Cited by 803Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

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The role of microbiome in central nervous system disorders

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Wang, Yan, Kasper, Lloyd H.·2014·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2013.12.015PMC PMC4062078

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Abstract

Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut-brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome-gut-brain axis is emerging. Studies are revealing how diverse forms of neuro-immune and neuro-psychiatric disorders are correlated with or modulated by variations of microbiome, microbiota-derived products and exogenous antibiotics and probiotics. The microbiome poises the peripheral immune homeostasis and predisposes host susceptibility to CNS autoimmune diseases such as multiple sclerosis. Neural, endocrine and metabolic mechanisms are also critical mediators of the microbiome-CNS signaling, which are more involved in neuro-psychiatric disorders such as autism, depression, anxiety, stress. Research on the role of microbiome in CNS disorders deepens our academic knowledge about host-microbiome commensalism in central regulation and in practicality, holds conceivable promise for developing novel prognostic and therapeutic avenues for CNS disorders.

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Additional file 6 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15162101
Additional file 3 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203531
Additional file 5 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
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Additional file 7 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15162104
Additional file 1 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203525
Additional file 16 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203522
Additional file 15 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203519
Additional file 4 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203534
Additional file 12 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203510
Additional file 8 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203546
Additional file 2 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203528
Additional file 4 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15162095
Additional file 3 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15162092
Additional file 9 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203549
Additional file 6 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203540
Additional file 10 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203504
Additional file 11 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203507
Additional file 13 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203513
Additional file 14 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203516
Additional file 2 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15162089
Additional file 1 of Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15162086
Additional file 5 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203537
Additional file 7 of Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications
van de Guchte, M., Burz, S. D., Cadiou, J., Wu, J., Mondot, S., Blottière, H. M., & Dore, J. M. (2020) · Figshare · doi:10.6084/m9.figshare.13203543
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Authors: Wang, Y., & Kasper, L. H.
Affiliations: Dartmouth College (US)
Corresponding author: Kasper, Lloyd H.
ORCID: Wang, Yan
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2014-05
Volume: 38
Pages: 1-12
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2013.12.015
PMC: PMC4062078
OpenAlex: W1991521547
Cited by: 803
References: 160
Citations by year: 2026: 26 · 2025: 54 · 2024: 58 · 2023: 81 · 2022: 70 · 2021: 73 · 2020: 98 · 2019: 69 · 2018: 77 · 2017: 69 · 2016: 65 · 2015: 41 · 2014: 21
FWCI: 3.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R56AI098282)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: microbiome, central nervous system disorders, gut microbiota, microbiome-gut-brain axis, neuropsychiatric disorders, multiple sclerosis, autism spectrum disorder, depression, anxiety, stress, probiotics, antibiotics
MeSH terms: Animals, Brain, Central Nervous System Diseases, Humans, Gastrointestinal Tract, Microbiota

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