Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation
Open accessAbstract
Bacosides, class of compounds extracted from the Bacopa monniera plant, exhibit interesting therapeutic properties, particularly enhancing cognitive functions and putative anti-amyloid activity. We show that bacoside-A exerted significant effects upon fibrillation and membrane interactions of the amyloidogenic fragment of the prion protein [PrP(106-126)]. Specifically, when co-incubated with PrP(106-126), bacoside-A accelerated fibril formation in the presence of lipid bilayers and in parallel inhibited bilayer interactions of the peptide aggregates formed in solution. These interesting phenomena were studied by spectroscopic and microscopic techniques, which suggest that bacoside A-promoted fibrillation reduced the concentration of membrane-active pre-fibrillar species of the prion fragment. This study suggests that induction of fibril formation and corresponding inhibition of membrane interactions are likely the underlying factors for ameliorating amyloid protein toxicity by bacoside-A.
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Bacoside-A has notable impacts on the fibrillation process and membrane interactions of the amyloidogenic fragment of the prion protein (PrP(106-126)).
“Our findings indicate that bacoside-A has notable impacts on the fibrillation process and membrane interactions of the amyloidogenic fragment of the prion protein (PrP(106-126)).”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [127]
Bacoside-A expedites fibril formation in presence of lipid bilayers and impedes interactions of peptide aggregates with bilayers in solution when coincubated with PrP(106-126).
“Specifically, when coincubated with PrP(106-126), bacoside-A expedites the formation of fibrils in the presence of lipid bilayers while simultaneously impeding the interactions of the peptide aggregates with the bilayers formed in solution.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [127]
Bacosides enhance cognitive functions and potentially exhibit anti-amyloid activity.
“Bacosides, a group of compounds derived from the BM plant, demonstrate noteworthy therapeutic characteristics, particularly in enhancing cognitive functions and potentially exhibiting anti-amyloid activity.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [127]
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- Authors
- Malishev, R., Nandi, S., Kolusheva, S., Shaham-Niv, S., Gazit, E., & Jelinek, R.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Tel Aviv University (IL)
- Corresponding author
- Jelinek, Raz
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 1858
- Issue
- 9
- Pages
- 2208-2214
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2460324495
- Cited by
- 21
- References
- 44
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- bacoside A, Bacopa monnieri, prion protein, amyloid fibril formation, membrane damage, lipid bilayers, amyloid toxicity, anti-amyloid activity, phytochemicals
- MeSH terms
- Prion Proteins, Amyloid, Membranes, Artificial, Saponins, Triterpenes
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