Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix
Abstract
The first experiment assessed the effects of neurotoxic lesions in either the anterior cingulate cortex (ACc) or the retrosplenial cortex (RSc) on a test of object recognition. Neither lesion affected performance on this task, which takes advantage of the rat's normal preference to spend more time investigating novel rather than familiar stimuli. In response to this negative result, a second experiment assessed the effects of much more extensive cingulate lesions (Cg) on both object recognition and object location memory. The latter task also used a preference measure, but in this case it concerned preference for a novel location. For comparison purposes this second study included groups of rats with lesions in closely allied regions: the fornix (Fx), the cingulum bundle (CB) and the medial prefrontal cortex (Pfc). Comparisons with sham-operated control rats showed that none of the four groups (Cg, Fx, CB, Pfc) was impaired on the object recognition task, adding further weight to the view that these structures are not necessary for assessing stimulus familiarity. The Fx and Cg groups were, however, impaired on the object location task, suggesting that these regions are necessary for remembering other attributes of a stimulus (spatial location).
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Spontaneous object exploration can be used to assess memory for what (NOP), for where (OPP), and for when (TOM).
“Spontaneous object exploration can be used to assess memory for “what” (novel object preference; NOP) (Ennaceur and Delacour, 1988), for “where” (object place preference; OPP) (Ennaceur et al., 1997), and for “when” (memory for temporal order or recency; TOM) (Mitchell and Laiacona, 1998).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ennaceur et al., 1997
Lesions in the mPFC do not affect NOP performance.
“However, lesions in the mPFC did not affect NOP performance (Ennaceur et al., 1997; Mitchell and Laiacona, 1998), consistent with subsequent studies in rats and mice (Baran et al., 2010; Barker et al., 2007; Barker and Warburton, 2011b; Cross et al., 2012; McAllister et al., 2015; Spanswick and Dyck, 2012).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ennaceur et al., 1997
Cites
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Self-citationHippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018 · see citing works
The effects of hippocampal lesions upon spatial and non-spatial tests of working memory
Aggleton, J. P., Hunt, P. R., & Rawlins, J. N. P. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90011-2 · Cited by 496 · see citing works
Bachevalier, J., & Mishkin, M. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90225-1 · Cited by 446 · see citing works
Contributions of cingulate cortex to two forms of spatial learning and memory
Sutherland, R., Whishaw, I., & Kolb, B. E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01863.1988 · Cited by 424 · see citing works
Connections between the retrosplenial cortex and the hippocampal formation in the rat: A review
Wyss, J. M., & van Groen, T. (1992) · Hippocampus · doi:10.1002/hipo.450020102 · Cited by 379 · see citing works
Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys
Alvarez, P., Zola-Morgan, S. M., & Squire, L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03796.1995 · Cited by 376 · see citing works
Ennaceur, A., Neave, N., & Aggleton, J. P. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00006-x · Cited by 351 · see citing works
Form and distribution of neurons in rat cingulate cortex: Areas 32, 24, and 29
Vogt, B. A., & Peters, A. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901950406 · Cited by 341 · see citing works
Amnesia and recognition memory: A re-analysis of psychometric data
Aggleton, J. P., & Shaw, C. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00150-6 · Cited by 323 · see citing works
de Bruin, J. P. C., Sánchez-Santed, F., Heinsbroek, R. P. W., Donker, A., & Postmes, P. (1994) · Brain Research · doi:10.1016/0006-8993(94)90243-7 · Cited by 285 · see citing works
Ennaceur, A., & Meliani, K. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80315-8 · Cited by 276 · see citing works
Mumby, D. G., Wood, E. R., & Pinel, J. P. J. (1992) · Psychobiology · doi:10.3758/bf03327156 · Cited by 219 · see citing works
Hippocampal function required for nonspatial working memory
Olton, D. S., & Feustle, W. A. (1981) · Experimental Brain Research · doi:10.1007/bf00238896 · Cited by 205 · see citing works
Zhu, X. O., Brown, M. W., McCabe, B. J., & Aggleton, J. P. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00320-i · Cited by 205 · see citing works
Aggleton, J., Neave, N., Nagle, S., & Sahgal, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07270.1995 · Cited by 196 · see citing works
Self-citationZhu, X. O., Brown, M. W., & Aggleton, J. P. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00679.x · Cited by 194 · see citing works
Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions
Bartolini, L., Casamenti, F., & Pepeu, G. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02021-7 · Cited by 193 · see citing works
A comparative analysis of the role of fornix and cingulate cortex in memory: rats
Markowska, A. L., Olton, D. S., Murray, E. A., & Gaffan, D. (1989) · Experimental Brain Research · doi:10.1007/bf00248292 · Cited by 190 · see citing works
Kesner, R. P., Farnsworth, G., & DiMattia, B. V. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.5.956 · Cited by 184 · see citing works
The effects of fornix and medial prefrontal lesions on delayed non-matching-to-sample by rats
Shaw, C., & Aggleton, J. P. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90051-q · Cited by 181 · see citing works
Aggleton, J. P., Neave, N., Nagle, S., & Hunt, P. R. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00163-a · Cited by 180 · see citing works
Object recognition memory in the rat: the role of the hippocampus
Rothblat, L. A., & Kromer, L. F. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80036-1 · Cited by 167 · see citing works
Giovannelli, L., Casamenti, F., Scali, C., Bartolini, L., & Pepeu, G. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00610-h · Cited by 167 · see citing works
Rawlins, J. N. P., Lyford, G. L., Seferiades, A., Deacon, R. M. J., & al, E. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.3.420 · Cited by 158 · see citing works
Brito, G. N. O., & Brito, L. S. O. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90167-d · Cited by 157 · see citing works
Posterior Cingulate Cortex and Spatial Memory: A Microlimnology Analysis
Sutherland, R. J., & Hoesing, J. M. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6704-6_17 · Cited by 153 · see citing works
Hippocampal and amygdaloid involvement in working memory for nonspatial stimuli.
Raffaele, K. C., & Olton, D. S. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.3.349 · Cited by 145 · see citing works
Ennaceur, A., & Meliani, K. (1992) · Psychopharmacology · doi:10.1007/bf02245880 · Cited by 134 · see citing works
Bussey, T. J., Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)81107-2 · Cited by 126 · see citing works
Dunnett, S. B. (1990) · Canadian Journal of Psychology/Revue Canadienne de Psychologie · doi:10.1037/h0084240 · Cited by 122 · see citing works
Spontaneous recognition of object configurations in rats: effects of fornix lesions
Ennaceur, A., & Aggleton, J. P. (1994) · Experimental Brain Research · doi:10.1007/bf00227281 · Cited by 121 · see citing works
Prelimbic cortex, mediodorsal thalamus, septum, and delayed alternation in rats
Brito, G. N. O., Thomas, G. J., Davis, B. J., & Gingold, S. I. (1982) · Experimental Brain Research · doi:10.1007/bf00238097 · Cited by 115 · see citing works
Ennaceur, A., Cavoy, A., da Costa, J. C., & Delacour, J. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80051-8 · Cited by 106 · see citing works
Neave, N., Lloyd, S. R., Sahgal, A., & Aggleton, J. P. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90077-9 · Cited by 102 · see citing works
Aggleton, J. P., Hunt, P. R., & Shaw, C. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90006-z · Cited by 90 · see citing works
Recovery of delayed alternation in rats after lesions in medial frontal cortex and septum.
Thomas, G. J., & Brito, G. N. O. (1980) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077834 · Cited by 86 · see citing works
Medial dorsal thalamic lesions and working memory in the rat
Hunt, P. R., & Aggleton, J. P. (1991) · Behavioral and Neural Biology · doi:10.1016/0163-1047(91)80141-z · Cited by 82 · see citing works
Scali, C., Casamenti, F., Pazzagli, M., Bartolini, L., & Pepeu, G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90253-4 · Cited by 78 · see citing works
Mumby, D. G., Pinel, J. P. J., Kornecook, T. J., Shen, M. J., & Redila, V. A. (1995) · Psychobiology · doi:10.3758/bf03327055 · Cited by 67 · see citing works
Ennaceur, A., & Delacour, J. (1987) · Psychopharmacology · doi:10.1007/bf00215480 · Cited by 50 · see citing works
Fornix^fimbria section and working memory deficits in rats: Stimulus complexity and stimulus size.
Cassaday, H. J., & Rawlins, J. N. P. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.4.594 · Cited by 43 · see citing works
Mickley, G. A., Cobb, B. L., Mason, P. A., & Farrell, S. T. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90384-0 · Cited by 41 · see citing works
Chronic administration of l-NAME in drinking water alters working memory in rats
Cobb, B. L., Ryan, K. L., Frei, M. R., Guel, V., & Mickley, G. A. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)00095-v · Cited by 36 · see citing works
Meunier, M., & Destrade, C. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90041-1 · Cited by 35 · see citing works
Steele, K., & Rawlins, J. N. P. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90043-p · Cited by 33 · see citing works
Kynurenic acid and 5,7-dichlorokynurenic acids improve social and object recognition in male rats
Hlinak, Z., & Krejčı́, I. (1995) · Psychopharmacology · doi:10.1007/bf02245819 · Cited by 32 · see citing works
DELAYED-NON-MATCH-TO-SAMPLE (DNMS) TASKS
Ennaceur, A., Aggleton, J. P., & Neave, N. (1996) · Behavioural Pharmacology · doi:10.1097/00008877-199605001-00077 · Cited by 1 · see citing works
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The role of medial prefrontal cortex in memory and decision making
Euston, D. R., Gruber, A. J., & McNaughton, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.12.002 · Cited by 1,541 · see citing works
The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714 · see citing works
Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-06.2007 · Cited by 691 · see citing works
One-trial object recognition in rats and mice: Methodological and theoretical issues
Ennaceur, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.036 · Cited by 676 · see citing works
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.005 · Cited by 669 · see citing works
Dix, S. L., & Aggleton, J. P. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00079-5 · Cited by 598 · see citing works
SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-10.2010 · Cited by 541 · see citing works
On the delay-dependent involvement of the hippocampus in object recognition memory
HAMMOND, R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.005 · Cited by 476 · see citing works
Aggleton, J. P., O’Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M., & Erichsen, J. T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07251.x · Cited by 468 · see citing works
Different Contributions of the Hippocampus and Perirhinal Cortex to Recognition Memory
Wan, H., Aggleton, J. P., & Brown, M. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01142.1999 · Cited by 449 · see citing works
An analysis of rat prefrontal cortex in mediating executive function
Kesner, R. P., & Churchwell, J. C. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.07.002 · Cited by 365 · see citing works
Rapid enhancement of visual and place memory by estrogens in rats.
Luine, V., Jacome, L. F., & MacLusky, N. (2003) · Endocrinology · doi:10.1210/en.2003-0004 · Cited by 375 · see citing works
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356 · see citing works
Li, C., Brake, W. G., Romeo, R. D., Dunlop, J. C., Gordon, M., Buzescu, R., Magariños, A. M., Allen, P. B., Greengard, P., Luine, V. N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307313101 · Cited by 345 · see citing works
Integrated Memory for Object, Place, and Context in Rats: A Possible Model of Episodic-Like Memory?
Eacott, M. J., & Norman, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2975-03.2004 · Cited by 344 · see citing works
A critical review of chronic stress effects on spatial learning and memory
Conrad, C. D. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.003 · Cited by 335 · see citing works
Neural circuitry for rat recognition memory
Warburton, E. C., & Brown, M. W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.050 · Cited by 307 · see citing works
Chronic stress effects on memory: sex differences in performance and monoaminergic activity
Bowman, R. E., Beck, K. D., & Luine, V. N. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00022-3 · Cited by 290 · see citing works
O’Shea, M., Singh, M. E., McGregor, I. S., & Mallet, P. E. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104047277 · Cited by 292 · see citing works
Rossato, J. I., Bevilaqua, L. R. M., Myskiw, J. C., Medina, J. H., Izquierdo, I., & Cammarota, M. (2007) · Learning & Memory · doi:10.1101/lm.422607 · Cited by 282 · see citing works
Engel, T., Hernández, F., Ávila, J., & Lucas, J. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0604-06.2006 · Cited by 261 · see citing works
Wallace, M. E., Luine, V. N., Arellanos, A., & Frankfurt, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.064 · Cited by 255 · see citing works
Bussey, T. J., Muir, J. L., & Aggleton, J. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00495.1999 · Cited by 255 · see citing works
Benice, T. S., Rizk, A., Kohama, S., Pfankuch, T., & Raber, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.029 · Cited by 254 · see citing works
Bussey, T. J., Duck, J., Muir, J. L., & Aggleton, J. P. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00155-8 · Cited by 252 · see citing works
Wistar rats show episodic-like memory for unique experiences
KARTTEKE, E., DESOUZASILVA, M., HUSTON, J., & DERE, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.10.002 · Cited by 250 · see citing works
Frye, C. A., Duffy, C. K., & Walf, A. A. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.04.003 · Cited by 248 · see citing works
Langston, R. F., & Wood, E. R. (2009) · Hippocampus · doi:10.1002/hipo.20714 · Cited by 244 · see citing works
Integrated memory for objects, places, and temporal order: Evidence for episodic-like memory in mice
Dere, E., Huston, J. P., & De Souza Silva, M. A. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.07.002 · Cited by 243 · see citing works
Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.08.001 · Cited by 242 · see citing works
Walf, A. A., Rhodes, M. E., & Frye, C. A. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.01.004 · Cited by 240 · see citing works
Akirav, I., & Maroun, M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj114 · Cited by 240 · see citing works
MacLusky, N., Luine, V., Hajszán, T., & Léránth, C. (2005) · Endocrinology · doi:10.1210/en.2004-0730 · Cited by 228 · see citing works
Interactions between estradiol, BDNF and dendritic spines in promoting memory
Luine, V. N., & Frankfurt, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.019 · Cited by 234 · see citing works
Norman, G., & Eacott, M. J. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.2.557 · Cited by 217 · see citing works
Mitchell, J. B. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00032-1 · Cited by 212 · see citing works
Richetin, K., Steullet, P., Pachoud, M., Perbet, R., Parietti, E., Maheswaran, M., Eddarkaoui, S., Bégard, S., Pythoud, C., Rey, M. J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00728-x · Cited by 212 · see citing works
Sex differences in behavioral and neurochemical profiles after chronic stress
Beck, K. D., & Luine, V. N. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00670-4 · Cited by 211 · see citing works
Behavioral tests in rodent models of stroke
Ruan, J., & Yao, Y. (2020) · Brain Hemorrhages · doi:10.1016/j.hest.2020.09.001 · Cited by 213 · see citing works
Characteristics of object location memory in mice: Behavioral and pharmacological studies
Murai, T., Okuda, S., Tanaka, T., & Ohta, H. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.013 · Cited by 203 · see citing works
The case for episodic memory in animals
Dere, E., KARTTEKE, E., Huston, J. P., & DESOUZASILVA, M. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.09.005 · Cited by 202 · see citing works
King, M. V., Sleight, A. J., Woolley, M. L., TOPHAM, I. A., Marsden, C. A., & Fone, K. C. F. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.03.012 · Cited by 198 · see citing works
The effect of cingulate lesions on social behaviour and emotion
Hadland, K. A., Rushworth, M. F. S., Gaffan, D., & Passingham, R. E. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00325-1 · Cited by 225 · see citing works
Duarte-Guterman, P., Yagi, S., Chow, C., & Galea, L. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.024 · Cited by 194 · see citing works
Ennaceur, A., Michalíková, S., Bradford, A., & Ahmed, S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.006 · Cited by 195 · see citing works
Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning
Hamson, D. K., Roes, M., & Galea, L. A. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150031 · Cited by 205 · see citing works
Understanding stress: Insights from rodent models
Atrooz, F., Alkadhi, K. A., & Salim, S. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100013 · Cited by 201 · see citing works
Pang, T., & Hannan, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.029 · Cited by 182 · see citing works
Bertaina‐Anglade, V., Enjuanes, E., Morillon, D., & Rochelle, C. D. L. (2006) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2006.04.001 · Cited by 168 · see citing works
Macbeth, A. H., & Luine, V. N. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.011 · Cited by 169 · see citing works
Neotic preferences in laboratory rodents: Issues, assessment and substrates
Hughes, R. N. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.004 · Cited by 160 · see citing works
Inagaki, T., Gautreaux, C., & Luine, V. N. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.013 · Cited by 164 · see citing works
Selective early-acquired fear memories undergo temporary suppression during adolescence
Pattwell, S. S., Bath, K. G., Casey, B. J., Ninan, I., & Lee, F. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012975108 · Cited by 161 · see citing works
Assini, F. L., Duzzioni, M., & Takahashi, R. N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.005 · Cited by 161 · see citing works
Retrograde and anterograde object recognition in rats with hippocampal lesions
Gaskin, S., Tremblay, A., & Mumby, D. G. (2003) · Hippocampus · doi:10.1002/hipo.10154 · Cited by 160 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Sex Steroids and Cognitive Function
Luine, V. N. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01710.x · Cited by 159 · see citing works
Walf, A., Koonce, C. J., Manley, K., & Frye, C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.016 · Cited by 153 · see citing works
Neuronal circuitry for recognition memory of object and place in rodent models
Chao, O. Y.-H., Nikolaus, S., Yang, Y., & Huston, J. P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104855 · Cited by 157 · see citing works
Jacome, L. F., Gautreaux, C., Inagaki, T., Mohan, G., Alves, S. E., Lubbers, L. S., & Luine, V. N. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.016 · Cited by 150 · see citing works
The evolving role of dendritic spines and memory: Interaction(s) with estradiol
Frankfurt, M., & Luine, V. N. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.004 · Cited by 148 · see citing works
Eiland, L. R., & McEwen, B. S. (2010) · Hippocampus · doi:10.1002/hipo.20862 · Cited by 148 · see citing works
Dandi, Ε., Kalamari, A., Touloumi, O., Lagoudaki, R., Nousiopoulou, E., Simeonidou, C., Spandou, E., & Tata, D. Α. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.03.003 · Cited by 146 · see citing works
Eacott, M. J., & Gaffan, E. A. (2005) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990444000203 · Cited by 145 · see citing works
Young hippocampal neurons are critical for recent and remote spatial memory in adult mice
Goodman, T. H., Trouche, S. G., Massou, I., Verret, L., Zerwas, M., Roullet, P., & Rampon, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.047 · Cited by 136 · see citing works
Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005272 · Cited by 138 · see citing works
Distinct contributions of frontal areas to emotion and social behaviour in the rat
Rudebeck, P. H., Walton, M. E., Millette, B. H. P., Shirley, E., Rushworth, M. F. S., & Bannerman, D. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05844.x · Cited by 139 · see citing works
Cognitive impairment in rats after long‐term exposure to GSM‐900 mobile phone radiation
Redebrandt, H. N., Grafström, G., Tian, D. P., Malmgren, L. O. G., Brun, A. E., Persson, B., Salford, L. G., & Eberhardt, J. L. (2007) · Bioelectromagnetics · doi:10.1002/bem.20386 · Cited by 136 · see citing works
The role of aquaporin-4 in synaptic plasticity, memory and disease
Hubbard, J. A., Szu, J. I., & Binder, D. K. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.011 · Cited by 137 · see citing works
Regulation of object recognition and object placement by ovarian sex steroid hormones
Tuscher, J. J., Fortress, A. M., Kim, J., & Frick, K. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.001 · Cited by 134 · see citing works
Novel Object Recognition in the Rat: A Facile Assay for Cognitive Function
Mathiasen, J. R., & DiCamillo, A. (2010) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0559s49 · Cited by 134 · see citing works
Lissner, L. J., Wartchow, K. M., Toniazzo, A. P., Gonçalves, C., & Rodrigues, L. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173273 · Cited by 133 · see citing works
Reichel, C. M., Schwendt, M., McGinty, J. F., Olive, M. F., & See, R. E. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.212 · Cited by 131 · see citing works
Cooper, B. G., Manka, T. F., & Mizumori, S. J. Y. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1012 · Cited by 131 · see citing works
Unraveling the contributions of the diencephalon to recognition memory: A reviewPreprint
Aggleton, J. P., Dumont, J. R., & Warburton, E. C. (2011) · Learning & Memory · doi:10.1101/lm.1884611 · Cited by 132 · see citing works
Howland, J. G., Cazakoff, B. N., & Zhang, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.011 · Cited by 127 · see citing works
The 5-HT7 receptor is involved in allocentric spatial memory information processing
Sarkisyan, G., & Hedlund, P. B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.011 · Cited by 126 · see citing works
Prieto, G. A., Snigdha, S., Baglietto-Vargas, D., Smith, E. D., Berchtold, N. C., Tong, L., Ajami, D., LaFerla, F. M., Rebek, J., & Cotman, C. W. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514486112 · Cited by 126 · see citing works
The mammillary bodies and memory
Vann, S. D., & Nelson, A. J. D. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.03.006 · Cited by 126 · see citing works
RECOGNITION MEMORY IN RATS—I.CONCEPTS AND CLASSIFICATION
Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A., & Aggleton, J. P. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00060-9 · Cited by 126 · see citing works
Working memory deficits in retinoid X receptor γ-deficient micePreprint
Wietrzych, M., Méziane, H., Sutter, A., Ghyselinck, N. B., Chapman, P. F., Chambon, P., & Krężel, W. (2005) · Learning & Memory · doi:10.1101/lm.89805 · Cited by 126 · see citing works
Morrow, B. A., Roth, R. H., & Elsworth, J. D. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00290-2 · Cited by 124 · see citing works
The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function
Kealy, J., & Commins, S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.03.002 · Cited by 123 · see citing works
Woolley, M. L., Marsden, C. A., Sleight, A. J., & Fone, K. C. F. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1552-5 · Cited by 125 · see citing works
BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.
Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.09.027 · Cited by 124 · see citing works
Paris, J. J., & Frye, C. A. (2008) · Reproduction · doi:10.1530/rep-07-0512 · Cited by 124 · see citing works
Walf, A., Koonce, C. J., & Frye, C. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.01.008 · Cited by 137 · see citing works
Subregional analysis of mnemonic functions of the prefrontal cortex in the rat
Kesner, R. P. (2000) · Psychobiology · doi:10.3758/bf03331980 · Cited by 121 · see citing works
Keene, C. S., & Bucci, D. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012895 · Cited by 117 · see citing works
McCormick, C. M., Thomas, C. M., Sheridan, C. S., Nixon, F., Flynn, J. A., & Zovkic, I. B. (2011) · Hippocampus · doi:10.1002/hipo.20966 · Cited by 118 · see citing works
Lopresto, D., Schipper, P., & Homberg, J. R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.009 · Cited by 117 · see citing works
Automation of the novel object recognition task for use in adolescent rats
Silvers, J. M., Harrod, S. B., Mactutus, C. F., & Booze, R. M. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.06.032 · Cited by 118 · see citing works
Inagaki, T., Frankfurt, M., & Luine, V. N. (2012) · Endocrinology · doi:10.1210/en.2012-1121 · Cited by 116 · see citing works
Astrocytic cAMP modulates memory via synaptic plasticity
Zhou, Z.-W., Okamoto, K., Onodera, J., Hiragi, T., Andoh, M., Ikawa, M., Tanaka, K., Ikegaya, Y., & Koyama, R. (2021) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2016584118 · Cited by 107 · see citing works
Aubele, T., Kaufman, R., Montalmant, F., & Kritzer, M. F. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.04.001 · Cited by 115 · see citing works
Rutten, K., van Donkelaar, E. L., Ferrington, L., Blokland, A., Bollen, E., Steinbusch, H. W. M., Kelly, P. A., & Prickaerts, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.24 · Cited by 114 · see citing works
Abush, H., & Akirav, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031731 · Cited by 114 · see citing works
Whishaw, I. Q., Maaswinkel, H., Gonzalez, C. L. R., & Kolb, B. E. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00312-0 · Cited by 112 · see citing works
Hippocampal damage and anterograde object-recognition in rats after long retention intervals
Mumby, D. G., Tremblay, A., Lecluse, V., & Lehmann, H. (2005) · Hippocampus · doi:10.1002/hipo.20122 · Cited by 112 · see citing works
- Authors
- Ennaceur, A., Neave, N., & Aggleton, J. P.
- Affiliations
- Durham University (GB)
- University of Wales (GB)
- Venue
- Experimental Brain Research
- Published
- 1997-03-17
- Volume
- 113
- Issue
- 3
- Pages
- 509-519
- ISSN
- 0014-4819 (ISSN-L)
- OpenAlex
- W2059215368
- Cited by
- 670
- References
- 50
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 13 · 2023: 22 · 2022: 23 · 2021: 22 · 2020: 25 · 2019: 31 · 2018: 43 · 2017: 39 · 2016: 23 · 2015: 37 · 2014: 34 · 2013: 33 · 2012: 48
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Sunderland Repository (University of Sunderland) (acceptedVersion)
- Northumbria Research Link (Northumbria University) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- object recognition memory, object location memory, cingulate cortex, anterior cingulate cortex, retrosplenial cortex, medial prefrontal cortex, cingulum, fornix, neurotoxic lesion, novel object preference, spatial memory, rats
- MeSH terms
- Animals, Gyrus Cinguli, Male, Memory, Prefrontal Cortex, Rats
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