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Spiritual Absence and 1-Year Mortality after Hematopoietic Stem Cell Transplant

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Pereira, Deidre B., Christian, Lisa M., Patidar, Seema, Bishop, Michelle M., Dodd, Stacy M., Athanason, Rebecca, Wingard, John R., Reddy, Vijay S.·2010·Biology of Blood and Marrow Transplantation
DOI 10.1016/j.bbmt.2010.03.003
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Abstract

Religiosity and spirituality have been associated with better survival in large epidemiologic studies. This study examined the relationship between spiritual absence and 1-year all-cause mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Depression and problematic compliance were examined as possible mediators of a significant spiritual absence-mortality relationship. Eighty-five adults (mean = 46.85 years old, SD = 11.90 years) undergoing evaluation for allogeneic HSCT had routine psychologie evaluation prior to HSCT admission. The Millon Behavioral Medicine Diagnostic was used to assess spiritual absence, depression, and problematic compliance, the psychosocial predictors of interest. Patient status at 1 year and survival time in days were abstracted from medical records. Cox regression analysis was used to examine the relationship between the psychosocial factors of interest and mortality after adjusting for relevant biobehavioral factors. Twenty-nine percent (n = 25) of participants died within 1 year of HSCT. After covarying for disease type, individuals with the highest spiritual absence and problematic compliance scores were significantly more likely to die 1-year post-HSCT (hazard ratio [HR] = 2.49, P = .043 and HR = 3.74, P = .029, respectively), particularly secondary to infection, sepsis, or graft-versus-host disease (GVHD) (HR = 4.56, P = .01 and HR = 5.61, P = .014), relative to those without elevations on these scales. Depression was not associated with 1-year mortality, and problematic compliance did not mediate the relationship between spiritual absence and mortality. These preliminary results suggest that both spiritual absence and problematic compliance may be associated with poorer survival following HSCT. Future research should examine these relations in a larger sample using a more comprehensive assessment of spirituality.

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  • Of the 14 highest-quality immune function studies, 10 (71%) reported significant positive associations or increased immune functions in response to an R/S intervention.

    “Of the 14 studies with the highest quality ratings, 10 (71%) reported significant positive associations [437–443] or increased immune functions in response to a R/S intervention [444–447].”

    From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [444]

    The Introduction (page unavailable) says this study examined spirituality and 1-year survival after stem cell transplant; the Patients and Methods section describes a sample of 85 recipients. Our copy does not report a quality-rated set of 14 immune-function studies or the claimed 10 positive findings. I searched for immune-function associations and religious/spiritual interventions. (LLM, conf=0.75)

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Research works printed but not linked: 5

  1. Chang G, Orav EJ, McNamara T, Tong MY, Antin JH. Depres- sion, cigarette smoking, and hematopoietic stem cell transplan- tation outcome. Cancer. 2004;101:782-789.
  2. Holland JC, Kash KM, Passik S, et al. A brief spiritual beliefs inventory for use in quality of life research in life-threatening illness. Psychooncology. 1998;7:460-469.
  3. Beck AT, Steer RA, Brown GK. The Beck Depression Inventory- Second Edition. San Antonio, TX: The Psychological Corpora- tion; 1996.
  4. Chaturvedi SK, Venkateswaran C. New research in psychoon- cology. Curr Opin Psychiatry. 2008;21:206-210.
  5. Delaney C, Barrere C. Blessings: the influence of a spirituality- based intervention on psychospiritual outcomes in a cardiac population. Holist Nurs Pract. 2008;22:210-219.

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Authors
Pereira, D. B., Christian, L. M., Patidar, S., Bishop, M. M., Dodd, S. M., Athanason, R., Wingard, J. R., & Reddy, V. S.
Affiliations
  • University of Florida Health (US)
  • The Ohio State University (US)
  • AdventHealth (US)
Corresponding author
Pereira, Deidre B.
ORCID
Venue
Biology of Blood and Marrow Transplantation
Publisher
Elsevier BV
Published
2010-08
Volume
16
Issue
8
Pages
1171-1179
ISSN
1083-8791 (ISSN-L)
DOI
10.1016/j.bbmt.2010.03.003
OpenAlex
W2061461922
Cited by
94
References
40
Citations by year
2025: 3 · 2024: 1 · 2023: 44 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
2.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Transplantation and Cellular Therapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Health › Religion, Spirituality, and Psychology
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Demography › Workplace Spirituality and Leadership
Keywords
spirituality, religiosity, allogeneic hematopoietic stem cell transplantation, post-transplant mortality, depression, graft-versus-host disease, sepsis, infection, survival
MeSH terms
Female, Humans, Male, Middle Aged, Health Behavior, Hematopoietic Stem Cell Transplantation, Spirituality

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