COVID-19 presenting as stroke
Open accessAbstract
Objective Acute stroke remains a medical emergency even during the COVID-19 pandemic. Most patients with COVID-19 infection present with constitutional and respiratory symptoms; while others present with atypical gastrointestinal, cardiovascular, or neurological manifestations. Here we present a series of four patients with COVID-19 that presented with acute stroke.Methods We searched the hospital databases for patients that presented with acute stroke and concomitant features of suspected COVID-19 infection. All patients who had radiographic evidence of stroke and PCR-confirmed COVID-19 infection were included in the study. Patients admitted to the hospital with PCR- confirmed COVID-19 disease whose hospital course was complicated with acute stroke while inpatient were excluded from the study. Retrospective patient data were obtained from electronic medical records. Informed consent was obtained.Results We identified four patients who presented with radiographic confirmation of acute stroke and PCR-confirmed SARS-CoV-2 infection. We elucidate the clinical characteristics, imaging findings, and the clinical course.Conclusions Timely assessment and hyperacute treatment is the key to minimize mortality and morbidity of patients with acute stroke. Stroke teams should be wary of the fact that COVID-19 patients can present with cerebrovascular accidents and should dawn appropriate personal protective equipment in every suspected patient. Further studies are urgently needed to improve current understandings of neurological pathology in the setting of COVID-19 infection.
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Both intracerebral hemorrhage and clots are responsible for the primary stroke in the brain.
“Both intracerebral hemorrhage, against which the P2X7 receptor antagonist protects [124], and clots are responsible for the primary stroke in the brain [128].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [128]
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286 · see citing works
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166 · see citing works
Incidence of thrombotic complications in critically ill ICU patients with COVID-19
Klok, F. A., Kruip, M. J. H. A., van der Meer, N. J. M., Arbous, M. S., Gommers, D. A. M. P. J., Kant, K. M., Kaptein, F. H. J., van Paassen, J., Stals, M. A. M., Huisman, M. V., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.013 · Cited by 5,028 · see citing works
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
Wu, A., Peng, Y., Huang, B., Ding, X. L., Wang, X., Niu, P., Meng, J., Zhu, Z., Zhang, Z., Wang, J., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.02.001 · Cited by 2,363 · see citing works
Nervous system involvement after infection with COVID-19 and other coronaviruses
Wu, Y., Xu, X., Chen, Z., Duan, J., Hashimoto, K., Yang, L., Liu, C., & Yang, C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.03.031 · Cited by 2,046 · see citing works
A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
Moriguchi, T., Harii, N., Goto, J., Harada, D., Sugawara, H., Takamino, J., Ueno, M., Sakata, H., Kondo, K., Myose, N., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.03.062 · Cited by 2,024 · see citing works
Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)
Inciardi, R. M., Lupi, L., Zaccone, G., Italia, L., Raffo, M., Tomasoni, D., Cani, D., Cerini, M., Farina, D., Gavazzi, E., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.1096 · Cited by 1,860 · see citing works
Fox, S., Akmatbekov, A., Harbert, J. L., Li, G., Brown, J. Q., & Heide, R. S. V. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30243-5 · Cited by 1,524 · see citing works
Li, Y., 王梦嵽, Zhou, Y., Chang, J., Xian, Y., Mao, L., Hong, C., Chen, S., Wang, Y., Wang, H., et al. (2020) · Stroke and Vascular Neurology · doi:10.1136/svn-2020-000431 · Cited by 1,062 · see citing works
[A pathological report of three COVID-19 cases by minimal invasive autopsies].
Yao, X. H., Li, T. Y., He, Z. C., Ping, Y. F., Liu, H. W., Yu, S. C., Mou, H. M., Wang, L. H., Zhang, H. R., Fu, W. J., et al. (2020) · PubMed · doi:10.3760/cma.j.cn112151-20200312-00193 · Cited by 963 · see citing works
COVID-19 Autopsies, Oklahoma, USA
Barton, L. M., Duval, E. J., Stroberg, E., Ghosh, S., & Mukhopadhyay, S. (2020) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqaa062 · Cited by 832 · see citing works
Acute pulmonary embolism and COVID-19 pneumonia: a random association?
Danzi, G. B., Loffi, M., Galeazzi, G., & Gherbesi, E. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa254 · Cited by 657 · see citing works
Evolutionary history, potential intermediate animal host, and cross‐species analyses of SARS‐CoV‐2
Li, X., Zai, J., Zhao, Q., Nie, Q. H., Li, Y., Foley, B. T., & Chaillon, A. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25731 · Cited by 428 · see citing works
Pulmonary and Cardiac Pathology in Covid-19: The First Autopsy Series from New OrleansPreprint
Fox, S., Akmatbekov, A., Harbert, J. L., et al. (2020) · medRxiv · doi:10.1101/2020.04.06.20050575 · Cited by 410 · see citing works
Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID‐19
Steardo, L., Steardo, L., Zorec, R., & Verkhratsky, A. (2020) · Acta Physiologica · doi:10.1111/apha.13473 · Cited by 367 · see citing works
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS)
Umapathi, T., Kor, A. C., Venketasubramanian, N., Lim, C. C. T., Pang, B. C., Yeo, T. T., Lee, C. C., Lim, P. L., Kuperan, P., Chuah, K. L., et al. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0519-8 · Cited by 259 · see citing works
Khosravani, H., Rajendram, P., Notario, L., Chapman, M., & Menon, B. K. (2020) · Stroke · doi:10.1161/strokeaha.120.029838 · Cited by 237 · see citing works
Neurological manifestations in severe acute respiratory syndrome.
Tsai, L., Hsieh, S., & Chang, Y. (2005) · PubMed · Cited by 235 · see citing works
Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia
Grau, A., Buggle, F., Becher, H., Zimmermann, E., SPIEL, M. S., Fent, T., Maiwald, M., Werle, E., Zorn, M., Hengel, H., et al. (1998) · Neurology · doi:10.1212/wnl.50.1.196 · Cited by 209 · see citing works
Coronaviren als Ursache respiratorischer Infektionen
Corman, V. M., Lienau, J., & Witzenrath, M. (2019) · Der Internist · doi:10.1007/s00108-019-00671-5 · Cited by 140 · see citing works
Tan, C. W., Low, J. G. H., Wong, W. H., Chua, Y. Y., Goh, S. L., & Ng, H. J. (2020) · American Journal of Hematology · doi:10.1002/ajh.25822 · Cited by 103 · see citing works
Flagged first, then by citations
1 of the 23 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Neurological associations of COVID-19
Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., & Solomon, T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30221-0 · Cited by 2,156 · see citing works
Li, Y., 王梦嵽, Zhou, Y., Chang, J., Xian, Y., Mao, L., Hong, C., Chen, S., Wang, Y., Wang, H., et al. (2020) · Stroke and Vascular Neurology · doi:10.1136/svn-2020-000431 · Cited by 1,062 · see citing works
COVID-19 Image Data Collection: Prospective Predictions are the Future
Cohen, J., Morrison, P., Dao, L., Roth, K., Duong, T. Q., & Ghassemi, M. (2020) · The Journal of Machine Learning for Biomedical Imaging · doi:10.59275/j.melba.2020-48g7 · Cited by 1,026 · see citing works
Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review
Montalván, V., Lee, J., Bueso, T., Toledo, J. D., & Rivas, K. M. R. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.105921 · Cited by 659 · see citing works
COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation
Zabetakis, I., Lordan, R., Norton, C., & Τσούπρας, Α. (2020) · Nutrients · doi:10.3390/nu12051466 · Cited by 535 · see citing works
COVID-19 and multiorgan failure: A narrative review on potential mechanisms
Mokhtari, T., Hassani, F., Ghaffari, N., Ebrahimi, B., Yarahmadi, A., & Hassanzadeh, G. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09915-3 · Cited by 440 · see citing works
Neurological Manifestations of COVID‐19: A systematic review and current update
Whittaker, A., Anson, M., & Harky, A. (2020) · Acta Neurologica Scandinavica · doi:10.1111/ane.13266 · Cited by 430 · see citing works
COVID-19: from an acute to chronic disease? Potential long-term health consequences
Higgins, V., Sohaei, D., Diamandis, E. P., & Prassas, I. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1860895 · Cited by 414 · see citing works
Fotuhi, M., Mian, A., Meysami, S., & Raji, C. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200581 · Cited by 388 · see citing works
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital
Thakur, K. T., Miller, E. H., Glendinning, M. D., Al‐Dalahmah, O., Banu, M. A., Boehme, A. K., Boubour, A., Bruce, S. S., Chong, A. M., Claassen, J., et al. (2021) · Brain · doi:10.1093/brain/awab148 · Cited by 385 · see citing works
Miskowiak, K., Johnsen, S., Sattler, S., Nielsen, S., Kunalan, K., Rungby, J., Lapperre, T., & Porsberg, C. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.03.019 · Cited by 365 · see citing works
COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature
Tan, Y. K., Goh, C. M. J. L., Leow, A. S., Tambyah, P. A., Ang, A., Yap, E. S., Tu, T. M., Sharma, V. K., Yeo, L. L. L., Chan, B., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02228-y · Cited by 318 · see citing works
A metabolic handbook for the COVID-19 pandemic
Ayres, J. S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0237-2 · Cited by 289 · see citing works
COVID‐19–associated Guillain‐Barré syndrome: The early pandemic experience
Caress, J. B., Castoro, R. J., Simmons, Z., Scelsa, S. N., Lewis, R. A., Ahlawat, A., & Narayanaswami, P. (2020) · Muscle & Nerve · doi:10.1002/mus.27024 · Cited by 286 · see citing works
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 283 · see citing works
Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow’s triad
Ahmed, S., Zimba, O., & Gasparyan, A. Y. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05275-1 · Cited by 251 · see citing works
COVID-19 and metabolic disease: mechanisms and clinical management
Steenblock, C., Schwarz, P. E. H., Ludwig, B., Linkermann, A., Zimmet, P., Kulebyakin, K. Y., Va, T., Markov, A. G., Lehnert, H., de Angelis, M. H., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00244-8 · Cited by 248 · see citing works
Zaki, N., Alashwal, H., & Ibrahim, S. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.07.005 · Cited by 240 · see citing works
Spectrum of neuropsychiatric manifestations in COVID-19.
Nalleballe, K., Reddy Onteddu, S., Sharma, R., Dandu, V., Brown, A., Jasti, M., Yadala, S., Veerapaneni, K., Siddamreddy, S., Avula, A., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.06.020 · Cited by 235 · see citing works
Self-citationMaury, A., Lyoubi, A., Peiffer‐Smadja, N., de Broucker, T., & Meppiel, E. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.10.001 · Cited by 232 · see citing works
Neurological and Neuropsychiatric Impacts of COVID-19 Pandemic
Roy, D., Ghosh, R., Dubey, S., Dubey, M. J., Benito‐León, J., & Ray, B. K. (2020) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2020.173 · Cited by 228 · see citing works
Sharifian, M., Huot, P., Osherov, M., Wen, D., Saveriano, A., Giacomini, P. S., Antel, J. P., & Mowla, A. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117085 · Cited by 224 · see citing works
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection
Synowiec, A., Szczepański, A., Barreto-Durán, E., Lie, L. K., & Pyrć, K. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00133-20 · Cited by 221 · see citing works
Mirabelli, C., Wotring, J. W., Zhang, C. J., McCarty, S. M., Fursmidt, R. M., Pretto, C. D., Qiao, Y., Zhang, Y., Frum, T., Kadambi, N. S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105815118 · Cited by 218 · see citing works
COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke
Belani, P. B., Schefflein, J., Kihira, S., Rigney, B., Delman, B. N., Mahmoudi, K., Mocco, J., Majidi, S., Yeckley, J., Aggarwal, A., et al. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6650 · Cited by 214 · see citing works
Neurological Manifestations of COVID-19 (SARS-CoV-2): A Review
Ahmed, M. U., Hanif, M., Ali, M. J., Haider, M. A., Kherani, D., Memon, G. M., Karim, A. H., & Sattar, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00518 · Cited by 212 · see citing works
Peripheral Nervous System Manifestations Associated with COVID-19
Andalib, S., Biller, J., Napoli, M. D., Moghimi, N., McCullough, L. D., Rubiños, C., Nobleza, C. O., Azarpazhooh, M. R., Catanese, L., Elicer, I., et al. (2021) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-021-01102-5 · Cited by 194 · see citing works
Climate change, environment pollution, COVID-19 pandemic and mental health
Marazziti, D., Cianconi, P., Mucci, F., Crowther, L. F., Chiarantini, I., & Vecchia, A. D. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145182 · Cited by 193 · see citing works
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
Rutkai, I., Mayer, M. G., Hellmers, L., Ning, B., Huang, Z. J., Monjure, C. J., Coyne, C., Silvestri, R., Golden, N., Hensley, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29440-z · Cited by 188 · see citing works
Chidambaram, V., Tun, N. L., Haque, W. Z., Majella, M. G., Sivakumar, R. K., Kumar, A., Hsu, A. T., Ishak, I. A., Nur, A. A., Ayeh, S. K., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241541 · Cited by 176 · see citing works
Shibata, S., Arima, H., Asayama, K., Hoshide, S., Ichihara, A., Ishimitsu, T., Kario, K., Kishi, T., Mogi, M., Nishiyama, A., et al. (2020) · Hypertension Research · doi:10.1038/s41440-020-0515-0 · Cited by 175 · see citing works
COVID-19–Associated Nonocclusive Fibrin Microthrombi in the Heart
Bois, M. C., Boire, N. A., Layman, A. J., Aubry, M.-C., Alexander, M. P., Roden, A. C., Hagen, C. E., Quinton, R. A., Larsen, C. P., Erben, Y., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.050754 · Cited by 163 · see citing works
Panda, P. K., Sharawat, I. K., Panda, P., Natarajan, V., Bhakat, R., & Dawman, L. (2020) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmaa070 · Cited by 160 · see citing works
Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses
Gavriilaki, E., Anyfanti, P., Gavriilaki, M., Lazaridis, A. A., Δούμα, Σ., & Gkaliagkousi, Ε. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01078-6 · Cited by 158 · see citing works
Achar, A., & Ghosh, C. (2020) · Cells · doi:10.3390/cells9112360 · Cited by 159 · see citing works
COVID-19: Complement, Coagulation, and Collateral Damage
Lo, M. W., Kemper, C., & Woodruff, T. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000644 · Cited by 157 · see citing works
Jha, N. K., Ojha, S. K., Jha, S. K., Dureja, H., Singh, S. K., Shukla, S. D., Chellappan, D. K., Gupta, G., Bhardwaj, S., Kumar, N., et al. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01767-6 · Cited by 151 · see citing works
Review of Current COVID-19 Diagnostics and Opportunities for Further Development
Mardian, Y., Kosasih, H., Karyana, M., Neal, A., & Lau, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.615099 · Cited by 147 · see citing works
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology
Deigendesch, N., Sironi, L., Kutza, M., Wischnewski, S., Fuchs, V., Hench, J., Frank, A., Nienhold, R., Mertz, K. D., Cathomas, G., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02213-y · Cited by 140 · see citing works
The Impact of SARS‐CoV ‐2 on Stroke Epidemiology and Care: A Meta‐Analysis
Katsanos, A. H., Palaiodimou, L., Zand, R., Yaghi, S. R., Kamel, H., Navi, B. B., Turc, G., Romoli, M., Sharma, V. K., Mavridis, D., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25967 · Cited by 138 · see citing works
Pinzon, R. T., Wijaya, V. O., Buana, R. B., Jody, A. A., & Nunsio, P. N. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00565 · Cited by 133 · see citing works
Neuropsychiatric aspects of COVID-19 pandemic: A selective review
Dinakaran, D., Manjunatha, N., Kumar, C. N., & Suresh, B. M. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102188 · Cited by 129 · see citing works
Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019
Sweid, A., Hammoud, B., Bekelis, K., Missios, S., Tjoumakaris, S. I., Gooch, M. R., Herial, N. A., Zarzour, H. K., Romo, V. M., DePrince, M., et al. (2020) · International Journal of Stroke · doi:10.1177/1747493020937189 · Cited by 128 · see citing works
Post-COVID 19 neurological syndrome: Implications for sequelae’s treatment
Camargo-Martínez, W., Lozada-Martínez, I. D., Escobar-Collazos, A., Navarro-Coronado, A., Moscote‐Salazar, L. R., Pacheco-Hernández, A., Janjua, T. M., & Bosque‐Varela, P. (2021) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2021.04.001 · Cited by 128 · see citing works
Central Nervous System Manifestations Associated with COVID-19
Divani, A. A., Andalib, S., Biller, J., Napoli, M. D., Moghimi, N., Rubiños, C., Nobleza, C. O., Sylaja, P. N., Toledano, M., Lattanzi, S., et al. (2020) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01079-7 · Cited by 128 · see citing works
Intracerebral haemorrhage and COVID-19: Clinical characteristics from a case series
Benger, M., Williams, O., Siddiqui, J., & Sztriha, L. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.005 · Cited by 124 · see citing works
Neurological involvement of coronavirus disease 2019: a systematic review
Ghannam, M., Alshaer, Q., Al-Chalabi, M., Zakarna, L., Robertson, J., & Manousakis, G. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09990-2 · Cited by 119 · see citing works
Alquisiras-Burgos, I., Peralta-Arrieta, I., Alonso-Palomares, L. A., Zacapala-Gómez, A. E., Salmerón-Bárcenas, E. G., & Aguilera, P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02134-7 · Cited by 115 · see citing works
Coronavirus Disease 2019–Associated Coagulopathy
Lippi, G., Sanchis‐Gomar, F., Favaloro, E. J., Lavie, C. J., & Henry, B. M. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.10.031 · Cited by 110 · see citing works
Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic
Attal, N., Martinez, V., & Bouhassira, D. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000884 · Cited by 107 · see citing works
Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series
Reddy, S. T., Garg, T., Shah, C., Nascimento, F. A., Imran, R., Kan, P. T. M., Bowry, R., Gonzales, N. R., Barreto, A. D., Kumar, A., et al. (2020) · Case Reports in Neurology · doi:10.1159/000508958 · Cited by 106 · see citing works
Does COVID‐19 contribute to development of neurological disease?
Mahalakshmi, A. M., Ray, B., Tuladhar, S., Bhat, A., Paneyala, S., Patteswari, D., Sakharkar, M. K., Hamdan, H., Ojcius, D. M., Bolla, S. R., et al. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.387 · Cited by 100 · see citing works
Pediatric Ischemic Stroke: An Infrequent Complication of SARS‐CoV ‐2
Beslow, L. A., Linds, A. B., Fox, C. K., Kossorotoff, M., Zambrano, Y. C. Z., Hernández, M., Hassanein, S. M. A., Byrne, S., Lim, M. J., Maduaka, N., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25991 · Cited by 99 · see citing works
COVID‑19 and ischemic stroke: Mechanisms of hypercoagulability (Review)
Zhang, S., Zhang, J., Wang, C., Chen, X., Zhao, X., Jing, H., Liu, H., Li, Z., Wang, L., & Shi, J. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4854 · Cited by 99 · see citing works
Vonck, K. E. J., Garrez, I., Herdt, V. D., Hemelsoet, D., Laureys, G., Raedt, R., & Boon, P. (2020) · European Journal of Neurology · doi:10.1111/ene.14329 · Cited by 98 · see citing works
Erythropoietin as candidate for supportive treatment of severe COVID-19
Ehrenreich, H., Weißenborn, K., Begemann, M., Busch, M., Vieta, E., & Miskowiak, K. W. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00186-y · Cited by 96 · see citing works
Banerjee, D., & Viswanath, B. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102350 · Cited by 96 · see citing works
Janardhan, V., Janardhan, V., & Kalousek, V. (2020) · Journal of Neuroimaging · doi:10.1111/jon.12770 · Cited by 95 · see citing works
Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men
Tu, T. M., Seet, C. Y. H., Koh, J. S., Tham, C. H., Chiew, H. J., Angon, J., Chua, C. Y. K., Hui, A. C.-F., Tan, S. S. Y., Vasoo, S. S., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.7498 · Cited by 95 · see citing works
A review of pathophysiology and neuropsychiatric manifestations of COVID-19
Jasti, M., Nalleballe, K., Dandu, V., & Onteddu, S. R. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09950-w · Cited by 90 · see citing works
Self-citationRevzin, M. V., Raza, S., Srivastava, N. C., Warshawsky, R., D’Agostino, C. A., Malhotra, A., Bader, A. S., Patel, R. D., Chen, K., Kyriakakos, C., et al. (2020) · Radiographics · doi:10.1148/rg.2020200195 · Cited by 90 · see citing works
Kihira, S., Schefflein, J., Mahmoudi, K., Rigney, B., Delman, B. N., Mocco, J., Doshi, A. H., & Belani, P. B. (2020) · American Journal of Roentgenology · doi:10.2214/ajr.20.23847 · Cited by 89 · see citing works
Gulko, E., Oleksk, M. L., Gomes, W. A., Ali, S., Mehta, H. B., Overby, P. J., Al‐Mufti, F., & Rozenstein, A. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6805 · Cited by 87 · see citing works
Wang, Z., Yang, Y., Liang, X., Gao, B., Liu, M., Li, W., Chen, Z., & Wang, Z. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.571996 · Cited by 87 · see citing works
Orsini, A. A., Corsi, M., Santangelo, A., Riva, A., Peroni, D. G., Foiadelli, T., Savasta, S., & Striano, P. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04544-w · Cited by 86 · see citing works
Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations
Thepmankorn, P., Bach, J. R., Lasfar, A., Zhao, X., Souayah, S., Chong, Z. Z., & Souayah, N. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155404 · Cited by 86 · see citing works
SARS-CoV-2 and Stroke Characteristics
Shahjouei, S., Tsivgoulis, G. K., Farahmand, G., Koza, E., Mowla, A., Sadr, A. V., Kia, A., Far, A. V., Mondello, S., Cernigliaro, A., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.032927 · Cited by 86 · see citing works
Siepmann, T., Sedghi, A., SIMON, E., Winzer, S., Barlinn, J., de With, K., Mirow, L., Wolz, M., Gruenewald, T., Schroettner, P., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14535 · Cited by 85 · see citing works
THE NERVOUS SYSTEM DAMAGE IN COVID-19 PATIENTS
Викторович, Б. В., Samoilova, E. M., & Baklaushev, V. P. (2020) · Journal of clinical practice · doi:10.17816/clinpract34851 · Cited by 84 · see citing works
Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis
Yamakawa, M., Kuno, T., Mikami, T., Takagi, H., & Gronseth, G. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105288 · Cited by 83 · see citing works
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients
DeKosky, S. T., Kochanek, P. M., Valadka, A. B., Clark, R. S. B., Chou, S., Au, A. K., Horvat, C. M., Jha, R. M., Mannix, R., Wisniewski, S. R., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7332 · Cited by 83 · see citing works
Higher albumin levels on admission predict better prognosis in patients with confirmed COVID-19
Kheir, M. M., Saleem, F., Wang, C., Mann, A. S., & Chua, J. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248358 · Cited by 81 · see citing works
Ning, X., Yu, F., Huang, Q., Li, X., Luo, Y., Huang, Q. M., & Chen, C. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02838-z · Cited by 79 · see citing works
Prudencio, M., Erben, Y., Marquez, C. P., Jansen-West, K. R., Franco-Mesa, C., Heckman, M. G., White, L. J., Dunmore, J. A., Cook, C. N., Lilley, M. T., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abi7643 · Cited by 78 · see citing works
COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management
Fraiman, P. H. A., Godeiro-Junior, C. D. O., Moro, E., Cavallieri, F., & Zedde, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.574694 · Cited by 78 · see citing works
Neurological involvement in SARS-CoV-2 infection: A clinical systematic review
Scoppettuolo, P., Borrelli, S., & Naeije, G. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100094 · Cited by 77 · see citing works
Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review
Orrù, G., Conversano, C., Malloggi, E., Francesconi, F., Ciacchini, R., & Gemignani, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186688 · Cited by 77 · see citing works
Johnsen, S., Sattler, S. M., Miskowiak, K. W., Kunalan, K., Victor, A., Pedersen, L., Andreassen, H. F., Jørgensen, B. J., Heebøll, H., Andersen, M. B., et al. (2021) · ERJ Open Research · doi:10.1183/23120541.00205-2021 · Cited by 77 · see citing works
Manca, R., Marco, M. D., Ince, P. G., & Venneri, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646908 · Cited by 76 · see citing works
Wijeratne, T., Crewther, S. G., Sales, C., & Karimi, L. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.607221 · Cited by 75 · see citing works
Sen, S., Kannan, N. B., Kumar, J., Rajan, R. P., Kumar, K., Baliga, G., Reddy, H., Upadhyay, A., & Ramasamy, K. (2021) · International Ophthalmology · doi:10.1007/s10792-021-01996-7 · Cited by 75 · see citing works
COVID‐19: Neuroimaging Features of a Pandemic
Ladopoulos, T., Zand, R., Shahjouei, S., Chang, J. J., Motte, J., James, J. C., Katsanos, A. H., Kerro, A., Farahmand, G., Far, A. V., et al. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12819 · Cited by 71 · see citing works
Nguyen‐Huynh, M. N., Tang, X. N., Vinson, D. R., Flint, A. C., Alexander, J., Meighan, M., Burnett, M. M., Sidney, S., & Klingman, J. G. (2020) · Stroke · doi:10.1161/strokeaha.120.031099 · Cited by 64 · see citing works
Neurological manifestations in COVID-19: A narrative review
Rahman, A., Niloofa, R., Zoysa, I. D., Cooray, A., Kariyawasam, J., & Seneviratne, S. L. (2020) · SAGE Open Medicine · doi:10.1177/2050312120957925 · Cited by 64 · see citing works
Central Nervous System Targets and Routes for SARS-CoV-2: Current Views and New Hypotheses
Barrantes, F. J. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00434 · Cited by 63 · see citing works
Characteristics of Large-Vessel Occlusion Associated with COVID-19 and Ischemic Stroke
John, S., Kesav, P., Mifsud, V. A., Piechowski‐Jóźwiak, B., Dibu, J. R., Bayrlee, A., Elkambergy, H., Röser, F., Elhammady, M. S., Zahra, K., et al. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6799 · Cited by 62 · see citing works
Neurological manifestations of coronavirus disease 2019: exploring past to understand present
Desai, I., Manchanda, R., Kumar, N., Tiwari, A., & Kumar, M. (2021) · Neurological Sciences · doi:10.1007/s10072-020-04964-8 · Cited by 61 · see citing works
Qi, X., Keith, K. A., & Huang, J. H. (2020) · Brain Hemorrhages · doi:10.1016/j.hest.2020.11.001 · Cited by 61 · see citing works
Battaglini, D., Santori, G., Chandraptham, K., Iannuzzi, F., Bastianello, M., Tarantino, F., Ball, L., Giacobbe, D. R., Vena, A., Bassetti, M., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.602114 · Cited by 60 · see citing works
Anbazhagan, S., Karthikeyan, R., Singh, S. V., Sankar, M., Thomas, P., Dhama, K., Malik, Y. S., Singh, R. K., & Chaudhuri, P. (2020) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.14.spl1.37 · Cited by 58 · see citing works
SARS-CoV-2, More than a Respiratory Virus: Its Potential Role in Neuropathogenesis
Singal, C. M. S., Jaiswal, P., & Seth, P. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00251 · Cited by 58 · see citing works
A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View
Zangbar, H. S., Gorji, A., & Ghadiri, T. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02149-0 · Cited by 57 · see citing works
Neuropathogenesis of SARS-CoV-2 infection
Khan, S., & Gomes, J. (2020) · eLife · doi:10.7554/elife.59136 · Cited by 53 · see citing works
Stroke in Coronavirus Disease 2019: A Systematic Review
Bhatia, R., Pedapati, R., Komakula, S., Srivastava, M. V. P., Vishnubhatla, S., & Khuranac, D. (2020) · Journal of Stroke · doi:10.5853/jos.2020.02264 · Cited by 52 · see citing works
Mariet, A., Giroud, M., Benzenine, É., Cottenet, J., Roussot, A., Aho, S., Tubert‐Bitter, P., Béjot, Y., & Quantin, C. (2021) · Stroke · doi:10.1161/strokeaha.120.032312 · Cited by 52 · see citing works
Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19
Bodnar, B. H., Patel, K., Ho, W., Luo, J. J., & Hu, W. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26720 · Cited by 51 · see citing works
Lordan, R. (2021) · Nutrients · doi:10.3390/nu13030740 · Cited by 50 · see citing works
Stroke Care during the COVID-19 Pandemic: International Expert Panel Review
Venketasubramanian, N., Anderson, C. S., Ay, H., Aybek, S., Brinjikji, W., de Freitas, G. R., Brutto, Ó. H. D., Fassbender, K. C., Fujimura, M., Goldstein, L. B., et al. (2021) · Cerebrovascular Diseases · doi:10.1159/000514155 · Cited by 49 · see citing works
Cooper, J. G., Stukas, S. K., Hoiland, R. L., Fergusson, N. A., Thiara, S., Foster, D., Mitra, A. R., Stoessl, A. J., Panenka, W. J., Sekhon, M. S., et al. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000238 · Cited by 48 · see citing works
- Authors
- Avula, A., Nalleballe, K., Narula, N., Sapozhnikov, S., Dandu, V., Toom, S., Glaser, A., & Elsayegh, D.
- Affiliations
- Northwell Health (US)
- University of Arkansas for Medical Sciences (US)
- Maimonides Medical Center (US)
- Corresponding author
- Avula, Akshay
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 87
- Pages
- 115-119
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC7187846
- OpenAlex
- W3018857106
- Cited by
- 558
- References
- 23
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 22 · 2023: 27 · 2022: 78 · 2021: 172 · 2020: 251 · 2019: 1
- FWCI
- 57.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- COVID-19 pandemic, SARS-CoV-2, acute stroke, stroke, atypical presentation, neurological symptoms, personal protective equipment, stroke team
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Female, Hospitalization, Humans, Male, Pneumonia, Viral, Retrospective Studies, Coronavirus Infections, Stroke, Pandemics
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