BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation.
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Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic factor (BDNF) modulates both short-term synaptic function and activity-dependent synaptic plasticity in the adult hippocampus, we examined the role of BDNF in STM and LTM formation of a hippocampal-dependent one-trial fear-motivated learning task in rats. Using a competitive RT-PCR quantitation method, we found that inhibitory avoidance training is associated with a rapid and transient increase in BDNF mRNA expression in the hippocampus. Bilateral infusions of function-blocking anti-BDNF antibody into the CA, region of the dorsal hippocampus decreased extracellular signal-regulated kinase 2 (ERK2) activation and impaired STM retention scores. Inhibition of ERK1/2 activation by PD098059 produced similar effects. In contrast, intrahippocampal administration of recombinant human BDNF increased ERK1/2 activation and facilitated STM. The infusion of anti-BDNF antibody impaired LTM when given 15 min before or 1 and 4 hr after training, but not at 0 or 6 hr posttraining, indicating that two hippocampal BDNF-sensitive time windows are critical for LTM formation. At the same time points, PD098059 produced no LTM deficits. Thus, our results indicate that endogenous BDNF is required for both STM and LTM formation of an inhibitory avoidance learning. Additionally, they suggest that this requirement involves ERK1/2-dependent and -independent mechanisms.
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Manipulation of brain-derived neurotrophic factor expression directly impacts upon performance in spatial and contextual memory tasks.
“The importance of BDNF to hippocampal neuroplasticity is epitomized by animal studies, which have found that the manipulation of BDNF expression directly impacts upon performance in spatial and contextual memory tasks (Linnarsson et al., 1997; Alonso et al., 2002; Heldt et al., 2007; Peters et al., 2010), and also that the downregulation of BDNF inhibits AE induced improvements in spatial memory”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Alonso et al., 2002
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- Authors
- Alonso, M., Vianna, M. R. M., Depino, A. M., Mello e Souza, T., Pereira, P., Szapiro, G., Viola, H., Pitossi, F., Izquierdo, I., & Medina, J. H.
- Affiliations
- Universidad de Buenos Aires (AR)
- Corresponding author
- Medina, Jorge H.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 12
- Issue
- 4
- Pages
- 551-560
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2130743873
- Cited by
- 339
- References
- 83
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 10 · 2021: 17 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 29 · 2016: 20 · 2015: 13 · 2014: 20 · 2013: 23 · 2012: 16
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Agencia Nacional de Promoción Científica y Tecnológica (CONICET)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, short-term memory, long-term memory, passive avoidance, ERK signaling, PD98059, synaptic plasticity
- MeSH terms
- Animals, Antibodies, Avoidance Learning, Drug Administration Schedule, Enzyme Activation, Enzyme Inhibitors, Fear, Flavonoids, Hippocampus, Learning, Male, Memory, Memory, Short-Term, Recombinant Proteins, Retention, Psychology, RNA, Messenger, Time Factors, Rats, Wistar, Brain-Derived Neurotrophic Factor, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Rats
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