Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex

Barker, Gareth R. I.; Bird, Flora; Alexander, Victoria; Warburton, E. Clea

doi:10.1523/jneurosci.5289-06.2007

Cited by 691Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex

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Barker, Gareth R. I., Bird, Flora, Alexander, Victoria, Warburton, E. Clea·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.5289-06.2007PMC PMC6672574

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Abstract

Recognition memory requires judgments of the previous occurrence of stimuli made on the basis of the relative familiarity of individual objects, or by integrating information concerning objects and location, or by using recency information. The present study examined the role of the medial prefrontal cortex (mPFC) and perirhinal cortex (PRH) in these distinct recognition memory processes using a series of behavioral tests: a novel object preference task, an object-in-place task, and a temporal order memory task. Also, a disconnection procedure was used to test whether these regions form components of an integrated system for recognition memory. Male DA rats received bilateral lesions in the PRH or mPFC or unilateral lesions placed in both cortices in either the same (PRH-mPFC IPSI) or contralateral (PRH-mPFC CONTRA) hemispheres. A fifth group underwent sham surgery (SHAM). In the object-in-place and temporal order memory tasks, the PRH, mPFC, and PRH-mPFC CONTRA groups were significantly impaired. However, performance in the novel object preference task was only impaired in the PRH group. No group was impaired in the object location task. These results demonstrate that the mPFC and PRH are crucial for object-in-place associational and recency discriminations, whereas the PRH but not the mPFC is important for the discrimination of novel and familiar individual objects. Importantly, these results provide direct support for the hypothesis that to make discriminations based on associational or recency information, both cortical regions operate within an integrated neural network for recognition memory.

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Rats recognize object information in the TOM test with an interval of 3 hours but not after 24 hours.
“It was also reported that object information in the TOM test with interval of 3 (Barker et al., 2007), but not after 24 (Mitchell and Laiacona, 1998), hours could be “recognized” by rats.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Barker et al., 2007
Lesion of the mPFC disrupts memory in the OiP test in rats.
“Consistently, lesion of the mPFC disrupted memory in the OiP test in rats (Barker et al., 2007; Barker and Warburton, 2011b; Cross et al., 2012).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Barker et al., 2007
Processing of OiP memory requires participation of the mPFC.
“The processing of OiP memory requires the participation of the mPFC, as evidenced by studies of lesions or blocking of glutamate-, acetylcholine (ACh)- or dopamine (DA)-R (Barker et al., 2007; Barker and Warburton, 2008, 2009, 2015; Savalli et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Barker et al., 2007
When the PFC is damaged, OPP memory is not influenced.
“When the PFC was damaged, however, the OPP memory was not influenced (Baran et al., 2010; Barker et al., 2007; Barker and Warburton, 2011b).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Barker et al., 2007
TOM is impaired in rodents with selective lesions of the mPFC or lidocaine injection.
“TOM was impaired in rodents with selective lesions of the mPFC (Barker et al., 2007; Barker and Warburton, 2011b; Cross et al., 2012; Mitchell and Laiacona, 1998) or lidocaine injection (Hannesson et al., 2004).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Barker et al., 2007

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Authors: Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C.
Affiliations: University of Bristol (GB)
ORCID: Warburton, E. Clea
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-03-14
Volume: 27
Issue: 11
Pages: 2948-2957
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5289-06.2007
PMC: PMC6672574
OpenAlex: W2095056606
Cited by: 691
References: 48
Citations by year: 2026: 27 · 2025: 35 · 2024: 50 · 2023: 45 · 2022: 43 · 2021: 45 · 2020: 40 · 2019: 34 · 2018: 45 · 2017: 55 · 2016: 39 · 2015: 41 · 2014: 33 · 2013: 38 · 2012: 32
FWCI: 8.99
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (publishedVersion)
Explore Bristol Research (submittedVersion)
Funders: Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council (S18861)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: recognition memory, medial prefrontal cortex, perirhinal cortex, object recognition, place recognition, temporal order memory, novel object preference, cortical disconnection, lesion studies, rats, neural integration
MeSH terms: Animals, Exploratory Behavior, Male, Memory, Time Factors, Prefrontal Cortex, Entorhinal Cortex, Recognition, Psychology, Rats

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Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex

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