The DOI matches its Crossref record; 123 of the 124 references it cites were found in a registry or an index.
CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice
Open accessAbstract
Neuroinflammation is a major contributor to disease progression in Alzheimer’s disease (AD) and is characterized by the activity of brain resident glial cells, in particular microglia cells. However, there is increasing evidence that peripheral immune cells infiltrate the brain at certain stages of AD progression and shape disease pathology. We recently identified CD8+ T-cells in the brain parenchyma of APP-PS1 transgenic mice being tightly associated with microglia as well as with neuronal structures. The functional role of CD8+ T-cells in the AD brain is however completely unexplored. Here, we demonstrate increased numbers of intra-parenchymal CD8+ T-cells in human AD post-mortem hippocampus, which was replicated in APP-PS1 mice. Also, aged WT mice show a remarkable infiltration of CD8+ T-cells, which was more pronounced and had an earlier onset in APP-PS1 mice. To address their functional relevance in AD, we successfully ablated the pool of CD8+ T-cells in the blood, spleen and brain from 12 months-old APP-PS1 and WT mice for a total of 4 weeks using an anti-CD8 antibody treatment. While the treatment at this time of disease stage did neither affect the cognitive outcome nor plaque pathology, RNAseq analysis of the hippocampal transcriptome from APP-PS1 mice lacking CD8+ T-cells revealed highly altered neuronal- and synapse-related gene expression including an up-regulation for neuronal immediate early genes (IEGs) such as the Activity Regulated Cytoskeleton Associated Protein (Arc) and the Neuronal PAS Domain Protein 4 (Npas4). Gene ontology enrichment analysis illustrated that the biological processes “regulation of neuronal synaptic plasticity” and the cellular components “postsynapses” were over-represented upon CD8+ T-cell ablation. Additionally, Kegg pathway analysis showed up-regulated pathways for “calcium signaling”, “long-term potentiation”, “glutamatergic synapse” and “axon guidance”. Therefore, we conclude that CD8+ T-cells infiltrate the aged and AD brain and that brain CD8+ T-cells might directly contribute to neuronal dysfunction in modulating synaptic plasticity. Further analysis will be essential to uncover the exact mechanism of how CD8+ T-cells modulate the neuronal landscape and thereby contribute to AD pathology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Dysfunctional meninges also represent an important contributor to neuroinflammation in neurodegenerative diseases by acting as a checkpoint for T-cell infiltration.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [684]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
REVIGO summarizes and visualizes long lists of gene ontology terms
Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Self-citationThe amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164
Flagged first, then by citations
1 of the 124 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 265
Xia, M., Liu, Q., Zhang, W., Ge, J., & Mei, Z. (2025) · MedComm · doi:10.1002/mco2.70328 · Cited by 15
Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease
Bastiani, M. A. D., Bellaver, B., Carello‐Collar, G., Zimmermann, M., Kunach, P., Lima‐Filho, R. A. S., Forner, S., Martini, A. C., Pascoal, T. A., Lourenco, M. V., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108671 · Cited by 13
Altendorfer, B., Benedetti, A., Mrowetz, H., Bernegger, S., Bretl, A., Preishuber‐Pflügl, J., de Sousa, D. M. B., Ladek, A., Koller, A., Faouder, P. L., et al. (2025) · Nutrients · doi:10.3390/nu17071108 · Cited by 12
Self-citationZhang, Y., Zhang, J., Wang, Y., & Yao, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1234719 · Cited by 12
Liao, J., Zhang, Y., Tang, Z., Liu, P., & He, L. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07324-y · Cited by 11
Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer’s Disease
Qiu, H., & Weng, Q. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221116220 · Cited by 10
Mrowetz, H., Kotob, M. H., Forster, J., Aydin, I., Unger, M. S., Lubec, J., Hussein, A. M., Maliković, J., Feyissa, D. D., Korz, V., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1140708 · Cited by 10
Self-citationβ-Amyloids and Immune Responses Associated with Alzheimer’s Disease
Kolobova, E. A., Petrushanko, I. Y., Mitkevich, V. A., Makarov, A. А., & Grigorova, I. (2024) · Cells · doi:10.3390/cells13191624 · Cited by 10
Approaches for studying neuroimmune interactions in Alzheimer’s disease
Lin, C., Tian, Y., Tanzi, R. E., & Jorfi, M. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.10.002 · Cited by 11
Afify, R. A. A., Lipsius, K., Wyatt‐Johnson, S. K., & Brutkiewicz, R. R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1488382 · Cited by 11
Microglial Responses to Alzheimer's Disease Pathology: Insights From “Omics” Studies
Reid, A. N., Jayadev, S., & Prater, K. E. (2025) · Glia · doi:10.1002/glia.24666 · Cited by 10
Herrera, M. G., Ciccone, L., Moleiro, L. H., Tonali, N., & Dodero, V. I. (2025) · ACS Nano · doi:10.1021/acsnano.5c01662 · Cited by 11
DeepRetention: A Deep Learning Approach for Intron Retention Detection
Wu, Z., Zheng, J., Liu, J., Lin, C., & Li, H. (2023) · Big Data Mining and Analytics · doi:10.26599/bdma.2022.9020023 · Cited by 10
Age-associated systemic factors change central and peripheral immunity in adult male mice
van Olst, L., Kamermans, A., van der Pol, S. M. A., Rodríguez, E., Hulshof, L. A., van Dijk, R. E., Vonk, D., Schouten, M., Witte, M. E., de Vries, H. E., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.05.004 · Cited by 10
Immune senescence in aged APP/PS1 mice
Abdelmoaty, M. M., Yeapuri, P., Machhi, J., Lu, Y., Namminga, K. L., Kadry, R., Lu, E., Bhattarai, S., Mosley, R. L., & Gendelman, H. E. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0015 · Cited by 12
Duan, T., Chu, J., & Hu, F. (2023) · PubMed Central · doi:10.12182/20230960107 · Cited by 9
Lobos, P., Vega-Vásquez, I., Bruna, B., Gleitze, S., Toledo, J. A., Härtel, S., Hidalgo, C., & Paula-Lima, A. C. (2023) · Antioxidants · doi:10.3390/antiox12111972 · Cited by 9
Aziz, N., Wal, P., Patel, A., & Prajapati, H. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03109-4 · Cited by 12
T Lymphocytes and Their Potential Role in Dementia with Lewy Bodies
Amin, J., Gee, C., Stowell, K., Coulthard, D., & Boche, D. (2023) · Cells · doi:10.3390/cells12182283 · Cited by 10
Zhou, Z., Bai, J., Zhong, S., Zhang, R., Kang, K., Zhang, X., Xu, Y., Zhao, C., & Zhao, M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5552623 · Cited by 9
Zhao, K., Wu, Y., Zhao, D., Zhang, H., Lin, J., & Wang, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1125281 · Cited by 10
Kadam, R., Gupta, M., Lazarov, O., & Prabhakar, B. S. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae134 · Cited by 8
T Cells Trafficking into the Brain in Aging and Alzheimer’s Disease
Ma, Y., Cao, J., Zhang, Y., Su, X.-M., Jing, Y., & Gao, L. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10147-5 · Cited by 11
Kang, S., Kim, Y.-H., Nguyen-Phuong, T., Kim, Y., Oh, J., Go, J.-C., Kim, D. S., Park, C., Lee, H., & Kim, H. J. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578488 · Cited by 9
Cantone, A. F., Burgaletto, C., Benedetto, G. D., Gaudio, G., Giallongo, C., Caltabiano, R., Broggi, G., Bellanca, C. M., Cantarella, G., & Bernardini, R. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10177-7 · Cited by 10
Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases
Ramos-Vicente, D., Monterosso, P., de Fàbregues, O., Roch, G., Vila, M., & Bové, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1599303 · Cited by 8
Prasad, S., Singh, A. R., Hu, S., Sheng, W. S., Chauhan, P., & Lokensgard, J. R. (2023) · iScience · doi:10.1016/j.isci.2023.106628 · Cited by 8
CD8+ T cells pump the brakes on Alzheimer’s disease
Reagin, K. L., & Funk, K. E. (2023) · Nature Immunology · doi:10.1038/s41590-023-01622-x · Cited by 8
Nie, B., Duan, Y., Xie, X., Qiu, L., Shi, S., Fan, Z., Zheng, X., & Jiang, L. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1204530 · Cited by 8
IQGAP2 regulates blood-brain barrier immune dynamics
Katdare, K. A., Kjar, A., O’Brown, N. M., Neal, E. H., Sorets, A. G., Shostak, A., Romero‐Fernandez, W., Kwiatkowski, A. J., Mlouk, K., Kim, H., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111994 · Cited by 8
Zuo, Z., Xiao, Z., Zhang, L., Deng, S., He, X., Mu, Y., Wang, P., Feng, Y., Wang, Z., Li, S., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123574 · Cited by 7
Davidi, A. F., Shirenova, S. D., Michaelovich, D., Benedetti, G., Shtrasberg, H., Shoval, I., Hauschner, H., Oz, G., Vardy, K., Hirsh, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2425081122 · Cited by 11
Zattoni, M., Bernegger, S., Weinbender, S., Altendorfer, B., Mrowetz, H., Benedetti, A., Poupardin, R., Unger, M. S., & Aigner, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-22137-5 · Cited by 7
Self-citationType I interferon drives T cell responses to amyloid beta in the central nervous system
Michel, J. J., Sanghvi, K., Rosenbauer, J., Humbs, L., Tejido, C., Grudzenski, S., Sachs, V., Jähne, K., Degenhardt, K., Froelich, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72262-6 · Cited by 9
Aged circulating CD8+ T cells and their secreted factors drive cognitive decline
Sucharov, J., Bieri, G., Pratt, K. J. B., Philp, A. R., Aghayev, T., Sahota, S., Remesal, L., Schroer, A. B., Snethlage, C. E., Chu, R., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.014 · Cited by 8
Crosstalk between peripheral immunity and central nervous system in Alzheimer’s disease
Yang, H.-C., Qin, Q., Wang, M., Yin, Y., Li, R., & Tang, Y. (2023) · Cellular Immunology · doi:10.1016/j.cellimm.2023.104743 · Cited by 9
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest
Hou, H. X., Pang, L., Zhao, L., & Xing, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301647 · Cited by 7
Non-Communicable Neurological Disorders and Neuroinflammation
Ballerini, C., NJAMNSHI, A. K., Juliano, S. L., Kalaria, R. N., Furlan, R., & Akinyemi, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.834424 · Cited by 7
Chen, Z., Ford, K. P., Islam, M. B. A. R., Iamsawat, S., Davis, B. T., Weiss, C., & Schwulst, S. J. (2023) · Shock · doi:10.1097/shk.0000000000002256 · Cited by 6
Zhou, J., Gong, L., Liu, X., Chen, L., & Yang, Z. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.007 · Cited by 6
Deciphering T Cell Dynamics in Alzheimer's Disease Pathogenesis: Insights and Implications
Yang, Q., Qiu, Y., Ni, J., Li, H., & Qing, H. (2025) · Current Neuropharmacology · doi:10.2174/011570159x350611250303044527 · Cited by 7
Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases
Foster‐Powell, A., Rostami‐Hodjegan, A., Meno‐Tetang, G. M. L., Mager, D. E., & Ogungbenro, K. (2025) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.70064 · Cited by 7
Immune signaling and function in neurodegeneration
Latour, Y. L., & McGavern, D. B. (2026) · Journal of Clinical Investigation · doi:10.1172/jci199850 · Cited by 9
Experimental procedures for flow cytometry of wild-type mouse brain: a systematic review
Sharp, R. C., Guenther, D. T., & Farrer, M. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1281705 · Cited by 7
Joshi, A., Giorgi, F. M., & Sanna, P. P. (2024) · eNeuro · doi:10.1523/eneuro.0118-24.2024 · Cited by 6
The association of microbial infection and adaptive immune cell activation in Alzheimer’s disease
Clement, M. (2023) · Discovery Immunology · doi:10.1093/discim/kyad015 · Cited by 6
Microbial and immune factors regulate brain maintenance and aging
Travier, L., Singh, R., Fernández, D. S., & Deczkowska, A. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102607 · Cited by 6
Xu, R., & Gao, Y. (2025) · BMC Neurology · doi:10.1186/s12883-025-04194-5 · Cited by 5
The therapeutic potential of early exercise in Alzheimer's disease: Focus on the brain-spleen axis
Wang, T., Feng, L., & Tian, Z. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102980 · Cited by 6
Singh, A. S., Naqvi, A. R., & Chanu, M. T. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.01.050 · Cited by 7
Zhang, X., He, G., Hu, Y., Liu, B., Xu, Y., Li, X., Lv, X., & Li, J. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00448-x · Cited by 6
Zhou, X., Hu, J., Xu, D., Zhang, S., & Wang, Q. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11833 · Cited by 5
Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone
Quinn, J. P., Fisher, K., Corbett, N. J., Warwood, S., Knight, D., Kellett, K. A. B., & Hooper, N. M. (2024) · Biochemical Journal · doi:10.1042/bcj20240007 · Cited by 5
Frontiers of Neurodegenerative Disease Treatment: Targeting Immune Cells in Brain Border Regions
Satyanarayanan, S. K., Han, Z., Xiao, J., Yuan, Q., Yung, W., Ke, Y., Chang, R. C., Zhu, M. H., Su, H., Su, K. P., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.007 · Cited by 5
Zhou, J., Sun, X., Wang, K., Shen, M., Yu, J., Yao, Q., Hong, H. S., Tang, C., & Wang, Q. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01399-z · Cited by 4
Si, Y., Zhang, Y., & Yang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1619196 · Cited by 4
HLA’s hidden hand in Alzheimer’s disease—five research questions en route to an answer
Capitani, L., & Carpanini, S. M. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf438 · Cited by 4
Lin, H., Su, L., Mao, D., Yang, G. E., Huang, Q., Lan, Y., Zeng, J., Song, W., Liang, G., Wei, Q., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1477327 · Cited by 5
Chen, J., Xie, J., Deng, F., Cai, J., Chen, S., Song, X., Xia, S., Shen, Q., Guo, X., & Tang, Y. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110976 · Cited by 5
Plasma ceramide mediates the association of peripheral T cells with Alzheimer’s disease
Sun, Y., Xia, L., Xu, X.-F., Wang, X., Guo, J., Cheng, R., Yang, N., Shen, L., Liu, N., Mo, X., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.027 · Cited by 5
Smoking Impacts Alzheimer’s Disease Progression Through Oral Microbiota Modulation
Dai, X., Liang, R., Dai, M., Li, X., & Zhao, W. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04241-1 · Cited by 6
Neuroimmune Dysfunction in Alzheimer’s Disease and Other Forms of Dementia
Yamane, T., Yoshioka, T., & Shimo, Y. (2024) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c23-00464 · Cited by 4
Multifactorial glial responses and their contributions to Alzheimer's disease continuum
Hijioka, M., Manabe, T., & Saito, T. (2023) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12745 · Cited by 4
Hu, Y., Zhao, Z., Xu, F., Ren, X., Liu, M., Zheng, Z., & Wang, Q. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02221-7 · Cited by 3
MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice
Zhang, Y., Yang, Z., Jiang, N., Tan, X., Jiang, P., Cao, G., & Yang, Q. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03413-7 · Cited by 3
Sun, Y., Jiang, M., Xiang, L., Miao, Y., Du, H., Zhang, T., Ma, X., Zhang, Y., & Meng, H. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02225-3 · Cited by 4
Zou, C., Cai, R., Li, Y., Yu, X., Zhang, G., Alitongbieke, G., Pan, Y., & Zhang, S. Q. (2024) · iScience · doi:10.1016/j.isci.2024.110766 · Cited by 3
Neglected cytotoxic T cell invasion of the brain: how specific for Parkinson’s disease?
Halliday, G. M. (2020) · Brain · doi:10.1093/brain/awaa390 · Cited by 3
Immunotherapies: A Treasure Trove of Alzheimer's Disease
Kolay, A., Neelam, N., Gupta, P., Shaikh, A. M., Goel, R., Nagpal, D., & Chitme, H. R. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010308600240709052539 · Cited by 2
Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice
Marsden, M., McLaren, J. E., Bevan, R. J., Penn-Ripley, D., Somerville, M. S., Lauder, S. N., Jones, M. H., Maros, L.-B., McGurk, M. R., Gallimore, A., et al. (2026) · Brain · doi:10.1093/brain/awag043 · Cited by 2
C‐reactive protein‐mediated dementia
Tang, J., Lu, Q., Lin, H., Li, J., Zhu, X., & Ma, T. (2025) · Psychogeriatrics · doi:10.1111/psyg.70032 · Cited by 3
Maynes, M. A., Owens, C. A., Wolf, D. M., Tritz, Z. P., Jin, F., Hansen, M. J., Seady, M., & Johnson, A. J. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578646 · Cited by 2
O’Niel, A., Parkins, C. J., Pederson, A., Saltonstall, E., Bunnell, E., Aggarwal, R., Sandholm, P., Kessler, K., Harrison, H. F., Smith, J. R., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1600119 · Cited by 2
Acero, G., Rodríguez-López, A., Díaz, G., Esteban, D., Herrera-Ángeles, M., & Gevorkian, G. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08884-8 · Cited by 2
Bacterial infection hypothesis-based therapies for Alzheimer's disease
Teng, M., Ma, R., Liu, S., Zhang, G., Zou, J., & Fu, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169535 · Cited by 3
Saha, T., Vats, T., & Mehan, S. (2026) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2026.2671714 · Cited by 2
Merino, J. J., Rodriguez, J. J., Busquets, X., Álvarez-Vicente, I., Cabaña-Muñoz, M. E., Flores, A. I., & Tolédano, A. (2026) · Biomolecules · doi:10.3390/biom16060855 · Cited by 2
Adaptive immunity in the pathogenesis of neurodegeneration
Li, Y., Ulrich, J. D., & Holtzman, D. M. (2026) · Nature Immunology · doi:10.1038/s41590-026-02538-y · Cited by 4
TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells
Nissen, T. A. D., Baig, A., Farmand, S., Rock, D. T., Shibu, S., Lee, H., O'Neill, L. A., Houghton, V., John, S., Klavinskis, L. S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74104-x · Cited by 2
Ma, Y., Huang, S., Jiang, H., & Yang, W. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/5708769 · Cited by 2
Identification of biomarkers of Alzheimer's disease and their characterization of immune function
Lin, M., Zhou, Y., Liang, P., Zheng, R., Du, M., Ke, X., Zhang, W., & Shang, P. (2024) · Archives of Medical Science · doi:10.5114/aoms/188721 · Cited by 2
Autoimmune hypothesis of Alzheimer’s disease: unanswered question
Arshavsky, Y. I. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00259.2024 · Cited by 2
Biomarkers for Neurodegenerative Diseases
Abdelmoaty, M. M., Lu, E., & Foster, E. G. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_44 · Cited by 2
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through lncRNA genes
Wang, Q., Chen, H., Du, B., Wang, L., Jing, P., Wu, H., Lin, J., & Gao, Y. (2025) · Genomics · doi:10.1016/j.ygeno.2025.111085 · Cited by 2
Dunacka, J., Grembecka, B., & Wrona, D. (2025) · Cells · doi:10.3390/cells14151189 · Cited by 3
Bairwa, S. C., Shaw, C., Kuo, M., Yoo, J., Tomljenovic, L., & Eidi, H. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100267 · Cited by 2
Xia, C., & Ma, Q. (2021) · Computational and Mathematical Methods in Medicine · doi:10.1155/2021/7135399 · Cited by 2
RetractedAdaptive immune changes associate with clinical progression of Alzheimer’s diseasePreprint
van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3204149/v1 · Cited by 2
Molecular Mechanism Analysis of Intensive Light-Induced Retinal Damages
Rostami‐Nejad, M., Razzaghi, Z., ROBATI, R. M., Arjmand, B., Rezaei–Tavirani, M., Moghadam, M. H., & Keramatinia, A. (2024) · Journal of lasers in medical sciences · doi:10.34172/jlms.2024.47 · Cited by 1
Identification of GABBR2 as a diagnostic marker and its association with Aβ in Alzheimer's disease
Li, H., Fan, Y., Chen, C., Xu, Y., Wang, X., & Liu, W. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102035 · Cited by 1
Jurcău, M. C., Iovanovici, D. C., Jurcău, A., Militaru, M., Udrea, R. B., Comanescu, A. D., & Nunkoo, V. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189009 · Cited by 2
Kolypetri, P., da Silva, P., Francisco, R. D. S., Frenkel, D., Cecere, R. R., Kiliaan, P. C. J., Montini, F., Saxena, S., Clementi, W. A., Liu, X., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00397-3 · Cited by 3
Zhang, Y., Ju, M., Chen, S., Yang, W., Cai, Y., Yu, X., Chen, G., Shen, Z., Bai, Y., Ren, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65112-4 · Cited by 1
White Blood Cells in Neurodegenerative Diseases in the Context of Neuroinflammation
Wełnicka, A., & Gołąb-Janowska, M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05476-2 · Cited by 1
Calderazzo, S. M., Butler, M. L. M. D., Breen, K., Kanner, H., Tripodis, Y., Stein, T. D., Holtzman, D. M., Cherry, J. D., Huber, B. R., & McKee, A. C. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02285-z · Cited by 2
Duggan, M. R., Jacobsen, E. P., Yang, S., Zeng, X., Kandala, S., Joynes, C. M., Karikari, T. K., Nimgaonkar, V. L., Kamboh, M. I., Snitz, B. E., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03800-8 · Cited by 1
APOE, Inflammation, and T Cells in Translational Disease Models and Clinical Medicine
Adlimoghaddam, A., Cervantes, D., & Wheeler, C. J. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_35 · Cited by 1
The tango of immune and neural cells: orchestrating neuroinflammation mediated brain disorders
Wu, Y., Lyu, W., Xie, X., Fu, X., Zhang, L., & Pan, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1827437 · Cited by 1
From transmission to manipulation: Ecological dynamics of the oral microbiota
Liu, X., Cai, Y., Huang, D., Xu, J. Q., Niu, C., Tu, Y., Chen, Z., Hou, L., Li, H., & Huang, Z. Z. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128633 · Cited by 1
Jasak, P., Wesołowska, A., Żółtowska, M., Alster, P., & Madetko‐Alster, N. (2026) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2026.108917 · Cited by 1
Metadata
- Authors
- Unger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., Heneka, M. T., Attems, J., & Aigner, L.
- Affiliations
- Paracelsus Medical University (AT)
- University of Salzburg (AT)
- University Hospital Bonn (DE)
- Newcastle University (GB)
- Corresponding author
- Aigner, L.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 89
- Pages
- 67-86
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W3032539442
- Cited by
- 248
- References
- 124
- Citations by year
- 2026: 34 · 2025: 43 · 2024: 63 · 2023: 62 · 2022: 28 · 2021: 15 · 2020: 3
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
- DZNE Pub (submittedVersion, cc-by)
- Funders
- Austrian Science Fund (P 31362-B34, F4413-B23)
- Seventh Framework Programme (HEALTH-F2-2011-278850)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- CD8+ T cells, Alzheimer's disease, APP/PS1 mice, neuroinflammation, hippocampus, synaptic plasticity, neuronal gene expression, Arc, Npas4, immediate early genes, calcium signaling, long-term potentiation, glutamatergic synapses, axon guidance
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Mice, Transgenic, Synapses, Gene Expression, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, CD8-Positive T-Lymphocytes, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
