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Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat
Abstract
The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of CSE (30 and 60 g/kg) successfully counteracted extinction of recognition memory in the normal rat, suggesting that CSE modulates storage and/or retrieval of information. In a subsequent study, pre-training treatment with CSE (30 and 60 mg/kg) significantly antagonized the scopolamine (0.75 mg/kg)-induced performance deficits in the step-through passive avoidance test. These results support and extend prior findings about the implication of CSE in learning and memory mechanisms.
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A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223
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Akhondzadeh, S., Sabet, M. S., Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. S., Yousefi, M. H., Alimardani, R., Jamshidi, A., et al. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2009.01133.x · Cited by 249
Ghajar, A., Neishabouri, S., Velayati, N., Jahangard, L., Matinnia, N., Haghighi, M., Ghaleiha, A., Afarideh, M., Salimi, S., Meysamie, A., et al. (2017) · Pharmacopsychiatry · doi:10.1055/s-0042-116159 · Cited by 110
Baziar, S., Aqamolaei, A., Khadem, E., Mortazavi, S. H., Naderi, S., Sahebolzamani, E., Mortezaei, A., Jalilevand, S., Mohammadi, M.-R., Shahmirzadi, M., et al. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0146 · Cited by 46
Metadata
- Authors
- PITSIKAS, N., & SAKELLARIDIS, N.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-10-02
- Volume
- 173
- Issue
- 1
- Pages
- 112-115
- ISSN
- 0166-4328
- Cited by
- 79
- References
- 1
- Language
- en
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