Cited by 16Medicinal Plants and NeuroprotectionParkinson's Disease Mechanisms and TreatmentsParaquat toxicity studies and treatments

Bacopa monnieri supplements offset paraquat-induced behavioral phenotype and brain oxidative pathways in mice

Krishna, Gokul, Hosamani, Ravikumar, Muralidhara·2019·Central Nervous System Agents in Medicinal Chemistry

Abstract

BACKGROUND: Parkinson's Disease (PD) is characterized by alterations in cerebellum and basal ganglia functioning with corresponding motor deficits and neuropsychiatric symptoms. Involvement of oxidative dysfunction has been implicated for the progression of PD, and environmental neurotoxin exposure could influence such behavior and psychiatric pathology. Assessing dietary supplementation strategies with naturally occurring phytochemicals to reduce behavioral anomalies associated with neurotoxin exposure would have major clinical importance. The present investigation assessed the influence of Bacopa monneri (BM) on behaviors considered to reflect anxiety-like state and motor function as well as selected biochemical changes in brain regions of mice chronically exposed to ecologically relevant herbicide, paraquat (PQ). MATERIALS & METHODS: Male mice (4-week old, Swiss) were daily provided with oral supplements of standardized BM extract (200 mg/kg body weight/day; 3 weeks) and PQ (10 mg/kg, i.p. three times a week; 3 weeks). RESULTS: We found that BM supplementation significantly reversed the PQ-induced reduction of exploratory behavior, gait abnormalities (stride length and mismatch of paw placement) and motor impairment (rotarod performance). In a separate study, BM administration prevented the reduction in dopamine levels and reversed cholinergic activity in brain regions important for motor (striatum) pathology. Further, in mitochondria, PQ-induced decrease in succinate dehydrogenase (SDH) activity and energy charge (MTT reduction), was restored with BM supplementation. CONCLUSION: These findings suggest that BM supplementation mitigates paraquat-induced behavioral deficits and brain oxidative stress in mice. However, further investigations would enable us to identify specific molecular mechanism by which BM influences behavioural pathology.

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Crossref · 10.2174/1871524919666190115125900

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Authors
Krishna, G., Hosamani, R., & Muralidhara
Affiliations
  • Central Food Technological Research Institute (IN)
  • Department of Biochemistry, Council of Scientific & Industrial Research (CSIR)-Central Food Technological Research Institute (CFTRI), Mysore, Karnataka, India
Corresponding author
Krishna, Gokul
Venue
Central Nervous System Agents in Medicinal Chemistry
Published
2019-03-18
Volume
19
Issue
1
Pages
57-66
ISSN
  • 1568-0150 (ISSN-L)
  • 1871-5249
OpenAlex
W2909225012
Cited by
16
References
69
Citations by year
2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Locations
  • Central Nervous System Agents in Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Surgery › Paraquat toxicity studies and treatments
Keywords
Bacopa monnieri, paraquat, Parkinson's disease, oxidative stress, neuroprotection, herbicide neurotoxicity, anxiety-like behavior, motor impairment, dopamine, cholinergic activity, striatum, mitochondria, succinate dehydrogenase
MeSH terms
Animals, Brain, Exploratory Behavior, Male, Paraquat, Phenotype, Oxidative Stress, Dietary Supplements, Parkinsonian Disorders, Bacopa, Mice

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