways

Kosako, H., & Nagano, K. (2011) · Expert Review of Proteomics · doi:10.1586/epr.10.104 · Cited by 75 · see citing works

Reference-facilitated Phosphoproteomics

Imanishi, S. Y., Kochin, V., Ferraris, S. E., de Thonel, A., Pallari, H., Corthals, G. L., & Eriksson, J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600480-mcp200 · Cited by 75 · see citing works

Proteomics of the Synapse – A Quantitative Approach to Neuronal Plasticity

Dieterich, D. C., & Kreutz, M. R. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.051482 · Cited by 73 · see citing works

A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database

Jiménez, J. L., Hegemann, B., Hutchins, J. R. A., Peters, J., & Durbin, R. M. (2007) · Genome biology · doi:10.1186/gb-2007-8-5-r90 · Cited by 72 · see citing works

Phosphosite Mapping of P-type Plasma Membrane H+-ATPase in Homologous and Heterologous Environments

Rudashevskaya, E. L., Ye, J., Jensen, O. N., Fuglsang, A. T., & Palmgren, M. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307264 · Cited by 71 · see citing works

PACAP type I receptor transactivation is essential for IGF‐1 receptor signalling and antiapoptotic activity in neurons

Delcourt, N., Thouvenot, É., Chanrion, B., Galéotti, N., Jouin, P., Bockaert, J., & Marin, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601608 · Cited by 69 · see citing works

Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis

Sugawara, K., Shibasaki, T., Mizoguchi, A., Saito, T., & Seino, S. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01285.x · Cited by 69 · see citing works

Using phosphoproteomics to reveal signalling dynamics in plants

van Bentem, S. D. L. F., & Heribert Hirt, A. (2007) · Trends in Plant Science · doi:10.1016/j.tplants.2007.08.007 · Cited by 69 · see citing works

Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs

Zhu, J., Zhou, Q., Shang, Y., Li, H., Peng, M., Ke, X., Weng, Z., Zhang, R., Huang, X., Li, S. S. C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.107 · Cited by 68 · see citing works

Synapse diversity and synaptome architecture in human genetic disorders

Grant, S. G. N. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz178 · Cited by 67 · see citing works

Advances and applications

Fegade, U. A., & Jethave, G. (2021) · Interface science and technology · doi:10.1016/b978-0-12-818805-7.00008-4 · Cited by 68 · see citing works

The Big Picture of Synaptic Phosphorylation

(2005) · Science s STKE · doi:10.1126/stke.2722005tw73

Phosphoproteomic Analysis of Synaptosomes from Human Cerebral Cortex

DeGiorgis, J. A., Jaffe, H., Moreira, J. E., Carlotti, C. G., Leite, J. P., Pant, H. C., & Dosemeci, A. (2005) · Journal of Proteome Research · doi:10.1021/pr0498436 · Cited by 56 · see citing works

Profiling of mouse synaptosome proteome and phosphoproteome by IEF

Filiou, M. D., Bisle, B., Reckow, S., Teplytska, L., Maccarrone, G., & Turck, C. W. (2010) · Electrophoresis · doi:10.1002/elps.200900647 · Cited by 60 · see citing works

Regulatory mechanisms in postsynaptic phosphorylation networks

Coba, M. P. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.01.003 · Cited by 16 · see citing works

The synapse proteome and phosphoproteome: a new paradigm for synapse biology

Grant, S. G. N. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340059 · Cited by 50 · see citing works