Spectrum of neuropsychiatric manifestations in COVID-19.
Open accessAbstract
Corona Virus Disease 2019 (COVID-19) emerged in December 2019 from Wuhan, China. It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure, shock, and even death. Coronavirus infections are known to have neuroinvasive potential with consequent neuropsychiatric manifestations. We analyzed COVID-19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic medical records data from a network of health care organizations (HCOs) from January 20, 2020 to June 10th, 2020. 40,469 patients were diagnosed with COVID-19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations. The most common neurologic manifestations included headache (3.7%) and sleep disorders (3.4%), Encephalopathy (2.3%), Stroke and transient ischemic attack (TIA) (1.0%) and 0.6% had seizures. Most common psychiatric manifestations included anxiety and other related disorders (4.6%), mood disorders (3.8%), while 0.2% patients had suicidal ideation. Early recognition and prompt management of neuropsychiatric manifestations in these patients have a potential to decrease overall morbidity and mortality.
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A study of TriNetX records of people with COVID-19 (n=40,469) found that 0.2% (62 individuals) had suicidal thoughts recorded.
“A study of TriNetX records of people with COVID-19 (n=40,469) found that 0.2% (62 individuals) had suicidal thoughts recorded, although clinicians may not have systematically asked about suicidality ( Nalleballe et al., 2020).”
From The impact of the COVID-19 pandemic on self-harm and suicidal behaviour: update of living systematic review (2021) · cites this paper as Nalleballe et al., 2020
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- Authors
- Nalleballe, K., Reddy Onteddu, S., Sharma, R., Dandu, V., Brown, A., Jasti, M., Yadala, S., Veerapaneni, K., Siddamreddy, S., Avula, A., Kapoor, N., Mudassar, K., & Kovvuru, S.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- University of Arkansas Medical Center (US)
- University of Maryland Baltimore Washington Medical Center (US)
- Staten Island University Hospital (US)
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 88
- Pages
- 71-74
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC7297688
- OpenAlex
- W3034205253
- Cited by
- 235
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 19 · 2023: 38 · 2022: 53 · 2021: 83 · 2020: 38
- FWCI
- 22.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Arkansas
- University of Arkansas for Medical Sciences
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, neuropsychiatric symptoms, neurologic manifestations, psychiatric symptoms, headache, sleep disorders, encephalopathy, stroke, transient ischemic attack, seizures, anxiety, mood disorders, suicidal ideation, TriNetX
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Adult, Aged, Aged, 80 and over, Ageusia, Olfaction Disorders, Anxiety, Brain Diseases, Ischemic Attack, Transient, Female, Headache, Humans, Male, Middle Aged, Pain, Pneumonia, Viral, Seizures, Sleep Wake Disorders, Databases, Factual, Coronavirus Infections, Mood Disorders, Stroke, Young Adult, Pandemics, Suicidal Ideation, Myalgia
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