Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer’s disease
Open accessAbstract
Alzheimer’s disease (AD) is the foremost cause of dementia among other neurodegenerative diseases, leading to memory loss and cognitive deficits. AD has gained extensive attention in research for exploring possible interventions. One promising field is natural substances and compounds that could provide a wide range of neuroprotection against AD. This study aimed to investigate the possible effects of melatonin (MEL) and resveratrol (RES) in improving memory deficits in a sporadic mouse model of AD. Memory deficit was induced using AlCl3 and d-galactose for generating an AD mouse model. Mice were randomly distributed into five groups (n = 13): control, AD, AD + MEL (AD mice treated with 80 mg/kg of MEL), AD + RES (AD mice treated with 40 mg/kg of RES), and AD + Combination)AD mice that received 80 mg/kg MEL and 40 mg/kg RES). A novel object recognition task (NORT) and passive avoidance task (PAT) were used for assessing memory. Moreover, acetylcholinesterase (AChE) level, brain-derived neurotrophic factor (BDNF), and cAMP-response element binding (CREB) protein expression were measured in the prefrontal cortex tissue. Our results showed that MEL significantly improved memory deficits in both the NORT and PAT of the AD model, while RES improved the PAT only in the AD model. Co-treatment with MEL and RES exerted beneficial additive effects on recognition memory impairment in the AD mouse model. Moreover, our results demonstrated that both MEL and RES enhanced the cholinergic system and BDNF and CREB signaling pathways in the prefrontal cortex in an AD mouse model.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications.
“There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications [48,49,50,51,52,53,54].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multiple Dirac cones at the surface of the topological metal LaBi
Nayak, J., Wu, S.-C., Kumar, N., Shekhar, C., Singh, S., Fink, J., Rienks, E. E. D., Fecher, G. H., Parkin, S., Yan, B., et al. (2017) · Nature Communications · doi:10.1038/ncomms13942 · Cited by 1,179 · see citing works
Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-06.2007 · Cited by 691 · see citing works
Antiinflammatory Activity of Melatonin in Central Nervous System
Esposito, E., & Cuzzocrea, S. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246155 · Cited by 408 · see citing works
The human pineal gland and melatonin in aging and Alzheimer's disease
Wu, Y., & Swaab, D. F. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00196.x · Cited by 368 · see citing works
Sharma, M., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02083-0 · Cited by 326 · see citing works
Melatonin: Action as antioxidant and potential applications in human disease and aging
Bonnefont-Rousselot, D., & Collin, F. (2010) · Toxicology · doi:10.1016/j.tox.2010.04.008 · Cited by 320 · see citing works
The role of CREB signaling in Alzheimer’s disease and other cognitive disorders
Saura, C. A., & Valero, J. (2011) · revneuro · doi:10.1515/rns.2011.018 · Cited by 312 · see citing works
Ali, T., Badshah, H., Kim, T. H., & Kim, M. O. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12194 · Cited by 269 · see citing works
Neuroprotective effects of resveratrol in Alzheimer disease pathology
Rege, S. D., Geetha, T., Griffin, G. D., Broderick, T. L., & Babu, J. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00218 · Cited by 243 · see citing works
Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
Pugazhenthi, S., Wang, M., Pham, S. T., Sze, C., & Eckman, C. B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-60 · Cited by 240 · see citing works
Akirav, I., & Maroun, M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj114 · Cited by 240 · see citing works
Pasinetti, G. M., Wang, J., Ho, L., Zhao, W., & Dubner, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.006 · Cited by 238 · see citing works
The neuroprotective role of melatonin in neurological disorders
Alghamdi, B. S. A. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24220 · Cited by 234 · see citing works
Resveratrol, A Neuroprotective Supplement for Alzheimer's Disease
Li, F., Gong, Q., Dong, H., & Shi, J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212798919075 · Cited by 231 · see citing works
Lowe, A. D., Bawazeer, S., Watson, D. G., McGill, S., Burchmore, R., Pomeroy, P. P., & Kennedy, M. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-16187-7 · Cited by 225 · see citing works
Melatonin in Alzheimer’s Disease
Li, L., Qiong-xia, H., Yang, S.-S., Chu, J., Wang, J., & Tian, Q. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714575 · Cited by 216 · see citing works
Muhammad, T., Ali, T., Ikram, M. A., Khan, A., Alam, S. I., & Kim, M. O. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9824-3 · Cited by 201 · see citing works
Reagh, Z. M., Noche, J. A., Tustison, N. J., Delisle, D., Murray, E. A., & Yassa, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.039 · Cited by 195 · see citing works
Eybl, V., Kotyzová, D., & Koutensky, J. (2006) · Toxicology · doi:10.1016/j.tox.2006.05.011 · Cited by 188 · see citing works
The role of BDNF in Alzheimer's disease
Tanila, H. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.008 · Cited by 186 · see citing works
Resveratrol and Alzheimer’s Disease: Mechanistic Insights
Ahmed, T., Javed, S., Javed, S., Tariq, A., Šamec, D., Tejada, S., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9839-9 · Cited by 179 · see citing works
Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment
Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173 · see citing works
Zheng, F., Qin, C., Chang, Y. S., & Zhang, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.014 · Cited by 156 · see citing works
Kumar, A., Naidu, P. S., Seghal, N., & Padi, S. S. V. (2006) · Pharmacology · doi:10.1159/000097511 · Cited by 147 · see citing works
Resveratrol as a Therapeutic Agent for Alzheimer’s Disease
Ma, T., Tan, M., Yu, J., & Tan, L. (2014) · BioMed Research International · doi:10.1155/2014/350516 · Cited by 144 · see citing works
Pathophysiology of Alzheimer's Disease
Imbimbo, B. P., Lombard, J., & Pomara, N. (2005) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2005.09.009 · Cited by 133 · see citing works
Zhao, H., Li, N., Wang, Q.-N., Cheng, X., Li, X. M., & Liu, T. T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.006 · Cited by 131 · see citing works
Wang, C., Cai, X., Hu, W., Li, Z., Kong, F., Chen, X., & Wang, D. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.4032 · Cited by 128 · see citing works
Haider, S., Liaquat, L., Ahmad, S., Batool, Z., Siddiqui, R. A., Tabassum, S., Shahzad, S., Rafiq, S., & Naz, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227631 · Cited by 127 · see citing works
Yoo, D. Y., Kim, W., Lee, C. H., Shin, B. N., Nam, S. M., Choi, J. H., Won, M., Yoon, Y. S., & Hwang, I. K. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00912.x · Cited by 120 · see citing works
Advance of sporadic Alzheimer's disease animal models
Zhang, L., Chen, C., Mak, M. S., Lu, J., Wu, Z., Chen, Q., Han, Y., Li, Y., & Pi, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21624 · Cited by 116 · see citing works
Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease
Wang, X., Ma, S., Yang, B., Huang, T., Meng, N., Xu, L., Xing, Q., Zhang, Y.-T. Y., Zhang, K., Li, Q., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.032 · Cited by 112 · see citing works
Wang, G., Chen, L., Pan, X., Chen, J., Wang, L., Wang, W., Cheng, R., Wu, F., Feng, X., Yu, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8041 · Cited by 110 · see citing works
Walker, M. P., LaFerla, F. M., Oddo, S., & Brewer, G. J. (2012) · AGE · doi:10.1007/s11357-011-9375-5 · Cited by 106 · see citing works
Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice
Li, C., Zug, C., Qu, H., Schluesener, H. J., & Zhang, Z. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.012 · Cited by 102 · see citing works
Combined administration of D-galactose and aluminium induces Alzheimerlike lesions in brain
Xiao, F., Xiao-guang, L., Zhang, X., Hou, J.-D., Lin, L.-F., Gao, Q. F., & Luo, H. (2011) · Neuroscience Bulletin · doi:10.1007/s12264-011-1028-2 · Cited by 100 · see citing works
Kwon, K. J., Kim, H.-J., Shin, C. Y., & Han, S. (2010) · Journal of Clinical Neurology · doi:10.3988/jcn.2010.6.3.127 · Cited by 100 · see citing works
Weinstock, M., & Shoham, S. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0058-y · Cited by 95 · see citing works
Xu, P., Wang, K., Lü, C., Dong, L., Gao, L., Yan, M., Aibai, S., Yang, Y., & Liu, X. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/7426538 · Cited by 94 · see citing works
Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
Schweiger, S., Matthes, F., Posey, K. L., Kickstein, E., Weber, S. S., Hettich, M. M., Pfurtscheller, S., Ehninger, D., Schneider, R., & Krauß, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12974-4 · Cited by 92 · see citing works
Zhang, R., Zhang, J., Fang, L., Li, X., Zhao, Y., Shi, W., & An, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150814396 · Cited by 88 · see citing works
LSD1 protects against hippocampal and cortical neurodegeneration
Christopher, M. A., Myrick, D. A., Barwick, B. G., Engstrom, A., Porter‐Stransky, K. A., Boss, J. M., Weinshenker, D., Levey, A. I., & Katz, D. J. (2017) · Nature Communications · doi:10.1038/s41467-017-00922-9 · Cited by 88 · see citing works
Effects of caffeic acid on learning deficits in a model of Alzheimer's disease
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2683 · Cited by 84 · see citing works
Melatonin Therapy in Patients with Alzheimer’s Disease
Cardinali, D. P., Vigo, D. E., Olivar, N., Vidal, M., & Brusco, L. I. (2014) · Antioxidants · doi:10.3390/antiox3020245 · Cited by 73 · see citing works
Resveratrol in experimental Alzheimer’s disease models: A systematic review of preclinical studies
Chen, J.-Y., Zhu, Q., Zhang, S., Ouyang, D., & Lu, J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104476 · Cited by 67 · see citing works
Potential for Stem Cells Therapy in Alzheimer’s Disease: Do Neurotrophic Factors Play Critical Role?
Bali, P., Lahiri, D. K., Banik, A., Nehru, B., & Anand, A. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160314145347 · Cited by 63 · see citing works
Lin, Y., Wu, Y., Sun, G., Ho, C., Wong, T., Lin, C., Chen, H., Yeh, T., Li, C., Tseng, C., et al. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100329 · Cited by 60 · see citing works
Hernández‐Hernández, E. M., Serrano-García, C., Vázquez‐Roque, R. A., Díaz, A., Monroy, E., Moreno, A. R., Florán, B., & Flores, G. (2016) · Synapse · doi:10.1002/syn.21888 · Cited by 57 · see citing works
Yang, W., Shi, L., Chen, L., Zhang, B., Ma, K., Liu, Y., & Qian, Y. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.09.010 · Cited by 54 · see citing works
AboTaleb, H. A., & Alghamdi, B. S. A. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01425-6 · Cited by 53 · see citing works
Moriguchi, S., Ishizuka, T., Yabuki, Y., Shioda, N., Sasaki, Y., Tagashira, H., Yawo, H., Yeh, J. Z., Sakagami, H., Narahashi, T., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.187 · Cited by 52 · see citing works
Yang, W., Hu, X., Han, H., Shi, L., Feng, G.-F., Liu, Y., & Qian, Y. (2014) · Neurological Research · doi:10.1179/1743132813y.0000000295 · Cited by 47 · see citing works
Chen, B. H., Park, J. H., Lee, T.-K., Song, M., Kim, H. J., Lee, J. C., Kim, Y., Lee, C. H., Hwang, I. K., Kang, I., et al. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.023 · Cited by 47 · see citing works
Effect of resveratrol on scopolamine-induced cognitive impairment in mice
Rachna, G., Lalit, K., Pramod, K. M., & Swapan, K. B. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70785-5 · Cited by 46 · see citing works
Alghamdi, B. S. A. (2018) · Journal of Integrative Neuroscience · doi:10.3233/jin-180089 · Cited by 46 · see citing works
Zhao, H., Niu, Q. L., Li, X., Liu, T., Xu, Y., Han, H., Wang, W., Fan, N., Tian, Q., Zhang, H., et al. (2012) · Brain Research · doi:10.1016/j.brainres.2012.05.040 · Cited by 45 · see citing works
Belrose, J. C., Masoudi, R., Michalski, B., & Fahnestock, M. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.029 · Cited by 43 · see citing works
Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model
Gong, Y., Hua, N., Zang, X., Huang, T., & He, L. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12830 · Cited by 39 · see citing works
Goodarzi, P., Payab, M., Alavi-Moghadam, S., Larijani, B. A., Rahim, F., Bana, N., Sarvari, M., Adibi, H., Heravani, N. F., Hadavandkhani, M., et al. (2019) · Cell and Tissue Banking · doi:10.1007/s10561-019-09773-8 · Cited by 38 · see citing works
Jürgenson, M., Zharkovskaja, T., Noortoots, A., Ma, M., Герович, Б. А., Zapolski, M., & Zharkovsky, A. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13165 · Cited by 38 · see citing works
Etiology of Alzheimer's Disease
Zhang, C. M. (2023) · Discovery Medicine · doi:10.24976/discov.med.202335178.71 · Cited by 37 · see citing works
Delineating Prefrontal Cortex Region Contributions to Crossmodal Object Recognition in Rats
Reid, J. M., Jacklin, D. L., & Winters, B. D. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht061 · Cited by 36 · see citing works
Turriziani, P., Oliveri, M., Salerno, S., Costanzo, F., Koch, G., Caltagirone, C., & Carlesimo, G. (2008) · Behavioural Neurology · doi:10.1155/2008/568057 · Cited by 36 · see citing works
Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model
Psotta, L., Rockahr, C., Gruß, M., Kirches, E., Braun, K., Leßmann, V., Bock, J., & Endres, T. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00058 · Cited by 34 · see citing works
Bavithra, S., Priya, E. S., Selvakumar, K., Krishnamoorthy, G., & Arunakaran, J. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1677-z · Cited by 33 · see citing works
Shen, D., Tian, X., Sang, W., & Song, R. (2016) · NeuroImmunoModulation · doi:10.1159/000454681 · Cited by 27 · see citing works
Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases
Petrova, T., Orellana, C., Jelić, V., Oeksengaard, A., Snædal, J., Høgh, P., Andersen, B. B., Naik, M., Engedal, K., Wahlund, L., et al. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111099 · Cited by 26 · see citing works
The Melatonin Signaling Pathway in a Long-Term Memory In Vitro Study
Sung, J., Bae, J.-H., Lee, J.-H., Kim, Y.-N., & Kim, D.-K. (2018) · Molecules · doi:10.3390/molecules23040737 · Cited by 24 · see citing works
Özyurt, H., Özyurt, B., Sarsılmaz, M., Kuş, I., Songür, A., & Akyol, Ö. (2014) · PubMed · Cited by 22 · see citing works
Visual Recognition Memory in Alzheimer's Disease: Repetition-Lag Effects
Viggiano, M. P., Galli, G., Righi, S., Brancati, C., Gori, G., & Cincotta, M. (2008) · Experimental Aging Research · doi:10.1080/03610730802070241 · Cited by 19 · see citing works
Ahmed, H. H., Estefan, S. F., Mohamd, E. M., Farrag, A. E. R. H., & Salah, R. S. (2012) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-012-0284-x · Cited by 17 · see citing works
Oxidative stress precedes mitochondrial dysfunction in gerbil brain after aluminum ingestion
Vucetic-Arsic, S., Radonjić, N. V., Jovanović, M., Selaković, V., Nikolić, T., Velimirović, M., Stojković, T., Milovanović, A., Milovanovic, J. P., & Petronijević, N. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.10.008 · Cited by 17 · see citing works
Resveratrol Attenuates Neuroinflammation-mediated Cognitive Deficits in Rats
Gong, Q., Li, F., Jin, F. J., & Shi, J. (2010) · Eisei kagaku · doi:10.1248/jhs.56.655 · Cited by 16 · see citing works
Peng, C., Hong, X., Chen, W., Zhang, H., Tan, L., Wang, X., Ding, Y., & He, J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.066 · Cited by 16 · see citing works
Zhang, Z., & Yu, C. (2002) · PubMed · Cited by 12 · see citing works
Tabrizian, K., Yazdani, A., Baheri, B., Payandemehr, B., Sanati, M., Hashemzaei, M., Miri, A., Zandkarimi, M., Belaran, M., Fanoudi, S., et al. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0399-z · Cited by 10 · see citing works
Liu, B., Xu, L., Guo, M., Du, X., Yan, L., Wang, Q., Wang, J., & Qin, C. (2017) · Biomedical Research-tokyo · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 78 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Role of Cholinergic Signaling in Alzheimer’s Disease
Chen, Z.-R., Huang, J.-B., Yang, S.-L., & Hong, F.-F. (2022) · Molecules · doi:10.3390/molecules27061816 · Cited by 922 · see citing works
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
Numakawa, T., & Odaka, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115719 · Cited by 108 · see citing works
Sadovnikova, I. S., Gureev, A. P., Ignatyeva, D. A., Vladimirovna, G. M., Chernyshova, E. V., Krutskikh, E. P., Novikova, A. G., & Popov, V. N. (2021) · Pharmaceuticals · doi:10.3390/ph14070607 · Cited by 73 · see citing works
Yang, A. J. T., Bagit, A., & MacPherson, R. E. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094628 · Cited by 75 · see citing works
Alqurashi, G. K., Hindi, E. A., Zayed, M. A., El-Aziz, G. S. A., Alturkistani, H. A., Ibrahim, R. F., Al-Thepyani, M. A., Bakhlgi, R., Alzahrani, N. A., Ashraf, G. M., et al. (2022) · Behavioral Sciences · doi:10.3390/bs12060166 · Cited by 72 · see citing works
Roy, J., Wong, K. Y., Aquili, L., Uddin, M. S., Heng, B. C., Tipoe, G. L., Wong, K.-H., Fung, M., & Lim, L. W. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100986 · Cited by 64 · see citing works
Natural product-based pharmacological studies for neurological disorders
Puri, V., Kanojia, N., Sharma, A., Huanbutta, K., Dheer, D., & Sangnim, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1011740 · Cited by 71 · see citing works
The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes
Abbas, H., Gad, H. A., Khattab, M. A., & Mansour, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101635 · Cited by 62 · see citing works
Regulation of Melatonin and Neurotransmission in Alzheimer’s Disease
Roy, J., Tsui, K. C., Ng, J., Fung, M., & Lim, L. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136841 · Cited by 55 · see citing works
Chen, Z., Wang, X., Du, S., Liu, Q., Xu, Z., Guo, Y., & Lin, X. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00900-6 · Cited by 54 · see citing works
Melatonin: A Neurotrophic Factor?
Miranda-Riestra, A., Estrada‐Reyes, R., Torres-Sánchez, E. D., Carreño, S., Ortíz, G. G., & Benítez‐King, G. (2022) · Molecules · doi:10.3390/molecules27227742 · Cited by 45 · see citing works
Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus
Huang, J., Huang, N., Mao, Q., Shi, J., & Qiu, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1130253 · Cited by 42 · see citing works
Aldhahri, R. S., Alghamdi, B. S. A., Alzahrani, N. A., Bahaidrah, K. A., Alsufiani, H. M., Mansouri, R. A., & Ashraf, G. M. (2022) · Behavioral Sciences · doi:10.3390/bs12030070 · Cited by 35 · see citing works
Caruso, G. I., Spampinato, S. F., Costantino, G., Merlo, S., & Sortino, M. A. (2021) · Biomedicines · doi:10.3390/biomedicines9050466 · Cited by 34 · see citing works
Alzahrani, N. A., Bahaidrah, K. A., Mansouri, R. A., Alsufiani, H. M., & Alghamdi, B. S. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2102049 · Cited by 34 · see citing works
Wei, Y., Zhang, C., Wang, D., Wang, C., Sun, L., & Chen, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.782358 · Cited by 31 · see citing works
Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
Liu, N., Ruan, J., Li, H., & Fu, J.-H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1112435 · Cited by 30 · see citing works
The protective role of resveratrol in diabetic wound healing
Bi, M., Qin, Y., Wang, L., & Zhang, J. (2023) · Phytotherapy Research · doi:10.1002/ptr.7981 · Cited by 29 · see citing works
Ribeiro, R. F. N., Santos, M. R. D. M. C., Aquino, M., de Almeida, L. P., Cavadas, C., & Silva, M. M. (2025) · Medicinal Research Reviews · doi:10.1002/med.22117 · Cited by 28 · see citing works
Yehia, A., & Abulseoud, O. A. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00728-6 · Cited by 34 · see citing works
Socała, K., Żmudzka, E., Lustyk, K., Zagaja, M., Brighenti, V., Costa, A., Andres-Mach, M., Pytka, K., Martinelli, I., Mandrioli, J., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8101 · Cited by 24 · see citing works
Galvani, F., Cammarota, M., Vacondio, F., Rivara, S., & Boscia, F. (2024) · Journal of Pineal Research · doi:10.1111/jpi.70008 · Cited by 22 · see citing works
Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia
Pluta, R. M., Furmaga-Jabłońska, W., Januszewski, S., & Tarkowska, A. (2023) · Molecules · doi:10.3390/molecules28031105 · Cited by 20 · see citing works
Noroozi, N., Shayan, M., Maleki, A., Eslami, F., Rahimi, N., Zakeri, R., Abdolmaleki, Z., & Dehpour, A. R. (2022) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000522163 · Cited by 18 · see citing works
Mansouri, S., Salari, A., Abedi, A. J., Mohammadi, P., & Amani, M. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113919 · Cited by 18 · see citing works
Molecular mechanisms of Alzheimer’s disease: From therapeutic targets to promising drugs
Alan, E., Kerry, Z., & Sevin, G. (2023) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.12861 · Cited by 17 · see citing works
Rajkhowa, B., Mehan, S., Sethi, P., & Prajapati, A. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00480-z · Cited by 17 · see citing works
Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease
Ilina, A., Khavinson, V., Linkova, N. S., & Petukhov, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084259 · Cited by 17 · see citing works
Recent Nanoscale Carriers for Therapy of Alzheimer's Disease: Current Strategies and Perspectives
Zakharova, L. Y., Gaynanova, G. A., Vasilieva, E. A., Vasileva, L. A., Pavlov, R. V., Kashapov, R. R., Petrov, K. A., & Sinyashin, O. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221115103513 · Cited by 16 · see citing works
Javaid, U., Afroz, S., Ashraf, W., Saghir, K. A., Alqahtani, F., Anjum, S. M. M., Ahmad, T., & Imran, I. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116791 · Cited by 16 · see citing works
Alshammari, G. M., Al-Qahtani, W. H., Alshuniaber, M. A., Yagoub, A. E. A., Al-Khalifah, A. S., Al‐Harbi, L. N., Alhussain, M. H., AlSedairy, S. A., & Yahya, M. A. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104675 · Cited by 16 · see citing works
The Effect of Melatonin and Exercise on Social Isolation-Related Behavioral Changes in Aged Rats
Alghamdi, B. S. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.828965 · Cited by 15 · see citing works
Pirmoradi, Z., Nakhaie, M., Ranjbar, H., Kalantar-Neyestanaki, D., Kohlmeier, K. A., Asadi‐Shekaari, M., Hassanshahi, A., & Shabani, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-60518-4 · Cited by 16 · see citing works
Tao, Q., Yang, D., Qin, K., Liu, L., Jin, M., Zhang, F., Zhu, J., Wang, J., Luo, Q., Du, J., et al. (2023) · Parasites & Vectors · doi:10.1186/s13071-022-05618-8 · Cited by 15 · see citing works
Alzheimer, Parkinson, dementia, and phytochemicals: insight review
Başak, C. A. N., & Şanlıer, N. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2299340 · Cited by 14 · see citing works
Maury, J., Delbrut, A., Villard, V., & Pradelles, R. (2024) · Marine Drugs · doi:10.3390/md22030099 · Cited by 13 · see citing works
Protective role of resveratrol against VCM-induced hepatotoxicity in male wistar rats
Alshehri, F. S., & Alorfi, N. M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1130670 · Cited by 12 · see citing works
Yusof, N. I. S. M., & Fauzi, F. M. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105738 · Cited by 12 · see citing works
Rai, R., Jat, D., & Mishra, S. K. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23717 · Cited by 12 · see citing works
Potential mechanisms of action of resveratrol in prevention and therapy for mental disorders
Menegas, S., Keller, G. S., Della, T. P., Aguiar‐Geraldo, J. M., Quevedo, J., & Valvassori, S. S. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109435 · Cited by 12 · see citing works
Barrón‐González, M., Rosales‐Hernández, M. C., Abad-García, A., Ocampo-Néstor, A. L., Santiago-Quintana, J. M., Pérez‐Capistran, T., Trujillo-Ferrara, J. G., Martínez, I. I. P., Farfán‐García, E. D., & Soriano-Ursua, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063229 · Cited by 12 · see citing works
Merlo, S., Caruso, G. I., Korde, D. S., Khodorovska, A. A., Humpel, C., & Sortino, M. A. (2023) · Biomolecules · doi:10.3390/biom13020373 · Cited by 11 · see citing works
Ünal, Ö., Akgun-Unal, N., & Baltacı, A. K. (2025) · Biogerontology · doi:10.1007/s10522-025-10254-7 · Cited by 11 · see citing works
Merlo, S., Caruso, G. I., Bonfili, L., Spampinato, S. F., Costantino, G., Eleuteri, A. M., & Sortino, M. A. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115151 · Cited by 10 · see citing works
Boondam, Y., Saefoong, C., Niltup, N., Monteil, A., & Kitphati, W. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00373 · Cited by 11 · see citing works
Alzahrani, N. A., Bahaidrah, K. A., Mansouri, R. A., Aldhahri, R. S., El-Aziz, G. S. A., & Alghamdi, B. S. A. (2024) · Biomedicines · doi:10.3390/biomedicines12051107 · Cited by 7 · see citing works
Chen, S., Hsu, T.-C., Chew, C. H., Huang, W., Chen, A. L., Lin, Y., Eddarkaoui, S., Buée, L., & Chen, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126855 · Cited by 7 · see citing works
Mahmoudian, Z. G., Komaki, A., Rashidi, I., Amiri, I., & Ghanbari, A. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102158 · Cited by 7 · see citing works
Jatav, S., Pandey, N., Dwivedi, P., Akhtar, A., Jyoti, J., Singh, R., Bansal, R., & Mishra, B. B. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00328 · Cited by 7 · see citing works
Crosstalk between copper, Alzheimer’s disease, and melatonin
Deepika, Thakur, A., Panghal, A., Pundir, R., Singh, C., Goyal, M., Namdeo, A. G., & Kumar, J. (2025) · BioMetals · doi:10.1007/s10534-025-00712-7 · Cited by 6 · see citing works
Qutifan, S., Saleh, T., Shahin, N. A., ELBeltagy, M., Obeidat, F. N., Qattan, D., Kalbouneh, H., Barakat, N. A., & Alsalem, M. (2024) · Neuroreport · doi:10.1097/wnr.0000000000002049 · Cited by 6 · see citing works
Alam, M. Z., Bagabir, H. A., Zaher, M. A. F., Alqurashi, T. M. A., Alghamdi, B. S. A., Kazi, M., Ashraf, G. M., Alshahrany, G. A., Alzahrani, N. A., Bakhalgi, R. M., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04310-5 · Cited by 6 · see citing works
Elfouly, A., Awny, M. M., Ibrahim, M. K., Aboelsaad, M., Tian, J., & Sayed, M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03357-3 · Cited by 6 · see citing works
Wang, H., Li, F., Wang, H., Tian, Z., Fan, H., & 时志斌 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1758356 · Cited by 5 · see citing works
Eladawy, R. M., Ahmed, L. A., Salem, M. B., Hammam, O. A., Mohamed, A. F., Salem, H. A., & El‐Sayed, R. M. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117126 · Cited by 5 · see citing works
Exploring the Neuroprotective Effects of Rufinamide in a Streptozotocin-Induced Dementia Model
Kaur, D., Grewal, A. K., Fouad, D., Kumar, A., Singh, V., Alexiou, A. T., Papadakis, M., Batiha, G. E., Welson, N. N., & Singh, T. G. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01521-1 · Cited by 5 · see citing works
Khan, G. U., Khan, S. S., Naeem, S., Awan, A. N., Siddiqui, H., Siddiqui, H., Shuja, A. A., & Tahir, A. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120141 · Cited by 4 · see citing works
Delving into Autophagy: Utilizing Natural Bioactive Compounds to Combat Alzheimer's Disease
Singh, A., Mazumder, A., Das, S., Kanda, A., Mishra, R., & Chaitanya, M. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072311552240718112619 · Cited by 4 · see citing works
Aliashrafi, M., Nasehi, M. M., Siadat, S. D., Mohammadi-Mahdiabadi-Hasani, M.-H., Zali, H., & Niknam, Z. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00257-8 · Cited by 4 · see citing works
Eladawy, R. M., Ahmed, L. A., Salem, M. B., El‐Sayed, R. M., Salem, H. A., & Mohamed, A. F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114227 · Cited by 4 · see citing works
The Role of Resveratrol in Alzheimer's Disease: A Comprehensive Review of Current Research
Kumar, S., Saha, S., Sharma, B., Singh, S., Shukla, P., Mukherjee, S., Agarwal, M., Singh, K., & Singh, T. (2023) · Current Functional Foods · doi:10.2174/0126668629269244231127071411 · Cited by 3 · see citing works
TECHNOLOGIES, INNOVATIVE AND MODERN THEORIES OF SCIENTISTS
International Science Group, & Vladlenov, D. (2023) · doi:10.46299/isg.p.2023.1.20 · Cited by 3 · see citing works
Alyami, K. A., Alshahrany, G. A., Al-Otaibi, K. M., Alam, M. Z., Alghamdi, B. S. A., Alsufiani, H. M., Alshareef, N. O., Alhoraibi, H., Alkhodair, S. A., & Omar, U. M. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1567226 · Cited by 2 · see citing works
EFFECT OF MELATONIN IN POST-STROKE RECOVERY
Shreen, S., NOOREEN, N., ZAHID, U., MALEEHA, A., SAMREEN, A., & ZOHEB, M. (2022) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2022.v15i4.43466 · Cited by 2 · see citing works
ADVANCEMENT IN THE TREATMENT OF ALZHEIMER'S DISEASE, 2023
Safdar, A., Ghani, M. U., Sabar, M. F., Khan, M. U., Hussain, M., aziz, K., & Hussain, T. (2024) · International Journal of Pharmacy & Integrated Health Sciences · doi:10.56536/ijpihs.v5i1.114 · Cited by 2 · see citing works
PEKMEZ, H., Özkaya, A., Uçkun, M., Zayman, E., Aydin, M., Canpolat, S., & GüL, M. (2025) · Sleep and Biological Rhythms · doi:10.1007/s41105-025-00576-x · Cited by 2 · see citing works
Galactose Impairs Motor Performance and Cerebellar Signaling in Young Male Wistar Rats
Ferreira, B. K., Paz-Simões, T., Melo, T. N., Gonçalves, P. F. R., Kubrusly, R. C. C., Reis, R. A. D. M., Neves, G. A., Ferreira, G. C., & Schuck, P. F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04684-6 · Cited by 1 · see citing works
One-Trial Learning: Review of Experimental Models
Zamorina, T. A., Toropova, K. A., Ivashkina, O. I., & Анохин, К. В. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01883-z · Cited by 1 · see citing works
Chen, Y.-C., Chou, M.-Y., Li, P., Lin, Y.-S., Yang, M., Chi, C.-H., Huang, P., Wei, Y.-J., Wang, M.-F., & Kuo, C.-Y. (2025) · Antioxidants · doi:10.3390/antiox14111337 · Cited by 1 · see citing works
Baher, N. K., Heikal, L., El-Salamouni, N. S., Gaafar, P. M. E., Bakr, B. A., Badae, N. M., & ElGamal, S. S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107925 · Cited by 1 · see citing works
Ghosh, A., Karmakar, V., Saha, B., Lye, A., Nandi, U., & Gorain, B. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06043-z · Cited by 1 · see citing works
Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats
Barrón‐González, M., Rivera-Antonio, A. M., Luna, R. A. J., Santiago-Quintana, J. M., Levaro‐Loquio, D., Pérez‐Capistran, T., Guerra‐Araiza, C., Soriano-Ursua, M. A., & Farfán‐García, E. D. (2024) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12997 · Cited by 1 · see citing works
Olfactory neuronal precursors as a model to analyze the effects of melatonin in Alzheimer's disease.
Santillán-Morales, V., & Benítez‐King, G. (2023) · Melatonin Research · doi:10.32794/mr112500164
Polyphenol: Development of Polyphenol-Inspired Derivatives Targeting Pathological Factors of AD
Das, B., Baidya, A. T. K., & Kumar, R. (2023) · Springer eBooks · doi:10.1007/978-981-99-6038-5_10
Mesole, S. B., Ibegbu, A., Musa, S., Bauchi, Z. M., Agbon, A., Okpanachi, O., & Ivang, A. E. (2021) · Series of Medical Science · doi:10.54178/2771-0629.2021a3
Rabie, S., Ibrahim, M. K., Zaki, H. F., & Said, H. M. (2024) · Research Square · doi:10.21203/rs.3.rs-5040660/v1
Rabbani, M., Abaei, M. K., & Hosseini-Sharifabad, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5092353
Rashmi, T., Monika, S., & Kumar, N. (2025) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/apjtb.apjtb_232_25
Abaei, M. K., Hosseini-Sharifabad, A., & Rabbani, M. (2025) · Next research. · doi:10.1016/j.nexres.2025.101237
Mohammadi, S., Ghorbandaiepour, T., Zahmatkesh, M., Karimi‐Zandi, L., & Mirzakhani, A. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00401
Youssef, B., Ibrahim, E., Moselhy, S. S., ElShebiney, S. A., & ELabd, W. K. (2026) · Discover Nano · doi:10.1186/s11671-026-04506-9
Zhang, X., Chen, F., Luo, Y., Li, D., Ji, J., Ma, L., Ma, C., & Hu, X. (2026) · Nutrients · doi:10.3390/nu18081193
Shahsavari, F., Rajizadeh, M. A., Pirmoradi, Z., Sabzalizadeh, M., Kohlmeier, K. A., Soti, M., & Shabani, M. (2026) · Neuroscience Letters · doi:10.1016/j.neulet.2026.138619
Alshahrany, G. A., Alyami, K. A., Alzahrani, N. A., Alam, M. Z., Alghamdi, B. S. A., Omar, U. M., Banjabi, A. A., Alshaibi, H. F., Jambi, R. J., Al-Otaibi, K. M., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19071004
Bioactive Food Ingredients in the Treatment of Neuroinflmammatory Disorders
Sehar, N., & Sehar, S. (2026) · Food bioactive ingredients · doi:10.1007/978-3-032-23814-6_11
Wiprich, M. T., Vasques, R. D. R., Zaluski, A. B., Bertoncello, K. T., Altenhofen, S., Gusso, D., Rodrigues, G., Sachett, A., Piato, Â., Maito, F. L. D. M., et al. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111840
Babajani, F., Behrestaq, S. F., & Taghipoor, A. (2026) · Iranian Journal of Nutrition Sciences and Food Technology · doi:10.66224/nsft.21.2.19
Rashidi, S. K., Dezfouli, M. A., Dayer, D., & Saeidi, F. (2026) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp-171761
Melatonin and Neurobehavioral Functions
Ekimova, I. V., & Chesnokova, A. Y. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040058
Mishra, A., Satapathy, B. S., & Sahu, P. K. (2026) · RSC Pharmaceutics · doi:10.1039/d6pm00478d
- Authors
- Labban, S., Alghamdi, B. S., Alshehri, F. S., & Kurdi, M.
- Affiliations
- King Abdulaziz University (SA)
- Umm al-Qura University (SA)
- Corresponding author
- Alghamdi, Badrah S.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 402
- Pages
- 113100
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W3120536115
- Cited by
- 92
- References
- 78
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 21 · 2023: 12 · 2022: 22 · 2021: 9
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Behavioural Brain Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- King Abdulaziz University
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- Alzheimer's disease, melatonin, resveratrol, recognition memory, passive avoidance, acetylcholinesterase, brain-derived neurotrophic factor, CREB signaling, prefrontal cortex, cholinergic system, neuroprotection, memory impairment
- MeSH terms
- Resveratrol, Alzheimer Disease, Animals, Avoidance Learning, Behavior, Animal, Disease Models, Animal, Male, Melatonin, Memory Disorders, Neuroprotective Agents, Recognition, Psychology, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review