Inflammation: Depression Fans the Flames and Feasts on the Heat

Kiecolt-Glaser, Janice K.; Derry, Heather M.; Fagundes, Christopher P.

doi:10.1176/appi.ajp.2015.15020152

Cited by 844Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Inflammation: Depression Fans the Flames and Feasts on the Heat

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Kiecolt-Glaser, Janice K., Derry, Heather M., Fagundes, Christopher P.·2015·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2015.15020152PMC PMC6511978

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Abstract

Depression and inflammation fuel one another. Inflammation plays a key role in depression's pathogenesis for a subset of depressed individuals; depression also primes larger cytokine responses to stressors and pathogens that do not appear to habituate. Accordingly, treatment decisions may be informed by attention to questions of how (pathways) and for whom (predispositions) these links exist, which are the focus of this article. When combined with predisposing factors (moderators such as childhood adversity and obesity), stressors and pathogens can lead to exaggerated or prolonged inflammatory responses. The resulting sickness behaviors (e.g., pain, disturbed sleep), depressive symptoms, and negative health behaviors (e.g., poor diet, a sedentary lifestyle) may act as mediating pathways that lead to further, unrestrained inflammation and depression. Depression, childhood adversity, stressors, and diet can all influence the gut microbiome and promote intestinal permeability, another pathway to enhanced inflammatory responses. Larger, more frequent, or more prolonged inflammatory responses could have negative mental and physical health consequences. In clinical practice, inflammation provides a guide to potential targets for symptom management by signaling responsiveness to certain therapeutic strategies. For example, a theme across research with cytokine antagonists, omega-3 fatty acids, celecoxib, and exercise is that anti-inflammatory interventions have a substantially greater impact on mood in individuals with heightened inflammation. Thus, when inflammation and depression co-occur, treating them in tandem may enhance recovery and reduce the risk of recurrence. The bidirectional links between depression, inflammation, and disease suggest that effective depression treatments could have a far-reaching impact on mood, inflammation, and health.

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Obesity and exposure to childhood adversity are associated with systemic inflammation.
“acknowledging factors that are associated with systemic inflammation, such as obesity and exposure to childhood adversity, is critical for better informing treatment selection in individuals with fearand anxiety-based disorders (Kiecolt-Glaser et al, 2015).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Kiecolt-Glaser et al, 2015
If combined with other predisposing factors, cytokine responses lead to prolonged pro-inflammatory and anti-inflammatory processes, prolonged dysregulation of various axes, stress, pain, mood changes, anxiety, and ultimately depression.
“If combined with other predisposing factors, these responses lead to a prolonged fight of pro-inflammatory and anti-inflammatory processes, prolonged dysregulation of various axes, stress, pain, mood changes, anxiety, and ultimately, depression [21,22].”
From Selected biomarkers of depression: what are the effects of cytokines and inflammation (2022) · cites this paper as [21]

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Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820573b6 · Cited by 430 · see citing works
Self-citation
Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression
Sublette, M. E., Ellis, S. P., Geant, A. L., & Mann, J. J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06634 · Cited by 420 · see citing works
An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline
Uher, R., Tansey, K. E., Dew, T., Maier, W., Mors, O., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010094 · Cited by 418 · see citing works
Yoga's Impact on Inflammation, Mood, and Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial
Kiecolt‐Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., Emery, C. F., Layman, R. M., Mrózek, E., & Glaser, R. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.8860 · Cited by 392 · see citing works
Self-citation
Stress, Visceral Obesity, and Metabolic Complications
Kyrou, I., Chrousos, G. P., & Tsigos, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.008 · Cited by 379 · see citing works
Resolvins and protectins in the termination program of acute inflammation
Ariel, A., & Serhan, C. N. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.02.007 · Cited by 379 · see citing works
Stressful early life experiences and immune dysregulation across the lifespan
Fagundes, C. P., Glaser, R., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.014 · Cited by 371 · see citing works
Self-citation
Immune regulation of central nervous system functions: from sickness responses to pathological pain
Watkins, L. R., & Maier, S. F. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01443.x · Cited by 367 · see citing works
EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials
Martins, J. G. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719785 · Cited by 362 · see citing works
Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy
O’Brien, S. M., Scully, P., Fitzgerald, P., Scott, L. V., & Dinan, T. G. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.05.013 · Cited by 355 · see citing works
Updated systematic review and meta-analysis of the effects of n−3 long-chain polyunsaturated fatty acids on depressed mood
Appleton, K. M., Rogers, P. J., & Ness, A. R. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28313 · Cited by 353 · see citing works
Paternal Transmission of Stress-Induced Pathologies
Dietz, D. M., LaPlant, Q., Watts, E. L., Hodes, G. E., Russo, S. J., Feng, J., Oosting, R. S., Vialou, V., & Nestler, E. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.005 · Cited by 346 · see citing works
Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?
Franceschi, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00358.x · Cited by 342 · see citing works
Stress, Inflammation, and Yoga Practice
Kiecolt-Glaser, J. K., Christian, L., Preston, H., Houts, C. R., Malarkey, W. B., Emery, C. F., & Glaser, R. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181cb9377 · Cited by 327 · see citing works
Self-citation
Bidirectional association between physical activity and symptoms of anxiety and depression: the Whitehall II study
Azevedo Da Silva, M., Singh-Manoux, A., Brunner, E. J., Kaffashian, S., Shipley, M. J., Kivimäki, M., & Nabi, H. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9692-8 · Cited by 324 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation
Jaremka, L. M., Fagundes, C. P., Glaser, R., Bennett, J. M., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.016 · Cited by 318 · see citing works
Self-citation
Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis
Anacker, C., Cattaneo, A., Luoni, A., Musaelyan, K., Zunszain, P. A., Milanesi, E., Rybka, J., Berry, A., Cirulli, F., Thuret, S., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.253 · Cited by 313 · see citing works
Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?
Franceschi, C. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s173-s176 · Cited by 306 · see citing works
Cognitive Behavioral Therapy vs. Tai Chi for Late Life Insomnia and Inflammatory Risk: A Randomized Controlled Comparative Efficacy Trial
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Breen, E. C., Witarama, T., Yokomizo, M., Lavretsky, H., Carroll, J. E., Motivala, S. J., et al. (2014) · Sleep · doi:10.5665/sleep.4008 · Cited by 303 · see citing works
Interferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis
Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works
Polymorphisms in Inflammation-Related Genes Are Associated with Susceptibility to Major Depression and Antidepressant Response
Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.59 · Cited by 295 · see citing works
Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
Bloch, M. H., & Hannestad, J. O. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.100 · Cited by 293 · see citing works
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290 · see citing works
Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial
Bower, J. E., Greendale, G., Crosswell, A. D., Garet, D., Sternlieb, B., Ganz, P. A., Irwin, M. R., Olmstead, R., Arevalo, J., & Cole, S. W. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.019 · Cited by 283 · see citing works
Sleep Loss Exacerbates Fatigue, Depression, and Pain in Rheumatoid Arthritis
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., FitzGerald, J. D., Ranganath, V. K., & Nicassio, P. M. (2012) · Sleep · doi:10.5665/sleep.1742 · Cited by 279 · see citing works
Depressive Symptoms and Stressful Life Events Predict Metabolic Syndrome Among Middle-Aged Women
Räikkönen, K., Matthews, K. A., & Kuller, L. H. (2007) · Diabetes Care · doi:10.2337/dc06-1857 · Cited by 276 · see citing works
Sex Differences in Depressive and Socioemotional Responses to an Inflammatory Challenge: Implications for Sex Differences in Depression
Moieni, M., Irwin, M. R., Jevtic, I., Olmstead, R., Breen, E. C., & Eisenberger, N. I. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.17 · Cited by 273 · see citing works
Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study
Rapaport, M. H., Nierenberg, A. A., Schettler, P. J., Kinkead, B. L., Cardoos, A., Walker, R., & Mischoulon, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.22 · Cited by 271 · see citing works
Prior Stressor Exposure Sensitizes LPS-Induced Cytokine Production
Johnson, J. D., O'Connor, K. A., Deak, T., Stark, M., Watkins, L. R., & Maier, S. F. (2002) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2001.0638 · Cited by 270 · see citing works
Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans
Kox, M., van Eijk, L. T., Zwaag, J., van den Wildenberg, J., Sweep, F. C. G. J., van der Hoeven, J. G., & Pickkers, P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322174111 · Cited by 268 · see citing works
Cumulative Depression Episodes Predict Later C-Reactive Protein Levels: A Prospective Analysis
Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., & Costello, E. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.023 · Cited by 265 · see citing works
Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression
Shelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 257 · see citing works
Loneliness Promotes Inflammation During Acute Stress
Jaremka, L. M., Fagundes, C. P., Peng, J., Bennett, J. M., Glaser, R., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013) · Psychological Science · doi:10.1177/0956797612464059 · Cited by 255 · see citing works
Self-citation
The impact of major depressive disorder on the short‐ and long‐term outcome of Crohn's disease treatment with infliximab
PERSOONS, P., VERMEIRE, S., DEMYTTENAERE, K., FISCHLER, B., VANDENBERGHE, J., VAN OUDENHOVE, L., PIERIK, M., HLAVATY, T., VAN ASSCHE, G., NOMAN, M., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02535.x · Cited by 253 · cited 1× · see citing works
“disease patients (179) Reduces the ability to fight infection;”
Background
Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity
Suri, D., & Vaidya, V. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.065 · Cited by 253 · see citing works
Differential immunomodulation with long-chainn-3 PUFA in health and chronic disease
Sijben, J., & Calder, P. C. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005472 · Cited by 249 · see citing works
Mild Depressive Symptoms Are Associated With Amplified and Prolonged Inflammatory Responses After Influenza Virus Vaccination in Older Adults
Glaser, R., Robles, T. F., Sheridan, J. F., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.10.1009 · Cited by 242 · see citing works
Self-citation
Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials
Rangel-Huerta, Ó. D., Aguilera, C. M., Mesa, M. D., & Gil, Á. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001559 · Cited by 241 · see citing works
Exercise as an Augmentation Treatment for Nonremitted Major Depressive Disorder
Trivedi, M. H., Greer, T. L., Church, T. S., Carmody, T. J., Grannemann, B. D., Galper, D. I., Dunn, A. L., Earnest, C. P., Sunderajan, P., Henley, S. S., et al. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06743 · Cited by 237 · see citing works
Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction
Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5584-07.2008 · Cited by 234 · see citing works
Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial
Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., Hwang, B. S., & Glaser, R. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.011 · Cited by 233 · see citing works
Self-citation
Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting.
Aksungar, F. B., Topkaya, A. E., & Akyildiz, M. (2007) · Annals of Nutrition and Metabolism · doi:10.1159/000100954 · Cited by 230 · see citing works
Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-α and ribavirin treatment
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, C., Miyazaki, C., Alexander, N., Hotopf, M., Cleare, A. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.48 · Cited by 228 · see citing works
Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression
Yoshimura, R., Hori, H., Ikenouchi, A., Umene‐Nakano, W., Ueda, N., & Nakamura, J. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.03.020 · Cited by 227 · see citing works
The inflammation hypothesis in geriatric depression
Alexopoulos, G. S., & Morimoto, S. S. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2672 · Cited by 225 · see citing works
Mediterranean dietary pattern and prevalence and incidence of depressive symptoms in mid-aged women: results from a large community-based prospective study
Rienks, J., Dobson, A. J., & Mishra, G. D. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.193 · Cited by 224 · see citing works
Ustekinumab significantly improves symptoms of anxiety, depression, and skin-related quality of life in patients with moderate-to-severe psoriasis: Results from a randomized, double-blind, placebo-controlled phase III trial
Langley, R. G. B., Feldman, S. R., Han, C., Schenkel, B., Szapary, P. O., Hsu, M.-C., Ortonne, J. P., Gordon, K. B., & Kimball, A. B. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.09.014 · Cited by 218 · see citing works
Inflammatory dietary pattern and risk of depression among women
Lucas, M., Chocano-Bedoya, P. O., Shulze, M. B., Mirzaei, F., O’Reilly, É. J., Okereke, O. I., Hu, F. B., Willett, W. C., & Ascherio, A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.014 · Cited by 217 · see citing works
Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol Dependence
Leclercq, S., De Saeger, C., Delzenne, N., de Timary, P., & Stärkel, P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.003 · Cited by 216 · see citing works
Cytokines as a Precipitant of Depressive Illness: Animal and Human Studies
Anisman, H., Merali, Z., Poulter, M. O., & Hayley, S. P. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381701 · Cited by 212 · see citing works
Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder
Rethorst, C. D., Toups, M. S. P., GREER, T. L., Nakonezny, P. A., Carmody, T. J., Grannemann, B. D., Huebinger, R. M., Barber, R. C., & Trivedi, M. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.125 · Cited by 211 · see citing works
High‐fat meal induced postprandial inflammation
Herieka, M., & Erridge, C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300104 · Cited by 208 · see citing works
Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial
Su, K.-P., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Chang, J. P.-C., Chang, H.-C., & Pariante, C. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.008 · Cited by 205 · see citing works
Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis
Tursich, M., Neufeld, R. W. J., Frewen, P. A., Harricharan, S., Kibler, J. L., Rhind, S. G., & Lanius, R. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.56 · Cited by 204 · see citing works
Sex Differences in Age Trajectories of Physiological Dysregulation: Inflammation, Metabolic Syndrome, and Allostatic Load
Yang, Y., & Kozloski, M. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr003 · Cited by 202 · see citing works
Depressive Symptoms and Change in Abdominal Obesity in Older Persons
Vogelzangs, N., Kritchevsky, S. B., Beekman, A. T. F., Newman, A. B., Satterfield, S., Simonsick, E. M., Yaffe, K., Harris, T. B., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1386 · Cited by 200 · see citing works
The Interleukin 1 Beta (IL1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depression
Baune, B. T., Dannlowski, U., Domschke, K., Janssen, D. G. A., Jordan, M. A., Ohrmann, P., Bauer, J., Biroš, E., Arolt, V., Kugel, H., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.004 · Cited by 193 · see citing works
The immunomodulating role of exercise in metabolic disease
Lancaster, G. I., & Febbraio, M. A. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.02.008 · Cited by 193 · see citing works
Dietary patterns and the risk of depression in adults: a systematic review of observational studies
Rahe, C., Unrath, M., & Berger, K. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0652-9 · Cited by 192 · see citing works
Depressive Symptoms, Health Behaviors, and Subsequent Inflammation in Patients With Coronary Heart Disease: Prospective Findings From the Heart and Soul Study
Duivis, H. E., de Jonge, P., Penninx, B. W., Na, B. Y., Cohen, B. E., & Whooley, M. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10081163 · Cited by 191 · see citing works
A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth
Miller, G. E., Brody, G. H., Yu, T., & Chen, E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406578111 · Cited by 180 · cited 1× · see citing works
“For example, in a randomized study, inflammation was lower in 17-year-olds who had been assigned to a brief family intervention 8 years earlier compared with controls (187).”
Background
Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients
Monk, J. P., Phillips, G., Waite, R., Kuhn, J., Schaaf, L. J., Otterson, G. A., Guttridge, D., Rhoades, C., Shah, M., Criswell, T., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2838 · Cited by 179 · see citing works
Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group
Grandner, M. A., Buxton, O. M., Jackson, N., Sands-Lincoln, M., Pandey, A., & Jean-Louis, G. (2013) · SLEEP · doi:10.5665/sleep.2646 · Cited by 178 · see citing works
A critical review of human endotoxin administration as an experimental paradigm of depression.
DellaGioia, N., & Hannestad, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.014 · Cited by 175 · see citing works
Cytokines and depression: fortuitous or causative association?
Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000572 · Cited by 174 · see citing works
The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: Implications for hippocampal volume reductions in depression
Tata, D. A., & Anderson, B. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.09.008 · Cited by 173 · cited 1× · see citing works
“Sustained glucocorticoid exposure leads to dendritic atrophy in hippocampal subfields and decreases neuronal cell survival by evoking a decline in BDNF expression in hippocampal and cortical regions (31, 32).”
Background
Short-term improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with comorbid osteoarthritis and insomnia
Vitiello, M. V., McCurry, S. M., Shortreed, S. M., Baker, L. D., Rybarczyk, B. D., Keefe, F. J., & Von Korff, M. (2014) · Pain · doi:10.1016/j.pain.2014.04.032 · Cited by 171 · see citing works
Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study
Farzaneh‐Far, R., Harris, W. S., Garg, S. K., Na, B., & Whooley, M. A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.013 · Cited by 170 · see citing works
Inflammatory responses to psychological stress in fatigued breast cancer survivors: Relationship to glucocorticoids
Bower, J. E., Ganz, P. A., Aziz, N., Olmstead, R. E., Irwin, M. R., & Cole, S. W. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.08.001 · Cited by 169 · see citing works
Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system
Carvalho, L. A., Torre, J. P., Papadopoulos, A. S., Poon, L., Juruena, M. F., Markopoulou, K., Cleare, A. J., & Pariante, C. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.036 · Cited by 167 · see citing works
Expression of toll-like receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder
Kéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165 · see citing works
Phospholipase A2 and Cyclooxygenase 2 Genes Influence the Risk of Interferon-α–Induced Depression by Regulating Polyunsaturated Fatty Acids Levels
Su, K., Huang, S., Peng, C., Lai, H., Huang, C., Chen, Y.-C., Aitchison, K. J., & Pariante, C. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.005 · Cited by 165 · see citing works
Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
Carlezon, W. A., Mague, S. D., Parow, A. M., Stoll, A. L., Cohen, B. M., & Renshaw, P. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.038 · Cited by 162 · see citing works
Effects of dietary n-3 or n-6 fatty acids on interleukin-1β-induced anxiety, stress, and inflammatory responses in rats
Song, C., Li, X., Leonard, B. E., & Horrobin, D. F. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300217-jlr200 · Cited by 161 · see citing works
Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults
Kalogeropoulos, N., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Rousinou, G., Toutouza, M., & Stefanadis, C. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.01.023 · Cited by 160 · see citing works
Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men
von Känel, R., Kudielka, B. M., Preckel, D., Hanebuth, D., & Fischer, J. E. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.03.013 · Cited by 158 · see citing works
Inflammation, Obesity, and Metabolic Syndrome in Depression: Analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES)
Rethorst, C. D., Bernstein, I., & Trivedi, M. H. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09009 · Cited by 152 · see citing works
Depressive symptoms enhance stress-induced inflammatory responses.
Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.006 · Cited by 151 · see citing works
Self-citation
Association Study of the Interleukin-1beta (C-511T) Genetic Polymorphism with Major Depressive Disorder, Associated Symptomatology, and Antidepressant Response
Yu, Y. W. ‐., Chen, T., Hong, C., Chen, H.-M., & Tsai, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300172 · Cited by 150 · see citing works
Exercise Training as a Treatment for Chronic Inflammation in the Elderly
Nicklas, B. J., & Brinkley, T. E. (2009) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181b7b3d9 · Cited by 148 · see citing works
Fasting in mood disorders: neurobiology and effectiveness. A review of the literature
Fond, G. B., Macgregor, A., Leboyer, M., & Michalsen, A. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2012.12.018 · Cited by 145 · see citing works
Adherence to the Mediterranean Diet Is Inversely Associated With Circulating Interleukin-6 Among Middle-Aged Men: A Twin Study
Dai, J., Miller, A. H., Bremner, J. D., Goldberg, J., Jones, L., Shallenberger, L., Buckham, R., Murrah, N. V., Veledar, E., Wilson, P. W., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.710699 · Cited by 145 · see citing works
Cognitive-behavioral therapy for sleep disturbance decreases inflammatory cytokines and oxidative stress in hemodialysis patients
Chen, H.-Y., Cheng, I.-C., Pan, Y.-J., Chiu, Y.-L., Hsu, S.-P., Pai, M.-F., Yang, J.-Y., Peng, Y.-S., Tsai, T.-J., & Wu, K.-D. (2011) · Kidney International · doi:10.1038/ki.2011.151 · Cited by 140 · see citing works
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice
Mirsoian, A., Bouchlaka, M. N., Sckisel, G. D., Chen, M., Pai, C.-C. S., Maverakis, E. M., Spencer, R. G. S., Fishbein, K. W., Siddiqui, S., Monjazeb, A. M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140116 · Cited by 138 · see citing works
Relation of smoking status to a panel of inflammatory markers: The Framingham offspring
Levitzky, Y. S., Guo, C., Rong, J., Larson, M. G., Walter, R. E., Keaney, J. F., Sutherland, P. A., Vasan, A., Lipinska, I., Evans, J. C., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.058 · Cited by 136 · see citing works
Inflammatory and Metabolic Dysregulation and the 2-Year Course of Depressive Disorders in Antidepressant Users
Vogelzangs, N., Beekman, A. T., van Reedt Dortland, A. K., Schoevers, R. A., Giltay, E. J., de Jonge, P., & Penninx, B. W. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.9 · Cited by 133 · see citing works
Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women?
Matthews, K. A., Schott, L. L., Bromberger, J. T., Cyranowski, J. M., Everson-Rose, S. A., & Sowers, M. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.005 · Cited by 132 · see citing works
Childhood Abuse and Inflammatory Responses to Daily Stressors
Gouin, J.-P., Glaser, R., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. K. (2012) · Annals of Behavioral Medicine · doi:10.1007/s12160-012-9386-1 · Cited by 130 · see citing works
Self-citation
The inflammatory response following delivery is amplified in women who previously suffered from major depression, suggesting that major depression is accompanied by a sensitization of the inflammatory response system
Maes, M., Ombelet, W., De Jongh, Kenis, G., & Bosmans, E. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00156-7 · Cited by 116 · see citing works
Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol
Raison, C. L., Rye, D. B., Woolwine, B. J., Vogt, G. J., Bautista, B. M., Spivey, J. R., & Miller, A. H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.019 · Cited by 116 · see citing works
Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant women
Christian, L. M., Franco, A., Iams, J. D., Sheridan, J. F., & Glaser, R. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.05.055 · Cited by 114 · see citing works
Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression.
Weinstein, A. A., Deuster, P. A., Francis, J. L., Bonsall, R. W., Tracy, R. P., & Kop, W. J. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.016 · Cited by 113 · see citing works
The maternal-neonatal neuro-immune interface: Are there long-term implications for inflammatory or stress-related disease?
Shanks, N. M., & Lightman, S. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14592 · Cited by 111 · see citing works
The maternal-neonatal neuro-immune interface: Are there long-term implications for inflammatory or stress-related disease?
Shanks, N., & Lightman, S. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114592 · Cited by 111 · see citing works
Inflammatory cytokines as biomarkers in heart failure
Ueland, T., Gullestad, L. L., Nymo, S. H., Yndestad, A., Aukrust, P., & Askevold, E. T. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.09.001 · Cited by 110 · see citing works
Malaise, melancholia and madness: The evolutionary legacy of an inflammatory bias
Raison, C. L., & Miller, A. H. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.009 · Cited by 109 · see citing works
Current and past depression as predictors of family functioning: A comparison of men and women in a community sample.
Herr, N. R., Hammen, C. L., & Brennan, P. A. (2007) · Journal of Family Psychology · doi:10.1037/0893-3200.21.4.694 · Cited by 108 · see citing works
Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Cho, H. J., Seeman, T. E., Kiefe, C. I., Lauderdale, D. S., & Irwin, M. R. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.02.023 · Cited by 108 · see citing works
Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders
Gerrits, M. M., van Oppen, P., Leone, S. S., van Marwijk, H. W., van der Horst, H. E., & Penninx, B. W. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-187 · Cited by 106 · see citing works
Inflammation-induced hyperalgesia: Effects of timing, dosage, and negative affect on somatic pain sensitivity in human experimental endotoxemia
Wegner, A., Elsenbruch, S., Maluck, J., Grigoleit, J., Engler, H., Jäger, M., Spreitzer, I., Schedlowski, M., & Benson, S. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.001 · Cited by 106 · see citing works
Depressive Symptoms, Race, and Circulating C-Reactive Protein: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Deverts, D. J., Cohen, S., DiLillo, V. G., Lewis, C. E., Kiefe, C. I., Whooley, M. A., & Matthews, K. A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181ec4b98 · Cited by 104 · see citing works
Lower subjective social status exaggerates interleukin-6 responses to a laboratory stressor
Derry, H. M., Fagundes, C. P., Andridge, R., Glaser, R., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.026 · Cited by 102 · see citing works
Self-citation
Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?: Where the Rubber Meets the Road
Miller, A. H., & Raison, C. L. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.22 · Cited by 101 · see citing works
Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects.
Pluess, T.-T., Hayoz, D., Berger, M. M., Tappy, L., Revelly, J.-P., Michaeli, B., Carpentier, Y. A., & Chioléro, R. L. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0591-5 · Cited by 94 · see citing works
Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans
Benson, S., Kattoor, J., Wegner, A., Hammes, F., Reidick, D., Grigoleit, J.-S., Engler, H., Oberbeck, R., Schedlowski, M., & Elsenbruch, S. (2012) · Pain · doi:10.1016/j.pain.2011.12.001 · Cited by 89 · cited 1× · see citing works
“Pain generates an inflammatory response (69, 70), and amplified pain sensitivity serves as an additional inflammatory source that in turnprovokesdepressive symptoms (71, 72).”
Background
Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey
Willette, A. A., Lubach, G. R., & Coe, C. L. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.01.007 · Cited by 89 · see citing works
Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress
McInnis, C. M., Thoma, M. V., Gianferante, D., Hanlin, L. C., Chen, X., Breines, J. G., Hong, S., & Rohleder, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.018 · Cited by 87 · see citing works
Do environments in infancy moderate the association between stress and inflammation in adulthood? Initial evidence from a birth cohort in the Philippines
McDade, T. W., Hoke, M., Borja, J. B., Adair, L. S., & Kuzawa, C. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.010 · Cited by 83 · see citing works
Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction
Fontana, L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.005 · Cited by 81 · see citing works
Inflammatory Markers and the Pathogenesis of Pediatric Depression and Suicide
Kim, J.-W., Szigethy, E., Melhem, N., Saghafi, E. M., & Brent, D. A. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08898 · Cited by 76 · see citing works
Stress-induced cytokine responses and central adiposity in young women
Brydon, L., Wright, C. E., O'Donnell, K., Zachary, I., Wardle, J., & Steptoe, A. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803767 · Cited by 72 · see citing works
Marital discord, past depression, and metabolic responses to high-fat meals: Interpersonal pathways to obesity
Kiecolt‐Glaser, J. K., Jaremka, L. M., Andridge, R., Peng, J., Habash, D., Fagundes, C. P., Glaser, R., Malarkey, W. B., & Belury, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.018 · Cited by 69 · see citing works
Self-citation
Molecular dynamics of ultradian glucocorticoid receptor action
Conway-Campbell, B. L., Pooley, J. R., Hager, G. L., & Lightman, S. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.014 · Cited by 68 · see citing works
The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4
Erridge, C. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003004 · Cited by 66 · see citing works
Serotonin and interleukin-6: The role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms
Udina, M., Moreno-España, J., Navinés, R., Giménez, M. D., Langohr, K., Gratacòs, M., Capuron, L., de la Torre, R., Sola, R. L., & Martín‐Santos, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.007 · Cited by 63 · see citing works
Past depression and gender interact to influence emotional reactivity to daily life stress
Husky, M. M., Mazure, C. M., Maciejewski, P. K., & Swendsen, J. D. (2009) · Cognitive Therapy and Research · doi:10.1007/s10608-008-9212-z · Cited by 62 · see citing works
The associations of adiposity, physical activity and inflammation with fatigue in older adults
Valentine, R. J., Woods, J. A., McAuley, E., Dantzer, R., & Evans, E. M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.002 · Cited by 57 · see citing works
Where there is depression, there is inflammation… sometimes!
Glassman, A. H., & Miller, G. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.032 · Cited by 51 · see citing works
Depressive symptoms and inflammation increase in a prospective study of older adults: a protective effect of a healthy (Mediterranean-style) diet
Milaneschi, Y., Bandinelli, S., Penninx, B. W. J. H., Vogelzangs, N., Corsi, A. M., Lauretani, F., Kisialiou, A., Vazzana, R., Terracciano, A., Guralnik, J. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.113 · Cited by 51 · see citing works
The impact of cognitive behavioral therapy on IL-6 levels in unmedicated women experiencing the first episode of depression: a pilot study
Gazal, M., Souza, L. D., Fucolo, B. A., Wiener, C. D., Silva, R. A., Pinheiro, R. T., Jansen, K., Ghislene, G., Oses, J. P., & Kaster, M. P. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.03.002 · Cited by 47 · see citing works
Does Pain Interfere with Antidepressant Depression Treatment Response and Remission in Patients with Depression and Pain? An Evidence-Based Structured Review
Fishbain, D. A., Cole, B., Lewis, J. E., & Gao, J. (2014) · Pain Medicine · doi:10.1111/pme.12448 · Cited by 42 · see citing works
Immune-to-brain signaling and central prostaglandin E2synthesis in fasted rats with altered lipopolysaccharide-induced fever
Inoue, W., Somay, G., Poole, S., & Luheshi, G. N. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90335.2008 · Cited by 42 · see citing works
Negative association of concomitant physical symptoms with the course of major depressive disorder: A systematic review
Huijbregts, K. M. L., Feltz-Cornelis, C. M. V. D., van Marwijk, H., de Jong, F. J., van der Windt, D., & Beekman, A. T. F. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.11.009 · Cited by 39 · see citing works
Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil
Pittet, Y. K., Berger, M. M., Pluess, T.-T., Voirol, P., Revelly, J., Tappy, L., & Chioléro, R. L. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1689-8 · Cited by 39 · see citing works
Omega-3 fatty acids influence mood in healthy and depressed individuals
Giles, G. E., Mahoney, C. R., & Kanarek, R. B. (2013) · Nutrition Reviews · doi:10.1111/nure.12066 · Cited by 36 · see citing works
Late-life depression symptom profiles are differentially associated with immunometabolic functioning
Vogelzangs, N., Comijs, H. C., Oude Voshaar, R. C., Stek, M. L., & Penninx, B. W. J. H. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.004 · Cited by 32 · see citing works

Flagged first, then by citations

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The compelling link between physical activity and the body's defense system
Nieman, D. C., & Wentz, L. M. (2019) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2018.09.009 · Cited by 1,340 · see citing works
Physical activity and depression: towards understanding the antidepressant mechanisms of physical activity
Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309 · see citing works
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592 · see citing works
Inflammation–Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases
Bennett, J. M., Reeves, G., Billman, G. E., & Sturmberg, J. P. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00316 · Cited by 531 · see citing works
Inflammation in psychiatric disorders: what comes first?
Bauer, M. E., & Teixeira, A. L. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13712 · Cited by 500 · see citing works
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
McGuinness, A. J., Davis, J. A., Dawson, S. L., Loughman, A., Collier, F., O’Hely, M., Simpson, C. A., Green, J., Marx, W., Hair, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01456-3 · Cited by 502 · see citing works
Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works
Rethinking minority stress: A social safety perspective on the health effects of stigma in sexually-diverse and gender-diverse populations
Diamond, L. M., & Alley, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104720 · Cited by 412 · see citing works
Selected biomarkers of depression: what are the effects of cytokines and inflammation
Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299 · see citing works
Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities
Slyepchenko, A., Maes, M., Jacka, F. N., Köhler, C. A., Barichello, T., McIntyre, R. S., Berk, M., Grande, I., Foster, J. A., Vieta, E., et al. (2017) · Psychotherapy and Psychosomatics · doi:10.1159/000448957 · Cited by 278 · see citing works
Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders
Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216 · see citing works
Dietary fiber and its associations with depression and inflammation
Swann, O. G., Kilpatrick, M., Breslin, M., & Oddy, W. H. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuz072 · Cited by 185 · see citing works
The association between cardiorespiratory fitness and the incidence of common mental health disorders: A systematic review and meta-analysis
Kandola, A., Ashdown-Franks, G., Stubbs, B., Osborn, D. P. J., & Hayes, J. F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.088 · Cited by 172 · see citing works
Role of microbiota and tryptophan metabolites in the remote effect of intestinal inﬂammation on brain and depression
Waclawiková, B., & El Aidy, S. (2018) · Pharmaceuticals · doi:10.3390/ph11030063 · Cited by 172 · see citing works
Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes
Belvederi Murri, M., Ekkekakis, P., Magagnoli, M., Zampogna, D., Cattedra, S., Capobianco, L., Serafini, G., Calcagno, P., Zanetidou, S., & Amore, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00762 · Cited by 163 · see citing works
Symptoms of persistent complex bereavement disorder, depression, and PTSD in a conjugally bereaved sample: a network analysis
Malgaroli, M., Maccallum, F., & Bonanno, G. A. (2018) · Psychological Medicine · doi:10.1017/s0033291718001769 · Cited by 116 · see citing works
Metabolomic and inflammatory signatures of symptom dimensions in major depression
Brydges, C. R., Bhattacharyya, S., Dehkordi, S. M., Milaneschi, Y., Penninx, B., Jansen, R., Kristal, B. S., Han, X., Arnold, M., Kastenmüller, G., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.02.003 · Cited by 108 · see citing works
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine
Verdonk, F., Petit, A.-C., Abdel-Ahad, P., Vinckier, F., Jouvion, G., de Maricourt, P., De Medeiros, G. F., Danckaert, A., Van Steenwinckel, J., Blatzer, M., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.033 · Cited by 99 · see citing works
Future directions in the study of early-life stress and physical and emotional health: implications of the neuroimmune network hypothesis.
Hostinar, C. E., Nusslock, R., & Miller, G. E. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1266647 · Cited by 90 · see citing works
Increased neutrophil-lymphocyte ratios in depressive adolescents is correlated with the severity of depression
Özyurt, G., & Binici, N. C. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.007 · Cited by 74 · see citing works
Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial
Sánchez-Villegas, A., Álvarez-Pérez, J., Toledo, E., Salas-Salvadó, J., Ortega-Azorín, C., Zomeño, M. D., Vioque, J., Martínez, J. A., Romaguera, D., Pérez-López, J., et al. (2018) · Nutrients · doi:10.3390/nu10122000 · Cited by 72 · see citing works
Decreased survival in cystic fibrosis patients with a positive screen for depression
Schechter, M. S., Ostrenga, J. S., Fink, A. K., Barker, D. H., Sawicki, G. S., & Quittner, A. L. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.07.020 · Cited by 71 · see citing works
Psoriasis and Depression: The Role of Inflammation
González-Parra, S., & Daudén, E. (2019) · Actas Dermo-Sifiliográficas (English Edition) · doi:10.1016/j.adengl.2018.05.035 · Cited by 70 · see citing works
Physical activity before and during pregnancy and maternal mental health: A systematic review and meta-analysis of observational studies
Cai, C., Busch, S., Wang, R., Sivak, A., & Davenport, M. H. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.143 · Cited by 65 · see citing works
The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats
Lv, W.-J., Wu, X.-L., Chen, W.-Q., Li, Y.-F., Zhang, G.-F., Chao, L.-M., Zhou, J.-H., Guo, A., Liu, C., & Guo, S.-N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7902874 · Cited by 61 · see citing works
Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices
Kiecolt-Glaser, J. K., Fagundes, C. P., Andridge, R., Peng, J., Malarkey, W. B., Habash, D., & Belury, M. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.149 · Cited by 54 · see citing works
Self-citation
The association between immune markers and recent suicide attempts in patients with serious mental illness: A pilot study
Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K., Alaedini, A., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.05.005 · Cited by 41 · see citing works
Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.
Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37 · see citing works
The impact of comorbid pain and depression in the United States: results from a nationally representative survey
Dhanju, S., Kennedy, S. H., Abbey, S., Katz, J., Weinrib, A., Clarke, H., Bhat, V., & Ladha, K. (2019) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2018-0323 · Cited by 38 · see citing works
Emotion regulation and immune functioning during grief: testing the role of expressive suppression and cognitive reappraisal in inflammation among recently bereaved spouses
Lopez, R. B., Brown, R. L., Wu, E.-L. L., Murdock, K. W., Denny, B. T., Heijnen, C., & Fagundes, C. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000755 · Cited by 36 · see citing works
Self-citation
Anxiety independently contributes to elevated inflammation in humans with obesity
Pierce, G. L., Kalil, G. Z., Ajibewa, T., Holwerda, S. W., Persons, J., Moser, D. J., & Fiedorowicz, J. G. (2017) · Obesity · doi:10.1002/oby.21698 · Cited by 33 · see citing works
Biological Profiling of Prospective Antidepressant Response in Major Depressive Disorder: Associations with (Neuro)Inflammation, Fatty Acid Metabolism, and Amygdala-Reactivity
Mocking, R. J. T., Nap, T. S., Westerink, A. M., Assies, J., Vaz, F. M., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.019 · Cited by 34 · see citing works
Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey
Lee, S., Oh, S. S., Jang, S.-I., & Park, E.-C. (2019) · Scientific Reports · doi:10.1038/s41598-018-36402-3 · Cited by 29 · see citing works
Elevated hs-CRP level is associated with depression in younger adults: Results from the Korean National Health and Nutrition Examination Survey (KNHANES 2016)
Jung, Y.-E., & Kang, K. Y. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104397 · Cited by 29 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2021) · Focus · doi:10.1176/appi.focus.19304 · Cited by 22 · see citing works
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities
Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E. (2022) · Clinical Science · doi:10.1042/cs20211106 · Cited by 22 · see citing works
Circulating Cytokines as Predictors of Depression in Patients with Breast Cancer
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Authors: Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P.
Affiliations: From the Institute for Behavioral Medicine Research and the Department of Psychiatry and Behavioral Health, Ohio State University College of Medicine, Columbus; and the Department of Health Disparities Research, University of Texas MD Anderson Cancer Center, Houston.
The University of Texas MD Anderson Cancer Center (US)
ORCID: Derry, Heather M.
Fagundes, Christopher P.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2015-11-01
Volume: 172
Issue: 11
Pages: 1075-1091
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2015.15020152
PMC: PMC6511978
OpenAlex: W2159036260
Cited by: 844
References: 204
Citations by year: 2026: 61 · 2025: 117 · 2024: 109 · 2023: 93 · 2022: 91 · 2021: 83 · 2020: 58 · 2019: 77 · 2018: 78 · 2017: 47 · 2016: 26 · 2015: 4
FWCI: 2.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA186720, CA186251, CA172296, K05CA172296, R01CA186251, CA186720)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: depression, inflammation, cytokines, sickness behavior, childhood adversity, obesity, gut microbiota, intestinal permeability, stress response, diet, anti-inflammatory therapy, omega-3 fatty acids, celecoxib, physical activity, depression recurrence
MeSH terms: Gastrointestinal Microbiome, Adult Survivors of Child Adverse Events, Depression, Major Depressive Disorder, Humans, Inflammation, Intestinal Mucosa, Obesity, Permeability, Stress, Psychological, Health Behavior, Cytokines, Dysbiosis

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