Behavioral characteristics of 5-HT2C receptor knockout mice: Locomotor activity, anxiety- and fear memory-related behaviors

A review of central 5-HT receptors and their function

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Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

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Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on

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Ethopharmacological analysis of rat behavior on the elevated plus-maze

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SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

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5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

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Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

Fletcher, P. J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00342-1 · Cited by 251 · see citing works

Serotonin 5‐HT 2C receptors regulate anxiety‐like behavior

Heisler, L. K., Zhou, L., Bajwa, P., Hsu, J. C., & Tecott, L. H. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00316.x · Cited by 243 · see citing works

The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution

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Regulating anxiety with extrasynaptic inhibition

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Risk taking during exploration of a plus-maze is greater in adolescent than in juvenile or adult mice

Macrı̀, S., Adriani, W., Chiarotti, F., & Giovanni Laviola, A. (2002) · Animal Behaviour · doi:10.1006/anbe.2002.4004 · Cited by 165 · see citing works

The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory

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Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety

Martin, J. R., Ballard, T. M., & Higgins, G. A. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00713-4 · Cited by 136 · see citing works

CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.

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Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice

Ohmura, Y., Tanaka, K. F., Tsunematsu, T., Yamanaka, A., & Yoshioka, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000637 · Cited by 122 · see citing works

Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval

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Elevated Zero-maze: A paradigm to evaluate anti-anxiety effects of drugs

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6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist

Bromidge, S. M., Duckworth, M. D., Forbes, I. T., Ham, P., King, F. D., Thewlis, K. M., Blaney, F. E., Naylor, C. B., Blackburn, T. P., Kennett, G. A., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970424c · Cited by 84 · see citing works

Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

Bromidge, S. M., Dabbs, S., Davies, D. T., Davies, S., Duckworth, D. M., Forbes, I. T., Gaster, L. M., Ham, P., Jones, G. E., King, F. D., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990388c · Cited by 79 · see citing works

The role of 5-HT2C receptors in touchscreen visual reversal learning in the rat: a cross-site study

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Brain‐derived neurotrophic factor expression is increased in the hippocampus of 5‐HT2C receptor knockout mice

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Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice

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Serotonin 2C receptor antagonist improves fear discrimination and subsequent safety signal recall

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Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats

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Corticotropin releasing factor in the median raphe nucleus is involved in the retrieval of fear memory in rats

Ohmura, Y., Yamaguchi, T., Izumi, T., Matsumoto, M., & Yoshioka, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.023 · Cited by 18 · see citing works

Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model

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5‐HT depletion, but not 5‐HT1A antagonist, prevents the anxiolytic‐like effect of citalopram in rat contextual conditioned fear stress model

Masuda, T., Nishikawa, H., Inoue, T., Toda, H., Nakagawa, S., Boku, S., & Koyama, T. (2012) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2012.00669.x · Cited by 8 · see citing works

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats

Sugiyama, A., Yamada, M., Furuie, H., Gotoh, L., Saitoh, A., Nagase, H., Oka, J., & Yamada, M. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.01.002 · Cited by 8 · see citing works

To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers

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Murine Models of Obesity

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Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action

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The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior

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Differential contribution of CB1, CB2, 5‐HT1A, and PPAR‐γ receptors to cannabidiol effects on ischemia‐induced emotional and cognitive impairments

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Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C receptor heterocomplex.

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Hallucinogenic drugs and their potential for treating fear‐related disorders: Through the lens of fear extinction

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Neonatal Serotonin Depletion Induces Hyperactivity and Anxiolytic-like Sex-Dependent Effects in Adult Rats

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Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway

Süß, S. T., Kremer, D., Olbricht, L. M., Herlitze, S., & Spoida, K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02252-x · Cited by 12 · see citing works

Serotonin 5-HT2C receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning

Bouchekioua, Y., Nebuka, M., Sasamori, H., Nishitani, N., Sugiura, C., Sato, M., Yoshioka, M., & Ohmura, Y. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01815-2 · Cited by 12 · see citing works

Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders

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Loss of 5-HT2C receptor function alters motor behavior in male and female mice with and without spinal cord injury

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Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice

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Serotonin shapes the temporal window for associative fear learningPreprint

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Potential PTSD therapeutics targeting 5-HT2C receptors

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Biomedical and public health studies on susceptibility to post-traumatic stress disorder

Jowf, G. I. A. (2023) · doi:10.26481/dis.20230906ga

Genetic knockouts and the Hierarchical Taxonomy of Psychopathology (HiTOP): a path toward individualized psychiatry (a brief narrative review)

Алексеевна, М. М. (2026) · Психофармакология и биологическая наркология · doi:10.17816/phbn696660

Animal models of obsessive-compulsive disorder

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The roles of serotonin 5-HT2C receptor in locomotor activity, anxiety, and fear memory

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Serotonin 5-HT2C receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning

Bouchekioua, Y., Nebuka, M., Sasamori, H., Nishitani, N., Sugiura, C., Sato, M., Yoshioka, M., & Ohmura, Y. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01815-2 · Cited by 12 · see citing works

Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway

Süß, S. T., Kremer, D., Olbricht, L. M., Herlitze, S., & Spoida, K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02252-x · Cited by 12 · see citing works

P.2.b.020 5-HT2C receptor activation inhibits stress-induced increase in 5-HT transmission: relevance of receptor desensitization to the anxiolytic effect chronic antidepressant drugs and mutation in mice

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Serotonin 5‐HT 2C receptors regulate anxiety‐like behavior

Heisler, L. K., Zhou, L., Bajwa, P., Hsu, J. C., & Tecott, L. H. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00316.x · Cited by 243 · see citing works