Cited by 803Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

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The role of microbiome in central nervous system disorders

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Wang, Yan, Kasper, Lloyd H.·2014·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2013.12.015PMC PMC4062078

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Abstract

Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut-brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome-gut-brain axis is emerging. Studies are revealing how diverse forms of neuro-immune and neuro-psychiatric disorders are correlated with or modulated by variations of microbiome, microbiota-derived products and exogenous antibiotics and probiotics. The microbiome poises the peripheral immune homeostasis and predisposes host susceptibility to CNS autoimmune diseases such as multiple sclerosis. Neural, endocrine and metabolic mechanisms are also critical mediators of the microbiome-CNS signaling, which are more involved in neuro-psychiatric disorders such as autism, depression, anxiety, stress. Research on the role of microbiome in CNS disorders deepens our academic knowledge about host-microbiome commensalism in central regulation and in practicality, holds conceivable promise for developing novel prognostic and therapeutic avenues for CNS disorders.

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Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

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McGavigan, A. K., Henseler, Z. M., Garibay, D., Butler, S. D., Jayasinghe, S. U., Ley, R. E., Davisson, R. L., & Cummings, B. P. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.027474 · Cited by 36
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Chen, H., Chen, Z., Shen, L., Wu, X., Ma, X., Lin, D., Zhang, M., Ma, X., Liu, Y., Wang, Z., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00309-8 · Cited by 36
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Savidge, T. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00503 · Cited by 36
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Hugerth, L. W., Seifert, M., Pennhag, A. A. L., Du, J., Hamsten, M., Schuppe‐Koistinen, I., & Engstrand, L. G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/286526 · Cited by 33
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Qin, C., Hu, J., Wan, Y., Cai, M., Wang, Z., Peng, Z., Liao, Y., Li, D., Yao, P., Liu, L., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110093 · Cited by 32
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Cerdó, T., Garcia-Valdes, L., Altmäe, S., Ruiz-Rodriguez, A., Suárez, A., & Campoy, C. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.007 · Cited by 33
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Authors: Wang, Y., & Kasper, L. H.
Affiliations: Dartmouth College (US)
Corresponding author: Kasper, Lloyd H.
ORCID: Wang, Yan
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2014-05
Volume: 38
Pages: 1-12
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2013.12.015
PMC: PMC4062078
OpenAlex: W1991521547
Cited by: 803
References: 160
Citations by year: 2026: 26 · 2025: 54 · 2024: 58 · 2023: 81 · 2022: 70 · 2021: 73 · 2020: 98 · 2019: 69 · 2018: 77 · 2017: 69 · 2016: 65 · 2015: 41 · 2014: 21
FWCI: 3.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R56AI098282)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: microbiome, central nervous system disorders, gut microbiota, microbiome-gut-brain axis, neuropsychiatric disorders, multiple sclerosis, autism spectrum disorder, depression, anxiety, stress, probiotics, antibiotics
MeSH terms: Animals, Brain, Central Nervous System Diseases, Humans, Gastrointestinal Tract, Microbiota

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