Cited by 226Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersMemory and Neural Mechanisms

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Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

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Barrientos, Ruth M., Frank, Matthew G., Hein, Amy M., Higgins, Emily A., Watkins, Linda R., Rudy, Jerry W., Maier, Steven F.·2009·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2008.07.002PMC PMC2630971

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Abstract

We previously reported that aging F344XBN rats are more vulnerable to disruptions of memory consolidation processes following an injection of Escherichia coli than are young rats. Furthermore, this disruption was specific to hippocampal-dependent memory. In the present study we examined the time course of the proinflammatory cytokine IL-1 beta in young and old rats following a peripheral injection of E. coli. Compared to young rats, aging rats treated with E. coli showed an exaggerated and prolonged up-regulation of IL-1 beta protein in the hippocampus, but not in hypothalamus, parietal cortex, prefrontal cortex, serum or spleen. Aging rats showed greater hippocampal IL-1 beta protein levels than their young counterparts 4h after E. coli, and these levels remained significantly elevated for 8 but not 14 days after E. coli. In a second experiment, aging rats exhibited anterograde memory consolidation impairments 4 and 8 days after an E. coli injection, but not after 14 days. A third experiment revealed that following an E. coli injection, bacterial clearance from the spleen and peritoneum was not impaired in aged rats, suggesting that elevations in hippocampal IL-1 beta were not mediated by impaired clearance in the periphery in aging rats. These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection.

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Authors: Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Barrientos, Ruth M.
ORCID: Barrientos, Ruth M.
Frank, Matthew G.
Watkins, Linda R.
Rudy, Jerry W.
Maier, Steven F.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2009-01
Volume: 23
Issue: 1
Pages: 46-54
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2008.07.002
PMC: PMC2630971
OpenAlex: W2029300652
Cited by: 226
References: 57
Citations by year: 2026: 3 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 12 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 14 · 2013: 13 · 2012: 13
FWCI: 8.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5f32mh064339-03)
National Institute on Aging (R01AG028271)
National Institute of Mental Health (F32 MH064339)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: memory consolidation, aging, hippocampal-dependent memory, Escherichia coli infection, peripheral infection, inflammatory cytokines, neuroinflammation, bacterial clearance
MeSH terms: Aging, Animals, Conditioning, Psychological, Enzyme-Linked Immunosorbent Assay, Escherichia coli, Escherichia coli Infections, Fear, Hippocampus, Hypothalamus, Male, Memory, Parietal Lobe, Rats, Inbred BN, Rats, Inbred F344, Spleen, Prefrontal Cortex, Amnesia, Anterograde, Rats, Interleukin-1beta, Host-Pathogen Interactions

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Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

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