Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration

Neis, Vivian Binder; Manosso, Luana Meller; Moretti, Morgana; Freitas, Andiara E.; Daufenbach, Juliana; Rodrigues, Ana Lúcia S.

doi:10.1016/j.bbr.2013.12.038

Cited by 59Tryptophan and brain disordersTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration

Neis, Vivian Binder, Manosso, Luana Meller, Moretti, Morgana, Freitas, Andiara E., Daufenbach, Juliana, Rodrigues, Ana Lúcia S.·2014·Behavioural Brain Research

DOI 10.1016/j.bbr.2013.12.038

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Abstract

Agmatine, an endogenous cationic amine, has been shown to exert antidepressant-like effects. This study investigated the ability of agmatine administered orally to abolish the depressive-like behavior induced by the administration of the pro-inflammatory cytokine, tumor necrosis factor (TNF-α) in mice. In control animals, agmatine (0.001, 0.01, 0.1, and 1 mg/kg) reduced the immobility time in the tail suspension test (TST). Acute administration of TNF-α (0.001 fg/mouse, i.c.v.) increased immobility time in the TST, indicative of a depressive-like behavior, and agmatine (0.0001, 0.1, and 1 mg/kg) prevented this effect. Additionally, we examined the effects of the combined administration of sub-effective doses of agmatine with antidepressants, the NMDA receptor antagonist MK-801 and the neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) in mice exposed to either TNF-α or saline. In control mice, administration of a sub-effective dose of agmatine (0.0001 mg/kg) combined with sub-effective doses of either fluoxetine (5 mg/kg, p.o.), imipramine (0.1 mg/kg, p.o.), bupropion (1 mg/kg, p.o.), MK-801 (0.001 mg/kg, p.o.) or 7-NI (25 mg/kg, i.p.) produced a synergistic antidepressant-like effect in the TST. All these administrations prevented the increased immobility time induced by TNF-α. The effect of agmatine in the TNF-α model of depression appears to be associated, at least partially, with an activation of the monoaminergic systems and inhibition of NMDA receptors and…

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Administration of the polyamine agmatine ameliorated TNF-α-induced depression-like behaviors in mice.
“administration of the polyamine agmatine ameliorated experimentally (TNF-α)-induced depression-like behaviors in mice (Neis et al. 2014)”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Neis et al. 2014

1 retracted

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Authors: Neis, V. B., Manosso, L. M., Moretti, M., Freitas, A. E., Daufenbach, J., & Rodrigues, A. L. S.
Affiliations: Universidade Federal de Santa Catarina (BR)
Corresponding author: Rodrigues, Ana Lúcia S.
ORCID: Neis, Vivian Binder
Manosso, Luana Meller
Moretti, Morgana
Freitas, Andiara E.
Rodrigues, Ana Lúcia S.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2014-03
Volume: 261
Pages: 336-344
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2013.12.038
OpenAlex: W1965366717
Cited by: 59
References: 73
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 11 · 2015: 9 · 2014: 4
FWCI: 2.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES)
Fundação de Apoio a Pesquisa Científica e Tecnológica do Estado de Santa Catarina (FAPESC)
FINEP “Rede Instituto Brasileiro de Neurociências (IBNNet)” (01.06.0842-00)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: agmatine, TNF-α, depression-like behavior, depression, inflammation, antidepressant-like effects, tail suspension test, MK-801, 7-nitroindazole, nitric oxide, NMDA receptor, monoaminergic systems, fluoxetine, imipramine, bupropion, inflammatory depression
MeSH terms: Agmatine, Analysis of Variance, Animals, Antidepressive Agents, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Exploratory Behavior, Female, Indazoles, Tumor Necrosis Factor-alpha, Dizocilpine Maleate, Hindlimb Suspension, Immobility Response, Tonic, Mice

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Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration

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