Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

Zomkowski, Andréa D.E.; Engel, Daiane; Gabilan, Nelson H.; Rodrigues, Ana Lúcia S.

doi:10.1016/j.euroneuro.2010.07.011

Cited by 94Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

Zomkowski, Andréa D.E., Engel, Daiane, Gabilan, Nelson H., Rodrigues, Ana Lúcia S.·2010·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2010.07.011

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Abstract

Escitalopram is a serotonin reuptake inhibitor used in the treatment of depression and anxiety disorders. This study investigated the effect of escitalopram in forced swimming test (FST) and in the tail suspension test (TST) in mice, and tested the hypothesis that the inhibition of NMDA receptors and NO-cGMP synthesis is implicated in its mechanism of action in the FST. Escitalopram administered by i.p. route reduced the immobility time both in the FST (0.3-10 mg/kg) and in the TST (0.1-10 mg/kg). Administration of escitalopram by p.o route (0.3-10 mg/kg) also reduced the immobility time in the FST. The antidepressant-like effect of escitalopram (3mg/kg, p.o.) in the FST was prevented by the pretreatment of mice with NMDA (0.1 pmol/site, i.c.v.), l-arginine (750 mg/kg, i.p., a substrate for nitric oxide synthase) or sildenafil (5mg/kg, i.p., a phosphodiesterase 5 inhibitor). The administration of 7-nitroindazole (50 mg/kg, i.p., a neuronal nitric oxide synthase inhibitor), methylene blue (20 mg/kg, i.p., an inhibitor of both nitric oxide synthase and soluble guanylate cyclase) or ODQ (30 pmol/site i.c.v., a soluble guanylate cyclase inhibitor) in combination with a subeffective dose of escitalopram (0.1 mg/kg, p.o.) reduced the immobility time in the FST as compared with either drug alone. None of the drugs produced significant effects on the locomotor activity in the open-field test. Altogether, our data suggest that the antidepressant-like effect of escitalopram is dependent on inhibition of either NMDA receptors or NO-cGMP synthesis. The results contribute to the understanding of the mechanisms underlying the antidepressant-like effect of escitalopram and reinforce the role of NMDA receptors and l-arginine-NO-GMP pathway in the mechanism of action of antidepressant agents.

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The antidepressant-like effect of escitalopram in the forced swim test is prevented by pretreatment with NMDA, L-arginine, and sildenafil in female mice.
“The antidepressant-like effect of escitalopram in the forced swim test (FST) was prevented by pretreatment with N-methyl-D-aspartic acid (NMDA), L-arginine, and sildenafil (a phosphodiesterase inhibitor).”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [14]
Administration of 7-nitroindazole, methylene blue or ODQ in combination with escitalopram reduces immobility time in the FST.
“Also, the administration of 7-nitroindazole, methylene blue or ODQ (i.c.v., a soluble sGC inhibitor) in combination with escitalopram reduced the immobility time in the FST.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [14]
The NMDA receptors and L-arginine-NO-cGMP pathway play a role in the mechanism of action of antidepressant agents.
“This study highlights the role of NMDA receptors and L-arginine-NO-cGMP pathway in the mechanism of action of antidepressant agents [14].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [14]

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Moretti, M., Freitas, A. E., Budni, J., Fernandes, S. C. P., Balen, G. O., & Rodrigues, A. L. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.024 · Cited by 68 · see citing works
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NMDA Receptor Antagonists for Treatment of Depression
Ateş‐Alagöz, Z., & Adejare, A. (2013) · Pharmaceuticals · doi:10.3390/ph6040480 · Cited by 68 · see citing works
“Their data suggest that the antidepressant-like effects of escitalopram is dependent on inhibition of either NMDA receptors or NO-cGMP synthesis [55].”
Background
Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice
Camargo, A., Dalmagro, A. P., Rikel, L., da Silva, E. B., da Silva, K. A. B. S., & Zeni, A. L. B. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.002 · Cited by 61 · see citing works
Involvement of PKA, CaMKII, PKC, MAPK/ERK and PI3K in the acute antidepressant-like effect of ferulic acid in the tail suspension test
Zeni, A. L. B., Zomkowski, A. D. E., Maraschin, M., Rodrigues, A. L. S., & Tasca, C. I. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.08.020 · Cited by 60 · see citing works
“Open-field test The ambulatory behavior was assessed in an open-field test as described by Zomkowski et al. (2010).”
Self-citation
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration
Neis, V. B., Manosso, L. M., Moretti, M., Freitas, A. E., Daufenbach, J., & Rodrigues, A. L. S. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.038 · Cited by 59 · see citing works
Self-citation
Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin
Hersey, M., Samaranayake, S., Berger, S. N., Tavakoli, N. S., Mena, S., Nijhout, H. F., Reed, M. C., Best, J. A., Blakely, R., Reagan, L. P., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2618-20.2021 · Cited by 57 · see citing works
P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents
O'Brien, F. E., O’Connor, R. M., Clarke, G. A., Dinan, T. G., Griffin, B. T., & Cryan, J. F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.120 · Cited by 55 · see citing works
Antidepressant-like and neuroprotective effects of Aloysia gratissima: Investigation of involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway
Zeni, A. L. B., Zomkowski, A. D. E., Dal-Cim, T. A., Maraschin, M., Rodrigues, A. L. S., & Tasca, C. I. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.07.009 · Cited by 52 · see citing works
Self-citation
Nitric oxide: Antidepressant mechanisms and inflammation
Ghasemi, M. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.004 · Cited by 49 · see citing works
Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression
Ahmadimanesh, M., Abbaszadegan, M. R., Rad, D. M., Moallem, S. A., Mohammadpour, A. H., Ghahremani, M. H., Hosseini, F. F., Behdani, F., Manteghi, A. A., Jowsey, P. A., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119874461 · Cited by 47 · see citing works
“Recent studies have suggested that antidepressants can play a role as an antioxidant by reducing oxidative stress markers (Khanzode et al., 2003; Zomkowski et al., 2010).”
Background
The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test
Cunha, M. P., Pazini, F. L., Ludka, F. K., Rosa, J. M., Oliveira‐Giacomelli, Á., Budni, J., Ramos-Hryb, A. B., Lieberknecht, V., Bettio, L. E. B., Martin‐de‐Saavedra, M. D., et al. (2015) · Amino Acids · doi:10.1007/s00726-014-1910-0 · Cited by 45 · see citing works
Self-citation
Involvement of nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tropisetron and ondansetron in mice forced swimming test and tail suspension test
Haj-Mirzaian, A., Kordjazy, N., Amiri, S., Haj-Mirzaian, A., Amini-khoei, H., Ostadhadi, S., & Dehpour, A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.034 · Cited by 42 · see citing works
Involvement of N-methyl-d-aspartate receptors in the antidepressant-like effect of 5-hydroxytryptamine 3 antagonists in mouse forced swimming test and tail suspension test
Kordjazy, N., Haj‐Mirzaian, A., Amiri, S., Ostadhadi, S., Amini-Khoei, H., & Dehpour, A. R. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.11.009 · Cited by 43 · see citing works
“…it has been reported that a decrease in NO content in limbic regions such as the hippocampus is associated with the antidepressant activity of variousmedications such as selective serotonin reuptake inhibitors and imipramine (Dhir andKulkarni, 2007; Krass et al., 2011; Zomkowski et al., 2010).”
Background
Involvement of NMDA receptors and l-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test
Ostadhadi, S., Khan, M. I., Norouzi‐Javidan, A., Chamanara, M., Jazaeri, F., Zolfaghari, S., & Dehpour, A. R. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.004 · Cited by 41 · see citing works
Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation
Matsushita, H., Matsuzaki, M., Han, X.-J., Nishiki, T.-I., Ohmori, I., Michiue, H., Matsui, H., & Tomizawa, K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.001 · Cited by 41 · see citing works
Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model
Zhang, H., Zhou, Z., Chen, Z., Zhong, Z., & Li, Z. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.03.007 · Cited by 41 · see citing works
The role of the NMDA receptors and l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test
Zomkowski, A. D. E., Engel, D. F., Cunha, M. P., Gabilan, N. H., & Rodrigues, A. L. S. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.09.011 · Cited by 40 · see citing works
Self-citation
Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice
Wang, C., Zhang, J., Yang, L., Lin, P., Pan, T., Zhao, X., Liu, A., Wang, Q., Zhou, W., & Zhang, H. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9533-4 · Cited by 38 · see citing works
Antinociceptive activity of the new triple reuptake inhibitor NS 18283 in a mouse model of chemotherapy‐induced neuropathic pain
Hache, G., Guiard, B. P., Nguyen, T. H., Quesseveur, G., Gardier, A. M., Peters, D., Munro, G., & Coudoré, F. (2014) · European Journal of Pain · doi:10.1002/ejp.550 · Cited by 38 · see citing works
“The doses for escitalopram, venlafaxine and indatraline were chosen based on previous behavioural studies using comparable tests (Tirelli et al., 1998; Yalcin et al., 2009; Zomkowski et al., 2010).”
Method
Interactive effects of N-acetylcysteine and antidepressants
Costa-Campos, L., Herrmann, A. P., Pilz, L. K., Michels, M., Noetzold, G., & Elisabetsky, E. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.02.008 · Cited by 37 · see citing works
“Its effect in the mice FST was shown to be dependent on the inhibition of NMDA receptors (Zomkowski et al., 2010).”
Involvement of different types of potassium channels in the antidepressant-like effect of ascorbic acid in the mouse tail suspension test
Moretti, M., Budni, J., Ribeiro, C. M., & Rodrigues, A. L. S. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.04.041 · Cited by 37 · see citing works
Self-citation
Atorvastatin and Fluoxetine Prevent Oxidative Stress and Mitochondrial Dysfunction Evoked by Glutamate Toxicity in Hippocampal Slices
Ludka, F. K., Dal-Cim, T. A., Binder, L. B., Constantino, L. C., Massari, C. M., & Tasca, C. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9882-6 · Cited by 38 · see citing works
Pathologic role of nitrergic neurotransmission in mood disorders
Ghasemi, M., Claunch, J. D., & Niu, K. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.002 · Cited by 37 · see citing works
The role of NMDA receptor and nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effect of dextromethorphan in mice forced swimming test and tail suspension test
Sakhaee, E., Ostadhadi, S., Khan, M. I., Yousefi, F., Norouzi‐Javidan, A., Akbarian, R., Chamanara, M., Zolfaghari, S., & Dehpour, A. R. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.073 · Cited by 36 · see citing works
Blockade of the high‐affinity noradrenaline transporter (NET) by the selective 5‐HT reuptake inhibitor escitalopram: anin vivomicrodialysis study in mice
Nguyen, H. T., Guiard, B. P., Bacq, A., David, D. J. P., Mendez‐David, I., Quesseveur, G., Gautron, S., Sánchez, C., & Gardier, A. M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01850.x · Cited by 33 · see citing works
“addition, consistent with a previous study (Zomkowski et al., 2010), similar doses of escitalopram produced a robust antidepressant-like effect as shown by a significant increase in swimming duration (Figure 1C).”
Result
Antidepressant-like effect of Canavalia brasiliensis (ConBr) lectin in mice: Evidence for the involvement of the glutamatergic system
Rieger, D. K., Costa, A. P., Budni, J., Moretti, M., Barbosa, S. G. R., Nascimento, K. S., Teixeira, E. H., Cavada, B. S., Rodrigues, A. L. S., & Leal, R. B. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.008 · Cited by 32 · see citing works
“Indeed, the administration of L-arginine inhibits the activity of different antidepressants, such as escitalopram, imipramine, venlafaxine and bupropion, in preclinical studies (Harkin et al., 1999; Zomkowski et al., 2012).”
Self-citation
Involvement of NMDA receptors in the antidepressant-like action of adenosine
Kaster, M. P., Machado, D. G., Santos, A. R. S., & Rodrigues, A. L. S. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70865-4 · Cited by 31 · see citing works
Self-citation
Agmatine enhances the antidepressant-like effect of lithium in mouse forced swimming test through NMDA pathway
Mohseni, G., Ostadhadi, S., Imran-Khan, M., Norouzi‐Javidan, A., Zolfaghari, S., Haddadi, N., & Dehpour, A. R. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.119 · Cited by 30 · see citing works
“Additionally it was showed that NMDA and NO is a key signaling pathway in the antidepressant effect of various compoundS [56,60,72,73,93].”
Background
Novel Antidepressant-Like Activity of Propolis Extract Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus
Lee, M., Kim, Y. H., Park, W.-S., Ahn, W. G., Park, O. K., Kwon, S., Morita, K., Shim, I., & Her, S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/217853 · Cited by 30 · see citing works
Atorvastatin evokes a serotonergic system-dependent antidepressant-like effect in mice
Ludka, F. K., Constantino, L. C., Kuminek, G., Binder, L. B., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T. A., Rodrigues, A. L. S., & Tasca, C. I. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.04.005 · Cited by 27 · see citing works
Self-citation
Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test
Ostadhadi, S., Kordjazy, N., Haj‐Mirzaian, A., Ameli, S., Akhlaghipour, G., & Dehpour, A. R. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1203-5 · Cited by 26 · see citing works
“Sildenafil, a PDE5 inhibitor that causes an increase in level of cGMP in target tissues, is able to prevent the antidepressant-like effect elicited by some antidepressants (Dhir and Kulkarni 2007; Ghasemi et al. 2008; Zomkowski et al. 2010).”
Co-administration of the low dose of orexin and nitrergic antagonists induces an antidepressant-like effect in mice
Alijanpour, S., Khakpai, F., Ebrahimi-Ghiri, M., & Zarrindast, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.033 · Cited by 26 · see citing works
AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test
Linck, V. M., Costa-Campos, L., Pilz, L. K., Garcia, C. R. L., & Elisabetsky, E. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283512c3a · Cited by 26 · see citing works
“escitalopram, venlafaxine, and curcumin) (Wang et al., 2008; Zomkowski et al., 2010; Abdel-Wahab and Salama, 2011), whereas a-tocoferol (i.”
Method
Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors
Naserzadeh, R., Abad, N., Ghorbanzadeh, B., Dolatshahi, M., & Mansouri, M. T. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.002 · Cited by 27 · see citing works
Involvement of the Cerebral Monoamine Neurotransmitters System in Antidepressant-Like Effects of a Chinese Herbal Decoction, Baihe Dihuang Tang, in Mice Model
Chen, M., Gao, J., Xin-rong, H., & Qian, C. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/419257 · Cited by 24 · see citing works
Antidepressant-Like Effect of the Leaves ofPseudospondias microcarpain Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway
Adongo, D. W., Kukuia, K. K. E., Mante, P. K., Ameyaw, E. O., & Woode, E. (2015) · BioMed Research International · doi:10.1155/2015/397943 · Cited by 23 · see citing works
Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test
Gonçalves, F. M., Neis, V. B., Rieger, D. K., Peres, T. V., Lopes, M. W., Heinrich, I. A., Costa, A. P., Rodrigues, A. L. S., Kaster, M. P., & Leal, R. B. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1753-4 · Cited by 23 · see citing works
Self-citation
Antidepressant-like activity of sildenafil following acute and subchronic treatment in the forced swim test in mice: effects of restraint stress and monoamine depletion
Socała, K., Nieoczym, D., Pieróg, M., Szuster‐Ciesielska, A., Wyska, E., & Właź, P. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9852-8 · Cited by 21 · see citing works
“…antidepressant action of many compounds including adenosine (Kaster et al. 2005), memantine (Almeida et al. 2006), diphenyl diselenide (Savegnago et al. 2008), lithium (Ghasemi et al. 2008), escitalopram (Zomkowski et al. 2010), paroxetine (Socała et al. 2012d) or magnesium (Socała et al. 2012a).”
ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals
Tillmann, S., Pereira, V. S., Liebenberg, N., Christensen, A. K., & Wegener, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182698 · Cited by 20 · see citing works
Acute and subacute oral toxicity assessment of dry encapsulated and non-encapsulated green coffee fruit extracts
Faria, W. C. S., da Silva, A. A., Veggi, N., Kawashita, N. H., de França, S. A., de Barros, W. M., da Conceiç~ao Cardoso, E., Converti, A., Moura, W. D. M., & Bragagnolo, N. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.1067 · Cited by 20 · see citing works
Amelioration of the Reduced Antinociceptive Effect of Morphine in the Unpredictable Chronic Mild Stress Model Mice by Noradrenalin but Not Serotonin Reuptake Inhibitors
Ide, S., Satoyoshi, H., Minami, M., & Satoh, M. (2015) · Molecular Pain · doi:10.1186/s12990-015-0051-0 · Cited by 19 · see citing works
“Doses of serotonin transporter inhibitor (escitalopram; 1, 3 mg/ kg) used in the present study are thought to be sufficient for behavioral experiments [19].”
Method
Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice
Socała, K., Nieoczym, D., Wyska, E., Poleszak, E., & Właź, P. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0756-9 · Cited by 18 · see citing works
“…et al. 2008), dizocilpine (Dhir and Kulkarni 2008), venlafaxine (Dhir and Kulkarni 2007a), bupropion (Dhir and Kulkarni 2007b), escitalopram (Zomkowski et al. 2010), tramadol (Jesse et al. 2008), berberine chloride (Kulkarni and Dhir 2008), diphenyl diselenide (Savegnago et al. 2008), folic…”
First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides
Piétri, M., Djillani, A., Mazella, J., Borsotto, M., & Heurteaux, C. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107715 · Cited by 18 · see citing works
NMDA Receptors and the L-Arginine–Nitric Oxide–Cyclic Guanosine Monophosphate Pathway Are Implicated in the Antidepressant-Like Action of the Ethanolic Extract from Tabebuia avellanedae in Mice
Freitas, A. E., Moretti, M., Budni, J., Balen, G. O., Fernandes, S. C. P., Veronezi, P. O., Heller, M., Micke, G. A., Pizzolatti, M. G., & Rodrigues, A. L. S. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0276 · Cited by 15 · see citing works
“The implication of NMDA inhibition in the mechanism of action of conventional antidepressants and putative antidepressant agents has been suggested by several studies, which show that the administration of NMDA is able to reverse the antidepressant-like effects of these compounds.(15,19,26) In the present study, the p…”
Self-citation
Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice
Wolak, M., Siwek, A., Szewczyk, B., Poleszak, E., Bystrowska, B., Moniczewski, A., Rutkowska, A., Młyniec, K., & Nowak, G. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.003 · Cited by 15 · see citing works
Antidepressant-like effect of ethanol in mice forced swimming test is mediated via inhibition of NMDA/nitric oxide/cGMP signaling pathway
Khan, M. I., Nikoui, V., Naveed, A., Mumtaz, F., Zaman, H., Haider, A., Aman, W., Wahab, A., Khan, S. N., Ullah, N., et al. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.01.005 · Cited by 14 · see citing works
Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the activity of two atypical antidepressant drugs, mianserin and tianeptine, in the forced swim test in mice
Socała, K., Nieoczym, D., Wyska, E., Poleszak, E., & Właź, P. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.013 · Cited by 14 · see citing works
Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice
Socała, K., Nieoczym, D., Wyska, E., Poleszak, E., & Właź, P. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70922-2 · Cited by 12 · see citing works
“7-Nitroindazole (an NOS inhibitor) as well as methylene blue (an inhibitor of both NOS and sGC) potentiated, while L-arginine (an NO donor) and sildenafil (a selective PDE5 inhibitor) reduced the antidepressant action of the above mentioned drugs in the forced swim test [8, 9, 56].”
Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behaviorPreprint
Kim, S., Pick, J. E., Abera, S., Khatri, L., Ferreira, D. D. P., Sathler, M. F., Morison, S. L., Hofmann, F. B., & Ziff, E. B. (2016) · Learning & Memory · doi:10.1101/lm.042960.116 · Cited by 14 · see citing works
“Several studies suggest that the inhibition of both nNOS and guanylate cyclase shows antidepressant-like effects (Eroglu and Caglayan 1997; Heiberg et al. 2002; Kaster et al. 2005; Joca and Guimaraes 2006; Jesse et al. 2008; Zomkowski et al. 2010).”
Background
The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram
O'Brien, F. E., O’Connor, R. M., Clarke, G. A., Donovan, M. D., Dinan, T. G., Griffin, B. T., & Cryan, J. F. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.027 · Cited by 12 · see citing works
Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in mice
Socała, K., Nieoczym, D., Wyska, E., & Właź, P. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1334-3 · Cited by 12 · see citing works
“…sildenafil was shown to abolish the antidepressant-like effect of memantine (Almeida et al. 2006), lithium (Ghasemi et al. 2008), escitalopram (Zomkowski et al. 2010), duloxetine (Zomkowski et al. 2012), and paroxetine (Socała et al. 2012d) in the forced swim test in mice, whereas it failed…”
Background
Novel Targets in the Glutamate and Nitric Oxide Neurotransmitter Systems for the Treatment of Depression
O'Toole, E., Doucet, M. V., Sherwin, E., & Harkin, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802456-0.00003-0 · Cited by 11 · see citing works
Sex differences on the response to antidepressants and psychobiotics following early life stress in rats
Carlessi, A. S., Botelho, M. E. M., Manosso, L. M., Borba, L. A., Maciel, L. R., Andrade, N. M., Martinello, N. S., Padilha, A. P. Z., Generoso, C. M., Bencke, C. V., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173468 · Cited by 10 · see citing works
Nitric oxide mediates the antidepressant-like effect of modafinil in mouse forced swimming and tail suspension tests
Omidi-Ardali, H., Badi, A. G., Saghaei, E., & Amini-Khoei, H. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0021 · Cited by 10 · see citing works
Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers.
Daniels, S., Horman, T., Lapointe, T., Melanson, B., Storace, A., Kennedy, S., Frey, B., Rizvi, S., Hassel, S., Mueller, D., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.108 · Cited by 9 · see citing works
Multiple cellular targets involved in the antidepressant-like effect of glutathione
Dafré, A. L., Rosa, J. M., Rodrigues, A. L. S., & Cunha, M. P. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109195 · Cited by 8 · see citing works
Self-citation
Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression
Zhong, Q., Wu, W., Xie, J., Wang, J., Ke Cheng, X. U., Ren, Y., Chen, J., & Xie, P. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2417179 · Cited by 8 · see citing works
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice
de Arruda, C. M., Doneda, D. L., de Oliveira, V. V., da Silva, R. A. L., de Matos, Y. A. V., Fernandes, I. L., Rohden, C. A. H., Viola, G. G., Rios-Santos, F., de Lima, E., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173433 · Cited by 8 · see citing works
The role of nitric oxide–cGMP pathway in selegiline antidepressant-like effect in the mice forced swim test
Ostadhadi, S., Shakiba, S., Norouzi‐Javidan, A., Nikoui, V., Zolfaghari, S., Chamanara, M., & Dehpour, A. R. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.05.004 · Cited by 8 · see citing works
Pharmacological Screening of Mangifera indica Seeds for Antidepressant-like Action Along with a Mechanistic Study
Iman, S., Saleem, U., & Ahmad, B. (2020) · ACS Omega · doi:10.1021/acsomega.0c04187 · Cited by 7 · see citing works
Nitric Oxide Synthase inhibition counteracts the stress‐induced DNA methyltransferase 3b expression in the hippocampus of rats
Maciel, I. D. S., Sales, A. J., Casarotto, P. C., Ċastrén, E., Biojone, C., & Joca, S. R. L. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15042 · Cited by 7 · see citing works
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“Recordings were carried out for a total period of 6 min and compared with vehicle treated control (Zomkowski et al., 2010; Kulkarni and Dhir, 2007; Dhir and Kulkarni, 2008b; Steru et al., 1985).”
Method
Gastroprotective activity of mirtazapine, escitalopram and venlafaxine in depressed rats
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“The present results are in accordance with other studies that revealed the effectiveness of escitalopram and venlafaxine in FST (Zomkowski et al., 2010).”
Result
Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress
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“Apparatus and methods used were similar to those previously described (29).”
Method
Possible involvement of NO-sGC-cGMP signaling in the antidepressant like effect of pyridoxine in mice
Maratha, S. R., Sharma, V., & Walia, V. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00858-6 · Cited by 4 · see citing works
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Comparing the Efficacy of Escitalopram with and without Crocin in Restoring I/O Functions and LTP within the Hippocampal CA1 Region of Stressed Rats
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Maratha, S. R., Sharma, V., & Walia, V. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01006-4 · Cited by 1 · see citing works
Letter to editor
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Self-citation
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Authors: Zomkowski, A. D. E., Engel, D., Gabilan, N. H., & Rodrigues, A. L. S.
Affiliations: Universidade Federal de Santa Catarina (BR)
Corresponding author: Rodrigues, Ana Lúcia S.
ORCID: Engel, Daiane
Rodrigues, Ana Lúcia S.
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2010-11
Volume: 20
Issue: 11
Pages: 793-801
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2010.07.011
OpenAlex: W2017540151
Cited by: 94
References: 59
Citations by year: 2025: 1 · 2024: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 17
FWCI: 7.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: escitalopram, antidepressant mechanism, NMDA receptor, nitric oxide, L-arginine, NO-cGMP pathway, serotonin reuptake inhibitors, depression, forced swim test, tail suspension test, 7-nitroindazole, sildenafil, methylene blue, ODQ, locomotor activity
MeSH terms: Animals, Arginine, Depression, Exploratory Behavior, Female, Cyclic GMP, Nitric Oxide, Swimming, Citalopram, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Antidepressive Agents, Second-Generation, Hindlimb Suspension, Mice

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Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

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