Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior
Open accessAbstract
Persistent deficits in social behavior are among the major negative consequences associated with exposure to ethanol during prenatal development. Prior work from our laboratory has linked deficits in social behavior following moderate prenatal alcohol exposure (PAE) in the rat to functional alterations in the ventrolateral frontal cortex [21]. In addition to social behaviors, the regions comprising the ventrolateral frontal cortex are critical for diverse processes ranging from orofacial motor movements to flexible alteration of behavior in the face of changing consequences. The broader behavioral implications of altered ventrolateral frontal cortex function following moderate PAE have, however, not been examined. In the present study we evaluated the consequences of moderate PAE on social behavior, tongue protrusion, and flexibility in a variant of the Morris water task that required modification of a well-established spatial response. PAE rats displayed deficits in tongue protrusion, reduced flexibility in the spatial domain, increased wrestling, and decreased investigation, indicating that several behaviors associated with ventrolateral frontal cortex function are impaired following moderate PAE. A linear discriminant analysis revealed that measures of wrestling and tongue protrusion provided the best discrimination of PAE rats from saccharin-exposed control rats. We also evaluated all behaviors in young adult (4-5 months) or older (10-11 months) rats to address the persistence of behavioral deficits in adulthood and possible interactions between early ethanol exposure and advancing age. Behavioral deficits in each domain persisted well into adulthood (10-11 months), however, there was no evidence that aging enhances the effects of moderate PAE within the age ranges that were studied.
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Animal models demonstrate clearly that even low levels of prenatal alcohol exposure may lead to brain dysfunction which, in turn, contributes to behavioural abnormalities.
“Animal models demonstrate clearly that even low levels of prenatal alcohol exposure may lead to brain dysfunction which, in turn, contributes to behavioural abnormalities 64.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [64]
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- [27]Kelly SJ Day N Streissguth AP Effects of prenatal alcohol exposure on social behavior in humans and other species Neurotoxicol Teratol 2000 22 143 9 10758343 PMC2699590
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- Authors
- Hamilton, D. A., Barto, D., Rodriguez, C. I., Magcalas, C. M., Fink, B. C., Rice, J. P., Bird, C. W., Davies, S., & Savage, D. D.
- Affiliations
- University of New Mexico (US)
- Corresponding author
- Hamilton, Derek A.
- ORCID
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 269
- Pages
- 44-54
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC4134935
- OpenAlex
- W2009307577
- Cited by
- 73
- References
- 74
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 4 · 2020: 15 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 6 · 2014: 4
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001449, KL2TR001448, KL2TR000089)
- National Institute on Alcohol Abuse and Alcoholism (R01AA019462, AA019884, AA019462, R01AA019884, P50AA022534)
- National Institute of General Medical Sciences (P20GM130422)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prenatal alcohol exposure, fetal alcohol spectrum disorders, social behavior, Morris water task, tongue protrusion, behavioral flexibility, aging
- MeSH terms
- Aggression, Aging, Ethanol, Animals, Central Nervous System Depressants, Exploratory Behavior, Female, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Social Behavior, Tongue, Discriminant Analysis, Linear Models, Prefrontal Cortex, Rats, Long-Evans, Executive Function, Fetal Alcohol Spectrum Disorders, Spatial Navigation
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