Cited by 803Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.

The role of microbiome in central nervous system disorders

Open access

Wang, Yan, Kasper, Lloyd H.·2014·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2013.12.015PMC PMC4062078

Open this paper in CoChat — free account

Abstract

Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut-brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome-gut-brain axis is emerging. Studies are revealing how diverse forms of neuro-immune and neuro-psychiatric disorders are correlated with or modulated by variations of microbiome, microbiota-derived products and exogenous antibiotics and probiotics. The microbiome poises the peripheral immune homeostasis and predisposes host susceptibility to CNS autoimmune diseases such as multiple sclerosis. Neural, endocrine and metabolic mechanisms are also critical mediators of the microbiome-CNS signaling, which are more involved in neuro-psychiatric disorders such as autism, depression, anxiety, stress. Research on the role of microbiome in CNS disorders deepens our academic knowledge about host-microbiome commensalism in central regulation and in practicality, holds conceivable promise for developing novel prognostic and therapeutic avenues for CNS disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2013.12.015

Cites

159 of 159 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791
Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288
Inducible Foxp3 + regulatory T-cell development by a commensal bacterium of the intestinal microbiota
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832
The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661
Microbiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019378108 · Cited by 1,502
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394
Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 6×
“As accumulating literatures underpin the importance of the gut microbiome to intestinal functions, a novel concept of microbiome–gut– brain axis has been evolved (Rhee et al., 2009).”
Influential
Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251
Gastrointestinal regulation of food intake
Cummings, D. E., & Overduin, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30227 · Cited by 1,216
γ-Aminobutyric acid production by culturable bacteria from the human intestine
Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156
Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123
Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083
Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076
Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018
The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999
Commensal bacteria calibrate the activation threshold of innate antiviral immunity
Abt, M. C., Osborne, L. C., Monticelli, L. A., Doering, T. A., Alenghat, T., Sonnenberg, G. F., Paley, M. A., Antenus, M., Williams, K. L., Erikson, J., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.011 · Cited by 993
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976
The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952
Bacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
Is meconium from healthy newborns actually sterile?
Jiménez, E., Marín, M. L., Martı́n, R., Odriozola, J. M., Olivares, M. M., Xaus, J., Fernández, L., & Rodríguez, J. M. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2007.12.007 · Cited by 944
Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
Garrett, W. S., Lord, G. M., Punit, S., Lugo‐Villarino, G., Mazmanian, S. K., Ito, S., Glickman, J. N., & Glimcher, L. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.017 · Cited by 915
Bacterial infection causes stress-induced memory dysfunction in mice
Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909 · cited 3×
“GF animals displayed increased stress and impaired cognition (Gareau et al., 2011; Sudo et al., 2004).”
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793
Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742
Analysis of the Fecal Microbiota of Irritable Bowel Syndrome Patients and Healthy Controls with Real-Time PCR
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699
Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces
Corthésy, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00185 · Cited by 678
Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice
Bercik, P., Verdu, E. F., Foster, J. A., Macri, J., Potter, M., Huang, X., Malinowski, P., Jackson, W., Blennerhassett, P., Neufeld, K. A., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.063 · Cited by 674
Brain–Gut Interactions in Inflammatory Bowel Disease
Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667
Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis
Kuss-Duerkop, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J. P., Frierson, J. M., Hooper, L. V., Dermody, T. S., & Pfeiffer, J. K. (2011) · Science · doi:10.1126/science.1211057 · Cited by 631
The QseC sensor kinase: A bacterial adrenergic receptor
Clarke, M. B., Hughes, D. T., Zhu, C., Boedeker, E. C., & Sperandio, V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604343103 · Cited by 621
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614
Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats
Ait-Belgnaoui, A., Durand, H., Cartier, C., Chaumaz, G., Eutamene, H., Ferrier, L., Houdeau, E., Fioramonti, J., Bueno, L., & Theodorou, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.024 · Cited by 612
Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options.
Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2011) · PubMed · Cited by 598
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
Sawa, S., Lochner, M., Satoh‐Takayama, N., Dulauroy, S., Berard, M., Kleinschek, M. A., Cua, D., Santo, J. P. D., & Eberl, G. (2011) · Nature Immunology · doi:10.1038/ni.2002 · Cited by 596
Campylobacter Species and Guillain-Barre Syndrome
Nachamkin, I., Allos, B. M., & Ho, T. W. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.3.555 · Cited by 591
Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis
Ochoa-Repáraz, J., Mielcarz, D. W., Ditrio, L. E., Burroughs, A. R., Foureau, D. M., Haque-Begum, S., & Kasper, L. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900747 · Cited by 590
Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology
Dinan, T. G., & Cryan, J. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.007 · Cited by 577
Probiotics function mechanistically as delivery vehicles for neuroactive compounds: microbial endocrinology in the design, and use of probiotics.
Lyte, M. (2011) · BioEssays · doi:10.1002/bies.201100024 · Cited by 549
Linkage of gut microbiome with cognition in hepatic encephalopathy
Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2011 · Cited by 547
Understanding the role of gut microbiome–host metabolic signal disruption in health and disease
Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H., & Nicholson, J. K. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.05.006 · Cited by 541
Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 530
Tryptophan metabolism in the central nervous system: medical implications
Ruddick, J. P., Evans, A. K., Nutt, D. J., Lightman, S. L., Rook, G. A. W., & Lowry, C. A. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406000068 · Cited by 519
A Guide to Enterotypes across the Human Body: Meta-Analysis of Microbial Community Structures in Human Microbiome Datasets
Koren, O., Knights, D., Gonzalez, A., Waldron, L., Segata, N., Knight, R., Huttenhower, C., & Ley, R. E. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002863 · Cited by 508
A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
Ochoa-Repáraz, J., Mielcarz, D. W., Wang, Y., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.29 · Cited by 507
Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances
Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., Bennett, A., Jabado, O., Hirschberg, D. L., & Lipkin, W. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024585 · Cited by 492
Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice
Hildebrand, F., Nguyen, T. L. A., Brinkman, B. M. N., Yunta, R. G., Cauwe, B., Vandenabeele, P., Liston, A., & Raes, J. (2013) · Genome biology · doi:10.1186/gb-2013-14-1-r4 · Cited by 478
Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472
A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells
Lavasani, S., Dzhambazov, B. M., Nouri, M., Fåk, F., Buske, S., Molin, G., Thorlacius, H., Alenfall, J., Jeppsson, B. W., & Weström, B. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009009 · Cited by 461
The origin and application of experimental autoimmune encephalomyelitis
Baxter, A. G. (2007) · Nature reviews. Immunology · doi:10.1038/nri2190 · Cited by 458
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448
Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.
Macpherson, A. J., Khoo, U. Y., Forgács, I., Philpott‐Howard, J., & Bjarnason, I. (1996) · Gut · doi:10.1136/gut.38.3.365 · Cited by 435
Altered gut microbiota and activity in a murine model of autism spectrum disorders
de Theije, C. G. M., Wopereis, H., Ramadan, M., van Eijndthoven, T., Lambert, J., Knol, J., Garssen, J., Kraneveld, A. D., & Oozeer, R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.005 · Cited by 433
The role of the immune system in governing host-microbe interactions in the intestine
Brown, E., Sadarangani, M., & Finlay, B. B. (2013) · Nature Immunology · doi:10.1038/ni.2611 · Cited by 431
Mood and gut feelings
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429
Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress
Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423
Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder
Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-42 · Cited by 418
Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder
Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412
Compartmentalized and systemic control of tissue immunity by commensals
Belkaid, Y., & Naik, S. (2013) · Nature Immunology · doi:10.1038/ni.2604 · Cited by 382
Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances
Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012) · mBio · doi:10.1128/mbio.00261-11 · Cited by 378
Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression
Ochoa-Repáraz, J., Mielcarz, D. W., Ditrio, L. E., Burroughs, A. R., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001443 · Cited by 367 · cited 7×
“B. fragilis is a prominent probiotic strain that promotes Foxp3+Treg quantity and functional maturation in both EAE and IBD (Mazmanian et al., 2008; Ochoa-Reparaz et al., 2010a).”
Influential
Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365
Aquaporin 4‐specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter
Varrin‐Doyer, M., Spencer, C. M., Schulze‐Topphoff, U., Nelson, P. A., Stroud, R. M., C. Cree, B. A., & Zamvil, S. S. (2012) · Annals of Neurology · doi:10.1002/ana.23651 · Cited by 341
Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia citrobacter rodentium
LYTE, M., LI, W., OPITZ, N., GAYKEMA, R., & GOEHLER, L. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.06.019 · Cited by 334
Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium‐dependent potassium channel opening
Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328
Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls
Yap, I. K. S., Angley, M. T., Veselkov, K., Holmes, E. C., Lindon, J. C., & Nicholson, J. K. (2010) · Journal of Proteome Research · doi:10.1021/pr901188e · Cited by 315
Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
Santos, J., Yang, P.-C., Söderholm, J. D., Benjamin, M., & Perdue, M. H. (2001) · Gut · doi:10.1136/gut.48.5.630 · Cited by 313
Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System
Brun, P., Giron, M. C., Qesari, M., Porzionato, A., Caputi, V., Zoppellaro, C., Banzato, S., Grillo, A. R., Spagnol, L., De Caro, R., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.047 · Cited by 300
Intestinal microbiota in inflammatory bowel disease: Friend of foe?
Fava, F. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i5.557 · Cited by 297
Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome–gut–brain axis
Davari, S., Talaei, S. A., Alaei, H., & salami, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.055 · Cited by 290 · cited 1×
“Probiotics were able to improve infection-induced memory dysfunction and diabetes-induced cognitive defects (Davari et al., 2013; Gareau et al., 2011).”
Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior
Goehler, L. E., Park, S. M., Opitz, N., Lyte, M., & Gaykema, R. P. A. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.009 · Cited by 287
Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia
Barajon, I., Serrao, G., Arnaboldi, F., Opizzi, E., Ripamonti, G., Balsari, A., & Rumio, C. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953539 · Cited by 287
Th17 cytokines and mucosal immunity
Dubin, P. J., & Kolls, J. K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00703.x · Cited by 276
Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome
Ohland, C. L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., & Madsen, K. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.008 · Cited by 273
NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora
Yokote, H., Miyake, S., Croxford, J. L., Oki, S., Mizusawa, H., & Yamamura, T. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080622 · Cited by 271
The Gut Microbiome: A New Frontier in Autism Research
Mulle, J. G., Sharp, W. G., & Cubells, J. F. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-012-0337-0 · Cited by 262
Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria
Li, W., Dowd, S. E., Scurlock, B., Acosta-Martinez, V., & Lyte, M. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.004 · Cited by 246
Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia
Severance, E. G., Gressitt, K. L., Stallings, C. R., Origoni, A. E., Khushalani, S., Leweke, F. M., Dickerson, F. B., & Yolken, R. H. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.018 · Cited by 243
Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats
Kamiya, T., Wang, L., Forsythe, P., Goettsche, G., Mao, Y., Wang, Y., Tougas, G., & Bienenstock, J. (2006) · Gut · doi:10.1136/gut.2005.070987 · Cited by 242
Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis
Piccio, L. M., Stark, J. L., & Cross, A. H. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208133 · Cited by 235
Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study
Ming, X., Stein, T. P., Barnes, V., Rhodes, N., & Guo, L. (2012) · Journal of Proteome Research · doi:10.1021/pr300910n · Cited by 234
Autism and Clostridium tetani
Bolte, E. R. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90107-4 · Cited by 213
Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response
Kwon, H.-K., Kim, G.-C., Kim, Y., Hwang, W., Jash, A., Sahoo, A., Kim, J.-E., Nam, J. H., & Im, S.-H. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.01.001 · Cited by 212 · cited 3×
“The role of microbiom dx.doi.org/10.1016/j.bbi.2013.12.015 strains of Bifidobacterium genus, tend to alleviate murine EAE symptoms via reciprocal regulation of pro- and anti-inflammatory cytokine responses (Kobayashi et al., 2010, 2012; Kwon et al., 2013; Lavasani et al., 2010).”
Influential
Effect of Intestinal Microbial Ecology on the Developing Brain
Douglas‐Escobar, M., Elliott, E. C., & Neu, J. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.497 · Cited by 211
Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings
Gondalia, S. V., Palombo, E. A., Knowles, S. R., Cox, S. B., Meyer, D., & Austin, D. W. (2012) · Autism Research · doi:10.1002/aur.1253 · Cited by 208
The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat
McKernan, D. P., Fitzgerald, P., Dinan, T. G., & Cryan, J. F. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01520.x · Cited by 205
Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model
Arseneault-Bréard, J., Rondeau, I., Gilbert, K., Girard, S.-A., Tompkins, T. A., Godbout, R., & Rousseau, G. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511005137 · Cited by 205
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders
Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-153 · Cited by 200
Guillain-Barré Syndrome and Preceding Infection with Campylobacter, Influenza and Epstein-Barr Virus in the General Practice Research Database
Tam, C. C., O’Brien, S. J., Petersen, I., Islam, A., Hayward, A. C., & Rodrigues, L. C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000344 · Cited by 193
Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction
Ait-Belgnaoui, A. (2005) · Gut · doi:10.1136/gut.2005.084194 · Cited by 189
Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons
Mao, Y.-K., Kasper, D. L., Wang, B., Forsythe, P., Bienenstock, J., & Kunze, W. A. (2013) · Nature Communications · doi:10.1038/ncomms2478 · Cited by 178
Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease
Ochoa‐Repáraz, J., Mielcarz, D. W., Haque, S., & Kasper, L. H. (2010) · Annals of Neurology · doi:10.1002/ana.22344 · Cited by 162
Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin
de Lartigue, G., Serre, C. B. D. L., & Raybould, H. E. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.040 · Cited by 151
Brain microbial populations in HIV/AIDS: α-proteobacteria predominate independent of host immune status
Branton, W. G., Ellestad, K. K., Maingat, F., Wheatley, B. M., Rud, E., Warren, R. L., Holt, R. A., Surette, M. G., & Power, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054673 · Cited by 149 · cited 2×
“Interestingly, microbiota have been identified within immune-privileged sites such as the CNS. a-proteobacteria class is reported to be the major commensals persistent http:// in the human brain regardless of immune status (Branton et al., 2013).”
Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry
Gaykema, R. P. A., Goehler, L. E., & Lyte, M. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.08.002 · Cited by 147
Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora
Ochoa‐Repáraz, J., Mielcarz, D. W., Haque-Begum, S., & Kasper, L. H. (2010) · Gut Microbes · doi:10.4161/gmic.1.2.11515 · Cited by 143
Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
O’Malley, D., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.009 · Cited by 140
The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells
Takata, K., Kinoshita, M., Okuno, T., Moriya, M., Kohda, T., Honorat, J. A., Sugimoto, T., Kumanogoh, A., Kayama, H., Takeda, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027644 · Cited by 140
The putative role of the intestinal microbiota in the irritable bowel syndrome.
Collins, S., Denou, E., Verdú, E., & Bercik, P. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.023 · Cited by 130
Effects ofBifidobacterium animalisadministered during lactation on allergic and autoimmune responses in rodents
Ezendam, J., de Klerk, A., Gremmer, E. R., & Loveren, H. V. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03788.x · Cited by 121
Gut microbial communities modulating brain development and function
Al‐Asmakh, M., Anuar, F., Zadjali, F., Rafter, J. J., & Pettersson, S. (2012) · Gut Microbes · doi:10.4161/gmic.21287 · Cited by 120
Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis
Reber, S. O. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.014 · Cited by 116
Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety
Gundersen, B. B., & Blendy, J. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.04.008 · Cited by 112
Gut???brain axis
Romijn, J. A., Corssmit, E. P. M., Havekes, L. M., & Pijl, H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328302c9b0 · Cited by 112
Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
Maes, M. H. J., Twisk, F., Kubera, M., Ringel, K., Leunis, J., & Geffard, M. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.010 · Cited by 108
Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Autoimmune Encephalomyelitis
González‐Rey, E., Fernandez‐Martin, A., Chorny, A., Martin, J. J., Pozo, D., Ganea, D., & Delgado, M. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051081 · Cited by 95
A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
Bajaj, J. S., Gillevet, P. M., Patel, N. R., Ahluwalia, V., Ridlon, J. M., Kettenmann, B., Schubert, C. M., Sikaroodi, M., Heuman, D. M., Crossey, M. M. E., et al. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9303-0 · Cited by 95
Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells
Rezende, R. M., de Oliveira, R. P., Medeiros, S. R., Gomes-Santos, A. C., Alves, A. C., Loli, F. G., Guimarães, M. A. F., Amaral, S. S., da Cunha, A. P., Weiner, H. L., et al. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.07.012 · Cited by 88
Gene, environment, and brain‐gut interactions in irritable bowel syndrome
Fukudo, S., & Kanazawa, M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06631.x · Cited by 87
Unique Lipids from a Common Human Bacterium Represent a New Class of Toll-Like Receptor 2 Ligands Capable of Enhancing Autoimmunity
Nichols, F. C., Housley, W. J., O’Conor, C., Manning, T., Wu, S., & Clark, R. B. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090544 · Cited by 85
Cytokine and Other Immunologic Markers in Chronic Fatigue Syndrome and Their Relation to Neuropsychological Factors
Patarca-Montero, R., Antoni, M. H., FLETCHER, M. A., & Klimas, N. G. (2001) · Applied Neuropsychology · doi:10.1207/s15324826an0801_7 · Cited by 84
Commensal gut flora and brain autoimmunity: a love or hate affair?
Berer, K., & Krishnamoorthy, G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0949-9 · Cited by 82
Effects of Bifidobacterium infantis 35624 on Post-Inflammatory Visceral Hypersensitivity in the Rat
Johnson, A. C., Greenwood-Van Meerveld, B., & McRorie, J. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1730-y · Cited by 76
Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity
Maassen, C. B. M., & Claassen, E. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.02.035 · Cited by 75
IL-13 Production by Regulatory T Cells Protects against Experimental Autoimmune Encephalomyelitis Independently of Autoantigen
Ochoa‐Repáraz, J., Rynda, A., Ascón, M. A., Yang, X., Kochetkova, I., Riccardi, C., Callis, G. M., Trunkle, T., & Pascual, D. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.954 · Cited by 74
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine
Kusu, T., Kayama, H., Kinoshita, M., Jeon, S. G., Ueda, Y., Goto, Y., Okumura, R., Saiga, H., Kurakawa, T., Ikeda, K., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1103067 · Cited by 73
Regulatory T Cell Vaccination without Autoantigen Protects against Experimental Autoimmune Encephalomyelitis
Ochoa‐Repáraz, J., Riccardi, C., Rynda, A., Jun, S., Callis, G. M., & Pascual, D. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1791 · Cited by 71
It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro‐ and immune‐modulatory functions during development and adulthood
Diamond, B., Huerta, P. T., Tracey, K., & Volpe, B. T. (2011) · BioEssays · doi:10.1002/bies.201100042 · Cited by 69
Metagenomics and development of the gut microbiota in infants
Vallès, Y., Gosalbes, M. J., de Vries, L. E., Abelián, J. J., & Francino, M. P. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03876.x · Cited by 69
Attenuation of post-myocardial infarction depression in rats byn-3 fatty acids or probiotics starting after the onset of reperfusion
Kim, G., Arseneault-Bréard, J., Monaco, F. F., Beaudoin, A., Bah, T. M., Tompkins, T. A., Godbout, R., & Rousseau, G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003807 · Cited by 68
Lactobacillus caseiShirota administered during lactation increases the duration of autoimmunity in rats and enhances lung inflammation in mice
Ezendam, J., & Loveren, H. V. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507803412 · Cited by 61
Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system
Bánáti, M., Csécsei, P., Kőszegi, E., Nielsen, H. H., Sütő, G., Bors, L., Trauninger, A., Csépány, T., Rózsa, C., Jakab, G., et al. (2013) · European Journal of Neurology · doi:10.1111/ene.12072 · Cited by 57
Subgingival microbiota in adult Down syndrome periodontitis
Khocht, A., Yaskell, T., Janal, M. N., Turner, B. F., Rams, T. E., Haffajee, A. D., & Socransky, S. S. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01459.x · Cited by 55
Probiotics effects on gastrointestinal function: beyond the gut?
Verdu, E. F. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01297.x · Cited by 55
Role of Microbiome in Regulating the HPA Axis and Its Relevance to Allergy
Sudo, N. (2012) · Chemical Immunology and Allergy · doi:10.1159/000336510 · Cited by 54
Differential expression of the polysialyl capsule during blood-to-brain transit of neuropathogenic Escherichia coli K1
Zelmer, A., Bowen, M., Jokilammi, A., Finne, J., Luzio, J. P., & Taylor, P. W. (2008) · Microbiology · doi:10.1099/mic.0.2008/017988-0 · Cited by 47
Lymphocytes in neuroprotection, cognition and emotion: Is intolerance really the answer?
Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.005 · Cited by 44
The Relationship Between Gingivitis and the Serum Antibodies to the Microbiota Associated With Periodontal Disease in Children With Down's Syndrome
Morinushi, T., Lopatin, D. E., & Poperin, N. V. (1997) · Journal of Periodontology · doi:10.1902/jop.1997.68.7.626 · Cited by 43
Multiple sclerosis and viruses
Brahic, M. (2010) · Annals of Neurology · doi:10.1002/ana.22057 · Cited by 42
Probiotic upregulation of peripheral IL-17 responses does not exacerbate neurological symptoms in experimental autoimmune encephalomyelitis mouse models
Kobayashi, T., Suzuki, T., Kaji, R., Serata, M., Nagata, T., Ando, M., Iizuka, R., Tsujibe, S., Murakami, J., Kiyoshima‐Shibata, J., et al. (2011) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2010.617755 · Cited by 41
Oral administration of probiotic bacteria,Lactobacillus caseiandBifidobacterium breve, does not exacerbate neurological symptoms in experimental autoimmune encephalomyelitis
Kobayashi, T., Kato, I., Nanno, M., Shida, K., Shibuya, K., Matsuoka, Y., & Onoue, M. (2009) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923970903200716 · Cited by 38
Time-related Increase of Staphylococci, Enterobacteriaceae and Yeasts in the Oral Cavities of Comatose Patients
Cecon, F., Ferreira, L. E. N., Rosa, R. T., Gursky, L. C., Carvalho, A. D. P. E., Samaranayake, L. P., & Rosa, E. A. R. (2010) · Journal of Microbiology Immunology and Infection · doi:10.1016/s1684-1182(10)60071-0 · Cited by 16
Long-term dietary l-arginine supplementation increases endothelial nitric oxide synthase and vasoactive intestinal peptide immunoexpression in rat small intestine
Veličković, K., Markelic, M. B., Golić, I., Otašević, V., Stančić, A., Janković, A., Vučetić, M., Buzadžić, B., Korać, B., & Korać, A. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0585-8 · Cited by 14

Sorted by citations

Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275
The far-reaching scope of neuroinflammation after traumatic brain injury
Simon, D. W., McGeachy, M. J., Bayır, H., Clark, R. S. B., Loane, D. J., & Kochanek, P. M. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.13 · Cited by 1,190
The microbiome-gut-brain axis in health and disease
Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813

See all 803

Authors: Wang, Y., & Kasper, L. H.
Affiliations: Dartmouth College (US)
Corresponding author: Kasper, Lloyd H.
ORCID: Wang, Yan
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2014-05
Volume: 38
Pages: 1-12
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2013.12.015
PMC: PMC4062078
OpenAlex: W1991521547
Cited by: 803
References: 160
Citations by year: 2026: 26 · 2025: 54 · 2024: 58 · 2023: 81 · 2022: 70 · 2021: 73 · 2020: 98 · 2019: 69 · 2018: 77 · 2017: 69 · 2016: 65 · 2015: 41 · 2014: 21
FWCI: 3.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R56AI098282)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: microbiome, central nervous system disorders, gut microbiota, microbiome-gut-brain axis, neuropsychiatric disorders, multiple sclerosis, autism spectrum disorder, depression, anxiety, stress, probiotics, antibiotics
MeSH terms: Animals, Brain, Central Nervous System Diseases, Humans, Gastrointestinal Tract, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of microbiome in central nervous system disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks