Cited by 259Functional Brain Connectivity StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAdvanced Neuroimaging Techniques and Applications

Resting-state functional and structural connectivity within an insula–amygdala route specifically index state and trait anxiety

Baur, Volker, Hänggi, Jürgen, Langer, Nicolas, Jäncke, Lutz·2013·Biological Psychiatry

Abstract

Background Conjoint activity of the insula and amygdala has frequently been reported during emotional stimulation in general and in anxiety-related contexts in particular. However, direct connectivity between the insula and amygdala in this framework has received little attention so far. Studying whether inter-individual differences in anxiety reflect variation in insula-amygdala connectivity is a way to push forward the understanding of network-related aspects underlying anxious behavior.Methods To investigate functional and structural connectivity, we applied resting-state functional magnetic resonance imaging and diffusion tensor imaging in a group of 32 healthy subjects. Specific measures of connectivity between subregions of the insula and amygdala were related to subjects' anxiety levels.Results Resting-state functional connectivity between the anterior insula and the basolateral amygdala was strongly related to state anxiety, explaining 40% of behavioral variance across subjects. This was substantiated by applying tractography, yielding a relationship between trait anxiety and axial diffusivity for a direct pathway between anterior insula and basolateral amygdala.Conclusions Our results indicate that anterior insula and basolateral amygdala constitute a network part that is prominently linked to anxiety. Within this route, state and trait behavioral impacts seem to be specifically linked to dynamic functional and more static structural neural aspects, respectively. Insula-amygdala resting-state functional connectivity can be assessed in an easy and straightforward way and has high potential to serve as a biomarker for anxiety.

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Crossref · 10.1016/j.biopsych.2012.06.003

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  • Anxiety is associated with functional connectivity between the amygdala and the insula, as well as coupling between the amygdala and the OFC.

    “Investigators have previously shown that anxiety is associated with the functional connectivity between the amygdala and the insula (Baur et al., 2013; Shah et al., 2009; Stein et al., 2007) as well as the coupling between the amygdala and the OFC (Hahn et al., 2011; Sladky et al., 2013).”

    From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Baur et al., 2013

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Authors
Baur, V., Hänggi, J., Langer, N., & Jäncke, L.
Affiliations
University of Zurich (CH)
Corresponding author
Baur, Volker
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2013-01
Volume
73
Issue
1
Pages
85-92
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2040170011
Cited by
258
References
71
Citations by year
2026: 7 · 2025: 12 · 2024: 20 · 2023: 20 · 2022: 16 · 2021: 17 · 2020: 28 · 2019: 18 · 2018: 29 · 2017: 20 · 2016: 19 · 2015: 21 · 2014: 19 · 2013: 8 · 2012: 3
FWCI
8.34
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
anterior insula, basolateral amygdala, state anxiety, trait anxiety, resting-state functional connectivity, structural connectivity, axial diffusivity, individual differences, anxiety biomarkers
MeSH terms
Adult, Amygdala, Anxiety, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Neural Pathways, Personality Inventory, Diffusion Tensor Imaging, Functional Neuroimaging

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