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Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines
Open accessAbstract
In the elderly, systemic infection is associated with an increased frequency of behavioral and cognitive complications. We have reported that peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes an exaggerated neuroinflammatory response and prolonged sickness/depressive-like behaviors in aged BALB/c mice. Therefore, the purpose of this study was to determine the degree to which LPS-induced neuroinflammation was associated with microglia-specific induction of neuroinflammatory mediators. Here, we show that peripheral LPS challenge caused a hyperactive microglial response in the aged brain associated with higher induction of inflammatory IL-1beta and anti-inflammatory IL-10. LPS injection caused a marked induction of mRNA expression of both IL-1beta and IL-10 in the cortex of aged mice compared to adults. In the next set of studies, microglia (CD11b(+)/CD45(low)) were isolated from the brain of adult and aged mice following experimental treatments. An age-dependent increase in major histocompatibility complex (MHC) class II mRNA and protein expression was detected in microglia. Moreover, peripheral LPS injection caused a more pronounced increase in IL-1beta, IL-10, Toll-like receptor (TLR)-2, and indoleamine 2,3-dioxygenase (IDO) mRNA levels in microglia isolated from aged mice than adults. Intracellular cytokine protein detection confirmed that peripheral LPS caused the highest increase in IL-1beta and IL-10 levels in microglia of aged mice. Finally, the most prominent induction of IL-1beta was detected in MHC II(+) microglia from aged mice. Taken together, these findings provide novel evidence that age-associated priming of microglia plays a central role in exaggerated neuroinflammation induced by activation of the peripheral innate immune system.
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“Indeed, increased intestinal inflammation driven by either LPS or bacterial infection correlates with elevated levels of microglial activation and release of pro-inflammatory cytokines (Riazi et al., 2008; Henry et al., 2009).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Henry et al., 2009
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“In both humans [62] and mice [52,63,64], aged microglia adopt a pro-inflammatory profile including higher expression of genes including TNFα, IL-6, and IL-1β, as well as markers of ‘priming’ such as CD11b and MHC-II (Figure 1).”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [63]
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“Subsequent studies showed that the excessive IL-1β protein produced in the aged brain after LPS challenge was derived from the primed (MHCII positive) microglia (Henry et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Henry et al, 2009
In the citing paper
“Although IL-10 expression may indicate a compensatory step against the pro-inflammatory response, IL-1β production in aged mice was not attenuated despite presence of IL-10 (Henry et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Henry et al, 2009
In the citing paper
“It is important to note that LPS enhances expression of pro-inflammatory (eg, IL-1β) and anti-inflammatory (eg, IL-10) mediators in aged mice compared with the adult (Henry et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Henry et al, 2009
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From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071
Gene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Self-citationCunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768
Cytokine-induced sickness behavior
Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716
Innate immunity: the missing link in neuroprotection and neurodegeneration?
Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 710
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Sumsuzzman, D. M., Uddin, M. S., Kabir, M. T., Hasana, S., Perveen, A., Alanazi, I. S., Albadrani, G. M., Abdel‐Daim, M. M., & Ashraf, G. M. (2022) · Mediators of Inflammation · doi:10.1155/2022/6052932 · Cited by 12
Kumar, P., Mathew, S., Gamage, R. V., Bodkin, F., Doyle, K., Rosetti, I., Wagnon, I. M., Zhou, X., Raju, R., Gyengési, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311086 · Cited by 12
Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in App NLF Knock-In Mice
Barrett, T., Stangis, K. A., Saito, T., Saido, T. C., & Park, K. H. J. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210091 · Cited by 12
Anderson, S. T., O’Callaghan, E. K., Commins, S., & Coogan, A. N. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1124-8 · Cited by 11
Vojtěchová, I., Petrásek, T., Malenínská, K., Brožka, H., Tejkalová, H., Horáček, J., Stuchlı́k, A., & Valeš, K. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.001 · Cited by 13
Depression, Inflammation and Tryptophan Metabolism
McCusker, R. H., Kavelaars, A., Heijnen, C. J., Dantzer, R., & Kelley, K. W. (2013) · Wiley eBooks · doi:10.1002/9781118314814.ch23 · Cited by 9
Extracellular Vesicles and Immune System in Ageing and Immune Diseases
Cheon, S. Y., & Lee, J. E. (2021) · Experimental Neurobiology · doi:10.5607/en20059 · Cited by 11
Intestinal neuron-associated macrophages in health and disease
Stakenborg, N., Viola, M. F., & Boeckxstaens, G. E. (2025) · Nature Immunology · doi:10.1038/s41590-025-02150-6 · Cited by 10
Hopp, S. C., Royer, S. E., Brothers, H. M., Kaercher, R. M., D’Angelo, H. M., Bardou, I., & Wenk, G. L. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.12.010 · Cited by 9
Ohshima, R. (2015) · American Journal of BioScience · doi:10.11648/j.ajbio.20150301.13 · Cited by 10
Mansour, H. A., Hassan, W. A., & Georgy, G. S. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22020 · Cited by 10
Claudiano, G. D. S., de Moraes, F. R., Fernandes, D. C., Vantini, J. D. S., Yunis‐Aguinaga, J., Eto, S. F., Marinho-Neto, F. A., Macedo, H. J. A., Manrique, W. G., & de Moraes, J. R. E. (2020) · Comparative Clinical Pathology · doi:10.1007/s00580-020-03159-z · Cited by 10
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Cauwenberghe, C. V., Gorlé, N., & Vandenbroucke, R. E. (2020) · Physiology in health and disease · doi:10.1007/978-1-0716-0536-3_9 · Cited by 10
Hashemizadeh, S., Hosseindoost, S., Omidi, A., Aminianfar, H., Ebrahimi‐Barough, S., Ai, J., Arjmand, B., & Hadjighassem, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.993019 · Cited by 9
Vincenzo, F. D., Nicoletti, A., Negri, M., Vitale, F., Verme, L. Z. D., Gasbarrini, A., Ponziani, F. R., & Cerrito, L. (2023) · Antibiotics · doi:10.3390/antibiotics12061068 · Cited by 9
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Barrella, L., Ramírez-Ponce, M. P., Vázquez‐Román, V., Millán-Huang, M. S., y Aibar, M. D. M., Flores-Cordero, J. A., & Alés, E. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106170 · Cited by 9
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Hoogland, I. C. M., Westhoff, D., Engelen-Lee, J.-Y., Serón, M. V., Houben-Weerts, J. H. P. M., van Westerloo, D. J., van der Poll, T., van Gool, W. A., & van de Beek, D. (2021) · Cells · doi:10.3390/cells10020279 · Cited by 9
Davis, D. S., & Carson, M. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_1 · Cited by 8
Chen, L., Yue, Z., Liu, Z., Liu, H., Zhang, J., Zhang, F., Hu, T., & Fu, J. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115006 · Cited by 7
Capriotti, Z., & Klase, Z. A. (2024) · Journal of NeuroVirology · doi:10.1007/s13365-024-01239-2 · Cited by 11
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Ashraf, A., Aljuhani, M., Hubens, C. J., Jeandriens, J., Parkes, H. G., Geraki, K., Mahmood, A., Herlihy, A. H., & So, P. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1393351 · Cited by 9
Elliott, M. B., Ward, S. J., Abood, M. E., Tuma, R. F., & Jallo, J. (2017) · Concussion · doi:10.2217/cnc-2017-0010 · Cited by 8
Shah, S. Z. A., Zhao, D., Taglialatela, G., Hussain, T. A., Dong, H., Sabir, N., Mangi, M. H., Wu, W., Lai, M., Zhang, X., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051144 · Cited by 9
The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats
Barrientos, R. M., Thompson, V. M., Arnold, T. H., Frank, M. G., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.004 · Cited by 8
Tong, F., Lian, Y., & He, F. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.04.004 · Cited by 8
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Karyadi, K., Sinon, I. L. S., Yusuf, I., & Widyaningsih, S. W. (2018) · Scientiae Educatia · doi:10.24235/sc.educatia.v7i1.2415 · Cited by 9
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Siami, S., Polito, A., & Sharshar, T. (2009) · Springer eBooks · doi:10.1007/978-3-540-92276-6_74 · Cited by 8
Oxenkrug, G. F. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15630-9_8 · Cited by 8
Houle, S., Tapp, Z. M., Dobres, S., Ahsan, S., Reyes, Y., Cotter, C., Mitsch, J., Zimomra, Z., Peng, J., Rowe, R. K., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100797 · Cited by 9
Self-citationCostantini, E., Carrarini, C., Calisi, D., Rosa, M. D., Simone, M., Crosta, A. D., Palumbo, R., Cipollone, A., Aielli, L., Laurentis, M. D., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231471 · Cited by 8
Aktar, S., Kato, A., Toda, K., Takahashi, S., Maeda‐Yamamoto, M., Ferdousi, F., & Isoda, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117633 · Cited by 7
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Chen, F., Danladi, J., Ardalan, M., Nyengaard, J. R., Sánchez, C., & Wegener, G. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.008 · Cited by 7
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Salmani, H., Hosseini, M., Nabi, M. M., Noshahr, Z. S., Baghcheghi, Y., & Sadeghi, M. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.013 · Cited by 6
Kuhlman, K. R., Irwin, M. R., Ganz, P. A., Cole, S. W., Manigault, A. W., Crespi, C. M., & Bower, J. E. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.019 · Cited by 8
Shulyatnikova, T. V., Tumanskiy, V. A., & Hayden, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214455 · Cited by 8
Costa, M. R., Santos, A. Y. I. D., de Miranda, T. B., Aires, R., Coque, A. D. C., Hurtado, E. C. P., Bernardi, M. M., Pecorari, V. G. A., Andia, D. C., Birbrair, A., et al. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148180 · Cited by 7
Hoeijmakers, L., Meerhoff, G. F., de Vries, J. W., Ruigrok, S. R., van Dam, A., LEUVEN, F. V., Kőrösi, A., & Lucassen, P. J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.013 · Cited by 7
Deng, H., Li, J., Shah, A. A., Lin, G., Chen, H., & Ouyang, W. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108518 · Cited by 9
Nikaido, Y., Midorikawa, Y., Furukawa, T., Shimoyama, S., Takekawa, D., Kitayama, M., Ueno, S., Kushikata, T., & Hirota, K. (2022) · Scientific Reports · doi:10.1038/s41598-021-03981-7 · Cited by 6
Alves, A. C. D. B., Santos, N. D. S., Pires, A. S., Speck, A. E., Nery, T., Bastos-Pereira, A. L., Scheffer, D. D. L., Prediger, R. D., Latini, A., & Aguiar, A. S. (2025) · ACS Omega · doi:10.1021/acsomega.5c05266 · Cited by 5
Machado, R., Mathias, K., Coral, C., dos Santos, D. C., Bonfante, S., Stork, S. D. S., Tiscoski, A. D. B., Maragno, V. D. A., Silva, A. M., Gomes, H. M., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05557-2 · Cited by 4
Nizzero, M., Schweiger, V., Martini, A., Gottin, L., Varrassi, G., Balzo, G. D., Secchettin, E., Polati, L., Coaccioli, S., & Polati, E. (2025) · Exploration of Immunology · doi:10.37349/ei.2025.1003206 · Cited by 5
Xia, W., Xu, Y., Gong, Y., Cheng, X., Tian-gui, Y., & Yu, G. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2049371 · Cited by 5
RetractedUzoni, A., Ciobanu, O., Sandu, R. E., Bugă, A. M., & Popa‐Wagner, A. (2015) · Discoveries · doi:10.15190/d.2015.31 · Cited by 5
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Deak, T., Burzynski, H. E., Nunes, P. T., Day, S. M., & Savage, L. M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_12 · Cited by 3
Otto‐Dobos, L. D., dos Santos, J. C., Strehle, L. D., Grant, C. V., Simon, L. A., Oliver, B., Godbout, J. P., Sheridan, J. F., Barrientos, R. M., Glasper, E. R., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15830 · Cited by 4
Self-citationEffects of age on retinal macrophage responses to acute elevation of intraocular pressure
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Petitto, G. K. H. J. M. (2014) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000170 · Cited by 4
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Fourrier, C., Capuron, L., & Castanon, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00020-9 · Cited by 4
Reijne, A. C., Talarovičová, A., Čiapaitė, J., Bruggink, J. E., Bleeker, A., Groen, A. K., Reijngoud, D., Bakker, B. M., & van Dijk, G. (2019) · Aging · doi:10.18632/aging.101857 · Cited by 4
Fenn, A. M., Corona, A. W., & Godbout, J. P. (2013) · Wiley eBooks · doi:10.1002/9781118314814.ch16 · Cited by 4
Self-citationGenetic correlations between gut microbiota genera and Alzheimer’s DiseasePreprint
Cammann, D., Lu, Y., Cummings, M. J., Zhang, M. L., Cue, J. M., Do, J., Ebersole, J. L., Chen, X., Oh, E. C. T., Cummings, J. L., et al. (2022) · medRxiv · doi:10.1101/2022.09.26.22280374 · Cited by 4
Chowdhury, R., Hendlinger, A., Rieß, O., & Schulze-Hentrich, J. M. (2025) · Epigenomics · doi:10.1080/17501911.2025.2518909 · Cited by 3
Barbe, M. F., Lambi, A. G., Harris, M. Y., Patel, P. R., Tamas, I. P., McGonagle, E. R., Bas, M. V. D., Kalicharan, B. A., Holt-Bright, L. T., Popoff, S. N., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1500795 · Cited by 3
Qiao, S.-N., Wang, S. E., Kim, K.-Y., Jo, S., & Jiang, Y.-H. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03534-2 · Cited by 5
Bárány, Z. B., Tóth, I., Jócsák, G., Frenyó, L. V., Bartha, T., Sterczer, Á., & Kiss, D. S. (2021) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12650 · Cited by 3
Ilyin, N. P., Galstyan, D. S., Zolotova, A. E., Golushko, N. I., Tolkunova, V. N., Saklakova, D. K., Martynov, D. D., Apukhtin, K. V., Stewart, A., de Abreu, M. S., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115676 · Cited by 3
Electroacupuncture Alleviate Lung Injury of Sepsis Through α7nAChR and NF-κB Signaling Pathway
Shi, X.-X., Du, L., Fan, Z., Su, B., Chen, Y., Fang, Z., & Zhang, X. (2022) · Intensive Care Research · doi:10.1007/s44231-022-00008-1 · Cited by 3
Bryan, E. E., Bode, N., Chen, X., Burris, E. S., Johnson, D. C., Dilger, R. N., & Dilger, A. C. (2024) · Journal of Animal Science · doi:10.1093/jas/skad424 · Cited by 3
Dong, L., He, H., Chen, Z., Wang, X., Li, Y., Lü, G., Wang, B., & Kuang, L. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70269 · Cited by 3
Yang, A. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.1372 · Cited by 3
Green, C. L., Englund, D. A., Das, S., Herrerias, M. M., Yousefzadeh, M. J., Grant, R. A., Clark, J. P., Pak, H. H., Liu, P., Bai, H., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab210 · Cited by 4
Alves, A. C. D. B., Pires, A. S., Speck, A. E., Lopes, S. C., Scheffer, D. D. L., Melo, H. M., Prediger, R. D., Martins, R. D. P., Latini, A., & Aguiar, A. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.05.429925 · Cited by 3
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Bowen, J., Hanna, K., Young, A. M. J., Helfer, G., & McLean, S. L. (2026) · Brain and Behavior · doi:10.1002/brb3.71395 · Cited by 2
Mela, V., Gaban, A. S., Shatz, P. M., Guillot‐Sestier, M., & Lynch, M. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03235-9 · Cited by 2
Liu, L., Liu, M., Zhang, D., Song, Z., & Zhang, H. (2023) · Brain and Behavior · doi:10.1002/brb3.3180 · Cited by 2
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Yin, W., Godbout, J. P., & Sheridan, J. F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-817558-3.00007-x · Cited by 6
Self-citationRoles of Innate Immunity and Inflammation in the Aging Brain
Okun, E., Chen, X., Bašta, M., & Mattson, M. P. (2011) · Oxidative stress and disease · doi:10.1201/b11014-2 · Cited by 2
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Castanon, N. (2015) · Springer eBooks · doi:10.1007/978-3-319-11870-3_25 · Cited by 2
Teeling, J. L., & Asuni, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_8 · Cited by 3
Al-Mathkhury, H. J. F., Flayyih, M. T., & TAWFIQ, H. K. (2012) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1104-9 · Cited by 2
Anton, P. E., Nagpal, P., Moreno, J. A., Burchill, M. A., Chatterjee, A., Busquet, N., Mesches, M. H., Kovacs, E. J., & McCullough, R. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.26.582114 · Cited by 2
Louie, A. Y., Drnevich, J. M., Johnson, J. L., Woodard, M., Kukekova, A. V., Johnson, R. W., & Steelman, A. J. (2024) · iScience · doi:10.1016/j.isci.2024.110464 · Cited by 2
Breivik, T. J., Gjermo, P. E., Opstad, P. K., Murison, R. C. C., von Hörsten, S., & Fristad, I. (2025) · Life · doi:10.3390/life15101572 · Cited by 2
de Toledo, D. N. M., Carlos, N., Dantas-Vieira, G. C., Burle, M. M. D. C., Duarte-Junior, L. D. A., Castro, M. C. D. O., dos Santos, T. R., Costa, G. D. P., de Azevedo, C. S., Costa, D. C., et al. (2026) · Immunobiology · doi:10.1016/j.imbio.2026.153182 · Cited by 1
Lyu, J., Nagarajan, R., Sharmin, D., Mondal, P., Kambali, M., Wang, M., Zhou, J., Inoue, M., Cook, J. M., & Rudolph, U. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70474 · Cited by 1
Shan, X., Shi, L., Zhu, T., Liang, X., Yang, J., Zhou, G., He, L., Mei, B., Wang, S., & Li, F. (2026) · Environment International · doi:10.1016/j.envint.2026.110422 · Cited by 1
Ginsenoside Rg1 Attenuates Neuroinflammation Following Systemic Lipopolysaccharide Treatment in Mice
Shin, J.-W., Ma, S.-H., Lee, J.-W., Kim, D., Do, K., & Sohn, N. (2013) · The Korea Journal of Herbology · doi:10.6116/kjh.2013.28.6.145 · Cited by 1
5. T cell immunity and neuroplasticity.
Huang, Z. L., Ha, G. K., & Petitto, J. M. (2013) · PubMed · Cited by 1
Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration
Triolo-Mieses, M., Fadić, R., & Rommy von Bernhardi, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_180-1 · Cited by 1
Alsegiani, A. S., & Shah, Z. A. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.09.003 · Cited by 1
A model-based clinically-relevant chemotherapy scheduling algorithm for anticancer agents
Ho, T. (2014) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Boondam, Y., & Cheepsunthorn, P. (2014) · Asian Biomedicine · doi:10.5372/1905-7415.0802.299 · Cited by 1
Molecular Aspects of Hippocampal Aging
Temido‐Ferreira, M., & Lopes, L. V. (2020) · Springer eBooks · doi:10.1007/978-3-030-40955-5_3 · Cited by 1
Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration
Triolo-Mieses, M., Fadić, R., & Rommy von Bernhardi, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_180 · Cited by 1
Ferreira, J. P. S., Bella, D. D., Andreotti, D. Z., Cortes, B. F. S., de Carvalho, M. H. C., Kawamoto, E. M., & Rodrigues, S. F. (2023) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2023.3502 · Cited by 1
Fenn, A. M., Norden, D. M., & Godbout, J. P. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch6 · Cited by 1
Self-citationInfluenza A infection accelerates disease-associated microglia formation during physiological agingPreprint
Grant, R. A., Runyan, C. E., Minogue, G., Stoolman, J. S., Watanabe, S., Chen, F., Senkow, K. J., Cusick, L., Schleck, M. J., Nafikova, R. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.11.693336 · Cited by 1
Cleland, A. (2010) · The Knowledge Bank (The Ohio State University)
Deconstructing Neuronal and Astroglial Contributions to Sleep and Inflammatory Immune Responses.
Ingiosi, A. M. (2015) · Deep Blue (University of Michigan)
Obesity‐ and Neuroinflammation‐Associated Mood and Cognitive Disorders
Castanon, N., Luheshi, G. N., & Layé, S. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch9
Ageing and the Immune Response in the CNS
Raj, D. D. A., Eggen, B. J. L., & Boddeke, H. W. G. M. (2014) · Wiley eBooks · doi:10.1002/9781118406557.ch4
Metadata
- Authors
- Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Godbout, Jonathan P.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 23
- Issue
- 3
- Pages
- 309-317
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2692986
- OpenAlex
- W2159822434
- Cited by
- 565
- References
- 63
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 26 · 2023: 26 · 2022: 35 · 2021: 39 · 2020: 38 · 2019: 29 · 2018: 42 · 2017: 36 · 2016: 47 · 2015: 41 · 2014: 40 · 2013: 38 · 2012: 33
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG033028)
- National Institute of Mental Health (R21MH077817)
- National Institute of Allergy and Infectious Diseases (R32-AI-05-5411)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lipopolysaccharide challenge, neuroinflammation, aging, IL-1β, IL-10, MHC class II, TLR2, indoleamine 2,3-dioxygenase, microglia, cognitive aging, depression-like behavior, systemic infection
- MeSH terms
- Aging, Analysis of Variance, Animals, Brain, Cerebral Cortex, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Injections, Intraperitoneal, Lipopolysaccharides, Male, Mice, Inbred BALB C, RNA, Messenger, Polymerase Chain Reaction, Interleukin-10, Microglia, Mice, Interleukin-1beta
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