Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor
Abstract
Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression. Most important, we found that AhR antagonist efficiently revert the aging of skin cells. Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application.
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PAH-induced AhR activation reduces cell proliferation and induces apoptosis in keratinocytes and fibroblasts.
“Moreover, AhR influences growth factor modulation, such as epidermal growth factor, and PAH-induced AhR activation reduced cell proliferation and induced apoptosis in keratinocytes and fibroblasts40.”
From Air Pollution and Skin Diseases (2025) · cites this paper as [40]
Fine airborne PM activated the aryl hydrocarbon receptor (AHR) that resulted in detrimental effects on human keratinocytes.
“fine airborne PM activated the aryl hydrocarbon receptor (AHR) that resulted in detrimental effects on human keratinocytes [58,59]”
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- Authors
- Qiao, Y., Li, Q., Du, H.-Y., Wang, Q.-W., Huang, Y., & Liu, W.
- Affiliations
- Air Force General Hospital PLA (CN)
- Capital Medical University (CN)
- Corresponding author
- Liu, Wei
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 488
- Issue
- 3
- Pages
- 445-452
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2615975691
- Semantic Scholar
- 88f6a94a9da84c0db4770a9dfab923065f34aff7
- Cited by
- 53
- References
- 28
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 11 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 5
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (8157120980)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Keywords
- polycyclic aromatic hydrocarbons, skin aging, aryl hydrocarbon receptor, airborne particulate matter, urban dust, cell cycle arrest, apoptosis, ERK signaling, AhR antagonists, age-related gene expression
- MeSH terms
- Cells, Cultured, Dose-Response Relationship, Drug, Humans, Polycyclic Aromatic Hydrocarbons, Structure-Activity Relationship, Skin Aging, Keratinocytes, Apoptosis, Receptors, Aryl Hydrocarbon, Cell Proliferation, Cell Cycle Checkpoints
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