Inflammation-induced motivational changes: Perspective gained by evaluating positive and negative valence systems
Open accessAbstract
Inflammation can profoundly impact motivated behavior, as is the case with inflammation-induced depression. By evaluating objectively measurable basic neurobehavioral processes involved in motivation, recent research indicates that inflammation generally reduces approach motivation and enhances avoidance motivation. Increased effort valuation largely mediates the effects of inflammation on approach motivation. Changes in reward valuation are not uniformly observed in approach motivation. However, inflammation increases the averseness of negative stimuli. Within the context of both approach and avoidance motivation, inflammation appears to enhance the contrast between concurrently presented stimuli. While changes in both approach and avoidance motivation appear to be mediated by midbrain dopaminergic neurotransmission to the ventral striatum, it is unclear if the enhanced contrast is mediated by the same system.
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Blood cytokine levels affect motivational aspects in experimental models; inflammation tends to reduce approach motivation and enhance avoidance motivation.
“Blood cytokine levels also affect motivational aspects in experimental models. Although these interactions are complex [52,53,54], inflammation tends to reduce approach motivation and enhances avoidance motivation [55].”
From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [55]
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“to reduce approach motivation and enhances avoidance motivation [55].”
Background
- Authors
- Vichaya, E. G., & Dantzer, R.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Vichaya, Elisabeth G
- Venue
- Current Opinion in Behavioral Sciences
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 22
- Pages
- 90-95
- ISSN
- 2352-1546 (ISSN-L)
- PMC
- PMC5987547
- OpenAlex
- W2790063417
- Cited by
- 47
- References
- 56
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 2
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Behavioral Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 CA193522, R21 MH104694)
- MD Anderson Cancer Center Support Grant (P30 CA016672)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- inflammation, motivational behavior, approach motivation, avoidance motivation, effort valuation, reward valuation, midbrain dopamine, ventral striatum, stimulus contrast
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