The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway
Abstract
The crucial role of p38 mitogen-activated protein kinase for osteoclast differentiation has been suggested from studies with specific pharmacological inhibitors and dominant-negative forms of p38. However, the targets through which p38 regulates osteoclast differentiation have not been clearly revealed. Here, we show that inhibition of p38 activity with SB203580 reduced osteoclastogenesis from primary precursor cells, with concomitant suppression in the induction of both c-Fos and nuclear factor of activated T cells (NFAT) c1 by receptor activator of nuclear factor kappaB ligand (RANKL), the key osteoclast differentiation factor. Overexpression of dominant-negative forms of p38 upstream kinases MKK3 and MKK6 elicited similar reduction in RANKL-stimulated elevation of c-Fos and NFATc1. Interestingly, overexpression of c-Fos restored RANKL-induced osteoclast differentiation from and NFATc1 expression in SB203580-treated precursor cells. Our results demonstrate a previously unknown function of the p38 pathway in up-regulating c-Fos and NFATc1 expression during RANKL-induced osteoclastogenesis.
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“Prior research has emphasized the critical role of p38 in osteoclastogenesis, as it is associated with RANKL-induced c-Fos and NFATc1 expression, and it facilitates CtsK expression through its interaction with NFATc1 [28,29].”
From Anti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds (2023) · cites this paper as [29]
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Cites
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Cited by
Mohamed, S. G.-K., Sugiyama, E., Shinoda, K., Taki, H., Hounoki, H., Abdel-Aziz, H. O., Maruyama, M., Kobayashi, M., Ogawa, H., & Miyahara, T. (2007) · Bone · doi:10.1016/j.bone.2007.05.016 · Cited by 120
Yoon, J.-Y., Baek, C.-W., Kim, H.-J., Kim, E.-J., Byeon, G.-J., & Yoon, J.-U. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0116-z · Cited by 17
Self-citationAnti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds
Jang, S.-A., Lee, S.-J., Hwang, Y.-H., & Ha, H. (2023) · Nutrients · doi:10.3390/nu15194302 · Cited by 2
Metadata
- Authors
- Huang, H., Chang, E.-J., Ryu, J., Lee, Z. H., Lee, Y., & Kim, H.-H.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 351
- Issue
- 1
- Pages
- 99-105
- ISSN
- 0006-291X
- Cited by
- 154
- References
- 3
- Language
- en
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