Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing
Open accessAbstract
Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N=5909), cross-sectional analyses revealed a significant dose-response association between C-reactive protein and the symptoms of fatigue (P<0.001), restless sleep (P=0.03), low energy (P=0.02) and feeling depressed (P=0.04), but not other symptoms. These associations were absent in users of anti-depressant medication. Our findings suggest the C-reactive protein-depression association is symptom-specific and modified by antidepressant treatment.
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In 5909 patients, CRP levels were associated with symptoms of fatigue (p < 0.001), restless sleep (p = 0.03), low energy (p = 0.02) and feeling depressed (p = 0.04).
“A study involving 5909 patients aimed at investigating the possible association between inflammation and specific depressive symptoms, found that CRP levels were associated with symptoms of fatigue (p < 0.001), restless sleep (p = 0.03), low energy (p = 0.02) and feeling depressed (p = 0.04) [73].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [73]
These associations were absent in patients under antidepressant medication.
“These associations were absent in patients under antidepressant medication [73].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [73]
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- Authors
- White, J., Kivimäki, M., Jokela, M., & Batty, G. D.
- Affiliations
- Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement (GB)
- University of Helsinki (FI)
- University College London (GB)
- Corresponding author
- White, James
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 61
- Pages
- 27-30
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2518176941
- Cited by
- 99
- References
- 14
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 8 · 2020: 10 · 2019: 11 · 2018: 11 · 2017: 3 · 2016: 1
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Funders
- National Institute of Aging in the United States
- British Heart Foundation
- Cancer Research UK
- Economic and Social Research Council (ESRC RES-590-28-0005)
- Medical Research Council
- Welsh Assembly Government (Wellcome Trust, WT087640MA)
- UK Medical Research Council
- Academy of Finland
- Nordic Programme on Health and Welfare
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, inflammation, C-reactive protein, older adults, fatigue, restless sleep, low energy, antidepressant treatment, dose-response relationship, English Longitudinal Study of Ageing
- MeSH terms
- Aged, Aging, Antidepressive Agents, C-Reactive Protein, Depression, England, Female, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Biomarkers
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