Treatment of cytokine-induced depression
Abstract
A high proportion of cancer and hepatitis C patients who receive cytokine immunotherapy develop symptoms of depression that are indistinguishable from those found in major depressive disorders. These symptoms are alleviated by anti-depressant treatment. Moreover, preventive treatment with anti-depressants, in particular selective serotonin reuptake inhibitors (SSRIs) attenuates IFN-alpha-associated symptoms of depression, anxiety, and neurotoxicity. The intermediate mechanisms of these effects are still unclear. Studies suggest that the state of depression is associated with an increase in plasma levels of various cytokines and soluble cytokine receptors. Furthermore, anti-depressants have been shown to shift the cytokine network towards a decreased production of pro-inflammatory cytokines and an increased production of anti-inflammatory cytokines. Other studies suggest that anti-depressants can also modify immune reactivity by acting on neural structures involved in neuroimmunomodulation. It is possible that anti-depressants could help to normalize the serotoninergic neurotransmission that is likely disrupted during immunotherapy due to the potent effects of cytokines on the metabolism of the amino acid precursor tryptophan. Further work is needed to optimize strategies for preventing neuropsychiatric side effects of cytokine immunotherapy, to clarify the mechanisms involved in the alleviating effects of anti-depressants on cytokine-induced depression, as well as to assess the possible consequences of anti-depressant therapy on the efficacy of immunotherapy on the disease process.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inflammatory interventions can lead to symptoms of depression and anxiety, such as in patients receiving interferon alpha treatment.
“Additional evidence contributing to neuroimmune theories of depression and anxiety arise from observations that inflammatory interventions can lead to symptoms of these disorders, such as in the case of patients receiving interferon (IFN) alpha treatment [64].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [64]
Cites
Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.7 · Cited by 2,089 · see citing works
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797 · see citing works
Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · see citing works
Self-citationThe Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells
Denicoff, K. D., RUBINOW, D. R., PAPA, M. Z., SIMPSON, C., SEIPP, C. A., LOTZE, M. T., Chang, A. E., ROSENSTEIN, D., & Rosenberg, S. A. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-293 · Cited by 456 · see citing works
Maes, M. H. J., Scharpé, S., Meltzer, H. Y., Bosmans, E., Suy, E., Calabrese, J. R., & Cosyns, P. R. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90027-e · Cited by 439 · see citing works
Haack, M., Hinze‐Selch, D., Fenzel, T., Kraus, T., Kühn, M., Schuld, A., & Pollmächer, T. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00021-7 · Cited by 329 · see citing works
Mood and cognitive side effects of interferon-alpha therapy.
Valentine, A. D., Meyers, C. A., Kling, M. A., Richelson, E., & Hauser, P. (1998) · PubMed · Cited by 312 · see citing works
Maes, M., Bosmans, E., Suy, E., Vandervorst, C., DeJonckheere, C., & Raus, J. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03163.x · Cited by 268 · see citing works
Cytokine Production and Serum Proteins in Depression
SEIDEL, A., AROLT, V., HUNSTIGER, M., RINK, L., BEHNISCH, A., & KIRCHNER, H. (1995) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1995.tb03604.x · Cited by 244 · see citing works
Effects of Clozapine on Plasma Cytokine and Soluble Cytokine Receptor Levels
Pollmächer, T., Hinze‐Selch, D., & Mullington, J. M. (1996) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199610000-00011 · Cited by 232 · see citing works
Body Weight and Leptin Plasma Levels During Treatment With Antipsychotic Drugs
Kraus, T., Haack, M., Schuld, A., Hinze‐Selch, D., hn, M. K. ⁄., Uhr, M., & Pollm�cher, T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.312 · Cited by 221 · see citing works
Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., & Neveu, P. J. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00030-0 · Cited by 201 · see citing works
Capuron, L., & Ravaud, A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401716 · Cited by 169 · see citing works
Self-citationHinze‐Selch, D. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00089-0 · Cited by 141 · see citing works
Induction of circulating IL-1 receptor antagonist by IFN treatment
Tilg, H., Mier, J. W., Vogel, W., Aulitzky, W. E., Wiedermann, C. J., Vannier, E. G., Huber, C. H., & Dinarello, C. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.10.4687 · Cited by 136 · see citing works
Plasma concentrations of soluble TNF-alpha receptors in obese subjects
Hauner, H., Bender, M., Haastert, B., & Hube, F. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800773 · Cited by 131 · see citing works
Fluoxetine treatment of depression caused by interferon-alpha.
Levenson, J. L., & Fallon, H. J. (1993) · PubMed · Cited by 126 · see citing works
Five Cases of Interferon-Alpha–Induced Depression Treated With Antidepressant Therapy
Gleason, O. C., & Yates, W. R. (1999) · Psychosomatics · doi:10.1016/s0033-3182(99)71190-4 · Cited by 80 · see citing works
Plasma Levels of Cytokines and Soluble Cytokine Receptors During Treatment With Haloperidol
cher, T. P. ⁄., Hinze‐Selch, D., Fenzel, T., Kraus, T., Schuld, A., & Mullington, J. M. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.12.1763 · Cited by 72 · see citing works
Experimental Immunomodulation, Sleep, and Sleepiness in Humans
Pollmächer, T., Schuld, A., Kraus, T., Haack, M., Hinze‐Selch, D., & Mullington, J. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05413.x · Cited by 61 · see citing works
Prophylactic Treatment of Depression Induced by Interferon-α
Hauser, P., Soler, R., Reed, S., Kane, R., Gulati, M. S., Khosla, J., Kling, M. A., Valentine, A. D., & Meyers, C. A. (2000) · Psychosomatics · doi:10.1176/appi.psy.41.5.439 · Cited by 59 · see citing works
Successful Treatment of Interferon Alfa-Induced Mood Disorder With Nortriptyline
Goldman, L. S. (1994) · Psychosomatics · doi:10.1016/s0033-3182(94)71769-2 · Cited by 59 · see citing works
Syvälahti, E., Räkköläinen, V., Aaltonen, J., Lehtinen, V., & Hietala, J. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00027-4 · Cited by 43 · see citing works
Schiller, J. H., Hank, J. A., Storer, B. E., Borchert, A., Moore, K. H., Albertini, M. R., Bechhofer, R., Wesley, O., Brown, R. R., & Bastin, A. M. (1993) · PubMed · Cited by 29 · see citing works
Is There Evidence for an Effect of Antidepressant Drugs on Immune Function?
Neveu, P. J., & Castanon, N. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_15 · Cited by 26 · see citing works
Tilg, H., Atkins, M. B., Dinarello, C. A., & Mier, J. W. (1995) · Cytokine · doi:10.1006/cyto.1995.0087 · Cited by 24 · see citing works
Ravaud, A., Bédane, C., Geoffrois, L., Lesimple, T., & Delaunay, M. M. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690595 · Cited by 23 · see citing works
Tilg, H., Shapiro, L., Vannier, E. G., Poutsiaka, D. D., Trehu, E., Atkins, M. B., Dinarello, C. A., & Mier, J. W. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.6.3189 · Cited by 22 · see citing works
Meffert, M., Hänninen, E. L., Menzel, T., Schomburg, A., Duensing, S. M., Dallmann, I., Grosse, J., Vocke, S., Buer, J., Deckert, P. M., et al. (1994) · Cancer Biotherapy · doi:10.1089/cbr.1994.9.307 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235 · see citing works
The Semantics of Microglia Activation: Neuroinflammation, Homeostasis, and Stress
Woodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02309-6 · Cited by 783 · see citing works
The kynurenine pathway: a finger in every pie
Savitz, J. B. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0414-4 · Cited by 774 · see citing works
Major depression after breast cancer: a review of epidemiology and treatment
Fann, J. R., Thomas-Rich, A. M., Katon, W. J., Cowley, D., Pepping, M., McGregor, B. A., & Gralow, J. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.10.008 · Cited by 586 · see citing works
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
The menace of obesity to depression and anxiety prevalence
Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works
“observations that inflammatory interventions can lead to symptoms of these disorders, such as in the case of patients receiving interferon (IFN) alpha treatment [64].”
BackgroundImaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 432 · see citing works
Felger, J. C., & Miller, A. H. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.003 · Cited by 394 · see citing works
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works
Brain-Gut-Microbiota Axis and Mental Health
Dinan, T. G., & Cryan, J. F. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000519 · Cited by 325 · see citing works
Serotonin and Human Cognitive Performance
Schmitt, J. A. J., Wingen, M., Ramaekers, J. G., Evers, E. A. T., & Riedel, W. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698909 · Cited by 258 · see citing works
Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology
Goldsmith, D. R., Bekhbat, M., Mehta, N. D., & Felger, J. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.11.003 · Cited by 220 · see citing works
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165 · see citing works
TNF-α-mediated anxiety in a mouse model of multiple sclerosis
Haji, N., Mandolesi, G., Gentile, A., Sacchetti, L., Fresegna, D., Rossi, S., Musella, A., Sepman, H., Motta, C., Studer, V., et al. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.010 · Cited by 161 · see citing works
Glucocorticoid Dysregulations and Their Clinical Correlates: From Receptors to Therapeutics
Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04987.x · Cited by 158 · see citing works
The role of IL-12 and TGF-β1 in the pathophysiology of major depressive disorder
Lee, K.-M., & Kim, Y.-K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.015 · Cited by 150 · see citing works
Tucker, P., Ruwe, W. D., Masters, B., Parker, D. E., Hossain, A., Trautman, R. P., & Wyatt, D. B. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.009 · Cited by 148 · see citing works
Pro-inflammatory biomakers in depression: Treatment with venlafaxine
Piletz, J. E., Halaris, A. E., Iqbal, O., Hoppensteadt, D., Fareed, J., Zhu, H., Sinacore, J. M., & DeVane, C. L. (2009) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802573246 · Cited by 130 · see citing works
Maldonado‐Bouchard, S., Peters, K., Woller, S. A., Madahian, B., Faghihi, U., Patel, S. P., Bake, S., & Hook, M. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.009 · Cited by 127 · see citing works
Engler, H., Brendt, P., Wischermann, J., Wegner, A., Rohling, R., Schoemberg, T., Meyer, U., Gold, R., Peters, J., Benson, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.264 · Cited by 123 · see citing works
Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism?
Park, C., Brietzke, E. M., Rosenblat, J. D., Musial, N., Zuckerman, H., Ragguett, R., Pan, Z., Rong, C., Fus, D., & McIntyre, R. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.006 · Cited by 128 · see citing works
The role of dopamine in inflammation-associated depression: mechanisms and therapeutic implications
Felger, J. C. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_13 · Cited by 115 · see citing works
Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood
Grudet, C., Malm, J., Westrin, Å., & Brundin, L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.016 · Cited by 112 · see citing works
Nunes, E. J., Randall, P. A., Estrada, A., Epling, B. P., Hart, E. E., Lee, C. A., Baqi, Y., Müller, C. E., Correa, M., & Salamone, J. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3285-4 · Cited by 108 · see citing works
Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?
McNamara, R. K., & Lotrich, F. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.98 · Cited by 109 · see citing works
Pandey, G. N., Rizavi, H. S., Bhaumik, R., & Ren, X. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.024 · Cited by 108 · see citing works
Voinov, B., Richie, W. D., & Bailey, R. K. (2013) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.12r01468 · Cited by 98 · see citing works
Kraus, M. R., Schäfer, A., Al‐Taie, O., & Scheurlen, M. (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00554.x · Cited by 96 · see citing works
Feeding melancholic microbes: MyNewGut recommendations on diet and mood
Dinan, T. G., Stanton, C., Long-Smith, C., Kennedy, P., Cryan, J. F., Cowan, C. S. M., Cenit, M. C., van der Kamp, J.-W., & Sanz, Y. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.010 · Cited by 95 · see citing works
Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders
Savitz, J. B. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_12 · Cited by 96 · see citing works
Serum kynurenic acid is reduced in affective psychosis
Wurfel, B., Drevets, W., Bliss, S., Mcmillin, J., Suzuki, H., Ford, B., Morris, H., Teague, T., Dantzer, R., & Savitz, J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.88 · Cited by 92 · see citing works
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 92 · see citing works
The emerging tale of microglia in psychiatric disorders
Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 91 · see citing works
Role of IL-1 in Poststroke Depressive-like Behavior in Mice
Craft, T. K. S., & DeVries, A. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.011 · Cited by 87 · see citing works
Microglia activation is associated with IFN-α induced depressive-like behavior
Wachholz, S., Eßlinger, M., Plümper, J., Manitz, M. P., Juckel, G., & Friebe, A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.016 · Cited by 85 · see citing works
Laumet, G. O., Zhou, W., Dantzer, R., Edralin, J. D., Huo, X., Budac, D. P., O’Connor, J. C., Lee, A. W., Heijnen, C. J., & Kavelaars, A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.008 · Cited by 84 · see citing works
The Role of Cytokines in the Regulation of Neurotransmission
Camacho‐Arroyo, I., López-Griego, L., & Morales‐Montor, J. (2008) · NeuroImmunoModulation · doi:10.1159/000179661 · Cited by 75 · see citing works
Hestad, K. A., Engedal, K., Whist, J. E., & Farup, P. G. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01561 · Cited by 72 · see citing works
Major depression during interferon-α treatment: vulnerability and prevention
Lotrich, F. E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/felotrich · Cited by 71 · see citing works
Fibromyalgia: Present to future
Bennett, R. M. (2005) · Current Rheumatology Reports · doi:10.1007/s11926-005-0022-y · Cited by 71 · see citing works
Perioperative neurocognitive dysfunction: thinking from the gut?
Xu, X., Hu, Y., Yan, E., Zhan, G., Liu, C., & Yang, C. (2020) · Aging · doi:10.18632/aging.103738 · Cited by 69 · see citing works
Depression subtypes in pediatric inflammatory bowel disease
Szigethy, E. M., Youk, A. O., Benhayon, D., Fairclough, D. L., Newara, M. C., Kirshner, M. A., Bujoreanu, S. I., Mrakotsky, C., Bousvaros, A., Srinath, A. I., et al. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000262 · Cited by 65 · see citing works
Flux, M. C., & Lowry, C. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104578 · Cited by 68 · see citing works
Psychosocial influences on immunity, including effects on immune maturation and senescence
Coe, C. L., & Laudenslager, M. L. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.06.015 · Cited by 62 · see citing works
Depression, cytokines, and glial function
Miller, D. B., & O'Callaghan, J. P. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.011 · Cited by 62 · see citing works
Garza, R. D. L., & Asnis, G. M. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02757-4 · Cited by 63 · see citing works
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration
Neis, V. B., Manosso, L. M., Moretti, M., Freitas, A. E., Daufenbach, J., & Rodrigues, A. L. S. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.038 · Cited by 59 · see citing works
Kenis, G., Prickaerts, J., van Os, J., Koek, G. H., Robaeys, G., Steinbusch, H. W. M., & Wichers, M. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000830 · Cited by 58 · see citing works
Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents
Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., FLOURI, S., Mantzoros, C. S., & Kafatos, A. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.008 · Cited by 56 · see citing works
Cognitive changes after acute tryptophan depletion: what can they tell us?
Riedel, W. J. (2004) · Psychological Medicine · doi:10.1017/s0033291703008924 · Cited by 55 · see citing works
Toxicity as a result of immunostimulation by biologics
Gribble, E. J., Sivakumar, P. V., Ponce, R. A., & Hughes, S. D. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.2.209 · Cited by 51 · see citing works
Bassi, M. S., Gilio, L., Maffei, P., Dolcetti, E., Bruno, A., Buttari, F., Centonze, D., & Iezzi, E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00424 · Cited by 49 · see citing works
Munsterhjelm, C., Nordgreen, J., Aae, F., Heinonen, M., Valros, A., & Janczak, A. M. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.09.018 · Cited by 48 · see citing works
McFarland, D. C. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.04.001 · Cited by 47 · see citing works
Kulmatycki, K. M., & Jamali, F. (2006) · PubMed · Cited by 43 · see citing works
Potential roles for opioid receptors in motivation and major depressive disorder
Callaghan, C. K., Rouine, J., & O’Mara, S. M. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.07.009 · Cited by 44 · see citing works
Stress circuitry: mechanisms behind nervous and immune system communication that influence behavior
Tong, R. L., Kahn, U. N., Grafe, L. A., Hitti, F. L., Fried, N. T., & Corbett, B. F. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1240783 · Cited by 41 · see citing works
Quelhas, R., & Lopes, A. (2009) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000358313.06858.ea · Cited by 40 · see citing works
Hepatitis C Treatment for People With Severe Mental Illness
Mistler, L. A., Brunette, M. F., Marsh, B. J., Vidaver, R. M., Luckoor, R., & Rosenberg, S. D. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.2.93 · Cited by 39 · see citing works
Fibromyalgia: Present to future
Bennett, R. M. (2004) · Current Pain and Headache Reports · doi:10.1007/s11916-996-0011-5 · Cited by 39 · see citing works
Papageorgiou, C., Panagiotakos, D. B., Pitsavos, C. S., Tsetsekou, E., Kontoangelos, K. A., Stefanadis, C., & Soldatos, C. R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.05.018 · Cited by 37 · see citing works
Adverse Consequences of Immunostimulation
Ponce, R. A. (2008) · Journal of Immunotoxicology · doi:10.1080/15476910801897920 · Cited by 35 · see citing works
Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders
Kalinichenko, L. S., Kornhuber, J., & Müller, C. P. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100783 · Cited by 34 · see citing works
Garza, R. D. L. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00211-0 · Cited by 33 · see citing works
Gurgel, J. A., Lima‐Júnior, R. C. P., Rabelo, C. O., Pessoa, B. B. G. D. P., Brito, G. A. D. C., & Ribeiro, R. A. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2012-0977 · Cited by 32 · see citing works
McFarland, D. C., Shaffer, K. M., BREITBART, W. S., Rosenfeld, B. D., & Miller, A. H. (2018) · Cancer · doi:10.1002/cncr.31859 · Cited by 31 · see citing works
Tumor Mutation Burden and Depression in Lung Cancer: Association With Inflammation
McFarland, D. C., Jutagir, D. R., Miller, A. H., BREITBART, W. S., Nelson, C. J., & Rosenfeld, B. D. (2020) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.7374 · Cited by 30 · see citing works
A Reciprocal Link Between Gut Microbiota, Inflammation and Depression: A Place for Probiotics?
Eltokhi, A., & Sommer, I. E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.852506 · Cited by 32 · see citing works
Karrenbauer, B. D., Müller, C. P., Ho, Y., Spanagel, R., Huston, J. P., Schwarting, R. K. W., & Pawlak, C. R. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.05.011 · Cited by 29 · see citing works
Frank, P., Ajnakina, O., Steptoe, A., & Cadar, D. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0815-9 · Cited by 28 · see citing works
Linking depression and neuroinflammation: Crosstalk between glial cells
Yang, X., Wang, H., Wang, Z.-Z., & Chen, N. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177408 · Cited by 26 · see citing works
Astrocytic TNFα regulates the behavioral response to antidepressants
Duseja, R., Heir, R., Lewitus, G. M., Altimimi, H. F., & Stellwagen, D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.012 · Cited by 25 · see citing works
Psychobiotics: Evolution of Novel Antidepressants
Dinan, T. G., Butler, M., & Cryan, J. F. (2021) · Modern trends in psychiatry · doi:10.1159/000510424 · Cited by 25 · see citing works
Alessi, M. G., & Bennett, J. M. (2020) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.13386 · Cited by 24 · see citing works
Sun, X., Liu, Y., Dai, T., Ding, J. H., & Hu, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.047 · Cited by 24 · see citing works
The Association between Low Vitamin D Levels and Suicide Attempts in Adolescents
Gökalp, G. (2020) · Annals of Clinical Psychiatry · doi:10.1177/104012372003200208 · Cited by 20 · see citing works
Inflammation and its relevance to psychiatry
Cavanagh, J., & Mathias, C. (2008) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.106.003319 · Cited by 20 · see citing works
Chapman, J., Oser, M. L., Hockemeyer, J. R., Weitlauf, J. C., Jones, S., & Cheung, R. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.252 · Cited by 19 · see citing works
Matsushita, H., Ikeda, F., Iwasaki, Y., Seki, H., Nanba, S., Takeuchi, Y., Moritou, Y., Yasunaka, T., Onishi, H., Miyake, Y., et al. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12337 · Cited by 18 · see citing works
Markowitz, J. S., Gutterman, E. M., Hodes, D. S., & Klaskala, W. I. (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00607.x · Cited by 17 · see citing works
Bi, Z., Li, W., Zhao, J., Pang, L., Jing, Y., Zhang, X., Yao, S., Yin, X., Zuo, H., & Cheng, H. (2022) · PubMed Central · Cited by 17 · see citing works
The Contribution of TNFα to Synaptic Plasticity and Nervous System Function
Stellwagen, D. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6612-4_57 · Cited by 15 · see citing works
Do different depression phenotypes have different risks for recurrent coronary heart disease?
Shaffer, J. A., Whang, W., Shimbo, D., Burg, M. M., Schwartz, J. E., & Davidson, K. W. (2011) · Health Psychology Review · doi:10.1080/17437199.2010.527610 · Cited by 14 · see citing works
Meta-analysis of soluble tumour necrosis factor receptors in severe mental illnesses
Goh, X. X., Tang, P. Y., & Tee, S. F. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.07.014 · Cited by 13 · see citing works
Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice
Yu, Z., Lin, Y., & Chen, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147611 · Cited by 13 · see citing works
Rifai, M. A., & Rosenstein, D. L. (2005) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.3.2.194 · Cited by 13 · see citing works
The complex relationship between gut microbiota dysregulation and mood disorders: A narrative review
Minuti, A., Brufani, F., Menculini, G., Moretti, P., & Tortorella, A. A. V. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100044 · Cited by 13 · see citing works
Psychiatric Clearance for Patients Started on Interferon-Alpha-Based Therapies
Lotrich, F. E. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12121572 · Cited by 12 · see citing works
The janus face of serotonin: Regenerative promoter and chronic liver disease aggravator
Mao, B., Liu, S., Zhu, S., Wu, F., Yuan, W., Yan, Y., & Wang, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30703 · Cited by 11 · see citing works
Effects of selective serotonin reuptake inhibitors on platelet functions: a literature review
Mokhtarian, A., Siguret, V., & Jourdi, G. (2024) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000847 · Cited by 10 · see citing works
Moriarity, D. P. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100288 · Cited by 9 · see citing works
Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders
Ballaz, S., & Bourin, M. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_20 · Cited by 9 · see citing works
Psychiatric Assessment of Patients With Hepatitis C Virus Before Initiating Interferon Treatment
Goldsmith, R. J., Mindrum, G. M., & Myaing, M. (2003) · Psychiatric Annals · doi:10.3928/0048-5713-20030601-06 · Cited by 9 · see citing works
Inflammation as a mediator of stress-related psychiatric disorders
Flux, M. C., & Lowry, C. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00052-6 · Cited by 9 · see citing works
Targeting brain connectivity in Alzheimer’s disease with repurposed drugs
Pini, L., Imbimbo, B. P., Griffa, A., Allali, G., & Pomara, N. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.103001 · Cited by 7 · see citing works
Steel, J. L., Reyes, V. E., Zandberg, D. P., Nilsen, M. L., Terhorst, L. A., Richards, G., Pappu, B., Kiefer, G. J., Johnson, J. T., Antoni, M. H., et al. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106295 · Cited by 6 · see citing works
Advances in Stem Cells Biology: New Approaches to Understand Depression
Borsini, A., & Zunszain, P. A. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-41603-8_10 · Cited by 5 · see citing works
Hekler, E. B., Rubenstein, J., Coups, E. J., Gilligan, S., Kusnecov, A. W., Contrada, R. J., Steiner, M. J., Tannenbaum, A. K., Leventhal, E. A., & Krause, T. J. (2007) · Journal of Applied Biobehavioral Research · doi:10.1111/j.1751-9861.2007.00014.x · Cited by 5 · see citing works
Zhang, L., Zhang, H., Xie, J., & Wang, X. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s336686 · Cited by 4 · see citing works
Marron, M. M., Anderson, S., Garrity, J., Reynolds, C. F., & Lotrich, F. E. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000231 · Cited by 4 · see citing works
- Authors
- Capuron, L., Hauser, P., Hinze-Selch, D., Miller, A. H., & Neveu, P. J.
- Affiliations
- Emory University (US)
- Université de Bordeaux (FR)
- Corresponding author
- Neveu, Pierre J
- ORCID
- Capuron, Lucile
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 16
- Issue
- 5
- Pages
- 575-580
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2002423129
- Cited by
- 132
- References
- 30
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- cytokine therapy, antidepressants, selective serotonin reuptake inhibitors, interferon-alpha, cancer patients, hepatitis C, neurotoxicity, anxiety, neuroimmunomodulation, serotonergic neurotransmission, tryptophan metabolism, inflammatory cytokines, anti-inflammatory cytokines, soluble cytokine receptors, neuropsychiatric adverse effects
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Immunotherapy, Serotonin, Sleep, Tryptophan, Cytokines, Receptors, Cytokine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
