Cited by 132Tryptophan and brain disordersStress Responses and CortisolHealth disparities and outcomes

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Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women?

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Matthews, Karen A., Schott, Laura L., Bromberger, Joyce T., Cyranowski, Jill M., Everson-Rose, Susan A., Sowers, MaryFran·2010·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2009.08.005PMC PMC2844108

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Abstract

Objective To test whether depressive symptoms are related to subsequent C-reactive protein (CRP) levels and/or whether CRP levels are related to subsequent depressive symptoms in mid-life women.Methods Women enrolled in the Study of Women's Health Across the Nation (SWAN) were followed for 7years and had measures of CES-Depression scores and CRP seven times during the follow-up period. Women were pre- or early peri-menopausal at study entry and were of Caucasian, African American, Hispanic, Japanese, or Chinese race/ethnicity. Analyses were restricted to initially healthy women.Results Longitudinal mixed linear regression models adjusting for age, race, site, time between exams, and outcome variable at year X showed that higher CES-D scores predicted higher subsequent CRP levels and vice versa over a 7-year period. Full multivariate models adjusting for body mass index, physical activity, medications, health conditions, and other covariates showed that higher CRP levels at year X predicted higher CES-D scores at year X+1, p=0.03. Higher depressive symptoms predicted higher subsequent CRP levels at marginally significant levels, p=0.10.Conclusions Higher CRP levels led to higher subsequent depressive symptoms, albeit the effect was small. The study demonstrates the importance of considering bi-directional relationships for depression and other psychosocial factors and risk for heart disease.

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Self-citation

Authors: Matthews, K. A., Schott, L. L., Bromberger, J. T., Cyranowski, J. M., Everson-Rose, S. A., & Sowers, M.
Affiliations: University of Pittsburgh (US)
Corresponding author: Matthews, Karen A.
ORCID: Matthews, Karen A.
Schott, Laura L.
Bromberger, Joyce T.
Cyranowski, Jill M.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2010-01
Volume: 24
Issue: 1
Pages: 96-101
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2009.08.005
PMC: PMC2844108
OpenAlex: W2142710692
Cited by: 132
References: 27
Citations by year: 2026: 3 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 8 · 2012: 5
FWCI: 1.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (6u01ag012535-26)
National Institute on Aging (U01-AG-012535, AG012531, U01AG012539, U01AG012505, AG 012535, AG012495, AG 012554, U01AG012553, U01AG012495, AG 012505, AG 012546, AG012553, U01AG012554, U01AG012546, U01AG012531, AG012539)
National Institute of Nursing Research (NR-004061, U01NR004061)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Health › Health disparities and outcomes
Keywords: depressive symptoms, C-reactive protein, bidirectional relationship, middle-aged women, perimenopause, inflammation, heart disease risk, CES-D, Study of Women's Health Across the Nation
MeSH terms: C-Reactive Protein, Data Interpretation, Statistical, Depression, Female, Humans, Longitudinal Studies, Middle Aged, Motor Activity, Obesity, United States, Cohort Studies, Body Mass Index

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Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women?

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