The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines
Open accessAbstract
In the elderly, systemic infection is associated with an increased frequency of behavioral and cognitive complications. We have reported that peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes an exaggerated neuroinflammatory response and prolonged sickness/depressive-like behaviors in aged BALB/c mice. Therefore, the purpose of this study was to determine the degree to which LPS-induced neuroinflammation was associated with microglia-specific induction of neuroinflammatory mediators. Here, we show that peripheral LPS challenge caused a hyperactive microglial response in the aged brain associated with higher induction of inflammatory IL-1beta and anti-inflammatory IL-10. LPS injection caused a marked induction of mRNA expression of both IL-1beta and IL-10 in the cortex of aged mice compared to adults. In the next set of studies, microglia (CD11b(+)/CD45(low)) were isolated from the brain of adult and aged mice following experimental treatments. An age-dependent increase in major histocompatibility complex (MHC) class II mRNA and protein expression was detected in microglia. Moreover, peripheral LPS injection caused a more pronounced increase in IL-1beta, IL-10, Toll-like receptor (TLR)-2, and indoleamine 2,3-dioxygenase (IDO) mRNA levels in microglia isolated from aged mice than adults. Intracellular cytokine protein detection confirmed that peripheral LPS caused the highest increase in IL-1beta and IL-10 levels in microglia of aged mice. Finally, the most prominent induction of IL-1beta was detected in MHC II(+) microglia from aged mice. Taken together, these findings provide novel evidence that age-associated priming of microglia plays a central role in exaggerated neuroinflammation induced by activation of the peripheral innate immune system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Indeed, increased intestinal inflammation driven by either LPS or bacterial infection correlates with elevated levels of microglial activation and release of pro-inflammatory cytokines (Riazi et al., 2008; Henry et al., 2009).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Henry et al., 2009
In the citing paper
“In both humans [62] and mice [52,63,64], aged microglia adopt a pro-inflammatory profile including higher expression of genes including TNFα, IL-6, and IL-1β, as well as markers of ‘priming’ such as CD11b and MHC-II (Figure 1).”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [63]
In the citing paper
“Subsequent studies showed that the excessive IL-1β protein produced in the aged brain after LPS challenge was derived from the primed (MHCII positive) microglia (Henry et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Henry et al, 2009
In the citing paper
“Although IL-10 expression may indicate a compensatory step against the pro-inflammatory response, IL-1β production in aged mice was not attenuated despite presence of IL-10 (Henry et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Henry et al, 2009
In the citing paper
“It is important to note that LPS enhances expression of pro-inflammatory (eg, IL-1β) and anti-inflammatory (eg, IL-10) mediators in aged mice compared with the adult (Henry et al, 2009).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Henry et al, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071
Gene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Self-citationCunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768
Cytokine-induced sickness behavior
Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716
Innate immunity: the missing link in neuroprotection and neurodegeneration?
Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 710
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 566
Xu, Y., Au, N. P. B., & Ma, C. H. E. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.896852 · Cited by 68
Willette, A. A., Coe, C. L., Birdsill, A. C., Bendlin, B. B., Colman, R. J., Alexander, A. L., Allison, D. B., Weindruch, R. H., & Johnson, S. C. (2013) · AGE · doi:10.1007/s11357-013-9518-y · Cited by 62
Ghosh, A., Birngruber, T., Sattler, W., Altendorfer‐Kroath, T., Ratzer, M., Sinner, F. M., & Pieber, T. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098143 · Cited by 62
Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration
Catalão, C. H. R., Santos-Júnior, N. N., da Costa, L. H. A., Souza, A. D. O., Alberici, L. C., & Rocha, M. J. A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0218-3 · Cited by 63
Links between inflammation, amygdala reactivity, and social support in breast cancer survivors
Muscatell, K. A., Eisenberger, N. I., Dutcher, J. M., Cole, S. W., & Bower, J. E. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.008 · Cited by 60
Tyburski, A. L., Cheng, L., Assari, S., Darvish, K. K., & Elliott, M. B. (2017) · The Journal of Headache and Pain · doi:10.1186/s10194-017-0726-1 · Cited by 61
Healthy Brain Aging Modifies Microglial Calcium Signaling In Vivo
Olmedillas, M., Asavapanumas, N., Uzcategui, N. L., & Garaschuk, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030589 · Cited by 60
Dugan, A. M., Parrott, J. M., Redus, L., Hensler, J. G., & O’Connor, J. C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv089 · Cited by 61
Rodrigues, F. T. S., de Souza, M. R. M., Lima, C. N. D. C., da Silva, F. E. R., Costa, D. V. D. S., dos Santos, C. C., Miyajima, F., de Sousa, F. C. F., Vasconcelos, S. M. M., Barichello, T., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.10.003 · Cited by 64
Meng, J., Han, L., Zheng, N., Wang, T., Xu, H., Jiang, Y., Wang, Z., Liu, Z., Zheng, Q., Zhang, X., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1644-21.2022 · Cited by 66
Wangler, L. M., & Godbout, J. P. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.08.008 · Cited by 61
Self-citationThe Role of Glial Cell Senescence in Alzheimer's Disease
Alshaebi, F., Sciortino, A., & Kayed, R. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70051 · Cited by 60
Age-Dependent Changes in the Activation and Regulation of Microglia
Cornejo, F., & Rommy von Bernhardi, M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-40764-7_10 · Cited by 61
Schreuder, L., Eggen, B. J. L., Biber, K. P. H., Schoemaker, R. G., Laman, J. D., & de Rooij, S. E. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.010 · Cited by 61
Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities
Lyu, J., Jiang, X., Leak, R. K., Shi, Y., Hu, X., & Chen, J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00857-2 · Cited by 63
Aging, depression and dementia: The inflammatory process
Carrera-González, M. P., Cantón-Habas, V., & Rich‐Ruiz, M. (2022) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/149897 · Cited by 61
Immune and behavioral consequences of microglial reactivity in the aged brain
Wynne, A. M., Henry, C. J., & Godbout, J. P. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp009 · Cited by 60
Self-citationRigillo, G., Vilella, A., Benatti, C., Schaeffer, L., Brunello, N., Blom, J. M. C., Zoli, M., & Tascedda, F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.019 · Cited by 58
Perfusion deficits, inflammation and aging precipitate depressive behaviour
Popa‐Wagner, A., Bugă, A. M., Tica, A. A., & Albu, C. V. (2014) · Biogerontology · doi:10.1007/s10522-014-9516-1 · Cited by 59
Oxenkrug, G. F. (2011) · Europe PMC (PubMed Central) · Cited by 58
Interleukin-4 affects microglial autophagic flux
Tang, R.-H., Qi, R.-Q., & Liu, H.-Y. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.255975 · Cited by 59
Inflammation: A novel target of current therapies for hepatic encephalopathy in liver cirrhosis
Luo, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11815 · Cited by 60
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging
Wilhelm, I., Nyúl-Tóth, Á., Kozma, M., Farkas, A. E., & Krizbai, I. A. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00106.2017 · Cited by 56
Investigation of Sex Differences in the Microglial Response to Binge Ethanol and Exercise
Barton, E. A., Baker, C., & Leasure, J. L. (2017) · Brain Sciences · doi:10.3390/brainsci7100139 · Cited by 55
Ajikumar, A., Long, M. B., Heath, P. R., Wharton, S. B., Ince, P. G., Ridger, V. C., & Simpson, J. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205227 · Cited by 59
O’Neil, S. M., Hans, E., Jiang, S., Wangler, L. M., & Godbout, J. P. (2022) · Glia · doi:10.1002/glia.24147 · Cited by 60
Self-citationLow-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging
Yin, Z., Raj, D. D. A., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., Zhang, X., Moser, J., Brouwer, N., Heeringa, P., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00065 · Cited by 58
Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
Bok, E., Jo, M., Lee, S., Lee, B.-R., Kim, J., & Kim, H.-J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030464 · Cited by 53
“In addition, elevated levels of IL-1β after systemic injection of LPS were mainly derived from MHC II (a marker for primed microglia)-positive microglia in the aged mouse brain [37].”
BackgroundInfluentialPourganji, M., Hosseini, M., Soukhtanloo, M., Zabihi, H., & Hadjzadeh, M. A.-R. (2014) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.13954 · Cited by 53
Microglia modulate respiratory rhythm generation and autoresuscitation
Lorea-Hernández, J. J., Morales, T., Rivera‐Angulo, A., Alcantara‐Gonzalez, D., & Peña‐Ortega, F. (2015) · Glia · doi:10.1002/glia.22951 · Cited by 51
Loram, L. C., Grace, P. M., Strand, K. A., Taylor, F. R., Ellis, A., Berkelhammer, D. L., Bowlin, M., Skarda, B., Maier, S. F., & Watkins, L. R. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.003 · Cited by 53
Trojan, E., Ślusarczyk, J., Chamera, K., Kotarska, K., Głombik, K., Kubera, M., & Basta‐Kaim, A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00779 · Cited by 54
Long-term environmental enrichment affects microglial morphology in middle age mice
Ali, S., Liu, X., Queen, N. J., Patel, R. S., Wilkins, R. K., Mo, X. M., & Cao, L. (2019) · Aging · doi:10.18632/aging.101923 · Cited by 54
Zhang, Z., Zheng, X., Zhang, X., Zhang, Y., Huang, B., & Luo, T. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13271 · Cited by 51
Lassarén, P., Lindblad, C., Frostell, A., Carpenter, K. L. H., Guilfoyle, M. R., Hutchinson, P. J., Helmy, A. E., & Thelin, E. P. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02264-2 · Cited by 53
Intracranial electrode implantation produces regional neuroinflammation and memory deficits in rats
Hirshler, Y., Polat, U., & Biegon, A. R. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.006 · Cited by 52
Daulatzai, M. A. (2012) · Sleep Disorders · doi:10.1155/2012/251096 · Cited by 51
Ziebell, J. M., Rowe, R. K., Muccigrosso, M. M., Reddaway, J., Adelson, P. D., Godbout, J. P., & Lifshitz, J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.008 · Cited by 55
Self-citationBiological Aging and the Cellular Pathogenesis of Huntington’s Disease
Machiela, E., & Southwell, A. L. (2020) · Journal of Huntington s Disease · doi:10.3233/jhd-200395 · Cited by 54
Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain
Santoro, A., Spinelli, C. C., Martucciello, S., Nori, S. L., Capunzo, M., Puca, A. A., & Ciaglia, E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0118-003r · Cited by 50
Sulakhiya, K., Kumar, P., Gurjar, S. S., Barua, C. C., & Hazarika, N. K. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.02.015 · Cited by 50
Detection of Serum Interleukin‐6/10/18 Levels in Sepsis and Its Clinical Significance
Feng, M., Sun, T., Zhao, Y., & Zhang, H. (2016) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21977 · Cited by 50
Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes
Martins, R. D. P., Ghisoni, K., Lim, C. K., Aguiar, A. S., Guillemin, G. J., & Latini, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.022 · Cited by 50
Novel Players in the Aging Synapse: Impact on Cognition
Temido‐Ferreira, M., Coelho, J. E., Pousinha, P. A., & Lopes, L. V. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0013 · Cited by 57
Daulatzai, M. A. (2012) · Neurochemical Research · doi:10.1007/s11064-011-0680-2 · Cited by 49
Kure, C., Timmer, J. K., & Stough, C. K. K. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00117 · Cited by 51
Sepsis-associated encephalopathy
Sonneville, R., Rauturier, C., Verdonk, F., Chrétien, F. C., & Sharshar, T. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139248822.041 · Cited by 48
Luo, M., Xin, R., Hu, F.-R., Li, Y., Hu, S., & Bai, F. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.144 · Cited by 51
Elahi, M., Hasan, Z., Motoi, Y., Matsumoto, S., Ishiguro, K., & Hattori, N. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150820 · Cited by 47
Robson, M. J., Zhu, C.-B., Quinlan, M. A., Botschner, D. A., Baganz, N. L., Lindler, K. M., Thome, J. G., Hewlett, W. A., & Blakely, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150068 · Cited by 47
Basak, J. M., Ferreiro, A., Cohen, L. S., Sheehan, P. W., Nadarajah, C. J., Kanan, M. F., Sukhum, K. V., Dantas, G., & Musiek, E. S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105292 · Cited by 46
Basic Aspects of the Immunology of Neuroinflammation
Wohleb, E. S., & Godbout, J. P. (2013) · Modern trends in psychiatry · doi:10.1159/000343964 · Cited by 49
Self-citationFeeding the beast: Can microglia in the senescent brain be regulated by diet?
Johnson, R. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.022 · Cited by 44
Murta, V., Farías, M. I., Pitossi, F. J., & Ferrari, C. C. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.11.023 · Cited by 43
Antonson, A. M., Radlowski, E. C., Lawson, M. A., Rytych, J. L., & Johnson, R. W. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.019 · Cited by 47
Giridharan, V. V., Réus, G. Z., Selvaraj, S., Scaini, G., Barichello, T., & Quevedo, J. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.001 · Cited by 44
FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism
Criado‐Marrero, M., Smith, T. M., Gould, L. A., Kim, S., Penny, H. J., Sun, Z., Gulick, D., Dickey, C. A., & Blair, L. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100143 · Cited by 45
Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries
Hussain, M. S., Gupta, G., Samuel, V. P., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Saleem, S., Khan, R., Altwaijry, N., Patel, S. G., et al. (2023) · Reviews in Medical Virology · doi:10.1002/rmv.2491 · Cited by 43
Cytokines and neuronal channels: A molecular basis for age-related decline of neuronal function?
Viviani, B., & Boraso, M. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.008 · Cited by 46
Ghosh, S., Choudhury, S., Chowdhury, O., Mukherjee, S., Das, A., Sain, A., Gupta, P., Adhikary, A., & Chattopadhyay, S. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109521 · Cited by 44
The need to incorporate aged animals into the preclinical modeling of neurological conditions
Sun, M., McDonald, S. J., Brady, R. D., Collins‐Praino, L. E., Yamakawa, G. R., Monif, M., O'Brien, T. J., CLOUD, G. C., Sobey, C. G., Mychasiuk, R., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.027 · Cited by 44
The pro‐inflammatory microRNA miR‐155 influences fibrillar β‐Amyloid1‐42 catabolism by microglia
Aloi, M. S., Prater, K. E., Sopher, B., Davidson, S., Jayadev, S., & Garden, G. A. (2021) · Glia · doi:10.1002/glia.23988 · Cited by 43
Balietti, M., Giannubilo, S. R., Giorgetti, B., Solazzi, M., Turi, A., Casoli, T., Ciavattini, A., & Fattoretti, P. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7131 · Cited by 42
Neurological events related to influenza A ( H 1 N 1) pdm09
Cárdenas, G., Soto‐Hernández, J. L., Díaz-Alba, A., Ugalde, Y., Mérida‐Puga, J., Rosetti, M., & Sciutto, E. (2014) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12241 · Cited by 42
Elmore, M. R. P., Burton, M. D., Conrad, M. S., Rytych, J. L., Alstine, W. G. V., & Johnson, R. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2180-13.2014 · Cited by 41
Nikodémová, M., Small, A. L., Kimyon, R. S., & Watters, J. J. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00129.2015 · Cited by 46
Perkins, A. E., Piazza, M. K., & Deak, T. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.028 · Cited by 43
Singh, V., Mitra, S., Sharma, A. K., Gera, R., & Ghosh, D. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500046k · Cited by 41
Shinozaki, G., Braun, P., Hing, B. W. Q., Ratanatharathorn, A. D., Klisares, M. J., Duncan, G. N., Jellison, S. S., Heinzman, J. T., Nagahama, Y., Close, L. N., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00311 · Cited by 39
Xu, Y., Nygård, M., Kristensson, K., & Bentivoglio, M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.006 · Cited by 42
Neurologic Complications of Influenza B Virus Infection in Adults, Romania
Popescu, C. P., Florescu, S. A., Lupulescu, E., Zaharia, M. F., Ţârdei, G., Lazăr, M., Ceaușu, E., & Ruță, S. M. (2017) · Emerging infectious diseases · doi:10.3201/eid2304.161317 · Cited by 40
Sharma, R., Zamani, A., Dill, L. K., Sun, M., Chu, E., Robinson, M. J., O'Brien, T. J., Shultz, S. R., & Semple, B. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02114-1 · Cited by 40
Vojtěchová, I., Malenínská, K., Kútna, V., Klovrza, O., Tuckova, K., Petrásek, T., & Stuchlı́k, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063274 · Cited by 43
Chronic fatigue syndrome – A neuroimmunological model
Arnett, S., Alleva, L. M., Korossy-Horwood, R., & Clark, I. A. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.03.030 · Cited by 40
Astrocytic Neuroimmunological Roles Interacting with Microglial Cells in Neurodegenerative Diseases
Gotoh, M., Miyamoto, Y., & Ikeshima‐Kataoka, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021599 · Cited by 40
The role of cofilin in age-related neuroinflammation
Alsegiani, A. S., & Shah, Z. A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.274330 · Cited by 40
Liu, D., Bai, X., Ma, W., Xin, D., Chu, X., Yuan, H., Qiu, J., Ke, H., Yin, S., Chen, W., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00204 · Cited by 39
L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Impagnatiello, F., & Marchetti, B. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1134 · Cited by 39
Mok, S. W.-F., Wong, V. K. W., Lo, H. H., Dias, I. R. D. S. R., Leung, E. L., Law, B. Y. K., & Liu, L. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107480 · Cited by 39
Xie, J., Zhao, Z., Li, P., Zhu, C., Guo, Y., Wang, J., Deng, X., & Wang, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6647258 · Cited by 38
Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus
Klein, B., Mrowetz, H., Thalhamer, J., Scheiblhofer, S., Weiss, R., & Aigner, L. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00169 · Cited by 41
Intracerebral Hemorrhage: The Effects of Aging on Brain Injury
Watson, N. J., Bonsack, F., & Sukumari‐Ramesh, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.859067 · Cited by 37
Freria, C. M., Brennan, F. H., Sweet, D. R., Guan, Z., Hall, J. C. E., Kigerl, K. A., Nemeth, D. P., Liu, X., Lacroix, S., Quan, N., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-20.2020 · Cited by 38
de Sousa, V. L., Araújo, S. M. B., Antônio, L. M. D. S., Silva-Queiroz, M., Colodeti, L. C., Soares, C., Barros‐Aragão, F. G. Q., Mota-Araujo, H. P., Alves, V. S., Coutinho‐Silva, R., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.04.001 · Cited by 38
Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation?Preprint
Kriegel, J., Papadopoulos, Z., & McKee, A. C. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a024059 · Cited by 38
Antonson, A. M., Balakrishnan, B., Radlowski, E. C., Petr, G. T., & Johnson, R. W. (2018) · Developmental Neuroscience · doi:10.1159/000486850 · Cited by 38
Ali, S., Mansour, A. G., Huang, W., Queen, N. J., Mo, X. M., Anderson, J. E., Hassan, Q. N., Patel, R. S., Wilkins, R. K., Caligiuri, M. A., et al. (2020) · Aging · doi:10.18632/aging.102724 · Cited by 39
A role for microglia in mediating the microbiota–gut–brain axis
Keane, L., Clarke, G. A., & Cryan, J. F. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01188-9 · Cited by 43
Andraka, J. M., Sharma, N., & Marchalant, Y. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.08.001 · Cited by 36
Mawanda, F., Wallace, R. B., McCoy, K. D., & Abrams, T. E. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.08.004 · Cited by 36
Ruchika, F., Shah, S., Neupane, D., Vijay, R., Mehkri, Y., & Lucke-Wold, B. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031847 · Cited by 37
The Hallmarks of Ageing in Microglia
Carr, L. M., Mustafa, S., & Collins‐Praino, L. E. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01564-y · Cited by 37
The influence of mianserin on TNF-α, IL-6 and IL-10 serum levels in rats under chronic mild stress
Manikowska, K., Mikołajczyk, M., Mikołajczak, P. Ł., & Bobkiewicz-Kozłowska, T. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.06.003 · Cited by 34
Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury
Boland, R., & Kokiko‐Cochran, O. N. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1352790 · Cited by 32
Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1
Sriram, C. S., Jangra, A., Gurjar, S. S., Mohan, P., & Bezbaruah, B. K. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.10.029 · Cited by 33
TLR-4-Dependent and -Independent Mechanisms of Fetal Brain Injury in the Setting of Preterm Birth
Breen, K. E., Brown, A. G., Burd, I. D., Chai, J., Friedman, A., & Elovitz, M. A. (2012) · Reproductive Sciences · doi:10.1177/1933719112438439 · Cited by 32
Fathi, M., Vakili, K. G., Yaghoobpoor, S., Qadirifard, M. S., Kosari, M., Naghsh, N., Taei, A. A., Klegeris, A., Dehghani, M., Bahrami, A., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.855776 · Cited by 35
Peripheral tumors alter neuroinflammatory responses to lipopolysaccharide in female rats
Pyter, L., Bih, S. E. M., Sattar, H., & Prendergast, B. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.012 · Cited by 30
Dostal, C. R., Gamsby, N. S., Lawson, M. A., & McCusker, R. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.12.006 · Cited by 30
Gee, M. S., Kim, S.-W., Kim, N., Lee, S. J., Oh, M. S., Jin, H. K., Bae, J., Inn, K., Kim, N., & Lee, J. K. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2661-1 · Cited by 31
Metadata
- Authors
- Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Godbout, Jonathan P.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 23
- Issue
- 3
- Pages
- 309-317
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2692986
- OpenAlex
- W2159822434
- Cited by
- 565
- References
- 63
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 26 · 2023: 26 · 2022: 35 · 2021: 39 · 2020: 38 · 2019: 29 · 2018: 42 · 2017: 36 · 2016: 47 · 2015: 41 · 2014: 40 · 2013: 38 · 2012: 33
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG033028)
- National Institute of Mental Health (R21MH077817)
- National Institute of Allergy and Infectious Diseases (R32-AI-05-5411)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lipopolysaccharide challenge, neuroinflammation, aging, IL-1β, IL-10, MHC class II, TLR2, indoleamine 2,3-dioxygenase, microglia, cognitive aging, depression-like behavior, systemic infection
- MeSH terms
- Aging, Analysis of Variance, Animals, Brain, Cerebral Cortex, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Injections, Intraperitoneal, Lipopolysaccharides, Male, Mice, Inbred BALB C, RNA, Messenger, Polymerase Chain Reaction, Interleukin-10, Microglia, Mice, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
