Bacopa monnieri supplements offset paraquat-induced behavioral phenotype and brain oxidative pathways in mice
Abstract
BACKGROUND: Parkinson's Disease (PD) is characterized by alterations in cerebellum and basal ganglia functioning with corresponding motor deficits and neuropsychiatric symptoms. Involvement of oxidative dysfunction has been implicated for the progression of PD, and environmental neurotoxin exposure could influence such behavior and psychiatric pathology. Assessing dietary supplementation strategies with naturally occurring phytochemicals to reduce behavioral anomalies associated with neurotoxin exposure would have major clinical importance. The present investigation assessed the influence of Bacopa monneri (BM) on behaviors considered to reflect anxiety-like state and motor function as well as selected biochemical changes in brain regions of mice chronically exposed to ecologically relevant herbicide, paraquat (PQ). MATERIALS & METHODS: Male mice (4-week old, Swiss) were daily provided with oral supplements of standardized BM extract (200 mg/kg body weight/day; 3 weeks) and PQ (10 mg/kg, i.p. three times a week; 3 weeks). RESULTS: We found that BM supplementation significantly reversed the PQ-induced reduction of exploratory behavior, gait abnormalities (stride length and mismatch of paw placement) and motor impairment (rotarod performance). In a separate study, BM administration prevented the reduction in dopamine levels and reversed cholinergic activity in brain regions important for motor (striatum) pathology. Further, in mitochondria, PQ-induced decrease in succinate dehydrogenase (SDH) activity and energy charge (MTT reduction), was restored with BM supplementation. CONCLUSION: These findings suggest that BM supplementation mitigates paraquat-induced behavioral deficits and brain oxidative stress in mice. However, further investigations would enable us to identify specific molecular mechanism by which BM influences behavioural pathology.
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Bacopa monnieri supplementation improves symptoms of paraquat treatment of mice in a Parkinson's disease model.
“Furthermore, B.monnieri supplementation improves symptoms of paraquat treatment of mice in a Parkinson’s disease model12”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [12]
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- Authors
- Krishna, G., Hosamani, R., & Muralidhara
- Affiliations
- Central Food Technological Research Institute (IN)
- Department of Biochemistry, Council of Scientific & Industrial Research (CSIR)-Central Food Technological Research Institute (CFTRI), Mysore, Karnataka, India
- Corresponding author
- Krishna, Gokul
- Venue
- Central Nervous System Agents in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2019-03-18
- Volume
- 19
- Issue
- 1
- Pages
- 57-66
- ISSN
- 1568-0150 (ISSN-L)
- 1871-5249
- OpenAlex
- W2909225012
- Cited by
- 16
- References
- 69
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Central Nervous System Agents in Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Surgery › Paraquat toxicity studies and treatments
- Keywords
- Bacopa monnieri, paraquat, Parkinson's disease, oxidative stress, neuroprotection, herbicide neurotoxicity, anxiety-like behavior, motor impairment, dopamine, cholinergic activity, striatum, mitochondria, succinate dehydrogenase
- MeSH terms
- Animals, Brain, Exploratory Behavior, Male, Paraquat, Phenotype, Oxidative Stress, Dietary Supplements, Parkinsonian Disorders, Bacopa, Mice
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