Abnormal spontaneous neural activity in the anterior insular and anterior cingulate cortices in anxious depression
Abstract
Objective Anxious depression is a distinct clinical subtype of major depressive disorder (MDD) characterized by palpitations, somatic complaints, altered interoceptive awareness, high risk of suicide, and poor response to pharmacotherapy. However, the neural mechanisms of anxious depression are still not well understood. In this study we investigated changes in neural oscillation during the resting-state of patients with anxious depression by measuring differences in the amplitude of low-frequency fluctuation (ALFF).Methods Resting-state functional magnetic resonance imaging was acquired in 31 patients with anxious depression, 18 patients with remitted depression, as well as 68 gender- and age-matched healthy participants. We compared the differences both in the ALFF and fractional ALFF (fALFF) among the three groups. We also examined the correlation between the ALFF/fALFF and the severity of anxiety as well as depression.Results Anxious depression patients showed increased ALFF/fALFF in the right dorsal anterior insular cortex and decreased ALFF/fALFF in the bilateral lingual gyrus relative to remitted depression patients and healthy controls. The increased ALFF in the dorsal anterior insula was also positively correlated with stronger anxiety in the anxious depression group. Anxious depression patients also displayed increased fALFF in the right ventral anterior cingulate cortex (ACC) compared to remitted depression patients and healthy controls.Conclusions Our results suggest that alterations of the cortico-limbic networks, including the right dorsal anterior insula and right ventral ACC, may play a critical role in the physiopathology of anxious depression.
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Less temporal and insula thinning relative to nonanxious MDD has also been observed.
“However, less temporal and insula thinning relative to nonanxious MDD has also been observed [76,77].”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [76]
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- Authors
- Liu, C.-H., Ma, X., Song, L.-P., Fan, J., Wang, W.-D., Lv, X.-Y., Zhang, Y., Li, F., Wang, L., & Wang, C.-Y.
- Affiliations
- Capital Medical University (CN)
- Queens College, CUNY (US)
- Tsinghua University (CN)
- Corresponding author
- Ma, Xin
- Wang, Lihong
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 281
- Pages
- 339-347
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2139289770
- Cited by
- 71
- References
- 56
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Beijing Normal University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anxious depression, major depressive disorder, amplitude of low-frequency fluctuation, dorsal anterior insula, ventral anterior cingulate cortex, lingual gyrus, cortico-limbic network, anxiety levels, remitted depression, interoception
- MeSH terms
- Adult, Anxiety, Brain Mapping, Cerebral Cortex, Depression, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Case-Control Studies, Young Adult
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