The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory
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The active zone protein RIM1alpha is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1alpha(-/-) mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality. Our data suggest that a decrease in release probability or a loss of presynaptic LTP alone is not sufficient to cause major behavioral alterations, but the combination of presynaptic abnormalities in RIM1alpha(-/-) mice severely alters learning and memory.
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A targeted Rims1 mutation in the mouse leads to increased postsynaptic density and impaired associative learning, memory, and cognition.
“A targeted Rims1 mutation in the mouse leads to increased postsynaptic density and impaired associative learning as well as memory and cognition deficits (Powell et al., 2004; Schoch et al., 2002)”
From De Novo Gene Disruptions in Children on the Autistic Spectrum (2012) · cites this paper as Powell et al., 2004
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Self-citation
- Authors
- Powell, C. M., Schoch, S., Monteggia, L., Barrot, M., Matos, M. F., Feldmann, N., Südhof, T. C., & Nestler, E. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Powell, Craig M
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 42
- Issue
- 1
- Pages
- 143-153
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3910111
- OpenAlex
- W2011406868
- Cited by
- 143
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Mental Health (P50 MH66172, K08MH65975, K08MH065975, P50MH066172)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- active zone, presynaptic release probability, learning and memory, synaptotagmin-1, Rab3A, anxiety-like behavior, coordination, synaptic transmission
- MeSH terms
- Animals, Behavior, Animal, Brain, Calcium-Binding Proteins, Conditioning, Classical, Fear, Learning, Membrane Glycoproteins, Memory, Motor Activity, Nerve Tissue Proteins, Psychomotor Performance, Reaction Time, Space Perception, Spatial Behavior, Time Factors, Blotting, Western, In Situ Hybridization, Mice, Knockout, Maze Learning, GTP-Binding Proteins, rab3A GTP-Binding Protein, Synaptotagmins, Synaptotagmin I, Mice
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