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Cited by 198Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchRegulation of Appetite and Obesity

Functional Specificity of Ventral Striatal Compartments in Appetitive Behaviors

KELLEY, ANN E.·1999·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1999.tb09262.x
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Abstract

ABSTRACT:The nucleus accumbens and its associated circuitry subserve behaviors linked to natural or biological rewards, such as feeding, drinking, sex, exploration, and appetitive learning. We have investigated the functional role of neurotransmitter and intracellular transduction mechanisms in behaviors subserved by the core and shell subsystems within the accumbens. Local infusion of the selective NMDA antagonist, AP‐5, into the accumbens core, but not the shell, completely blocked acquisition of a bar‐press response for food in hungry rats. This effect was apparent only when infused during the early stages of learning. We have also recently shown that infusion of certain protein kinase inhibitors into the core also impairs learning in the same paradigm. These results suggest that plasticity‐related mechanisms within the accumbens core, involving glutamate‐linked intracellular second messengers, are important for response‐reinforcement learning. In contrast to the core, which primarily connects to somatic motor output systems, the shell is more intimately linked to viscero‐endocrine effector systems. We have shown that both AMPA and GABA receptors within the medial shell (but not the core) are critically involved in controlling the brain's feeding pathways, via activation of the lateral hypothalamus (LH). This effect is blocked by local inhibition of the LH in double‐cannulae experiments and also strongly and selectively activates Fos expression in the LH. These results provide a newly emerging picture of the differentiated functions of this forebrain region and suggest an integrated role in the elaboration of adaptive motor actions.

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Crossref · 10.1111/j.1749-6632.1999.tb09262.x

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  • There is extensive experimental evidence in animal contexts supporting a role for the mesolimbic reward pathway in appetitive and motivational behaviors.

    “In addition, there is extensive experimental evidence in animal contexts supporting a role for the mesolimbic reward pathway on appetitive and motivational behaviors [306,307].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [306]

  • The core of the nucleus accumbens is an important anatomical substrate for motivated behavior and has been specifically implicated as a site where dopamine acts to mediate the acquisition and/or performance of Pavlovian conditioned approach behavior.

    “The core of the nucleus accumbens is an important anatomical substrate for motivated behavior17,18 and has been specifically implicated as a site where dopamine acts to mediate the acquisition and/or performance of Pavlovian conditioned approach behavior19–22.”

    From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [19]

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Authors
KELLEY, A. E.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
KELLEY, ANN E.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1999-06
Volume
877
Issue
1
Pages
71-90
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1999.tb09262.x
OpenAlex
W2135412747
Cited by
198
References
110
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 7
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2442 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA09311, DA-04788, R01DA009311)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, appetitive learning, food reward, NMDA receptor antagonism, AP5, protein kinase inhibitors, glutamate signaling, AMPA receptors, GABA receptors, lateral hypothalamus, feeding behavior, Fos expression, neuroplasticity
MeSH terms
Animals, Appetitive Behavior, Corpus Striatum, Humans, Learning, Neuronal Plasticity, Nucleus Accumbens, Reinforcement, Psychology, Receptors, Glutamate, Rats

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