Bacopa monniera extract reduces amyloid levels in PSAPP mice

Holcomb, Leigh A.; Dhanasekaran, Muralikrishnan; Hitt, Angie R.; Young, Keith A.; Riggs, Mark; Manyam, Bala V.

doi:10.3233/jad-2006-9303

Cited by 156Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionGinkgo biloba and Cashew Applications

Bacopa monniera extract reduces amyloid levels in PSAPP mice

Holcomb, Leigh A., Dhanasekaran, Muralikrishnan, Hitt, Angie R., Young, Keith A., Riggs, Mark, Manyam, Bala V.·2006·Journal of Alzheimer's Disease

DOI 10.3233/jad-2006-9303

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Abstract

PSAPP mice expressing the "Swedish" amyloid precursor protein and M146L presenilin-1 mutations are a well-characterized model for spontaneous amyloid plaque formation. Bacopa monniera has a long history of use in India as an anti-aging and memory-enhancing ethnobotanical therapy. To evaluate the effect of Bacopa monniera extract (BME) on amyloid (Abeta) pathology in PSAPP mice, two doses of BME (40 or 160 mg/kg/day) were administered starting at 2 months of age for either 2 or 8 months. Our present data suggests that BME lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes present in PSAPP mice. The areas encompassed by Congo Red-positive fibrillar amyloid deposits, however, were not altered by BME treatment. The data suggest that BME has potential application in Alzheimer's disease therapeutics.

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Various CNS active Indian herbal medicines such as Withania somnifera, Centella asiatica, Celastrus paniculatus and Bacopa monnieri have shown cognitive improvement in experimental models of Alzheimer's disease when given as prophylactic treatment.
“Various CNS active Indian herbal medicines like Withania somnifera, Centella asiatica, Celastrus paniculatus and Bacopa monnieri have shown cognitive improvement in experimental models of AD when given as prophylactic treatment [43,44,45,46,47,48].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [43]
Ethanolic extract of Bacopa leaves at doses of 40 and 160 mg/kg for 2 and 8 months reduced Aβ 1-40 and 1-42 levels in the cortex of PSAPP mice.
“Holcomb et al. [43] reported that administration of ethanolic extract of Bacopa leaves at doses of 40 and 160 mg/kg for 2 and 8 months reduced Aβ 1–40 and 1–42 levels in the cortex of PSAPP mice.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [43]

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P2-072 The effect of Bacopa monniera extract on neuropathology in the doubly transgenic PSAPP Alzheimer's disease mouse model
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β amyloid precursor protein metabolism is regulated in vivo by protein kinase C in rat brain
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Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera
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Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model
Dhanasekaran, M., Holcomb, L. A., Hitt, A. R., Tharakan, B., Porter, J. W., Young, K. A., & Manyam, B. V. (2009) · Phytotherapy Research · doi:10.1002/ptr.2405 · Cited by 175 · see citing works
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Authors: Holcomb, L. A., Dhanasekaran, M., Hitt, A. R., Young, K. A., Riggs, M., & Manyam, B. V.
Affiliations: Texas A&M University System (US)
ORCID: Dhanasekaran, Muralikrishnan
Young, Keith A.
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2006-07-24
Volume: 9
Issue: 3
Pages: 243-251
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2006-9303
OpenAlex: W2403935232
Cited by: 156
References: 37
Citations by year: 2026: 5 · 2025: 6 · 2024: 14 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 13 · 2019: 9 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 10
FWCI: 2.86
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
Keywords: Bacopa monnieri, amyloid-beta
MeSH terms: Amyloid, Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cognition, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Humans, Mice, Transgenic, Motor Activity, Neurofibrils, Plant Extracts, Amyloid beta-Protein Precursor, Maze Learning, Bacopa, Mice, Presenilin-1

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Bacopa monniera extract reduces amyloid levels in PSAPP mice

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