The DOI matches its Crossref record; 254 of the 255 references it cites were found in a registry or an index.
Basal ganglia circuit loops, dopamine and motivation: A review and enquiry
Open accessAbstract
Dopamine neurons located in the midbrain play a role in motivation that regulates approach behavior (approach motivation). In addition, activation and inactivation of dopamine neurons regulate mood and induce reward and aversion, respectively. Accumulating evidence suggests that such motivational role of dopamine neurons is not limited to those located in the ventral tegmental area, but also in the substantia nigra. The present paper reviews previous rodent work concerning dopamine's role in approach motivation and the connectivity of dopamine neurons, and proposes two working models: One concerns the relationship between extracellular dopamine concentration and approach motivation. High, moderate and low concentrations of extracellular dopamine induce euphoric, seeking and aversive states, respectively. The other concerns circuit loops involving the cerebral cortex, basal ganglia, thalamus, epithalamus, and midbrain through which dopaminergic activity alters approach motivation. These models should help to generate hypothesis-driven research and provide insights for understanding altered states associated with drugs of abuse and affective disorders.
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“Intriguingly, the caudate nucleus receives projections from midbrain DA and is part of the nigrostriatal DA system, which, like the mesolimbic DA system, plays a role in reward and motivation (Ikemoto et al., 2015).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Ikemoto et al., 2015
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“First of all, functional anatomical data suggest that the medial part of the DStr is more important than the lateral DStr in affective functions, because the medial, but not lateral, DStr receives inputs from the prefrontal cortex and amygdala, which are strongly implicated in affective functions [32,90–92].”
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“Thus, administration of these drugs markedly increases extracellular DA concentrations in the striatum, especially the VStr [45].”
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1 of the 255 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Smith, 1998, Microcircuitry of the direct and indirect pathways of the basal ganglia, Neuroscience, 86, 353
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The connectome of an insect brain
Winding, M., Pedigo, B. D., Barnes, C. L., Patsolic, H. G., Park, Y., Kazimiers, T., Fushiki, A., Andrade, I. V., Khandelwal, A., Valdes-Aleman, J., et al. (2023) · Science · doi:10.1126/science.add9330 · Cited by 435
Mundy, P. C. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13720 · Cited by 460
Hein, T. C., & Monk, C. S. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12651 · Cited by 257
Secondary negative symptoms — A review of mechanisms, assessment and treatment
Kirschner, M., Aleman, A., & Kaiser, S. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.05.003 · Cited by 215
Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors
Chang, C. Y., Esber, G. R., Marrero-Garcia, Y., Yau, H., Bonci, A., & Schoenbaum, G. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4191 · Cited by 226
“This makes the task an excellent vehicle with which to dissociate effects of dopaminergic manipulation on learning from less specific effects dopamine may have on vigor or motivational level 29, 30 , attention or salience 11, 31 , or even aversiveness 32 .”
Metadata
- Authors
- Ikemoto, S., Yang, C., & Tan, A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ikemoto, Satoshi
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 290
- Pages
- 17-31
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC4447603
- OpenAlex
- W2081845928
- Semantic Scholar
- bb06782b6fb20361735cf21f960fea754adbcf67
- Cited by
- 226
- References
- 255
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 14 · 2023: 15 · 2022: 21 · 2021: 25 · 2020: 29 · 2019: 22 · 2018: 22 · 2017: 21 · 2016: 26 · 2015: 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Behavioural Brain Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (ZIADA000575, ZIADA000439, ZIADA000550)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine, approach motivation, substantia nigra, ventral tegmental area, reward, aversion, thalamus, epithalamus, drugs of abuse, mood disorders
- MeSH terms
- Animals, Basal Ganglia, Motivation, Nerve Net, Reward, Dopaminergic Neurons
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