Cited by 802Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingAmino Acid Enzymes and Metabolism

The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity

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Isaac, John T.R., Ashby, Michael C., McBain, Chris J.·2007·Neuron

Abstract

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a number of forms of long-term synaptic plasticity. Most neuronal AMPARs contain this critical subunit; however, in certain restricted neuronal populations and under certain physiological or pathological conditions, AMPARs that lack this subunit are expressed. There is a current surge of interest in such GluR2-lacking Ca2+-permeable AMPARs in how they affect the regulation of synaptic transmission. Here, we bring together recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity.

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Crossref · 10.1016/j.neuron.2007.06.001

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156 of 156 references verified0 citation errors · 0 not checkable

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  • NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).

    “NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”
  • The only case of potentially convergent selection on an AMPA receptor gene occurs on GRIA2 (AMH, cat, and pig), which is a crucial AMPA subunit at mature synapses.

    “On the other hand, the only case of potentially convergent selection on an AMPA receptor gene occurs on GRIA2 (AMH, cat, and pig), which is a crucial AMPA subunit at mature synapses (Isaac et al., 2007).”

    From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Isaac et al., 2007

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Authors
Isaac, J. T. R., Ashby, M. C., & McBain, C. J.
Affiliations
National Institutes of Health (US)
Corresponding author
Isaac, John T.R.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-06
Volume
54
Issue
6
Pages
859-871
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2074385487
Cited by
802
References
156
Citations by year
2026: 32 · 2025: 33 · 2024: 32 · 2023: 28 · 2022: 30 · 2021: 49 · 2020: 29 · 2019: 42 · 2018: 56 · 2017: 59 · 2016: 39 · 2015: 39 · 2014: 48 · 2013: 56 · 2012: 50
FWCI
3.46
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
GluR2 subunit, AMPA receptors, synaptic plasticity, Ca2+-permeable AMPA receptors, AMPA receptor trafficking, receptor assembly, synaptic transmission, long-term synaptic plasticity
MeSH terms
Animals, Calcium, Models, Biological, Neuronal Plasticity, Synapses, Receptors, AMPA

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