Hippocampal BDNF treatment facilitates consolidation of spatial memory in spontaneous place recognition in rats
Abstract
In order to investigate the role of brain-derived neurotrophic factor (BDNF) in the consolidation of spatial memory, we examined the relationship between the increase of hippocampal BDNF and the establishment of long-term spatial memory in spontaneous place recognition test in rats. The test consisted of a sample phase, delay interval, and a test phase, and preferred exploration of the object in a novel place compared with that in a familiar place was assessed in the test phase. In experiment 1, dorsal hippocampal administration of anisomycin, a protein synthesis inhibitor, before the sample phase (20 min) abolished the preference for the novel place object in the test phase conducted 24h later. This impairment was reversed by the dorsal hippocampal BDNF treatment immediately after the sample phase, although the BDNF treatment alone did not improve performance. In experiment 2, we used a shorter sample phase condition (5 min) in which control rats did not show any preference for the novel place object in the test phase after 24h delay, and found that BDNF treatment immediately after the sample phase caused rats' significant preference for it. Results suggest an important role of hippocampal BDNF as a product of protein synthesis that is required for the consolidation of spatial memory.
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Hippocampal BDNF is involved in protein synthesis for spatial memory consolidation.
“suggesting hippocampal BDNF is involved in protein synthesis for spatial memory consolidation”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ozawa et al., 2014
Post-sample intra-hippocampus BDNF infusions compensated OPP deficits induced by anisomycin, and hippocampal BDNF infusions facilitated long-term OPP memory.
“Post-sample intra-hippocampus BDNF infusions were found to compensate OPP deficits induced by anisomycin, and hippocampal BDNF infusions facilitated long-term OPP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ozawa et al., 2014
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- Authors
- Ozawa, T., Yamada, K., & Ichitani, Y.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Ichitani, Yukio
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 263
- Pages
- 210-216
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2006712760
- Cited by
- 31
- References
- 46
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society (24653209, 24530909)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, hippocampus, spatial memory consolidation, anisomycin, protein synthesis, long-term memory, novel object preference, rats
- MeSH terms
- Animals, Anisomycin, Exploratory Behavior, Hippocampus, Male, Memory, Neuropsychological Tests, Protein Synthesis Inhibitors, Space Perception, Task Performance and Analysis, Time Factors, Rats, Wistar, Brain-Derived Neurotrophic Factor, Recognition, Psychology, Rats
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