Anti-Parkinsonian effects of Bacopa monnieri: Insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s disease
Abstract
Neurodegenerative Parkinson's disease (PD) is associated with aggregation of protein alpha synuclein and selective death of dopaminergic neurons, thereby leading to cognitive and motor impairment in patients. The disease has no complete cure yet; the current therapeutic strategies involve prescription of dopamine agonist drugs which turn ineffective after prolonged use. The present study utilized the powerful genetics of model system Caenorhabditis elegans towards exploring the anti-Parkinsonian effects of a neuro-protective botanical Bacopa monnieri. Two different strains of C. elegans; a transgenic model expressing "human" alpha synuclein [NL5901 (P(unc-54)::alphasynuclein::YFP+unc-119)], and a pharmacological model expressing green fluorescent protein (GFP) specifically in the dopaminergic neurons [BZ555 (P(dat-1)::GFP)] treated with selective catecholaminergic neurotoxin 6-hydroxy dopamine (6-OHDA), were employed for the study. B. monnieri was chosen for its known neuroprotective and cognition enhancing effects. The study examined the effect of the botanical, on aggregation of alpha synuclein, degeneration of dopaminergic neurons, content of lipids and longevity of the nematodes. Our studies show that B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes, thereby proving its potential as a possible anti-Parkinsonian agent. These findings encourage further investigations on the botanical, and its active constituent compounds, as possible therapeutic intervention against Parkinson's disease.
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Studies have elucidated evidence for the role of Bacopa monnieri in epilepsy, dementia, and Parkinson's disease attenuation.
“There have been studies that have elucidated evidence for the role of B. monnieri in epilepsy, dementia, and Parkinson’s disease attenuation [96,97].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [97]
Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 14,985 · see citing works
Glossary of Indian Medicinal Plants
Chopra, R. N., Nayar, S. L., & Chopra, I. (1956) · Cited by 5,197 · see citing works
Strasser, A., O’Connor, L., & Dixit, V. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.217 · Cited by 1,369 · see citing works
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
Ashrafi, K., Chang, F., Watts, J. L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature · doi:10.1038/nature01279 · Cited by 972 · see citing works
WormBase: a multi-species resource for nematode biology and genomics
Harris, T. W. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh066 · Cited by 717 · see citing works
Gitler, A. D., Chesi, A., Geddie, M. L., Strathearn, K. E., Hamamichi, S., Hill, K. J., Caldwell, K. A., Caldwell, G. A., Cooper, A. A., Rochet, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.300 · Cited by 535 · see citing works
Craig, E. A., Weissman, J. S., & Horwich, A. L. (1994) · Cell · doi:10.1016/0092-8674(94)90416-2 · Cited by 426 · see citing works
Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
Nass, R., Hall, D. H., Miller, D. M., & Blakely, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042497999 · Cited by 420 · see citing works
C., S., P., N., J., L., J., C., C., H., L., D., & T., R. (2001) · Psychopharmacology · doi:10.1007/s002130100815 · Cited by 342 · see citing works
The Genetics of Parkinson Disease
Bekris, L. M., Mata, I. F., & Zabetian, C. P. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383572 · Cited by 307 · see citing works
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
Hamamichi, S., Rivas, R. N., Knight, A. L., Cao, S., Caldwell, K. A., & Caldwell, G. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711018105 · Cited by 285 · see citing works
Cognitive enhancement and neuroprotective effects of Bacopa monnieri in alzheimer’s disease model
Uabundit, N., Wattanathorn, J., Mucimapura, S., & Ingkaninan, K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.09.056 · Cited by 282 · see citing works
Abe, K., & Saito, H. (2000) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(200005)14:3 · Cited by 271 · see citing works
Cenci, M. A., & Lundblad, M. (2007) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0925s41 · Cited by 267 · see citing works
Ved, R., Saha, S., Westlund, B., Perier, C., Griffin, L. B., Sluder, A. E., Hoener, M. C., Rodrigues, C. M. P., Alfonso, A., Steer, C. J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505910200 · Cited by 256 · see citing works
Sairam, K., Dorababu, M., Goel, R. K., & Bhattacharya, S. K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00116 · Cited by 231 · see citing works
Hanrott, K., Gudmunsen, L., O’Neill, M. J., & Wonnacott, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511560200 · Cited by 231 · see citing works
Limpeanchob, N., Jaipan, S., Rattanakaruna, S., Phrompittayarat, W., & Ingkaninan, K. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.07.039 · Cited by 206 · see citing works
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans
Artal-Sanz, M., & Tavernarakis, N. (2009) · Nature · doi:10.1038/nature08466 · Cited by 196 · see citing works
Sämann, J., Hegermann, J., von Gromoff, E. D., Eimer, S., Baumeister, R., & Schmidt, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808255200 · Cited by 192 · see citing works
LRK-1, a C. elegans PARK8-Related Kinase, Regulates Axonal-Dendritic Polarity of SV Proteins
Sakaguchi-Nakashima, A., Meir, J. Y., Jin, Y., Matsumoto, K., & Hisamoto, N. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.074 · Cited by 192 · see citing works
Expression of Drosophila heat-shock cognate genes during heat shock and development
Craig, E. A., Ingolia, T. D., & Manseau, L. J. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90291-9 · Cited by 176 · see citing works
Chowdhuri, D. K., Parmar, D., Kakkar, P., Shukla, R., Seth, P. K., & Srimal, R. C. (2002) · Phytotherapy Research · doi:10.1002/ptr.1023 · Cited by 162 · see citing works
Hosamani, R., & ., M. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.08.012 · Cited by 158 · see citing works
Neuroprotective mechanisms of ayurvedic antidementia botanical <i>Bacopa monniera</i>
Dhanasekaran, M., Tharakan, B., Holcomb, L. A., Hitt, A. R., Young, K. A., & Manyam, B. V. (2007) · Phytotherapy Research · doi:10.1002/ptr.2195 · Cited by 148 · see citing works
Benedetto, A., Au, C., & Aschner, M. (2009) · Chemical Reviews · doi:10.1021/cr800536y · Cited by 127 · see citing works
Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic rats
Kapoor, R., Srivastava, S., & Kakkar, P. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.08.007 · Cited by 123 · see citing works
Anti-inflammatory activity of Bacopa monniera in rodents
Channa, S., Dar, A., Anjum, S., Yaqoob, M., & Rahman, A. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.10.009 · Cited by 115 · see citing works
Xu, Q., Kanthasamy, A. G., & Reddy, M. B. (2011) · Parkinson s Disease · doi:10.4061/2011/431068 · Cited by 112 · see citing works
Eminel, S., Klettner, A., Roemer, L., Herdegen, T., & Waetzig, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405858200 · Cited by 103 · see citing works
Binukumar, B. K., Bal, A., Kandimalla, R. J. L., & Gill, K. D. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-35 · Cited by 78 · see citing works
Paulose, C. S., Chathu, F., Khan, S. R., & Krishnakumar, A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9513-8 · Cited by 67 · see citing works
Zarse, K., Schulz, T. J., Birringer, M., & Ristow, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-6994com · Cited by 58 · see citing works
Genetic Mouse Models of Neurodegenerative Diseases
Trancikova, A. K., Ramonet, D., & Moore, D. J. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00012-1 · Cited by 46 · see citing works
Effect of Bacopa monniera Linn. (brahmi) extract on learning and memory in rats: A behavioral study
Vollala, V. R., Upadhya, S., & Nayak, S. B. (2010) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2009.08.007 · Cited by 46 · see citing works
Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea
Chaudhuri, P. K., Srivastava, R., Kumar, S., & Kumar, S. (2004) · Phytotherapy Research · doi:10.1002/ptr.1278 · Cited by 43 · see citing works
Mohanty, I. R., Maheswari, U., Joseph, D., & Deshmukh, Y. A. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01155.x · Cited by 23 · see citing works
Early intervention in Parkinson's disease: Epidemiologic considerations
Tanner, C. M. (1996) · Annals of Epidemiology · doi:10.1016/s1047-2797(96)00066-x · Cited by 18 · see citing works
Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity
Yamamori, T., Mizobata, A., Saito, Y., Urano, Y., Inanami, O., Irani, K., & Noguchi, N. (2010) · Free Radical Research · doi:10.3109/10715762.2010.532496 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Lei, L., Liu, M., Song, Y., Lu, S., Hu, J., Cao, C., Xie, B., Shi, H., & He, D. (2018) · Environmental Science Nano · doi:10.1039/c8en00412a · Cited by 429 · see citing works
Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310 · see citing works
Neuropharmacological Review of the Nootropic Herb <i>Bacopa monnieri</i>
Aguiar, S., & Borowski, T. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1431 · Cited by 295 · see citing works
Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160 · see citing works
Prosser, S. W. J., Velarde-Aguilar, M. G., León‐Régàgnon, V., & Hebert, P. D. N. (2013) · Molecular Ecology Resources · doi:10.1111/1755-0998.12082 · Cited by 146 · see citing works
Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
Fatima, U., Roy, S., Ahmad, S., Ali, S., Elkady, W. M., Khan, I., Alsaffar, R. M., Adnan, M., Islam, A., & Hassan, M. I. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.972379 · Cited by 130 · see citing works
Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
Javed, H., Meeran, M. F. N., Azimullah, S., Adem, A., Sadek, B. S., & Ojha, S. K. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01555 · Cited by 112 · see citing works
Chen, N., Li, J., Li, D., Yang, Y., & He, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113453 · Cited by 105 · see citing works
Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
Maulik, M., Mitra, S., Bult‐Ito, A., Taylor, B. E., & Vayndorf, E. M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00077 · Cited by 104 · see citing works
The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera)
Mathur, D., Goyal, K., Koul, V., & Anand, A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00044 · Cited by 101 · see citing works
Li, P., Xu, T., Wu, S., Lei, L., & He, D. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3468 · Cited by 101 · see citing works
Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders
Banerjee, S., Anand, U., Ghosh, S., Ray, D., Ray, P., Nandy, S., Deshmukh, G. D., Tripathi, V. S., & Dey, A. (2021) · Phytotherapy Research · doi:10.1002/ptr.7203 · Cited by 101 · see citing works
Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.03.016 · Cited by 88 · see citing works
Nellore, J., Pauline, C., & Amarnath, K. (2013) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/972391 · Cited by 88 · see citing works
Important medicinal herbs in Parkinson’s disease pharmacotherapy
Srivastav, S., Fatima, M., & Mondal, A. C. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.137 · Cited by 87 · see citing works
Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
Limanaqi, F., Biagioni, F., Busceti, C. L., Ryskalin, L., Polzella, M., Frati, A., & Fornai, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133274 · Cited by 86 · see citing works
Fu, R., Harn, H., Liu, S., Chen, C., Chang, W.-L., Chen, Y.-M., Huang, J.-E., Li, R.-J., Tsai, S.-Y., Hung, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085305 · Cited by 83 · see citing works
A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson’s Disease
Mittal, P., Dhankhar, S., Chauhan, S., Garg, N., Bhattacharya, T., Ali, M., Chaudhary, A. A., Rudayni, H. A., Al-Zharani, M. M., Ahmad, W., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16070908 · Cited by 82 · see citing works
Acrylamide induces locomotor defects and degeneration of dopamine neurons in Caenorhabditis elegans
Li, J., Li, D., Yang, Y., Xu, T., Li, P., & He, D. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3144 · Cited by 70 · see citing works
Mukherjee, P. K., Efferth, T., Das, B., Kar, A., Ghosh, S., Singha, S., Debnath, P., Sharma, N., Bhardwaj, P. K., & Haldar, P. K. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153930 · Cited by 65 · see citing works
Xu, T., Li, P., Wu, S., Lei, L., & He, D. (2016) · Toxicology Research · doi:10.1039/c6tx00306k · Cited by 64 · see citing works
Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
Sireeratawong, S., Jaijoy, K., Khonsung, P., Lertprasertsuk, N., & Ingkaninan, K. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1236-4 · Cited by 63 · see citing works
Jansen, R., Brogan, B., Whitworth, A. J., & Okello, E. J. (2014) · Phytotherapy Research · doi:10.1002/ptr.5199 · Cited by 63 · see citing works
Shinomol, G. K., Mythri, R. B., Bharath, M. M. S., & ., M. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9776-0 · Cited by 60 · see citing works
Calahorra, J., de la Riva, M. P., Martínez‐Lara, E., Siles, E., & Cañuelo, A. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.07.003 · Cited by 57 · see citing works
Enhanced bacoside content in polyamine treated in-vitro raised Bacopa monnieri (L.) Wettst
Dey, A., Hazra, A. K., Nongdam, P., Nandy, S., Tikendra, L., Mukherjee, A., Banerjee, S., Mukherjee, S., & Pandey, D. K. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.03.012 · Cited by 55 · see citing works
Fu, R., Wang, Y.-C., Chen, C., Tsai, R.-T., Liu, S., Chang, W.-L., Lin, H.-L., Lu, C.-H., Wei, J.-R., Wang, Z.-W., et al. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.007 · Cited by 54 · see citing works
Wu, S., Lei, L., Song, Y., Liu, M., Lu, S., Lou, D. W., Shi, Y., Wang, Z., & He, D. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.018 · Cited by 54 · see citing works
Shukla, V., Phulara, S. C., Yadav, D., Tiwari, S., Kaur, S., Gupta, M. M., Nazir, A., & Pandey, R. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311211080007 · Cited by 53 · see citing works
Wei, C.-C., Chang, C.-H., & Liao, V. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.002 · Cited by 43 · see citing works
Protective effect of Geraniol on the transgenic Drosophila model of Parkinson’s disease
Siddique, Y. H., Naz, F., Jyoti, S., Ali, F. R., Fatima, A., Rahul, & Khanam, S. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.03.018 · Cited by 52 · see citing works
Dexter, P. M., Caldwell, K. A., & Caldwell, G. A. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0109-x · Cited by 51 · see citing works
Dey, A., & De, J. N. (2015) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2015.01.002 · Cited by 51 · see citing works
Shahid, M. M., Subhan, F., Ahmad, N., & Ullah, I. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1807-z · Cited by 51 · see citing works
Dammarane triterpenoid glycosides in Bacopa monnieri: A review on chemical diversity and bioactivity
Bhandari, P., Sendri, N., & Devidas, S. B. (2020) · Phytochemistry · doi:10.1016/j.phytochem.2020.112276 · Cited by 53 · see citing works
Neuroprotection with Bacopa monnieri–A review of experimental evidence
Shalini, V. T., Sajjanar, N. J., & Sriranjini, J. S. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06236-w · Cited by 51 · see citing works
Singh, B., Pandey, S., Rumman, M., Kumar, S., Kushwaha, P. P., Verma, R., & Mahdi, A. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.616413 · Cited by 49 · see citing works
Shamsuzzama, S., Kumar, L., & Nazir, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00328 · Cited by 44 · see citing works
Sashidhara, K. V., Modukuri, R. K., Jadiya, P., Rao, K. B., Sharma, T., Haque, R., Singh, D. K., Banerjee, D., Siddiqi, M. I., & Nazir, A. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500222g · Cited by 44 · see citing works
Singh, B., Pandey, S., Yadav, S. K., Verma, R., Singh, S. P., & Mahdi, A. A. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.10.007 · Cited by 43 · see citing works
Siddique, Y. H., Mujtaba, S. F., Faisal, M., Jyoti, S., & Naz, F. (2014) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2014.05.007 · Cited by 42 · see citing works
Li, X., Chen, Y., Gao, W., Mo, A., Zhang, Y., Jiang, J., & He, D. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130051 · Cited by 41 · see citing works
The pharmacology of Bacopa monniera. A review
Al‐Snafi, A. E. (2014) · International Journal of Advances in Scientific Research · Cited by 41 · see citing works
Efficacy of Natural Compounds in Neurodegenerative Disorders
Srivastava, P., & Yadav, R. S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_7 · Cited by 41 · see citing works
Kamireddy, K., Salim, C., Priyanka, P. S., Rajini, P. S., & Giridhar, P. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.002 · Cited by 39 · see citing works
Studying Parkinson’s disease using Caenorhabditis elegans models in microfluidic devices
Youssef, K., Tandon, A., & Rezai, P. (2019) · Integrative Biology · doi:10.1093/intbio/zyz017 · Cited by 39 · see citing works
Muhammad, F., Liu, Y., Wang, N., Zhao, L., Zhou, Y., Yang, H., & Li, H. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.09.001 · Cited by 38 · see citing works
Plant-Derived Natural Products for Parkinson’s Disease Therapy
Sengupta, T. K., Vinayagam, J., Singh, R. P., Jaisankar, P., & Mohanakumar, K. P. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_23 · Cited by 39 · see citing works
Differential effect of Ayurvedic nootropics on C. elegans models of Parkinson’s disease
Jalagam, A., Vidyashankar, R., & Godbole, A. (2020) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2020.07.006 · Cited by 38 · see citing works
Chen, Q.-X., Zhou, L., Long, T., Qin, D., Wang, Y., Ye, Y., Zhou, X., Wu, J., & Wu, A. (2022) · Pharmaceuticals · doi:10.3390/ph15081014 · Cited by 35 · see citing works
Jadiya, P., Fatima, S., Baghel, T., Mir, S. S., & Nazir, A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9517-3 · Cited by 32 · see citing works
Ameliorative Effects of Nutraceuticals in Neurological Disorders
Chauhan, N. B., & Mehla, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00027-8 · Cited by 31 · see citing works
Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans
Cheon, S.-M., Insoo, J., Lee, M., Kim, D. K., Jeon, H., & Seok, D. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1251468 · Cited by 31 · see citing works
Gościniak, A., Stasiłowicz-Krzemień, A., Szeląg, M., Pawlak, J., Skiera, I., Kwiatkowska, H., Nowak, N., Bernady, K., Trzaskoma, P., Zimak-Krótkopad, O., et al. (2025) · Nutrients · doi:10.3390/nu17111939 · Cited by 30 · see citing works
Shi, Z., Lu, Z., Zhao, Y., Wang, Y., Zhao-Wilson, X., Guan, P., Duan, X., Chang, Y., & Zhao, B. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.03.001 · Cited by 30 · see citing works
Indian Herbs for the Treatment of Neurodegenerative Disease
Mannangatti, P., & Naidu, K. N. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_17 · Cited by 30 · see citing works
The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment
Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works
“monnieri in epilepsy, dementia, and Parkinson’s disease attenuation [96,97].”
BackgroundBacopa monnieri inhibits apoptosis and senescence through mitophagy in human astrocytes
Saha, S., Mahapatra, K. K., Mishra, S. R., Mallick, S., Negi, V. D., Sarangi, I., Patil, S., Patra, S. K., & Bhutia, S. K. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111367 · Cited by 29 · see citing works
In Quest of the Mysterious Holistic Vedic Herb Bacopa monnieri (L.) Pennell
Mondal, S., Bhar, K., Mondal, P., Panigrahi, N., Sahoo, S. K., Swetha, P., Chakraborty, S., Teja, N. Y., & Parveen, N. (2023) · Pharmacognosy Research · doi:10.5530/pres.15.3.045 · Cited by 29 · see citing works
HERBAL MEDICINES AS NEUROPROTECTIVE AGENT: A MECHANISTIC APPROACH
Roy, S., & Awasthi, H. (2017) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2017v9i11.19444 · Cited by 28 · see citing works
Fatima, S., Haque, R., Jadiya, P., Shamsuzzama, S., Kumar, L., & Nazir, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113986 · Cited by 27 · see citing works
Maulik, M., Mitra, S., Basmayor, A. M., Lu, B., Taylor, B. E., & Bult‐Ito, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00207 · Cited by 25 · see citing works
Ali, R., Pal, H. A., Hameed, R., Nazir, A., & Verma, S. K. (2019) · Chemical Communications · doi:10.1039/c9cc05153h · Cited by 24 · see citing works
Sudheer, W. N., Thiruvengadam, M., & Nagella, P. (2022) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2022.2085544 · Cited by 23 · see citing works
Bhardwaj, P., Jain, C. K., & Mathur, A. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12993 · Cited by 23 · see citing works
Wang, W., Wang, X., Gao, W., Cui, Z., Zhang, H., Lu, F., & Liu, F. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.05.045 · Cited by 22 · see citing works
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Dey, A., & De, J. N. (2015) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63460-3.00009-2 · Cited by 22 · see citing works
Dethe, S., Deepak, M., & Agarwal, A. (2016) · Pharmacognosy Magazine · doi:10.4103/0973-1296.191464 · Cited by 21 · see citing works
Save, S. N., & Choudhary, S. (2017) · RSC Advances · doi:10.1039/c6ra28440j · Cited by 21 · see citing works
Naseer, A., Mir, S., Takács-Vellai, K., & Nazir, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212263 · Cited by 11 · see citing works
Goyal, A., Gopika, S., Kumar, A., & Garabadu, D. (2022) · Current Drug Targets · doi:10.2174/1389450123666220316091734 · Cited by 19 · see citing works
Islam, M. R., Jony, M. H., Thufa, G. K., Akash, S., Dhar, P. S., Rahman, M. M., Afroz, T., Ahmed, M., Hemeg, H. A., Rauf, A., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03604-4 · Cited by 20 · see citing works
Saloni, S., Meena, S. K., Rai, D. C., Panda, P., & Kumar, S. (2022) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2022.11.1.14 · Cited by 18 · see citing works
Maulik, M., Mitra, S., Hunter, S., Hunstiger, M., Oliver, S. R., Bult‐Ito, A., & Taylor, B. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-26905-4 · Cited by 18 · see citing works
Krishna, G., Hosamani, R., & Muralidhara (2019) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524919666190115125900 · Cited by 16 · see citing works
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Tang, J., Li, J., Zhou, Q., Kuerban, G., Qin, J., Zhang, H., Sun, R., Yin, L., Pu, Y., & Zhang, J. (2022) · Toxicology · doi:10.1016/j.tox.2022.153211 · Cited by 15 · see citing works
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Charoenphon, N., Anandsongvit, N., Kosai, P., Sirisidthi, K., Kangwanrangsan, N., & Jiraungkoorskul, W. (2016) · Indian Journal of Agricultural Research · doi:10.18805/ijare.v50i1.8582 · Cited by 15 · see citing works
Eze, F. N., Ingkaninan, K., & Prapunpoj, P. (2019) · Biomolecules · doi:10.3390/biom9120845 · Cited by 15 · see citing works
Nandy, S., Mukherjee, A., Pandey, D. K., & Dey, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-1394-7_2 · Cited by 14 · see citing works
An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry
Khan, A. W., Khan, A., Shah, S. M. M., Ullah, A., Faheem, M., & Saleem, M. H. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/6191505 · Cited by 16 · see citing works
He, L., Du, J., Zhou, J., Chen, M.-T., Luo, L., Li, B., Zhang, X., Ma, W., Ma, A., & Feng, N. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.918116 · Cited by 14 · see citing works
RP-HPLC Analysis of Anti-Parkinson’s Drug l-DOPA Content in Mucuna Species from Indian Subcontinent
Patil, R., Aware, C. B., Gaikwad, S., Rajebhosale, M., Bapat, V. A., Yadav, S. R., & Jadhav, J. P. (2019) · Proceedings of the National Academy of Sciences India Section B Biological Sciences · doi:10.1007/s40011-018-01071-9 · Cited by 14 · see citing works
Bacopa monnieri for Disorders Affecting Brain: Current Perspectives
Vinod, A., Sankaran, S., Babu, A. E., Sadanandan, P., Venu, A. K., & Venkidasamy, B. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220119111538 · Cited by 14 · see citing works
Pandey, A. K. (2024) · Advances in Pharmacology and Pharmacy · doi:10.13189/app.2024.120103 · Cited by 13 · see citing works
Jadiya, P., Mir, S. S., & Nazir, A. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.01.027 · Cited by 13 · see citing works
Phytopharmaceuticals and Herbal Approaches to Target Neurodegenerative Disorders
Islam, A., Mishra, A., Ahsan, R., & Fareha, S. (2023) · Drug Research · doi:10.1055/a-2076-7939 · Cited by 13 · see citing works
Wang, Y. A., Snoek, B. L., Sterken, M. G., Riksen, J. A. G., Stastna, J. J., Kammenga, J. E., & Harvey, S. C. (2019) · BMC Genomics · doi:10.1186/s12864-019-5597-1 · Cited by 13 · see citing works
Andersen, N., Veuthey, T., Blanco, M. G., Silbestri, G. F., Rayes, D., & Rosa, M. J. D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.908696 · Cited by 12 · see citing works
Seth, B., Sahoo, K. K., Aravind, K. R., Sahu, B. B., Singh, V., & Patra, N. (2020) · 3 Biotech · doi:10.1007/s13205-020-02258-6 · Cited by 12 · see citing works
Promtang, S., Sanguanphun, T., Chalorak, P., Pe, L. S., Niamnont, N., Sobhon, P., & Meemon, K. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00008 · Cited by 11 · see citing works
Neuroprotective effect of damaurone D in a C. elegans model of Parkinson’s disease
Lee, S. H., Han, Y. T., & Seok, D. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135623 · Cited by 11 · see citing works
Gadhavi, J. D., Patel, M., Bhatia, D. D., & Gupta, S. K. (2021) · Biochimie · doi:10.1016/j.biochi.2021.09.012 · Cited by 11 · see citing works
Bacopa monnieri (Linn.) Pennell - A Possible Plant for Impossible Diseases (A Review)
Pandey, A. K. (2022) · Advances in Pharmacology and Pharmacy · doi:10.13189/app.2022.100104 · Cited by 10 · see citing works
A Comprehensive Review of Therapeutic Compounds from Plants forNeurodegenerative Diseases
Panneerselvam, D. S., Kanakaraja, A., Sakthivelu, M., Gopinath, S. C. B., & Pachaiappan, R. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673272435231204072922 · Cited by 10 · see citing works
Nicotine-mediated therapy for Parkinson’s disease in transgenic Caenorhabditis elegans model
Ullah, I., Zhao, L., Shahab Uddin, M. S., Zhou, Y., Wang, X., & Li, H. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1358141 · Cited by 10 · see citing works
Herbal biomolecules acting on central nervous system
Otimenyin, S. O. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85852-6.00030-5 · Cited by 10 · see citing works
Editorial: Current Trends in Medicinal Plant Research and Neurodegenerative Disorders
Ayaz, M., Ali, T., Sadiq, A., Ullah, F., & Naseer, M. I. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.922373 · Cited by 10 · see citing works
Dadhich, A., Jain, R., & Sharma, M. M. (2024) · Plant Nano Biology · doi:10.1016/j.plana.2024.100133 · Cited by 9 · see citing works
Maqbool, M., Rajvansh, R., Srividya, K., & Hoda, N. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115640 · Cited by 8 · see citing works
Nandy, S., Dey, A., & Mukherjeeb, A. (2019) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817901-7.00015-0 · Cited by 8 · see citing works
- Authors
- Jadiya, P., Khan, A., Sammi, S. R., Kaur, S., Mir, S. S., & Nazir, A.
- Affiliations
- Central Drug Research Institute (IN)
- Integral University (IN)
- Corresponding author
- Nazir, Aamir
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 413
- Issue
- 4
- Pages
- 605-610
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2053230417
- Cited by
- 168
- References
- 40
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 20 · 2022: 21 · 2021: 15 · 2020: 10 · 2019: 19 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 1
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH National Center for Research Resources (NCRR)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Bacopa monnieri, Parkinson's disease, alpha-synuclein aggregation, dopaminergic neuron loss, neuroprotection, Caenorhabditis elegans, transgenic models, lipid content, longevity, dopamine agonist resistance
- MeSH terms
- Animals, Antiparkinson Agents, Disease Models, Animal, Longevity, Parkinson Disease, Plant Extracts, Caenorhabditis elegans, Neuroprotective Agents, Cytoprotection, Animals, Genetically Modified, Bacopa, alpha-Synuclein, Dopaminergic Neurons
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