Cited by 92Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionAntioxidants, Aging, Portulaca oleracea

Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer’s disease

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Labban, Samah, Alghamdi, Badrah S., Alshehri, Fahad S., Kurdi, Maher·2021·Behavioural Brain Research

Abstract

Alzheimer’s disease (AD) is the foremost cause of dementia among other neurodegenerative diseases, leading to memory loss and cognitive deficits. AD has gained extensive attention in research for exploring possible interventions. One promising field is natural substances and compounds that could provide a wide range of neuroprotection against AD. This study aimed to investigate the possible effects of melatonin (MEL) and resveratrol (RES) in improving memory deficits in a sporadic mouse model of AD. Memory deficit was induced using AlCl3 and d-galactose for generating an AD mouse model. Mice were randomly distributed into five groups (n = 13): control, AD, AD + MEL (AD mice treated with 80 mg/kg of MEL), AD + RES (AD mice treated with 40 mg/kg of RES), and AD + Combination)AD mice that received 80 mg/kg MEL and 40 mg/kg RES). A novel object recognition task (NORT) and passive avoidance task (PAT) were used for assessing memory. Moreover, acetylcholinesterase (AChE) level, brain-derived neurotrophic factor (BDNF), and cAMP-response element binding (CREB) protein expression were measured in the prefrontal cortex tissue. Our results showed that MEL significantly improved memory deficits in both the NORT and PAT of the AD model, while RES improved the PAT only in the AD model. Co-treatment with MEL and RES exerted beneficial additive effects on recognition memory impairment in the AD mouse model. Moreover, our results demonstrated that both MEL and RES enhanced the cholinergic system and BDNF and CREB signaling pathways in the prefrontal cortex in an AD mouse model.

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  • There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications.

    “There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications [48,49,50,51,52,53,54].”

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Authors
Labban, S., Alghamdi, B. S., Alshehri, F. S., & Kurdi, M.
Affiliations
  • King Abdulaziz University (SA)
  • Umm al-Qura University (SA)
Corresponding author
Alghamdi, Badrah S.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2021-03
Volume
402
Pages
113100
ISSN
0166-4328 (ISSN-L)
OpenAlex
W3120536115
Cited by
92
References
78
Citations by year
2026: 14 · 2025: 14 · 2024: 21 · 2023: 12 · 2022: 22 · 2021: 9
FWCI
10.04
Type
journal article
Language
en
Open access
Locations
  • Behavioural Brain Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
King Abdulaziz University
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
Alzheimer's disease, melatonin, resveratrol, recognition memory, passive avoidance, acetylcholinesterase, brain-derived neurotrophic factor, CREB signaling, prefrontal cortex, cholinergic system, neuroprotection, memory impairment
MeSH terms
Resveratrol, Alzheimer Disease, Animals, Avoidance Learning, Behavior, Animal, Disease Models, Animal, Male, Melatonin, Memory Disorders, Neuroprotective Agents, Recognition, Psychology, Mice

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