Cited by 488Extracellular vesicles in diseaseMesenchymal stem cell researchAngiogenesis and VEGF in Cancer

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

Zhu, Wei, Huang, Ling, Li, Yahong, Zhang, Xu, Gu, Jianmei, Yan, Yongmin, Xu, Xiaomeng, Wang, Mei +2 more·2012·Cancer Letters

Abstract

Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell-cell interactions may contribute to tumor progression.

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Crossref · 10.1016/j.canlet.2011.10.002

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  • The utilization of exosomes in cancer cell cultures was based on an exosome concentration of 100-400 μg/ml reported in the literature.

    “The utilization of exosomes in cancer cell cultures were based on application of 100–400 μg/ml of exosomes concentration that has been reported in literature (Christianson et al., 2013; Zhu et al., 2012).”

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Authors
Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., Xu, X., Wang, M., Qian, H., & Xu, W.
Affiliations
Jiangsu University (CN)
Corresponding author
Xu, Wenrong
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2012-02
Volume
315
Issue
1
Pages
28-37
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2081191481
Cited by
488
References
36
Citations by year
2026: 12 · 2025: 28 · 2024: 31 · 2023: 30 · 2022: 55 · 2021: 50 · 2020: 48 · 2019: 44 · 2018: 37 · 2017: 33 · 2016: 37 · 2015: 25 · 2014: 23 · 2013: 25 · 2012: 10
FWCI
7.51
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (91129718, 81071421)
  • Natural Science Foundation of Jiangsu Province (BK2008232, BE2010703)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
exosomes, mesenchymal stem cells, bone marrow, tumor growth, tumor progression, vascular endothelial growth factor, ERK signaling, intercellular communication, xenograft models
MeSH terms
Animals, Bone Marrow Cells, Cell Differentiation, Humans, Immunohistochemistry, Male, Mice, Inbred BALB C, Neoplasms, Xenograft Model Antitumor Assays, Cell Growth Processes, Mice, Exosomes, Mesenchymal Stem Cells

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