The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Multiple faces of BDNF in cocaine addiction
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) has been found to play roles in many types of plasticity including drug addiction. Here we focus on rodent studies over the past two decades that have demonstrated diverse roles of BDNF in models of cocaine addiction. First, we will provide an overview of studies showing that cocaine exposure alters (and generally increases) BDNF levels in reward-related regions including the ventral tegmental area, nucleus accumbens, prefrontal cortex, and amygdala. Then we will review evidence that BDNF contributes to behavioral changes in animal models of cocaine addiction, focusing on conditioned place preference, behavioral sensitization, maintenance and reinstatement of self-administration, and incubation of cocaine craving. Last, we will review the role of BDNF in synaptic plasticity, particularly as it relates to plasticity of AMPA receptor transmission after cocaine exposure. We conclude that BDNF regulates cocaine-induced behaviors in a highly complex manner that varies depending on the brain region (and even among different cell types within the same brain region), the nature of cocaine exposure, and the “addiction phase” examined (e.g., acquisition vs maintenance; early vs late withdrawal). These complexities make BDNF a daunting therapeutic target for treating cocaine addiction. However, recent clinical evidence suggests that the serum BDNF level may serve as a biomarker in cocaine addicts to predict future relapse, providing an alternative direction for exploring BDNF’s potential relevance to treating cocaine addiction.
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Cites
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Cited by
Sex differences in neural mechanisms mediating reward and addiction
Becker, J. B., & Chartoff, E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0125-6 · Cited by 459
Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine
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The link between inflammation, bugs, the intestine and the brain in alcohol dependence
Leclercq, S., de Timary, P., Delzenne, N. M., & Stärkel, P. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.15 · Cited by 174
Integrins in synapse regulation
Park, Y. K., & Goda, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.138 · Cited by 167
Martínez-Rivera, A., Hao, J., Tropea, T. F., Giordano, T. P., Kosovsky, M., Rice, R. C., Lee, A., Huganir, R. L., Striessnig, J., Addy, N. A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.9 · Cited by 55
Metadata
- Authors
- Li, X., & Wolf, M. E.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 279
- Pages
- 240-254
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2014944895
- Cited by
- 168
- References
- 24
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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