Molecular mechanisms of Alzheimer’s disease: From therapeutic targets to promising drugs

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Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

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The role of oxidative stress in neurodegenerative diseases

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

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Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

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Current and Future Treatments in Alzheimer Disease: An Update

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The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

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Mitochondria and Mitochondrial Cascades in Alzheimer’s disease

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Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

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The β-Secretase BACE1 in Alzheimer’s Disease

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Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

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Cholinesterase inhibitors as Alzheimer's therapeutics (Review)

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Alzheimer’s disease hypothesis and related therapies

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Is CREB a key to neuronal survival?

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Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

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Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

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Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

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The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

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Antioxidant Therapies for Alzheimer's Disease

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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

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TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease

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The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

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Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation

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Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

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APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics

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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease

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Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

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A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer’s disease

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Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

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Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

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Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

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VDAC1, mitochondrial dysfunction, and Alzheimer’s disease

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Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

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Dysfunction of NMDA receptors in Alzheimer’s disease

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Role of tau protein in Alzheimer’s disease: The prime pathological player

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Mechanism for the α‐helix to β‐hairpin transition

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Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death

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NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

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Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

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Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

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Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

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TREM2, microglia, and Alzheimer’s disease.

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Combination Drug Therapy for the Management of Alzheimer’s Disease

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Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

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Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis

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Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

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Astrocytes in Alzheimer's disease: pathological significance and molecular pathways

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Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

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Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

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Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

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Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

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Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway

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Synaptic Therapy in Alzheimer's Disease: A CREB-centric Approach

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Beneficial Effects of Walnuts on Cognition and Brain Health

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Alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease

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Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer’s disease

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Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer’s Disease

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Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology

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Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?

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Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

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The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases

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Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases

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March separate, strike together — Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

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Nicotinic Acetylcholine Receptor Agonists for the Treatment of Alzheimer’s Dementia: An Update

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The Many Faces of Astrocytes in Alzheimer's Disease

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Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease

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Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

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Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

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PKR kinase directly regulates tau expression and Alzheimer's disease‐related tau phosphorylation

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Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?

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Casticin ameliorates scopolamine-induced cognitive dysfunction in mice

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Enhancement of neutral endopeptidase activity in SK-N-SH cells by green tea extract

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STIM Proteins and Glutamate Receptors in Neurons: Role in Neuronal Physiology and Neurodegenerative Diseases

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Role of Cdk5 in Amyloid-beta Pathology of Alzheimer’s Disease

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Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

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Alzheimer’s disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid

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Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β1–42

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Effect of Epilobium angustifolium L. extracts and polyphenols on cell proliferation and neutral endopeptidase activity in selected cell lines.

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Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid–induced Ca2+ hyperexcitation

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Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway

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Silent Mating–Type Information Regulation 2 Homolog 1 Attenuates the Neurotoxicity Associated with Alzheimer Disease via a Mechanism Which May Involve Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α

Dong, Y., Cao, K., Xiang, J., Shan, L., & Guan, Z.-Z. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.03.015 · Cited by 34 · see citing works

Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease.

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CD33‐Targeted Therapies: Beating the Disease or Beaten to Death?

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Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats

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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Sinha, N., Karche, N. P., Verma, M. K., Walunj, S. S., Nigade, P. B., Jana, G., Kurhade, S. P., Hajare, A. K., Tilekar, A. R., Jadhav, G. R., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01569 · Cited by 30 · see citing works

Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice

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Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease

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The flavonoids of okra insulates against oxidative stress, neuroinflammation and restores BDNF levels in Aβ1–42 induced mouse model of Alzheimer's disease

Yan, T., Liu, B., Wang, N., Liao, Z., Wu, B., He, B., & Jia, Y. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111263 · Cited by 29 · see citing works

Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation

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Neprilysin gene transfer: A promising therapeutic approach for A lzheimer's disease

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Endogenous hydrogen sulfide alleviates methotrexate‐induced cognitive impairment by attenuating endoplasmic reticulum stress‐induced apoptosis via CHOP and caspase‐12

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The age-related microglial transformation in Alzheimer's disease pathogenesis

Yuan, C., Aierken, A., Xie, Z., Li, N., Zhao, J., & Qing, H. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.03.024 · Cited by 27 · see citing works

Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats

Gomaa, A. A., Makboul, R. M., El‐Mokhtar, M. A., Abdel‐Rahman, E. A., Ahmed, E. A., & Nicola, M. A. (2020) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12585 · Cited by 27 · see citing works

An update on the therapeutic potential of calpain inhibitors: a patent review

Donkor, I. O. (2020) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2020.1797678 · Cited by 27 · see citing works

Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer’s disease

Tiwari, V., Mishra, A., Singh, S., Mishra, S. K., Sahu, K. K., Parul, P., Kulkarni, M. J., Shukla, R., & Shukla, S. (2021) · Brain Research · doi:10.1016/j.brainres.2020.147261 · Cited by 27 · see citing works

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently

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Galantamine Inhibits Aβ1–42-Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ1–42 Engulfment During Autophagic Degradation

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Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease

Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56 · see citing works

Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer’s Disease: AChE, MAO-B, and COX-2 as Molecular Targets

Asghar, S., Mushtaq, N., Ahmed, A., Anwar, L., Munawar, R., & Akhtar, S. (2024) · Molecules · doi:10.3390/molecules29020490 · Cited by 48 · see citing works

The double-edged nature of nicotine: toxicities and therapeutic potentials

Cao, Y., Sun, J., Wang, X., Zhang, X., Tian, H., Huang, L., Huang, Z. H., Zhang, Y., Zhang, J., Li, L., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1427314 · Cited by 24 · see citing works

A comprehensive computational and experimental study of novel imidazole linked thiadiazole based amide derivatives as cholinesterase duel-target inhibitor for the treatment of Alzheimer’s disease

Khan, Y., Naeem, M., Arooj, K., Naseem, M., Adnan, R., & Azmatullah (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108789 · Cited by 10 · see citing works

Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions

Olivero, G., Grilli, M., Marchi, M., & Pittaluga, A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109570 · Cited by 10 · see citing works

Aging and Alzheimer’s: the critical role of mitochondrial dysfunction and synaptic alterations

Pinky, Wali, Z., Neha, Tiwari, P., El‐Tanani, M., Rabbani, S. A., & Parvez, S. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1676317 · Cited by 10 · see citing works

Synthesis and evaluation of Fmoc-amino esters and amides bearing a substrate like quaternary ammonium group as selective butyrylcholinesterase inhibitors

Godinez, J., Lee, C. Y., & Schwans, J. P. (2023) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2023.129392 · Cited by 9 · see citing works

Navigating the Gene Co-Expression Network and Drug Repurposing Opportunities for Brain Disorders Associated with Neurocognitive Impairment

Manuel, M. T. A., & Tayo, L. L. (2023) · Brain Sciences · doi:10.3390/brainsci13111564 · Cited by 7 · see citing works

Cognitive Effect of Levetiracetam in Patients with Alzheimer’s Disease or Mild Cognitive Impairment: A Systematic Review

Mohamadi, M. H., Bavafa, A., Salehi, S., Abedi, M., Shahabi, F., Jafarlou, S., Kolivand, P., & Negah, S. S. (2025) · Current Therapeutic Research · doi:10.1016/j.curtheres.2025.100798 · Cited by 7 · see citing works

Molecular Mechanisms Underlying Alzheimer’s Disease Pathogenesis: Comprehensive Overview

Vecchio, F. L., la Torre, A., Gravina, C., D’Onofrio, G., & Greco, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104651 · Cited by 4 · see citing works

Targeting Adenylate Cyclase: A Novel Concept for Stimulation of Neurogenesis and Pharmacotherapy of Alzheimer's Disease

Zyuz’kov, G. N., Miroshnichenko, L. A., Polyakova, T. Y., Simanina, E. V., & Chaikovskii, A. V. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249302264240715060630 · Cited by 4 · see citing works

Design, Synthesis, and In Silico Analyses of Nitroimidazole Derivatives Targeting Cholinesterases

Biyik, B., Tarikogullari, A. H., Alagöz, M. A., Demir, Y., Gülçın, İ., Burmaoğlu, S., & Algül, Ö. (2025) · ChemistrySelect · doi:10.1002/slct.202502275 · Cited by 3 · see citing works

Synthesis, Bioactivity and Molecular Modeling Studies on Benzimidazole Derivatives and Its Isosteres as Potent AChE / BChE and GSK3β Inhibitors for Alzheimer's Disease

Sayar, G., Parlar, S., Tarikogullari, A. H., Erdoğan, M. A., Armağan, G., & Alptüzün, V. (2026) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70285 · Cited by 3 · see citing works

Xanthoangelol Mitigates Neuroinflammation and Hypoxia via MAPK and HIF-1 Signaling Modulation: Network Pharmacology and In-Vivo Approach in a Haloperidol-Induced Model of Parkinson’s DiseasePreprint

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Cracking geriatric complexity: key messages from the Italian Society of Geriatrics Hospital and Territory Young Masterclass

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Polygala tenuifolia as a multi-target therapeutic candidate for Alzheimer’s disease: Molecular mechanisms and translational perspectives

Khan, S. A., Ahmad, I., Faruk, M. O., Hariharasudhan, D., Баратова, Ш. Н., Djamolidinovna, D. S., Mim, T. J., O’gli, S. X. N., Mulik, R., Murad, A. B., et al. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100883

BindingDB Entry 50020438: Synthesis and evaluation of Fmoc-amino esters and amides bearing a substrate like quaternary ammonium group as selective butyrylcholinesterase inhibitors.

BindingDB (2024) · UC San Diego · doi:10.7270/q2rn3d8p

Mitochondria Are a Potential Therapeutic Target for Alzheimer’s Disease

Basavalingiah, A. J., Yan, S. F., & Yan, S. S. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190932183.013.23

Drug Target to Alleviate Mitochondrial Dysfunctions in Alzheimer’s Disease: Recent Advances and Therapeutic Implications

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Mitochondrial dysfunction: A potential target for Alzheimer’s disease intervention and treatment

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Mitochondria as a therapeutic target in Alzheimer's disease

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Mitochondria-targeting by small molecules against Alzheimer's disease: A mechanistic perspective

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