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Cited by 14

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts

Fujitani, Masashi, Honda, Akiko, Hata, Katsuhiko, Yamagishi, Satoru, Tohyama, Masaya, Yamashita, Toshihide·2005·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2004.11.151
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Abstract

The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells, is implicated in the control of neuronal morphology. Here, we report that neurotrophin dependent cytoskeletal changes, characteristic of the phenotype of Rac1, in the hippocampal neurons or PC12 cells are inhibited by the disruption of lipid raft integrity. Activation of Rac1 induced by NGF is impaired in cholesterol-depleted PC12 cells. Pretreatment with gammaGTP shifted significant amount of Rac1, presumably in a GTP-bound form, from non-raft to raft fractions. Proper recruitment of activated Rac1 to lipid rafts, structures that represent specialized signaling organelles, is of fundamental importance in determining neurotrophins' bioactivity.

Overview

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Crossref · 10.1016/j.bbrc.2004.11.151

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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Citations

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Metadata

Authors
Fujitani, M., Honda, A., Hata, K., Yamagishi, S., Tohyama, M., & Yamashita, T.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2005-02
Volume
327
Issue
1
Pages
150-154
ISSN
0006-291X
DOI
10.1016/j.bbrc.2004.11.151
Cited by
14
References
26
Language
en
Licence

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This page
CoChat. (2026). Citation check: Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. https://app.cochat.ai/papers/10.1016/j.bbrc.2004.11.151
The paper
Fujitani, M., Honda, A., Hata, K., Yamagishi, S., Tohyama, M., & Yamashita, T. (2005). Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2004.11.151

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.