Cited by 79

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Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat

PITSIKAS, N, SAKELLARIDIS, N·2006·Behavioural Brain Research

Abstract

The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of CSE (30 and 60 g/kg) successfully counteracted extinction of recognition memory in the normal rat, suggesting that CSE modulates storage and/or retrieval of information. In a subsequent study, pre-training treatment with CSE (30 and 60 mg/kg) significantly antagonized the scopolamine (0.75 mg/kg)-induced performance deficits in the step-through passive avoidance test. These results support and extend prior findings about the implication of CSE in learning and memory mechanisms.

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Crossref · 10.1016/j.bbr.2006.06.005

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Metadata

Authors
PITSIKAS, N., & SAKELLARIDIS, N.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2006-10-02
Volume
173
Issue
1
Pages
112-115
ISSN
0166-4328
Cited by
79
References
1
Language
en

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