Cited by 226Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersMemory and Neural Mechanisms

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

Open access

Barrientos, Ruth M., Frank, Matthew G., Hein, Amy M., Higgins, Emily A., Watkins, Linda R., Rudy, Jerry W., Maier, Steven F.·2009·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2008.07.002PMC PMC2630971

Open this paper in CoChat — free account

Abstract

We previously reported that aging F344XBN rats are more vulnerable to disruptions of memory consolidation processes following an injection of Escherichia coli than are young rats. Furthermore, this disruption was specific to hippocampal-dependent memory. In the present study we examined the time course of the proinflammatory cytokine IL-1 beta in young and old rats following a peripheral injection of E. coli. Compared to young rats, aging rats treated with E. coli showed an exaggerated and prolonged up-regulation of IL-1 beta protein in the hippocampus, but not in hypothalamus, parietal cortex, prefrontal cortex, serum or spleen. Aging rats showed greater hippocampal IL-1 beta protein levels than their young counterparts 4h after E. coli, and these levels remained significantly elevated for 8 but not 14 days after E. coli. In a second experiment, aging rats exhibited anterograde memory consolidation impairments 4 and 8 days after an E. coli injection, but not after 14 days. A third experiment revealed that following an E. coli injection, bacterial clearance from the spleen and peritoneum was not impaired in aged rats, suggesting that elevations in hippocampal IL-1 beta were not mediated by impaired clearance in the periphery in aging rats. These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2008.07.002

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Interleukin-1 and interleukin-1 antagonism
Dinarello, C. A. (1991) · Blood · doi:10.1182/blood.v77.8.1627.1627 · Cited by 2,292
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777
Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR
McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration
Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665
NMDA Receptor-Dependent Synaptic Reinforcement as a Crucial Process for Memory Consolidation
Shimizu, E., Tang, Y., Rampon, C., & Tsien, J. Z. (2000) · Science · doi:10.1126/science.290.5494.1170 · Cited by 546

Show all 57 references

Sorted by citations

Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792
Microglial regional heterogeneity and its role in the brain
Tan, Y.-L., Yuan, Y., & Tian, L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0609-8 · Cited by 571
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function
Tan, B. L., & Norhaizan, M. E. (2019) · Nutrients · doi:10.3390/nu11112579 · Cited by 546
The role of inflammation in epileptogenesis
Vezzani, A., Friedman, A., & Dingledine, R. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.004 · Cited by 506
Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457
Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease
Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.028 · Cited by 413
Microglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
Davizon‐Castillo, P., McMahon, B. J., Águila, S., Bark, D. L., Ashworth, K. J., Allawzi, A. M., Campbell, R. A., Montenont, E., Nemkov, T. G., D’Alessandro, A., et al. (2019) · Blood · doi:10.1182/blood.2019000200 · Cited by 327
Neuroinflammation in the normal aging hippocampus
Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.007 · Cited by 338
Self-citation
Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314
The impact of ageing on monocytes and macrophages
De Maeyer, R. P. H., & Chambers, E. S. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.003 · Cited by 275
Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity
Patterson, S. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.020 · Cited by 291
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia
Fenn, A. M., Gensel, J. C., Huang, Y., Popovich, P. G., Lifshitz, J., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.014 · Cited by 283
Microglia and Memory: Modulation by Early-Life Infection
Williamson, L. L., Sholar, P. W., Mistry, R. S., Smith, S. H., & Bilbo, S. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3688-11.2011 · Cited by 274
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder
Savitz, J., Drevets, W. C., Smith, C. M., Victor, T. A., Wurfel, B. E., Bellgowan, P. S., Bodurka, J., Teague, T. K., & Dantzer, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.194 · Cited by 272
An opportunistic theory of cellular and systems consolidation
Mednick, S. C., Cai, D. J., Shuman, T., Anagnostaras, S., & Wixted, J. T. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.003 · Cited by 267
Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase
Tong, L., Prieto, G. A., Kramár, E. A., Smith, E. D., Cribbs, D. H., Lynch, G., & Cotman, C. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1253-12.2012 · Cited by 254
The role of cytokines in modulating learning and memory and brain plasticity
Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 262
Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats
Barrientos, R. M., Hein, A. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2173-12.2012 · Cited by 235
Self-citation
Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders
Gibney, S. M., & Drexhage, H. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9462-8 · Cited by 245
Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences
Hart, A. D., Wyttenbach, A., Hugh Perry, V., & Teeling, J. L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.11.006 · Cited by 230
Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.05.011 · Cited by 224
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation
Wong, W. T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00022 · Cited by 241
Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury
Witcher, K. G., Eiferman, D. S., & Godbout, J. P. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.002 · Cited by 234
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory
Spencer, S. J., D’Angelo, H. M., Soch, A., Watkins, L. R., Maier, S. F., & Barrientos, R. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.014 · Cited by 223
Self-citation
Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling
Majumder, S., Caccamo, A., Medina, D. X., Benavides, A. D., Javors, M. A., Kraig, E., Strong, R., Richardson, A. G., & Oddo, S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00791.x · Cited by 207
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198
Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats
Speisman, R. B., Kumar, A., Rani, A., Foster, T. C., & Ormerod, B. K. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.013 · Cited by 187
Role of Peripheral Inflammatory Markers in Postoperative Cognitive Dysfunction (POCD): A Meta-Analysis
Peng, L., Xu, L., & Ouyang, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079624 · Cited by 188
Cognitive dysfunction with aging and the role of inflammation
Simen, A. A., Bordner, K. A., Martin, M. P., Moy, L. A., & Barry, L. C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311399145 · Cited by 186
Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly
Baierle, M., Nascimento, S., Moro, A. M., Brucker, N., Freitas, F., Gauer, B., Durgante, J., Bordignon, S., Zibetti, M. R., Trentini, C. M., et al. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/804198 · Cited by 185
Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
d’Avila, J. C., Siqueira, L. D., Mazeraud, A., Azevedo, E. P., Foguel, D., Castro-Faria-Neto, H. C., Sharshar, T., Chrétien, F., & Bozza, F. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1059-y · Cited by 168
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism
Sobesky, J. L., Barrientos, R. M., May, H. S. D., Thompson, B. M., Weber, M. D., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.017 · Cited by 160
Self-citation
Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes
Barrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2266-11.2011 · Cited by 148
Self-citation
Inflammation in Traumatic Brain Injury
Postolache, T. T., Wadhawan, A., Can, A., Lowry, C. A., Woodbury, M., Makkar, H., Hoisington, A. J., Scott, A. J., Potocki, E., Benros, M. E., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191150 · Cited by 154
Why Pleiotropic Interventions are Needed for Alzheimer's Disease
Frautschy, S. A., & Cole, G. M. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8137-1 · Cited by 152
Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge
Muccigrosso, M. M., Ford, J., Benner, B., Moussa, D., Burnsides, C., Fenn, A. M., Popovich, P. G., Lifshitz, J., Walker, F. R., Eiferman, D. S., et al. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.009 · Cited by 146
Thinking through postoperative cognitive dysfunction: How to bridge the gap between clinical and pre-clinical perspectives
Hovens, I. B., Schoemaker, R. G., van der Zee, E. A., Heineman, E., Izaks, G. J., & van Leeuwen, B. L. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.06.004 · Cited by 146
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
Fonken, L. K., Frank, M. G., Kitt, M. M., D'Angelo, H. M., Norden, D. M., Weber, M. D., Barrientos, R. M., Godbout, J. P., Watkins, L. R., & Maier, S. F. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1161-16.2016 · Cited by 139
Self-citation
Systemic inflammation enhances surgery-induced cognitive dysfunction in mice
Fidalgo, A. R., Cibelli, M., White, J. P. M., Nagy, I., Maze, M., & Ma, D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.04.063 · Cited by 137
The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review
Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126
A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells
Green, H. F., Treacy, E., Keohane, A., Sullivan, A. M., O’Keeffe, G. W., & Nolan, Y. M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.01.001 · Cited by 121
Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLCγ1, and ERK in Hippocampal Synaptoneurosomes
Cortese, G. P., Barrientos, R. M., Maier, S. F., & Patterson, S. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5818-10.2011 · Cited by 120
Self-citation
Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo
Frank, M. G., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.05.022 · Cited by 113
Self-citation
Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain
Yan, N., Liu, Y., Liu, S., Cao, S., Wang, F., Wang, Z., & Xi, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9380-2 · Cited by 104
Redox Signaling in Neurotransmission and Cognition During Aging
Kumar, A., Yegla, B., & Foster, T. C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7111 · Cited by 106
Suppression of Inflammation with Conditional Deletion of the Prostaglandin E 2 EP2 Receptor in Macrophages and Brain Microglia
Johansson, J. U., Pradhan, S., Lokteva, L. A., Woodling, N. S., Ko, N., Brown, H. D., Wang, Q., Loh, C., Cekanaviciute, E., Buckwalter, M., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2203-13.2013 · Cited by 96
Methylene Blue Attenuates Traumatic Brain Injury-Associated Neuroinflammation and Acute Depressive-Like Behavior in Mice
Fenn, A. M., Skendelas, J. P., Moussa, D. N., Muccigrosso, M. M., Popovich, P. G., Lifshitz, J., Eiferman, D. S., & Godbout, J. P. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3514 · Cited by 94
Acetylcholinesterase Inhibitors Reduce Neuroinflammation and -Degeneration in the Cortex and Hippocampus of a Surgery Stress Rat Model
Kalb, A., von Haefen, C., Sifringer, M., Tegethoff, A., Paeschke, N., Kostova, M. H., Feldheiser, A., & Spies, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062679 · Cited by 94
Stress and aging act through common mechanisms to elicit neuroinflammatory priming
Fonken, L. K., Frank, M. G., Gaudet, A. D., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.012 · Cited by 98
Self-citation
Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
Sun, L., Dong, R., Xu, X., Yang, X., & Peng, M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0913-7 · Cited by 92
Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia
Wu, Z., Sun, L., Hashioka, S., Yu, S., Schwab, C., Okada, R., Hayashi, Y., McGeer, P. L., & Nakanishi, H. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.018 · Cited by 91
Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression
Young, K. D., Drevets, W. C., Dantzer, R., Teague, T. K., Bodurka, J., & Savitz, J. B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.007 · Cited by 91
Peripheral bacterial endotoxin administration triggers both memory consolidation and reconsolidation deficits in mice
Kranjac, D., McLinden, K. A., Deodati, L. E., Papini, M. R., Chumley, M. J., & Boehm, G. W. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.08.005 · Cited by 91
Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics?
Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85
Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy
Li, Y., HE, R., CHEN, S., & Qu, Y.-L. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2726 · Cited by 85
Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging
Corona, A. W., Fenn, A. M., & Godbout, J. P. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9313-4 · Cited by 87
Neural Plasticity in Multiple Sclerosis: The Functional and Molecular Background
Ksiazek-Winiarek, D. J., Szpakowski, P., & Glabinski, A. R. (2015) · Neural Plasticity · doi:10.1155/2015/307175 · Cited by 88
Interleukin-1β with learning and memory
Huang, Z., & Sheng, G. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-6023-5 · Cited by 89
Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats
Ding, H., Deng, Y., Yang, R., Wang, Q.-S., Jiang, W., Han, Y., Huang, L., Wen, M., Zhong, W., Li, X., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1051-y · Cited by 82
Memory impairments in healthy aging: Role of aging-induced microglial sensitization.
Barrientos, R. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2010) · PubMed Central · Cited by 80
Self-citation
Aging-related changes in neuroimmune-endocrine function: Implications for hippocampal-dependent cognition
Barrientos, R. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.010 · Cited by 88
Self-citation
High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner
Spencer, S. J., Basri, B., Sominsky, L., Soch, A., Ayala, M. T., Reineck, P., Gibson, B. C., & Barrientos, R. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.018 · Cited by 80
Self-citation
Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions
Porcher, L., Bruckmeier, S., Burbano, S. D., Finnell, J. E., Gorny, N., Klett, J., Wood, S. K., & Kelly, M. P. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02252-6 · Cited by 83
IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 × BN F1 rats
Frank, M. G., Barrientos, R. M., Hein, A. M., Biedenkapp, J. C., Watkins, L. R., & Maier, S. F. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.005 · Cited by 79
Self-citation
Modulating Neuroinflammation to Treat Neuropsychiatric Disorders
Radtke, F., Chapman, G., Hall, J., & Syed, Y. A. (2017) · BioMed Research International · doi:10.1155/2017/5071786 · Cited by 80
Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide
Carvalho, F. B., Gutierres, J. M., Bueno, A., Agostinho, P. M., Zago, A. M., Vieira, J. M., Frühauf, P., Cechella, J. L., Nogueira, C. W., Oliveira, S. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9900-8 · Cited by 76
Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization
Fonken, L. K., Kitt, M. M., Gaudet, A. D., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.019 · Cited by 77
Self-citation
Microglial Function across the Spectrum of Age and Gender
Nissen, J. C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030561 · Cited by 83
Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer’s disease
Cortese, G. P., & Bürger, C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.027 · Cited by 77
Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-κB-dependent inflammation process in a mouse model of Parkinson's disease
Anitua, E., Pascual, C., Pérez‐González, R., Orive, G., & Carro, E. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.030 · Cited by 77
Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1
Chapman, T. R., Barrientos, R. M., Ahrendsen, J. T., Maier, S. F., & Patterson, S. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5172-09.2010 · Cited by 72
Self-citation
Effects of Moderate Aerobic Exercise on Cognitive Abilities and Redox State Biomarkers in Older Adults
Alghadir, A. H., Gabr, S. A., & Al-Eisa, E. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2545168 · Cited by 81
n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging
Joffre, C., Dinel, A., Chataigner, M., Pallet, V., & Layé, S. (2020) · Nutrients · doi:10.3390/nu12030647 · Cited by 80
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia
Barrientos, R. M., Thompson, V. M., Kitt, M. M., Amat, J., Hale, M. W., Frank, M. G., Crysdale, N. Y., Stamper, C. E., Hennessey, P. A., Watkins, L. R., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.003 · Cited by 70
Self-citation
Characterization of the sickness response in young and aging rats following E. coli infection
Barrientos, R. M., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.01.016 · Cited by 64
Self-citation
The Communication Between the Immune and Nervous Systems: The Role of IL-1β in Synaptopathies
Pozzi, D., Menna, E., Canzi, A., Desiato, G., Mantovani, C., & Matteoli, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00111 · Cited by 63
Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements
Poddar, J., Pradhan, M., Ganguly, G., & Chakrabarti, S. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.04.002 · Cited by 63
Microbiota-immune interactions: from gut to brain
Salvo‐Romero, E., Stokes, P., & Gareau, M. G. (2020) · LymphoSign Journal · doi:10.14785/lymphosign-2019-0018 · Cited by 63
Beta-adrenergic receptor activation primes microglia cytokine production
Johnson, J. D., Zimomra, Z. R., & Stewart, L. T. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.08.007 · Cited by 61
Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review
Schreuder, L., Eggen, B. J. L., Biber, K. P. H., Schoemaker, R. G., Laman, J. D., & de Rooij, S. E. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.010 · Cited by 61
Aged Microglia in Neurodegenerative Diseases: Microglia Lifespan and Culture Methods
Yoo, H.-J., & Kwon, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.766267 · Cited by 65
Immune and behavioral consequences of microglial reactivity in the aged brain
Wynne, A. M., Henry, C. J., & Godbout, J. P. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp009 · Cited by 60
Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?
Vauzour, D., Martinsen, A., & Layé, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.004 · Cited by 60
Role of cytokines and reactive oxygen species in brain aging
MohanKumar, S. M. J., Murugan, A., Palaniyappan, A., & MohanKumar, P. S. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111855 · Cited by 59
An integrated cytokine and kynurenine network as the basis of neuroimmune communication
Stone, T. W., Clanchy, F. I. L., Huang, Y., Chiang, N., Darlington, L. G., & Williams, R. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002004 · Cited by 57
Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
Bok, E., Jo, M., Lee, S., Lee, B.-R., Kim, J., & Kim, H.-J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030464 · Cited by 53
“Consistent with this, systemic injection of Escherichia coli resulted in an exaggerated and prolonged upregulation of IL-1β in hippocampus of aged rats compared with young adults [70].”
Background
‘Tagging’ along memories in aging: Synaptic tagging and capture mechanisms in the aged hippocampus
Shetty, M. S., & Sajikumar, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.008 · Cited by 54
Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction
Fonken, L. K., Frank, M. G., D’Angelo, H. M., Heinze, J. D., Watkins, L. R., Lowry, C. A., & Maier, S. F. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.012 · Cited by 57
Self-citation
Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ?
Cunningham, C. M., & Skelly, D. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9312-5 · Cited by 51
Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging
Blalock, E. M., Phelps, J. T., Pancani, T., Searcy, J. L., Anderson, K. L., Gant, J. C., Popović, J., Avdiushko, M. G., Cohen, D. A., Chen, K.-C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010405 · Cited by 51
Interleukin-1 Beta −511C/T Genetic Polymorphism is Associated with Age of Onset of Geriatric Depression
Hwang, J., Tsai, S., Hong, C., Yang, C.-H., Hsu, C.-D., & Liou, Y. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8078-x · Cited by 50
Heat Shock Protein 72 Overexpression Prevents Early Postoperative Memory Decline after Orthopedic Surgery under General Anesthesia in Mice
Vizcaychipi, M. P., Xu, L., Barreto, G. E., Ma, D., Maze, M., & Giffard, R. G. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31820ad3ce · Cited by 51
Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats
Muscat, S. M., Deems, N. P., D’Angelo, H. M., Kitt, M. M., Grace, P. M., Andersen, N. D., Silverman, S. N., Rice, K. C., Watkins, L. R., Maier, S. F., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.11.008 · Cited by 50
Self-citation
Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects
Tomasoni, R., Morini, R., López‐Atalaya, J. P., Corradini, I., Canzi, A., Rasile, M., Mantovani, C., Pozzi, D., Garlanda, C., Mantovani, A., et al. (2017) · eLife · doi:10.7554/elife.21735 · Cited by 52
EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice
Wang, W., Qin, X., Wang, R., Xu, J., Wu, H., Khalid, A., Jiang, H., Liu, D., & Pan, F. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.154 · Cited by 49
Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis
Braschi, C., Capsoni, S., Narducci, R., Poli, A., Sansevero, G., Brandi, R., Maffei, L., Cattaneo, A., & Berardi, N. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01646-5 · Cited by 53
The microbiome and cognitive aging: a review of mechanisms
Komanduri, M., Gondalia, S. V., Scholey, A. B., & Stough, C. K. K. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05231-1 · Cited by 49

Authors: Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Barrientos, Ruth M.
ORCID: Barrientos, Ruth M.
Frank, Matthew G.
Watkins, Linda R.
Rudy, Jerry W.
Maier, Steven F.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2009-01
Volume: 23
Issue: 1
Pages: 46-54
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2008.07.002
PMC: PMC2630971
OpenAlex: W2029300652
Cited by: 226
References: 57
Citations by year: 2026: 3 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 12 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 14 · 2013: 13 · 2012: 13
FWCI: 8.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5f32mh064339-03)
National Institute on Aging (R01AG028271)
National Institute of Mental Health (F32 MH064339)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: memory consolidation, aging, hippocampal-dependent memory, Escherichia coli infection, peripheral infection, inflammatory cytokines, neuroinflammation, bacterial clearance
MeSH terms: Aging, Animals, Conditioning, Psychological, Enzyme-Linked Immunosorbent Assay, Escherichia coli, Escherichia coli Infections, Fear, Hippocampus, Hypothalamus, Male, Memory, Parietal Lobe, Rats, Inbred BN, Rats, Inbred F344, Spleen, Prefrontal Cortex, Amnesia, Anterograde, Rats, Interleukin-1beta, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks