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Cited by 34Tryptophan and brain disordersStress Responses and CortisolAdipokines, Inflammation, and Metabolic Diseases

Depressive symptoms and levels of C-reactive protein: A population-based study

Pikhart, Hynek, Hubacek, Jaroslav A., Kubinova, Ruzena, Nicholson, Amanda, Peasey, Anne, Capkova, Nada, Poledne, Rudolf, Bobak, Martin·2009·Social Psychiatry and Psychiatric Epidemiology
DOI 10.1007/s00127-008-0422-1
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Abstract

Background Depression and depressive symptoms have been repeatedly linked to elevated levels of C-reactive protein (CRP) but questions remain as to the statistical robustness of the association and particularly whether the association between depression and CRP reflects the presence of a chronic disease.Methods A random sample of 6,126 men and women aged 45-69 years was examined in a cross-sectional study in seven towns in the Czech Republic. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CESD) scale.Results Center for Epidemiologic Studies Depression score was significantly related to increased levels of CRP in a linear fashion. After controlling for a range of potential confounders, subjects with depressive symptoms (CESD score >or= 16) had CRP concentrations 0.43 mg/l (95% CI 0.16-0.72) higher than those without symptoms. The association remained significant when study sample was restricted to healthy subjects; among individuals who did not report any chronic disease, the difference between those with and without depressive symptoms was 0.44 mg/l (95% CI 0.14-0.74), and among persons who did not visit a doctor in the last 12 months the difference was 1.20 mg/l (95% CI 0.52-1.87).Conclusions These results confirm that there is a statistically robust association between depressive symptoms and increased levels of CRP. We did not find evidence that the association is due presence of a chronic condition.

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  • This association persisted when the sample size was limited only to depressed patients without any chronic disease.

    “In addition, the authors found that this association appeared to persist, also when the sample size was limited only to depressed patients without any chronic disease.”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [70]

  • In 6126 adults, subjects with depressive symptoms (CESD ≥ 16) displayed on average a CRP concentration of 0.43 mg/L (95% CI = 0.16-0.72) higher than healthy controls.

    “A cross-sectional population-based study evaluated the association between depression and CRP in 6126 adults, assessed with the Center for Epidemiologic Studies Depression (CESD) scale [70]. Subjects with depressive symptoms (CESD ≥ 16) displayed on average a CRP concentration of 0.43 mg/L (95% CI = 0.16–0.72) higher than the healthy controls.”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [70]

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Authors
Pikhart, H., Hubacek, J. A., Kubinova, R., Nicholson, A., Peasey, A., Capkova, N., Poledne, R., & Bobak, M.
Affiliations
  • University College London (GB)
  • Institute of Clinical and Experimental Medicine (CZ)
Corresponding author
Pikhart, Hynek
ORCID
Venue
Social Psychiatry and Psychiatric Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2008-08-11
Volume
44
Issue
3
Pages
217-222
ISSN
  • 0933-7954 (ISSN-L)
  • 1433-9285
DOI
10.1007/s00127-008-0422-1
OpenAlex
W1580186637
Cited by
34
References
41
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Social Psychiatry and Psychiatric Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (064947 ⁄Z⁄ 01 ⁄ Z, 081081/Z/06/Z)
  • National Institutes of Health
  • National Institute on Aging (1R01AG23522-01, R01AG023522, R01AG013196)
  • National Institute on Minority Health and Health Disparities
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
depressive symptoms, C-reactive protein, inflammation, depression, chronic disease, middle-aged and older adults
MeSH terms
Aged, Anxiety Disorders, C-Reactive Protein, Chronic Disease, Cross-Sectional Studies, Depression, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Czech Republic

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