Heneka, Michael T.

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 6,226

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature

Inflammasome and immune disordersAlzheimer's disease research and treatments

Cited by 2,898

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., et al. (2019) · Nature

Alzheimer's disease research and treatmentsInflammasome and immune disorders

Cited by 1,487

Innate immune activation in neurodegenerative disease

Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 1,437

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Venegas, C., Kumar, S., Franklin, B. S., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M. P., et al. (2017) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 983

Microglia in Alzheimer's disease

Sarlus, H., & Heneka, M. T. (2017) · Journal of Clinical Investigation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 911

Innate immunity in Alzheimer's disease

Heneka, M. T., Golenbock, D. T., & Latz, E. (2015) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 902

Inflammasome signalling in brain function and neurodegenerative disease

Heneka, M. T., McManus, R. M., & Latz, E. (2018) · Nature Reviews Neuroscience

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 836

A guiding map for inflammation

Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., et al. (2017) · Nature Immunology

Immune Response and InflammationInflammation biomarkers and pathways

Cited by 831

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., et al. (2014) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 798

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 782

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Hanke, A., Dewachter, I., Kuiperi, C., O'Banion, K., Klockgether, T., Van Leuven, F., & Landreth, G. E. (2005) · Brain

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 565

Glial cells in (patho)physiology

Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 561

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Heneka, M. T., Golenbock, D., Latz, E., Morgan, D., & Brown, R. (2020) · Alzheimer's Research & Therapy

Long-Term Effects of COVID-19COVID-19 Clinical Research Studies

Cited by 555

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

Suárez‐Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., et al. (2016) · EMBO Molecular Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 522

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

Brosseron, F., Krauthausen, M., Kummer, M., & Heneka, M. T. (2014) · Molecular Neurobiology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 447

TLR2 Is a Primary Receptor for Alzheimer’s Amyloid β Peptide To Trigger Neuroinflammatory Activation

Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., Rübe, C. E., Walter, J., Heneka, M. T., Hartmann, T., et al. (2012) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 439

Neuroinflammatory processes in Alzheimer’s disease

Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 433

Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus

Bettcher, B. M., Tansey, M. G., Dorothée, G., & Heneka, M. T. (2021) · Nature Reviews Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 427

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

Sastre, M., Klockgether, T., & Heneka, M. T. (2006) · International Journal of Developmental Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 426

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Willem, M., Tahirovic, S., Busche, M. A., Ovsepian, S. V., Chafai, M., Kootar, S., Hornburg, D., Evans, L. D. B., Moore, S., Daria, A., et al. (2015) · Nature

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 398

Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsPeroxisome Proliferator-Activated Receptors

Cited by 373

Long-term cerebral consequences of sepsis

Widmann, C. N., & Heneka, M. T. (2014) · The Lancet Neurology

Sepsis Diagnosis and TreatmentIntensive Care Unit Cognitive Disorders

Cited by 361