Autophagy: a regulated bulk degradation process inside cells

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Molecular dissection of autophagy: two ubiquitin-like systems

Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network

Kihara, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve061 · Cited by 813

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

Kimura, S., Noda, T., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4451 · Cited by 2,278

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

Iwata, A., Riley, B. E., Johnston, J. A., & Kopito, R. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508786200 · Cited by 719

Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole

Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509157200 · Cited by 658

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

Kimura, S., Noda, T., & Yoshimori, T. (2008) · Cell Structure and Function · doi:10.1247/csf.08005 · Cited by 438

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

Raben, N., Hill, V., Shea, L., Takikita, S., Baum, R., Mizushima, N., Ralston, E., & Plotz, P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn292 · Cited by 352

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

Balgi, A. D., Fonseca, B. D., Donohue, E., Tsang, T. C. F., Lajoie, P., Proud, C. G., Nabi, I. R., & Roberge, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007124 · Cited by 344

HsAtg4B/HsApg4B/Autophagin-1 Cleaves the Carboxyl Termini of Three Human Atg8 Homologues and Delipidates Microtubule-associated Protein Light Chain 3- and GABAA Receptor-associated Protein-Phospholipid Conjugates

Tanida, I., Sou, Y.-S., Ezaki, J., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401461200 · Cited by 334

Autophagy is an immediate macrophage response to Legionella pneumophila

Amer, A. O., & Swanson, M. S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00509.x · Cited by 279

Intracellular Inclusions Containing Mutant α1-Antitrypsin Z Are Propagated in the Absence of Autophagic Activity

Kamimoto, T., Shoji, S., Hidvegi, T., Mizushima, N., Umebayashi, K., Perlmutter, D. H., & Yoshimori, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509409200 · Cited by 259

The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells

Ropolo, A., Grasso, D., Pardo, R., Sacchetti, M. L., Archange, C., Re, A. L., Seux, M., Nowak, J., Gonzalez, C. D., Iovanna, J. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706956200 · Cited by 223

Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes

Murase, D., Hachiya, A., Takano, K., Hicks, R., Visscher, M. O., Kitahara, T., Hase, T., Takema, Y., & Yoshimori, T. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.165 · Cited by 214

The role of larval fat cells in adult Drosophila melanogaster

Aguila, J. R., Suszko, J., Gibbs, A. G., & Hoshizaki, D. K. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.001586 · Cited by 212

The C. elegans LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39

Manil-Ségalen, M., Lefebvre, C., Jenzer, C., Trichet, M., Boulogne, C., Satiat-Jeunemaitre, B., & Legouis, R. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.11.022 · Cited by 144

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana

Williams, R. A., Tetley, L., Mottram, J. C., & Coombs, G. H. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05274.x · Cited by 140

In Situ Detection of Starvation-induced Autophagy

Martinet, W., De Meyer, G. R. Y., Andries, L., Herman, A. G., & Kockx, M. M. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6743.2005 · Cited by 139

Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium

Yao, J., Jia, L., Khan, N., Lin, C., Mitter, S. K., Boulton, M. E., Dunaief, J. L., Klionsky, D. J., Guan, J.-L., Thompson, D. A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1041699 · Cited by 130

Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells

Patschan, S., Chen, J., Polotskaia, A., Mendelev, N., Cheng, J., Patschan, D., & Goligorsky, M. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00713.2007 · Cited by 105

Intracellular survival of Shigella

Ogawa, M., & Sasakawa, C. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00652.x · Cited by 89

Mycobacterium marinum induces a marked LC3 recruitment to its containing phagosome that depends on a functional ESX-1 secretion system: Live M. marinum transiently resides in LC3-labelled compartments

Lerena, M. C., & Colombo, M. I. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01581.x · Cited by 85

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions

Szyniarowski, P., Corcelle-Termeau, E., Farkas, T., Høyer-Hansen, M., Nylandsted, J., Kallunki, T., & Jäättelä, M. (2011) · Autophagy · doi:10.4161/auto.7.8.15770 · Cited by 79

Glycogen autophagy

Kotoulas, O. B., Kalamidas, S. A., & Kondomerkos, D. J. (2004) · Microscopy Research and Technique · doi:10.1002/jemt.20046 · Cited by 70

Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium

Yao, J., Jia, L., Shelby, S. J., Ganios, A. M., Feathers, K., Thompson, D. A., & Zacks, D. N. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-13336 · Cited by 68

Loss of autophagy promotes murine acetaminophen hepatotoxicity

Igusa, Y., Yamashina, S., Izumi, K., Inami, Y., Fukada, H., Komatsu, M., Tanaka, K., Ikejima, K., & Watanabe, S. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-011-0500-0 · Cited by 66

TMEM74, a lysosome and autophagosome protein, regulates autophagy

Yu, C., Wang, L., Lv, B., Lu, Y., Zeng, L., Chen, Y., Ma, D., Shi, T., & Wang, L. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.055 · Cited by 66

Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases

Shah, S. Z. A., Zhao, D., Hussain, T., & Yang, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.004 · Cited by 55

Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling

Yang, Z., Zeng, B., Pan, Y., Huang, P., & Wang, C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.070 · Cited by 48

Autophagy and its implication in Chinese hamster ovary cell culture

Kim, Y. J., Baek, E., Lee, J. S., & Lee, G. M. (2013) · Biotechnology Letters · doi:10.1007/s10529-013-1276-5 · Cited by 40

Untitled work

(2009) · doi:10.1016/j.jembe.2009.05.007 · Cited by 35