The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
Open accessAbstract
The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a number of forms of long-term synaptic plasticity. Most neuronal AMPARs contain this critical subunit; however, in certain restricted neuronal populations and under certain physiological or pathological conditions, AMPARs that lack this subunit are expressed. There is a current surge of interest in such GluR2-lacking Ca2+-permeable AMPARs in how they affect the regulation of synaptic transmission. Here, we bring together recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity.
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NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).
“NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [8]
The only case of potentially convergent selection on an AMPA receptor gene occurs on GRIA2 (AMH, cat, and pig), which is a crucial AMPA subunit at mature synapses.
“On the other hand, the only case of potentially convergent selection on an AMPA receptor gene occurs on GRIA2 (AMH, cat, and pig), which is a crucial AMPA subunit at mature synapses (Isaac et al., 2007).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Isaac et al., 2007
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- Authors
- Isaac, J. T. R., Ashby, M. C., & McBain, C. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Isaac, John T.R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 54
- Issue
- 6
- Pages
- 859-871
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2074385487
- Cited by
- 802
- References
- 156
- Citations by year
- 2026: 32 · 2025: 33 · 2024: 32 · 2023: 28 · 2022: 30 · 2021: 49 · 2020: 29 · 2019: 42 · 2018: 56 · 2017: 59 · 2016: 39 · 2015: 39 · 2014: 48 · 2013: 56 · 2012: 50
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- GluR2 subunit, AMPA receptors, synaptic plasticity, Ca2+-permeable AMPA receptors, AMPA receptor trafficking, receptor assembly, synaptic transmission, long-term synaptic plasticity
- MeSH terms
- Animals, Calcium, Models, Biological, Neuronal Plasticity, Synapses, Receptors, AMPA
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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