Behavioral effects of SQSTM1/p62 overexpression in mice: Support for a mitochondrial role in depression and anxiety

A sharper Bonferroni procedure for multiple tests of significance

HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829 · see citing works

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088 · see citing works

Practical significance: a concept whose time has come

Kirk, R. E. (1996) · Educational and Psychological Measurement · doi:10.1177/0013164496056005002 · Cited by 1,778 · see citing works

Assessing antidepressant activity in rodents: recent developments and future needs

Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · see citing works

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118976 · Cited by 1,472 · see citing works

Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on

Carobrez, A. P., & Bertoglio, L. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.017 · Cited by 993 · see citing works

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

Wieckowski, M. R., Giorgi, C., Lebiedzinska, M., Duszynski, J., & Pinton, P. (2009) · Nature Protocols · doi:10.1038/nprot.2009.151 · Cited by 979 · see citing works

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs

Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works

Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions

Simon, P. Y. R., Dupuis, R., & Costentin, J. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90008-6 · Cited by 767 · see citing works

Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation

Seibenhener, M. L., Babu, J. R., Geetha, T., Wong, H. C., Krishna, N. R., & Wooten, M. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8055-8068.2004 · Cited by 710 · see citing works

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

Calkins, M. J., Manczak, M., Mao, P., Shirendeb, U., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr381 · Cited by 646 · see citing works

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.

Laurin, N., Brown, J. P., Morissette, J., & Raymond, V. (2002) · The American Journal of Human Genetics · doi:10.1086/340731 · Cited by 563 · see citing works

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

Duran, A., Linares, J. F., Galvez, A. S., Wikenheiser, K., Flores, J. M., Diaz-Meco, M. T., & Moscat, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.001 · Cited by 541 · see citing works

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

Lee, J., Nagano, Y., Taylor, J. P., Lim, K. L., & Yao, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201001039 · Cited by 517 · see citing works

Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors

Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works

Tau filament formation in transgenic mice expressing P301L tau

Götz, J., Chen, F., Barmettler, R., & Nitsch, R. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006531200 · Cited by 495 · see citing works

Impaired mitochondrial function in psychiatric disorders

Manji, H. K., Kato, T., Prospero, N. A. D., Ness, S. L., Beal, M. F., Krams, M., & Chen, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3229 · Cited by 478 · see citing works

Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase

Suter, M., Riek, U., Tuerk, R. D., Schlattner, U., Wallimann, T., & Neumann, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606357200 · Cited by 473 · see citing works

Mitochondrial transcription factor A (TFAM): Roles in maintenance of mtDNA and cellular functions

Kang, D., Kim, S. H., & Hamasaki, N. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.11.017 · Cited by 450 · see citing works

Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder

Andreazza, A. C., Shao, L., Wang, J.-F., & Young, L. T. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.22 · Cited by 448 · see citing works

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

Murphy, A. N., Bredesen, D. E., Cortopassi, G. A., Wang, E., & Fiskum, G. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9893 · Cited by 403 · see citing works

Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks

Harrison, F. E., Hosseini, A. H., & McDonald, M. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.015 · Cited by 399 · see citing works

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., et al. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01426.x · Cited by 397 · see citing works

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

Huang, C., Andres, A. M., Ratliff, E. P., Hernandez, G., Lee, P. P. W., & Gottlieb, R. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020975 · Cited by 344 · see citing works

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

Gardner, A., & Boles, R. G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.030 · Cited by 333 · see citing works

Architectural Role of Mitochondrial Transcription Factor A in Maintenance of Human Mitochondrial DNA

Kanki, T., Ohgaki, K., Gaspari, M., Gustafsson, C. M., Fukuoh, A., Sasaki, N., Hamasaki, N., & Kang, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9823-9834.2004 · Cited by 308 · see citing works

p62, a Phosphotyrosine-independent Ligand of the SH2 Domain of p56 , Belongs to a New Class of Ubiquitin-binding Proteins

Vadlamudi, R. K., Joung, I., Strominger, J. L., & Shin, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20235 · Cited by 299 · see citing works

Antidepressant-Like Behavioral Effects Mediated by 5-Hydroxytryptamine2C Receptors

Cryan, J. F., & Lucki, I. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39013-5 · Cited by 292 · see citing works

Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients

Gardner, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00067-8 · Cited by 272 · see citing works

Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle

Ojuka, E. O. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004339 · Cited by 271 · see citing works

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A., Kemppainen, R., Cox, N., Zhu, H., Wooten, M. C., Diaz‐Meco, M. T., Moscat, J., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05340.x · Cited by 258 · see citing works

The p62 Scaffold Regulates Nerve Growth Factor-induced NF-κB Activation by Influencing TRAF6 Polyubiquitination

Wooten, M. W., Geetha, T., Seibenhener, M. L., Babu, J. R., Díaz-Meco, M. T., & Moscat, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500237200 · Cited by 225 · see citing works

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation

Kuusisto, E., Salminen, A., & Alafuzoff, I. I. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00394.x · Cited by 213 · see citing works

Mitochondrial complex i subunits expression is altered in schizophrenia: a postmortem study

Karry, R., Klein, E., & Ben‐Shachar, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.012 · Cited by 208 · see citing works

Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice

Hayashi, Y., Yoshida, M., Yamato, M., Ide, T., Wu, Z., Ochi-Shindou, M., Kanki, T., Kang, D., Sunagawa, K., Tsutsui, H., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1957-08.2008 · Cited by 180 · see citing works

Isolation and Culture of Hippocampal Neurons from Prenatal Mice

Seibenhener, M. L., & Wooten, M. W. (2012) · Journal of Visualized Experiments · doi:10.3791/3634 · Cited by 178 · see citing works

Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes

Kasahara, T., Kubota, M., Miyauchi, T., Noda, Y., Mouri, A., Nabeshima, T., & Kato, T. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001824 · Cited by 176 · see citing works

Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.

Hu, T., Guan, T., & Gerace, L. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.589 · Cited by 176 · see citing works

Proteomics and Metabolomics Analysis of a Trait Anxiety Mouse Model Reveals Divergent Mitochondrial Pathways

Filiou, M. D., Zhang, Y., Teplytska, L., Reckow, S., Gormanns, P., Maccarrone, G., Frank, E., Kessler, M. S., Hambsch, B., Nußbaumer, M., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.009 · Cited by 155 · see citing works

Antidepressant-like behavioral effects of serotonin receptor agonists

Lucki, I., Singh, A., & Kreiss, D. S. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90039-6 · Cited by 151 · see citing works

A single mouse gene encodes the mitochondrial transcription factor A and a testis–specific nuclear HMG-box protein

Larsson, N., Garman, J. D., Oldfors, A., Barsh, G. S., & Clayton, D. A. (1996) · Nature Genetics · doi:10.1038/ng0796-296 · Cited by 147 · see citing works

c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formationPreprint

Ahn, H. J., Hernandez, C. M., Levenson, J. M., Lubin, F. D., Liou, H.-C., & Sweatt, J. D. (2008) · Learning & Memory · doi:10.1101/lm.866408 · Cited by 144 · see citing works

Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA

Kang, D., & Hamasaki, N. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.010 · Cited by 132 · see citing works

Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue

Rosenfeldt, F., Marasco, S., Lyon, W. J., Wowk, M., Sheeran, F. L., Bailey, M., Esmore, D. S., Davis, B. B., Pick, A., Rabinov, M., et al. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.03.034 · Cited by 131 · see citing works

Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: Further support for the involvement of mitochondrial function in anxiety disorders

Einat, H., YUAN, P., & Manji, H. K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.012 · Cited by 131 · see citing works

Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-κB p50-Deficient Mice

Denis‐Donini, S., Dellarole, A., Crociara, P., Francese, M. T., Bortolotto, V., Quadrato, G., Canonico, P. L., Orsetti, M., Ghi, P., Memo, M., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0148-08.2008 · Cited by 129 · see citing works

Structure of the Ubiquitin-associated Domain of p62 (SQSTM1) and Implications for Mutations That Cause Paget's Disease of Bone

Ciani, B., Layfield, R., Cavey, J. R., Sheppard, P. W., & Searle, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307416200 · Cited by 128 · see citing works

Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease

Acevedo‐Torres, K., Berríos, L., Rosario, N., Dufault, V. M., Skatchkov, S. N., Eaton, M. J., Torres‐Ramos, C. A., & Ayala‐Torres, S. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.09.004 · Cited by 126 · see citing works

Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

Park, I., Chung, J., Walsh, C. T., Yun, Y., Strominger, J. L., & Shin, J. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12338 · Cited by 112 · see citing works

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

Du, Y., Wooten, M. C., Gearing, M., & Wooten, M. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.003 · Cited by 104 · see citing works

5‐HT6receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms

Woods, S., Clarke, N., Layfield, R., & Fone, K. C. F. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02022.x · Cited by 100 · see citing works

Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

Du, Y., Wooten, M. C., & Wooten, M. W. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.015 · Cited by 96 · see citing works

Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice

Lalonde, R., & Strazielle, C. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.02.003 · Cited by 94 · see citing works

A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity

Seibenhener, M. L., Du, Y., Díaz-Meco, M. T., Moscat, J., Wooten, M. C., & Wooten, M. W. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.11.004 · Cited by 82 · see citing works

Fluoxetine interacts with the lipid bilayer of the inner membrane in isolated rat brain mitochondria, inhibiting electron transport and F1F0-ATPase activity

Curti, C., Mingattao, F. E., Polizello, A. C. M., Galastri, L. O., Uyemura, S. A., & Santos, A. C. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006912010550 · Cited by 74 · see citing works

The p62 P392L Mutation Linked to Paget’s Disease Induces Activation of Human Osteoclasts

Chamoux, E., Couture, J., Bisson, M., Morissette, J., Brown, J. P., & Roux, S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0066 · Cited by 73 · see citing works

Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA

Yoshida, Y., Izumi, H., Ise, T., Uramoto, H., Torigoe, T., Ishiguchi, H., Murakami, T., Tanabe, M., Nakayama, Y., Itoh, H., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00757-x · Cited by 70 · see citing works

Mechanism of mammalian mitochondrial DNA replication: import of mitochondrial transcription factor A into isolated mitochondria stimulates 7S DNA synthesis

Gensler, S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.3657 · Cited by 69 · see citing works

8-OH-DPAT facilitated memory consolidation and increased hippocampal and cortical cAMP production

Manuel‐Apolinar, L., & Meneses, A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00186-4 · Cited by 69 · see citing works

Posttranslational Modifications and Receptor-Associated Proteins in AMPA Receptor Trafficking and Synaptic Plasticity

Jiang, J., Suppiramaniam, V. D., & Wooten, M. W. (2006) · Neurosignals · doi:10.1159/000105517 · Cited by 65 · see citing works

Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases

Rocher, C., Taanman, J., Pierron, D., Faustin, B., Benard, G., Rossignol, R., Malgat, M., Pédespan, L., & Letellier, T. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9130-5 · Cited by 63 · see citing works

Sequestosome 1 Mutations in Paget's Disease of Bone in Australia: Prevalence, Genotype/Phenotype Correlation, and a Novel Non-UBA Domain Mutation (P364S) Associated With Increased NF-κB Signaling Without Loss of Ubiquitin Binding

Rea, S. L., Walsh, J. P., Ward, L., Magno, A. L., Ward, B. K., Shaw, B., Layfield, R., Kent, G. N., Xu, J., & Ratajczak, T. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090214 · Cited by 60 · see citing works

Fear decrease in transgenic mice over-expressing bcl-2 in neurons

Rondi‐Reig, L., Lemaigre‐Dubreuil, Y., Martinou, J., Delhaye‐Bouchaud, N., Caston, J., & Mariani, J. (1997) · Neuroreport · doi:10.1097/00001756-199707280-00004 · Cited by 53 · see citing works

p62 serves as a shuttling factor for TrkA interaction with the proteasome

Geetha, T., Seibenhener, M. L., Chen, L., Madura, K., & Wooten, M. W. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.082 · Cited by 53 · see citing works

AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62

Jiang, J., Parameshwaran, K., Seibenhener, M. L., Kang, M., Suppiramaniam, V. D., Huganir, R. L., Díaz-Meco, M. T., & Wooten, M. W. (2008) · Hippocampus · doi:10.1002/hipo.20528 · Cited by 49 · see citing works

BCL-2 Improves Oxidative Phosphorylation and Modulates Adenine Nucleotide Translocation in Mitochondria of Cells Harboring Mutant mtDNA

Manfredi, G., Kwong, J. Q., Oca‐Cossio, J., Woischnik, M., Gajewski, C. D., Martushova, K., D’Aurelio, M., Friedlich, A. L., & Moraes, C. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203080200 · Cited by 48 · see citing works

Atypical Protein Kinase C in Neurodegenerative Disease II

Shao, C., Crary, J. F., Rao, C., Sacktor, T. C., & Mirra, S. S. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000218441.00040.82 · Cited by 45 · see citing works

Mitochondrial Alterations and Neuropsychiatric Disorders

Marazziti, D., Baroni, S., Picchetti, M., Landi, P., Silvestri, S., Vatteroni, E., & Dell’Osso, M. C. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797379221 · Cited by 45 · see citing works

Nonmotor symptoms in Parkin gene‐related parkinsonism

Kägi, G., Klein, C., Wood, N. W., Schneider, S. A., Pramstaller, P. P., Tadić, V., Quinn, N. P., van de Warrenburg, B. P. C., & Bhatia, K. P. (2010) · Movement Disorders · doi:10.1002/mds.22897 · Cited by 36 · see citing works

Role of Somatodendritic and Postsynaptic 5-HT1A Receptors on Learning and Memory Functions in Rats

Haider, S., Khaliq, S., Tabassum, S., & Haleem, D. J. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0839-5 · Cited by 36 · see citing works

An updating of the biochemical function of Coenzyme Q in mitochondria

Lenaz, G., Fato, R., Castelluccio, C., Cavazzoni, M., Estornell, E., Huertas, J. R., Pallotti, F., Castelli, G. P., & Rauchová, H. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90010-8 · Cited by 32 · see citing works

The reporting of statistical significance in scientific journals

Hoem, J. M. (2008) · Demographic Research · doi:10.4054/demres.2008.18.15 · Cited by 32 · see citing works

An E3 Ubiquitin Ligase, Really Interesting New Gene (RING) Finger 41, Is a Candidate Gene for Anxiety-Like Behavior and β-Carboline-Induced Seizures

Kim, S., Zhang, S., Choi, K. H., Reister, R., Do, C., Baykız, A. F., & Gershenfeld, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.015 · Cited by 27 · see citing works

The effect of l-deprenyl, d-deprenyl and MDL72974 on mitochondrial respiration: a possible mechanism leading to an adaptive increase in superoxide dismutase activity

Thiffault, C., Quirion, R., & Poirier, J. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00135-6 · Cited by 21 · see citing works

The reporting of statistical significance in scientific journals

Hoem, J. M. (2007) · doi:10.4054/mpidr-wp-2007-037 · Cited by 20 · see citing works

Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats

Piechal, A., Blecharz‐Klin, K., Wyszogrodzka, E., Kołomańska, P., Rok-Bujko, P., Krząścik, P., Kostowski, W., Widy‐Tyszkiewicz, E., Filip, M., & Stefański, R. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70764-8 · Cited by 16 · see citing works

Triage of oxidation-prone proteins by Sqstm1/p62 within the mitochondria

Lee, M., & Shin, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.067 · Cited by 16 · see citing works

KF-1 ubiquitin ligase: an anxiety suppressor

Hashimoto-Gotoh, T. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.01.004.2009 · Cited by 13 · see citing works

Mitophagy in Human Diseases

Doblado, L., Lueck, C., Rey, C., Samhan-Arias, A. K., Priéto, I., Stacchiotti, A., & Monsalve, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083903 · Cited by 229 · see citing works

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

Ryoo, I.-G., & Kwak, M. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.014 · Cited by 221 · see citing works

KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

Dodson, M. B., Redmann, M., Rajasekaran, N. S., Darley-Usmar, V. M., & Zhang, J. (2015) · Biochemical Journal · doi:10.1042/bj20150568 · Cited by 203 · see citing works

Autophagy and ALS: mechanistic insights and therapeutic implications

Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

Itoh, K., Ye, P., Matsumiya, T., Tanji, K., & Ozaki, T. (2015) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.14-134 · Cited by 138 · see citing works

Mitochondrial dysfunction: A fatal blow in depression

Song, Y., Cao, H., Zuo, C., Gu, Z., Huang, Y., Miao, J., Fu, Y., Guo, Y., Jiang, Y., & Wang, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115652 · Cited by 138 · see citing works

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD

Lattante, S., de Calbiac, H., Le Ber, I., Brice, A., Ciura, S., & Kabashi, E. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu580 · Cited by 90 · see citing works

PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids

Wu, Y., Yang, Y., Wang, W., Sun, D., Zheng, M., Zhou, Y., Li, H., Zhu, M., Li, H., & Chen, L. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.07.007 · Cited by 67 · see citing works

Mitochondrial dysfunction in psychiatric disorders

Ni, P., Ma, Y., & Chung, S. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.08.027 · Cited by 55 · see citing works

The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

Poon, A., Saini, H. K., Sethi, S., O’Sullivan, G. A., Plun‐Favreau, H., Wray, S., Dawson, L. A., & McCarthy, J. M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.03.030 · Cited by 48 · see citing works

Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent

Sabbieti, M. G., Agas, D., Capitani, M., Marchetti, L., Concetti, A., Vullo, C., Catone, G., Gabai, V. L., Shifrin, V. I., Sherman, M. Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.2884 · Cited by 36 · see citing works

Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress

Ridout, K. K., Coe, J. L., Parade, S. H., Marsit, C. J., Kao, H., Porton, B., Carpenter, L. L., Price, L. H., & Tyrka, A. R. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104632 · Cited by 29 · see citing works

Stress can affect mitochondrial energy metabolism and AMPK/SIRT1 signaling pathway in rats

Zhao, A.-R., Li, J., Wang, S., Bian, L.-H., Li, W., & Guo, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110770 · Cited by 19 · see citing works

SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain

Yin, P., Bai, D., Deng, F., Zhang, C., Jia, Q., Zhu, L., Chen, L., Li, B., Guo, X., Ye, J., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.2013653 · Cited by 16 · see citing works

Natural products that alleviate depression: The putative role of autophagy

Zhou, Y., Nan, F., Zhang, Q., Xu, W., Fang, S., Liu, K., Zhao, B., Han, H., Xie, X., Qin, C., et al. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108731 · Cited by 11 · see citing works

Autophagy—Unlocking New Dimensions in the Pathology and Treatment of Depression

Luo, Q., Zhao, Y., Ren, P., Liu, X., Chen, Y., Ying, Q., & Zhou, J. (2025) · Cells · doi:10.3390/cells14110795 · Cited by 10 · see citing works

Urolithin A Abolishes High Anxiety and Rescues the Associated Mitochondria-Related Transcriptomic Signatures and Synaptic Function

Mallet, D., Ülgen, D. H., Grosse, J., Zanoletti, O., de Suduiraut, I. G., Monzel, A. S., D'Amico, D. F., Rinsch, C., Picard, M. A., Astori, S., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.07.020 · Cited by 6 · see citing works

Behavioral Studies of p62 KO Animals with Implications of a Modulated Function of the Endocannabinoid System

Keller, C., Rading, S., Bîndilă, L., & Karsak, M. (2022) · Cells · doi:10.3390/cells11091517 · Cited by 3 · see citing works

SNAT1 (SLC38A1) Is Not the Main Glutamine Transporter in Melanoma, but Controls Metabolism via Glutamine-Dependent Activation of P62 (SQSTM1)/cMYC-Axis

Lörentz, S., Böhme, I., König, J., Sticht, H., & Bosserhoff, A. (2026) · Cancers · doi:10.3390/cancers18071068 · Cited by 1 · see citing works

LHb Neuronal Autophagy: A Central Mechanism in the Stress Response

Liu, Z.-C., Chen, J., & Wang, F. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin41820

Mechanisms of C9ORF72 pathogenicity and related autophagy impairment in amyotrophic lateral sclerosis

de Calbiac, H. (2019) · theses.fr (ABES) · doi:10.70675/bafe951fz8332z4b0azb55bzac8a4af1955b

Plasma Acylcarnitine Alterations During Venlafaxine Treatment in Major Depressive Disorder: A Longitudinal Analysis

Liu, T., Lei, H., Wang, L., Tang, H., Chen, J., Tang, M., & Dang, R. (2026) · Neuropharmacology and Therapy · doi:10.15212/npt-2026-0020

SQSTM1/p62 overexpression in mice: Support for a mitochondrial role in depression, anxiety and cognition associated with Neurodegenerative disease

Seibenhener, M. L. (2015) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.s1.025

Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions

Gebara, E., Zanoletti, O., Ghosal, S., Grosse, J., Schneider, B. L., Knott, G. W., Astori, S., & Sandi, C. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.003 · Cited by 144 · see citing works

Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: Further support for the involvement of mitochondrial function in anxiety disorders

Einat, H., YUAN, P., & Manji, H. K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.012 · Cited by 131 · see citing works

Anxiety and mitochondria: Insights from the -omics world

Filiou, M. D., Teplytska, L., Gormanns, P., Reckow, S., Zhang, Y., Frank, E., Keßler, M., Nußbaumer, M., Maccarrone, G., Landgraf, R., et al. (2011) · Pharmacopsychiatry · doi:10.1055/s-0031-1292470

MitoQ administration exerts anxiolytic effects in vivo

Nußbaumer, M., Asara, J. M., Teplytska, L., Murphy, M. P., Chen, A., Turck, C. W., & Filiou, M. D. (2017) · Pharmacopsychiatry · doi:10.1055/s-0037-1606412